PubMed

Urinary L-FABP and anaemia: distinct roles of urinary markers in type 2 diabetes.

von Eynatten M, Baumann M, Heemann U, Zdunek D, Hess G, Nawroth PP, Bierhaus A, Humpert PM.

Eur J Clin Invest. 2009 Nov 11. [Epub ahead of print]PMID: 19912308 [PubMed - as supplied by publisher]Related articles

The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival.

Kang R, Tang D, Schapiro NE, Livesey KM, Farkas A, Loughran P, Bierhaus A, Lotze MT, Zeh HJ.

Cell Death Differ. 2009 Oct 16. [Epub ahead of print]PMID: 19834494 [PubMed - as supplied by publisher]Related articles

Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability.

Seehaus S, Shahzad K, Kashif M, Vinnikov IA, Schiller M, Wang H, Madhusudhan T, Eckstein V, Bierhaus A, Bea F, Blessing E, Weiler H, Frommhold D, Nawroth PP, Isermann B.

Circulation. 2009 Sep 1;120(9):774-84. Epub 2009 Aug 17.PMID: 19687358 [PubMed - indexed for MEDLINE]Related articles

Protective Effects and Anti-Inflammatory Pathways of Exogenous Calcitonin Gene-Related Peptide in Severe Necrotizing Pancreatitis.

Schneider L, Hartwig W, Flemming T, Hackert T, Fortunato F, Heck M, Gebhard MM, Nawroth PP, Bierhaus A, Büchler MW, Werner J.

Pancreatology. 2009 Aug 14;9(5):662-669. [Epub ahead of print]PMID: 19684430 [PubMed - as supplied by publisher]Related articles

C. elegans as model for the study of high glucose- mediated life span reduction.

Schlotterer A, Kukudov G, Bozorgmehr F, Hutter H, Du X, Oikonomou D, Ibrahim Y, Pfisterer F, Rabbani N, Thornalley P, Sayed A, Fleming T, Humpert P, Schwenger V, Zeier M, Hamann A, Stern D, Brownlee M, Bierhaus A, Nawroth P, Morcos M.

Diabetes. 2009 Nov;58(11):2450-6. Epub 2009 Aug 12.PMID: 19675139 [PubMed - in process]Related articles

Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications.

Bierhaus A, Nawroth PP.

Diabetologia. 2009 Nov;52(11):2251-63. Epub 2009 Jul 28.PMID: 19636529 [PubMed - in process]Related articles

Receptor for advanced glycation end products facilitates host defense during Escherichia coli-induced abdominal sepsis in mice.

van Zoelen MA, Schmidt AM, Florquin S, Meijers JC, de Beer R, de Vos AF, Nawroth PP, Bierhaus A, van der Poll T.

J Infect Dis. 2009 Sep 1;200(5):765-73. Erratum in: J Infect Dis. 2009 Nov 15;200(10):1629. PMID: 19627249 [PubMed - indexed for MEDLINE]Related articles

Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia.

van Zoelen MA, van der Sluijs KF, Achouiti A, Florquin S, Braun-Pater JM, Yang H, Nawroth PP, Tracey KJ, Bierhaus A, van der Poll T.

Virology. 2009 Sep 1;391(2):265-73. Epub 2009 Jul 9.PMID: 19592063 [PubMed - indexed for MEDLINE]Related articles

Receptors for Advanced Glycation End-products (RAGE) Targeting Protect against Hyperoxia-Induced Lung Injury in Mice.

Reynolds PR, Schmitt RE, Kasteler SD, Sturrock A, Sanders K, Bierhaus A, Nawroth PP, Paine Iii R, Hoidal JR.

Am J Respir Cell Mol Biol. 2009 Jun 25. [Epub ahead of print]PMID: 19541845 [PubMed - as supplied by publisher]Related articles

Urinary adiponectin excretion: a novel marker for vascular damage in type 2 diabetes.

von Eynatten M, Liu D, Hock C, Oikonomou D, Baumann M, Allolio B, Korosoglou G, Morcos M, Campean V, Amann K, Lutz J, Heemann U, Nawroth PP, Bierhaus A, Humpert PM.

Diabetes. 2009 Sep;58(9):2093-9. Epub 2009 Jun 9.PMID: 19509019 [PubMed - indexed for MEDLINE]Related articles

[The unsolved problem of diabetes mellitus type 2 and associated complications]

Morcos M, Humpert P, Bierhaus A, Nawroth P.

Chirurg. 2009 May;80(5):398, 400-4, 406-9. Review. German. PMID: 19440747 [PubMed - indexed for MEDLINE]Related articles

AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis.

Humpert PM, Lukic IK, Thorpe SR, Hofer S, Awad EM, Andrassy M, Deemer EK, Kasper M, Schleicher E, Schwaninger M, Weigand MA, Nawroth PP, Bierhaus A.

J Leukoc Biol. 2009 Sep;86(3):589-97. Epub 2009 Apr 28.PMID: 19401390 [PubMed - indexed for MEDLINE]Related articles

RAGE and Alzheimer's disease: a progression factor for amyloid-beta-induced cellular perturbation?

