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Clinical Applications of Diabetes Antibody Testing.

Bingley PJ.

J Clin Endocrinol Metab. 2009 Oct 29. [Epub ahead of print]PMID: 19875480 [PubMed - as supplied by publisher]Related articles

Azide and Tween-20 reduce binding to autoantibody epitopes of islet antigen-2; implications for assay performance and reproducibility.

Williams AJ, Somerville M, Rokni S, Bonifacio E, Yu L, Eisenbarth G, Akolkar B, Steffes M, Bingley PJ.

J Immunol Methods. 2009 Dec 31;351(1-2):75-9. Epub 2009 Oct 18.PMID: 19837075 [PubMed - in process]Related articles

Strategies to prevent type 1 diabetes.

Thrower SL, Bingley PJ.

Diabetes Obes Metab. 2009 Oct;11(10):931-8. Epub 2009 May 19.PMID: 19476469 [PubMed - in process]Related articles

The TrialNet Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial results.

Mahon JL, Sosenko JM, Rafkin-Mervis L, Krause-Steinrauf H, Lachin JM, Thompson C, Bingley PJ, Bonifacio E, Palmer JP, Eisenbarth GS, Wolfsdorf J, Skyler JS; TrialNet Natural History Committee; Type 1 Diabetes TrialNet Study Group.

Pediatr Diabetes. 2009 Apr;10(2):97-104. Epub 2008 Sep 24.PMID: 18823409 [PubMed - indexed for MEDLINE]Related articles

Diabetes mellitus among young adults in Sri Lanka--role of GAD antibodies in classification and treatment: the Sri Lanka Young Diabetes study.

Katulanda P, Shine B, Katulanda GW, Silva A, Asfir EL, Sheriff R, Somasundaram N, Long AE, Bingley PJ, McCarthy MI, Clark A, Matthews DR.

Diabetologia. 2008 Aug;51(8):1368-74. Epub 2008 Jun 5.PMID: 18528678 [PubMed - indexed for MEDLINE]Related articles

Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2.

Williams AJ, Aitken RJ, Chandler MA, Gillespie KM, Lampasona V, Bingley PJ.

Diabetologia. 2008 Aug;51(8):1444-8. Epub 2008 May 27.PMID: 18504544 [PubMed - indexed for MEDLINE]Related articles

Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2.

Törn C, Mueller PW, Schlosser M, Bonifacio E, Bingley PJ; Participating Laboratories.

Diabetologia. 2008 May;51(5):846-52. Epub 2008 Mar 29.PMID: 18373080 [PubMed - indexed for MEDLINE]Related articles

Autoantibodies to IA-2beta improve diabetes risk assessment in high-risk relatives.

Achenbach P, Bonifacio E, Williams AJ, Ziegler AG, Gale EA, Bingley PJ; ENDIT Group.

Diabetologia. 2008 Mar;51(3):488-92. Epub 2008 Jan 9.PMID: 18193190 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT).

Bingley PJ, Mahon JL, Gale EA; European Nicotinamide Diabetes Intervention Trial Group.

Diabetes Care. 2008 Jan;31(1):146-50. Epub 2007 Oct 24.PMID: 17959864 [PubMed - indexed for MEDLINE]Related articlesFree article

GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77.

Desai M, Cull CA, Horton VA, Christie MR, Bonifacio E, Lampasona V, Bingley PJ, Levy JC, Mackay IR, Zimmet P, Holman RR, Clark A.

Diabetologia. 2007 Oct;50(10):2052-60. Epub 2007 Jul 27.PMID: 17657474 [PubMed - indexed for MEDLINE]Related articles

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.

Thomson G, Valdes AM, Noble JA, Kockum I, Grote MN, Najman J, Erlich HA, Cucca F, Pugliese A, Steenkiste A, Dorman JS, Caillat-Zucman S, Hermann R, Ilonen J, Lambert AP, Bingley PJ, Gillespie KM, Lernmark A, Sanjeevi CB, Rønningen KS, Undlien DE, Thorsby E, Petrone A, Buzzetti R, Koeleman BP, Roep BO, Saruhan-Direskeneli G, Uyar FA, Günoz H, Gorodezky C, Alaez C, Boehm BO, Mlynarski W, Ikegami H, Berrino M, Fasano ME, Dametto E, Israel S, Brautbar C, Santiago-Cortes A, Frazer de Llado T, She JX, Bugawan TL, Rotter JI, Raffel L, Zeidler A, Leyva-Cobian F, Hawkins BR, Chan SH, Castano L, Pociot F, Nerup J.

Tissue Antigens. 2007 Aug;70(2):110-27.PMID: 17610416 [PubMed - indexed for MEDLINE]Related articles

Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerism.

Nelson JL, Gillespie KM, Lambert NC, Stevens AM, Loubiere LS, Rutledge JC, Leisenring WM, Erickson TD, Yan Z, Mullarkey ME, Boespflug ND, Bingley PJ, Gale EA.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1637-42. Epub 2007 Jan 23.PMID: 17244711 [PubMed - indexed for MEDLINE]Related articlesFree article

Cerebellar ataxia, peripheral neuropathy, "gluten sensitivity" and anti-neuronal autoantibodies.

Lock RJ, Tengah DP, Williams AJ, Ward JJ, Bingley PJ, Wills AJ, Unsworth DJ.

Clin Lab. 2006;52(11-12):589-92.PMID: 17175889 [PubMed - indexed for MEDLINE]Related articles

An association analysis of the HLA gene region in latent autoimmune diabetes in adults.

Desai M, Zeggini E, Horton VA, Owen KR, Hattersley AT, Levy JC, Walker M, Gillespie KM, Bingley PJ, Hitman GA, Holman RR, McCarthy MI, Clark A.

Diabetologia. 2007 Jan;50(1):68-73. Epub 2006 Dec 2.PMID: 17143607 [PubMed - indexed for MEDLINE]Related articles

Islet autoimmunity in children with Down's syndrome.

Gillespie KM, Dix RJ, Williams AJ, Newton R, Robinson ZF, Bingley PJ, Gale EA, Shield JP.

Diabetes. 2006 Nov;55(11):3185-8.PMID: 17065360 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization Program.

Achenbach P, Schlosser M, Williams AJ, Yu L, Mueller PW, Bingley PJ, Bonifacio E.

Clin Immunol. 2007 Jan;122(1):85-90. Epub 2006 Oct 23.PMID: 17059894 [PubMed - indexed for MEDLINE]Related articles

Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives.

Achenbach P, Warncke K, Reiter J, Williams AJ, Ziegler AG, Bingley PJ, Bonifacio E.

Diabetologia. 2006 Dec;49(12):2969-76. Epub 2006 Sep 26.PMID: 17019596 [PubMed - indexed for MEDLINE]Related articles

GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes.

Castleden HA, Shields B, Bingley PJ, Williams AJ, Sampson M, Walker M, Gibson JM, McCarthy MI, Hitman GA, Levy JC, Hattersley AT, Vaidya B, Pearson ER.

Diabet Med. 2006 Aug;23(8):834-8.PMID: 16911619 [PubMed - indexed for MEDLINE]Related articles

Non-specific binding to protein A Sepharose and protein G Sepharose in insulin autoantibody assays may be reduced by pre-treatment with glycine or ethanolamine.

Williams AJ, Norcross AJ, Chandler KA, Bingley PJ.

J Immunol Methods. 2006 Jul 31;314(1-2):170-3. Epub 2006 Jun 28.PMID: 16843481 [PubMed - indexed for MEDLINE]Related articles

HLA genotyping supports a nonautoimmune etiology in patients diagnosed with diabetes under the age of 6 months.

Edghill EL, Dix RJ, Flanagan SE, Bingley PJ, Hattersley AT, Ellard S, Gillespie KM.

Diabetes. 2006 Jun;55(6):1895-8.PMID: 16731860 [PubMed - indexed for MEDLINE]Related articlesFree article

IGF-secreting tumour treated with a combination of growth hormone and glucocorticoids.

Narendran P, Younger T, Au-Yeung A, Bingley PJ.

Clin Endocrinol (Oxf). 2006 May;64(5):596-7. No abstract available. PMID: 16649982 [PubMed - indexed for MEDLINE]Related articles

Progression to type 1 diabetes in islet cell antibody-positive relatives in the European Nicotinamide Diabetes Intervention Trial: the role of additional immune, genetic and metabolic markers of risk.

Bingley PJ, Gale EA; European Nicotinamide Diabetes Intervention Trial (ENDIT) Group.

Diabetologia. 2006 May;49(5):881-90. Epub 2006 Mar 3.PMID: 16514546 [PubMed - indexed for MEDLINE]Related articles

Continuing metformin when starting insulin in patients with Type 2 diabetes: a double-blind randomized placebo-controlled trial.

Douek IF, Allen SE, Ewings P, Gale EA, Bingley PJ; Metformin Trial Group.

Diabet Med. 2005 May;22(5):634-40.PMID: 15842521 [PubMed - indexed for MEDLINE]Related articles

Is puberty an accelerator of type 1 diabetes in IL6-174CC females?

Gillespie KM, Nolsøe R, Betin VM, Kristiansen OP, Bingley PJ, Mandrup-Poulsen T, Gale EA.