Yan SD, Bierhaus A, Nawroth PP, Stern DM.

J Alzheimers Dis. 2009 Apr;16(4):833-43. Review.PMID: 19387116 [PubMed - indexed for MEDLINE]Related articles

Reactive oxygen species in diabetes-induced vascular damage, stroke, and Alzheimer's disease.

Muhammad S, Bierhaus A, Schwaninger M.

J Alzheimers Dis. 2009 Apr;16(4):775-85. Review.PMID: 19387112 [PubMed - indexed for MEDLINE]Related articles

The Alzheimer's disease-diabetes angle: inevitable fate of aging or metabolic imbalance limiting successful aging. Preface.

Bierhaus A, Nawroth PP.

J Alzheimers Dis. 2009 Apr;16(4):673-5. No abstract available. PMID: 19387103 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of homozygous SDF-1 3'A genotype with proliferative diabetic retinopathy.

Djuric Z, Sharei V, Rudofsky G, Morcos M, Li H, Hammes HP, Nawroth PP, Bierhaus A, Humpert PM, Jonas JB.

Acta Diabetol. 2009 Apr 21. [Epub ahead of print]PMID: 19381432 [PubMed - as supplied by publisher]Related articles

Skin-autofluorescence is an independent predictor of graft loss in renal transplant recipients.

Hartog JW, Gross S, Oterdoom LH, van Ree RM, de Vries AP, Smit AJ, Schouten JP, Nawroth PP, Gans RO, van Son WJ, Bierhaus A, Bakker SJ.

Transplantation. 2009 Apr 15;87(7):1069-77.PMID: 19352130 [PubMed - indexed for MEDLINE]Related articles

The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia.

van Zoelen MA, Schouten M, de Vos AF, Florquin S, Meijers JC, Nawroth PP, Bierhaus A, van der Poll T.

J Immunol. 2009 Apr 1;182(7):4349-56.PMID: 19299735 [PubMed - indexed for MEDLINE]Related articles

Endothelial precursor cells and CRP on the RAGE: activation or cell death?

Yan SD, Bierhaus A, Nawroth PP, Stern DM.

J Cardiovasc Pharmacol. 2009 May;53(5):349-51. No abstract available. PMID: 19276986 [PubMed - indexed for MEDLINE]Related articles

Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo.

van Zoelen MA, Yang H, Florquin S, Meijers JC, Akira S, Arnold B, Nawroth PP, Bierhaus A, Tracey KJ, van der Poll T.

Shock. 2009 Mar;31(3):280-4.PMID: 19218854 [PubMed - indexed for MEDLINE]Related articles

External electric muscle stimulation improves burning sensations and sleeping disturbances in patients with type 2 diabetes and symptomatic neuropathy.

Humpert PM, Morcos M, Oikonomou D, Schaefer K, Hamann A, Bierhaus A, Schilling T, Nawroth PP.

Pain Med. 2009 Mar;10(2):413-9. Epub 2009 Jan 16.PMID: 19207234 [PubMed - in process]Related articles

Central sympatholytics prolong survival in experimental sepsis.

Hofer S, Steppan J, Wagner T, Funke B, Lichtenstern C, Martin E, Graf BM, Bierhaus A, Weigand MA.

Crit Care. 2009;13(1):R11. Epub 2009 Feb 6.PMID: 19196475 [PubMed - in process]Related articlesFree article

RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes.

Coughlan MT, Thorburn DR, Penfold SA, Laskowski A, Harcourt BE, Sourris KC, Tan AL, Fukami K, Thallas-Bonke V, Nawroth PP, Brownlee M, Bierhaus A, Cooper ME, Forbes JM.

J Am Soc Nephrol. 2009 Apr;20(4):742-52. Epub 2009 Jan 21.PMID: 19158353 [PubMed - indexed for MEDLINE]Related articles

The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complications.

Rudofsky G Jr, Schlotterer A, Reismann P, Engel J, Grafe IA, Tafel J, Morcos M, Humpert PM, Nawroth P, Bierhaus A, Hamann A.

Horm Metab Res. 2009 Apr;41(4):308-13. Epub 2009 Jan 12.PMID: 19140096 [PubMed - indexed for MEDLINE]Related articles

The HMGB1 receptor RAGE mediates ischemic brain damage.

Muhammad S, Barakat W, Stoyanov S, Murikinati S, Yang H, Tracey KJ, Bendszus M, Rossetti G, Nawroth PP, Bierhaus A, Schwaninger M.

J Neurosci. 2008 Nov 12;28(46):12023-31.PMID: 19005067 [PubMed - indexed for MEDLINE]Related articlesFree article

Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases.

Zhang L, Bukulin M, Kojro E, Roth A, Metz VV, Fahrenholz F, Nawroth PP, Bierhaus A, Postina R.

J Biol Chem. 2008 Dec 19;283(51):35507-16. Epub 2008 Oct 24.PMID: 18952609 [PubMed - indexed for MEDLINE]Related articles

Determinants of the NF-kappaB response to acute psychosocial stress in humans.