Diabetes. 2005 Apr;54(4):1245-8.PMID: 15793269 [PubMed - indexed for MEDLINE]Related articlesFree article

The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes.

Gillespie KM, Bain SC, Barnett AH, Bingley PJ, Christie MR, Gill GV, Gale EA.

Lancet. 2004 Nov 6-12;364(9446):1699-700.PMID: 15530631 [PubMed - indexed for MEDLINE]Related articles

Validation of autoantibody assays in type 1 diabetes: workshop programme.

Bingley PJ, Williams AJ.

Autoimmunity. 2004 Jun;37(4):257-60. Review. No abstract available. PMID: 15518037 [PubMed - indexed for MEDLINE]Related articles

Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom.

Lambert AP, Gillespie KM, Thomson G, Cordell HJ, Todd JA, Gale EA, Bingley PJ.

J Clin Endocrinol Metab. 2004 Aug;89(8):4037-43.PMID: 15292346 [PubMed - indexed for MEDLINE]Related articlesFree article

Mortality of South Asian patients with insulin-treated diabetes mellitus in the United Kingdom: a cohort study.

Swerdlow AJ, Laing SP, Dos Santos Silva I, Slater SD, Burden AC, Botha JL, Waugh NR, Morris AD, Gatling W, Bingley PJ, Patterson CC, Qiao Z, Keen H.

Diabet Med. 2004 Aug;21(8):845-51.PMID: 15270787 [PubMed - indexed for MEDLINE]Related articles

European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes.

Gale EA, Bingley PJ, Emmett CL, Collier T; European Nicotinamide Diabetes Intervention Trial (ENDIT) Group.

Lancet. 2004 Mar 20;363(9413):925-31.PMID: 15043959 [PubMed - indexed for MEDLINE]Related articles

Undiagnosed coeliac disease at age seven: population based prospective birth cohort study.

Bingley PJ, Williams AJ, Norcross AJ, Unsworth DJ, Lock RJ, Ness AR, Jones RW; Avon Longitudinal Study of Parents and Children Study Team.

BMJ. 2004 Feb 7;328(7435):322-3. No abstract available. PMID: 14764493 [PubMed - indexed for MEDLINE]Related articlesFree article

Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics.

Achenbach P, Warncke K, Reiter J, Naserke HE, Williams AJ, Bingley PJ, Bonifacio E, Ziegler AG.

Diabetes. 2004 Feb;53(2):384-92. Erratum in: Diabetes. 2004 Apr;53(4):1175-6. PMID: 14747289 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of intercellular adhesion molecule-1 gene with type 1 diabetes.

Nejentsev S, Guja C, McCormack R, Cooper J, Howson JM, Nutland S, Rance H, Walker N, Undlien D, Ronningen KS, Tuomilehto-Wolf E, Tuomilehto J, Ionescu-Tirgoviste C, Gale EA, Bingley PJ, Gillespie KM, Savage DA, Carson DJ, Patterson CC, Maxwell AP, Todd JA.

Lancet. 2003 Nov 22;362(9397):1723-4.PMID: 14643123 [PubMed - indexed for MEDLINE]Related articles

The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence.

Williams AJ, Norcross AJ, Dix RJ, Gillespie KM, Gale EA, Bingley PJ.

Diabetologia. 2003 Oct;46(10):1354-6. Epub 2003 Sep 9.PMID: 13680123 [PubMed - indexed for MEDLINE]Related articles

Three generations of autoimmune diabetes: an extended family study.

Douek IF, Gillespie KM, Dix RJ, Bingley PJ, Gale EA.

Diabetologia. 2003 Oct;46(10):1313-8. Epub 2003 Jul 30.PMID: 12898004 [PubMed - indexed for MEDLINE]Related articles

Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes.

Laing SP, Swerdlow AJ, Slater SD, Burden AC, Morris A, Waugh NR, Gatling W, Bingley PJ, Patterson CC.

Diabetologia. 2003 Jun;46(6):760-5. Epub 2003 May 28.PMID: 12774166 [PubMed - indexed for MEDLINE]Related articles

Diabetes Antibody Standardization Program: first assay proficiency evaluation.

Bingley PJ, Bonifacio E, Mueller PW.

Diabetes. 2003 May;52(5):1128-36.PMID: 12716742 [PubMed - indexed for MEDLINE]Related articlesFree article

-to: Pani MA, Van Autreve J, Van der Auwera BJ, Gorus FK, Badenhoop K (2002) Non-transmitted maternal HLA DQ2 or DQ8 alleles and risk of Type 1 diabetes in offspring: the importance of foetal or post partum exposure to diabetogenic molecules. Diabetologia 45:1340-1343.

Lambert AP, Gillespie KM, Bingley PJ, Gale EA.

Diabetologia. 2003 Apr;46(4):590-1; author reply 591-2. Epub 2003 Apr 5. No abstract available. PMID: 12679869 [PubMed - indexed for MEDLINE]Related articles

Identifying hepatic nuclear factor 1alpha mutations in children and young adults with a clinical diagnosis of type 1 diabetes.

Lambert AP, Ellard S, Allen LI, Gallen IW, Gillespie KM, Bingley PJ, Hattersley AT.

Diabetes Care. 2003 Feb;26(2):333-7.PMID: 12547858 [PubMed - indexed for MEDLINE]Related articlesFree article

Predicting type 1 diabetes using autoantibodies: the latest results from the diabetes autoantibody standardization program.

Mueller PW, Bingley PJ, Bonifacio E, Steinberg KK, Sampson EJ.

Diabetes Technol Ther. 2002;4(3):397-400. No abstract available. PMID: 12182146 [PubMed - indexed for MEDLINE]Related articles

Diabetes in the parents of children with Type I diabetes.

Douek IF, Gillespie KM, Bingley PJ, Gale EA.

Diabetologia. 2002 Apr;45(4):495-501.PMID: 12032624 [PubMed - indexed for MEDLINE]Related articles

Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens.

Bearzatto M, Naserke H, Piquer S, Koczwara K, Lampasona V, Williams A, Christie MR, Bingley PJ, Ziegler AG, Bonifacio E.

J Immunol. 2002 Apr 15;168(8):4202-8.PMID: 11937581 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet autoantibodies, nationality and gender: a multinational screening study in first-degree relatives of patients with Type I diabetes.

Williams AJ, Bingley PJ, Moore WP, Gale EA; ENDIT Screening Group. European Nicotinamide Diabetes Intervention Trial.

Diabetologia. 2002 Feb;45(2):217-23.PMID: 11935153 [PubMed - indexed for MEDLINE]Related articles

Eczema and Type 1 diabetes.

Douek IF, Leech NJ, Bingley PJ, Gale EA.

Diabet Med. 2002 Feb;19(2):174-5. No abstract available. PMID: 11874437 [PubMed - indexed for MEDLINE]Related articles

High familial risk and genetic susceptibility in early onset childhood diabetes.

Gillespie KM, Gale EA, Bingley PJ.

Diabetes. 2002 Jan;51(1):210-4.PMID: 11756343 [PubMed - indexed for MEDLINE]Related articlesFree article

Reanalysis of twin studies suggests that diabetes is mainly genetic.

Gale EA, Bingley PJ, Eisenbarth GS, Redondo MJ, Kyvik KO, Petersen JS.

BMJ. 2001 Oct 27;323(7319):997-8. No abstract available. PMID: 11679394 [PubMed - indexed for MEDLINE]Related articlesFree article

Proinsulin-specific autoantibodies are relatively infrequent in young offspring with pre-type 1 diabetes.

Hummel M, Williams AJ, Norcross A, Standl E, Bonifacio E, Ziegler AG, Bingley PJ.

Diabetes Care. 2001 Oct;24(10):1843-4. No abstract available. PMID: 11574455 [PubMed - indexed for MEDLINE]Related articlesFree article

Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT).

Schatz DA, Bingley PJ.

J Pediatr Endocrinol Metab. 2001;14 Suppl 1:619-22. Review.PMID: 11393553 [PubMed - indexed for MEDLINE]Related articles

The high prevalence of autoantibodies to tissue transglutaminase in first-degree relatives of patients with type 1 diabetes is not associated with islet autoimmunity.

Williams AJ, Norcross AJ, Lock RJ, Unsworth DJ, Gale EA, Bingley PJ.

Diabetes Care. 2001 Mar;24(3):504-9.PMID: 11289476 [PubMed - indexed for MEDLINE]Related articlesFree article

Proposed guidelines on screening for risk of type 1 diabetes.

Bingley PJ, Bonifacio E, Ziegler AG, Schatz DA, Atkinson MA, Eisenbarth GS; Immunology of Diabetes Society.

Diabetes Care. 2001 Feb;24(2):398. No abstract available. PMID: 11213898 [PubMed - indexed for MEDLINE]Related articlesFree article

A comparison of the prevalence of islet autoantibodies in children from two countries with differing incidence of diabetes.

Marciulionyte D, Williams AJ, Bingley PJ, Urbonaite B, Gale EA.

Diabetologia. 2001 Jan;44(1):16-21.PMID: 11206405 [PubMed - indexed for MEDLINE]Related articles