Wolf JM, Rohleder N, Bierhaus A, Nawroth PP, Kirschbaum C.

Brain Behav Immun. 2009 Aug;23(6):742-9. Epub 2008 Sep 26.PMID: 18848620 [PubMed - indexed for MEDLINE]Related articles

Changes in adiponectin multimer distribution in response to atorvastatin treatment in patients with type 2 diabetes.

von Eynatten M, Liu D, Bluemm A, Schuster T, Baumann M, Lutz J, Heemann U, Dugi KA, Nawroth PP, Bierhaus A, Humpert PM.

Clin Endocrinol (Oxf). 2009 Jul;71(1):27-32.PMID: 18778396 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone reduces angiotensin II and advanced glycation end product-dependent sustained nuclear factor-kappaB activation in cultured human proximal tubular epithelial cells.

Morcos M, Schlotterer A, Sayed AA, Kukudov G, Oikomonou D, Ibrahim Y, Pfisterer F, Schneider J, Bozorgmehr F, Rudofsky G Jr, Schwenger V, Kientsch-Engels R, Hamann A, Zeier M, Dugi K, Yard B, Humpert PM, van der Woude F, Nawroth PP, Bierhaus A.

Horm Metab Res. 2008 Nov;40(11):752-9. Epub 2008 Aug 18.PMID: 18711692 [PubMed - indexed for MEDLINE]Related articles

RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis.

Turovskaya O, Foell D, Sinha P, Vogl T, Newlin R, Nayak J, Nguyen M, Olsson A, Nawroth PP, Bierhaus A, Varki N, Kronenberg M, Freeze HH, Srikrishna G.

Carcinogenesis. 2008 Oct;29(10):2035-43. Epub 2008 Aug 9.PMID: 18689872 [PubMed - indexed for MEDLINE]Related articlesFree article

ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS (RAGE) IN HMGB1 INDUCED INFLAMMATION IN VIVO.

van Zoelen MA, Yang H, Florquin S, Meijers JC, Akira S, Arnold B, Nawroth PP, Bierhaus A, Tracey KJ, van der Poll T.

Shock. 2008 Jul 24. [Epub ahead of print]PMID: 18665043 [PubMed - as supplied by publisher]Related articles

A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10).

Raucci A, Cugusi S, Antonelli A, Barabino SM, Monti L, Bierhaus A, Reiss K, Saftig P, Bianchi ME.

FASEB J. 2008 Oct;22(10):3716-27. Epub 2008 Jul 4.PMID: 18603587 [PubMed - indexed for MEDLINE]Related articlesFree article

High-mobility group box-1 in ischemia-reperfusion injury of the heart.

Andrassy M, Volz HC, Igwe JC, Funke B, Eichberger SN, Kaya Z, Buss S, Autschbach F, Pleger ST, Lukic IK, Bea F, Hardt SE, Humpert PM, Bianchi ME, Mairbäurl H, Nawroth PP, Remppis A, Katus HA, Bierhaus A.

Circulation. 2008 Jun 24;117(25):3216-26.PMID: 18574060 [PubMed - indexed for MEDLINE]Related articlesFree article

Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes.

Soro-Paavonen A, Watson AM, Li J, Paavonen K, Koitka A, Calkin AC, Barit D, Coughlan MT, Drew BG, Lancaster GI, Thomas M, Forbes JM, Nawroth PP, Bierhaus A, Cooper ME, Jandeleit-Dahm KA.

Diabetes. 2008 Sep;57(9):2461-9. Epub 2008 May 28.PMID: 18511846 [PubMed - indexed for MEDLINE]Related articlesFree article

Aryl hydrocarbon receptor interacting protein gene (AIP) mutations are rare in patients with hormone secreting or non-secreting pituitary adenomas.

Buchbinder S, Bierhaus A, Zorn M, Nawroth PP, Humpert P, Schilling T.

Exp Clin Endocrinol Diabetes. 2008 Nov;116(10):625-8. Epub 2008 May 16.PMID: 18484068 [PubMed - indexed for MEDLINE]Related articles

Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs.

Tikellis C, Thomas MC, Harcourt BE, Coughlan MT, Pete J, Bialkowski K, Tan A, Bierhaus A, Cooper ME, Forbes JM.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E323-30. Epub 2008 May 13.PMID: 18477705 [PubMed - indexed for MEDLINE]Related articlesFree article

RAGE expression in the human peritoneal membrane.

Kihm LP, Wibisono D, Müller-Krebs S, Pfisterer F, Morath C, Gross ML, Morcos M, Seregin Y, Bierhaus A, Nawroth PP, Zeier M, Schwenger V.

Nephrol Dial Transplant. 2008 Oct;23(10):3302-6. Epub 2008 May 13.PMID: 18477569 [PubMed - indexed for MEDLINE]Related articles

The RAGE pathway: activation and perpetuation in the pathogenesis of diabetic neuropathy.

Lukic IK, Humpert PM, Nawroth PP, Bierhaus A.

Ann N Y Acad Sci. 2008 Apr;1126:76-80.PMID: 18448798 [PubMed - indexed for MEDLINE]Related articles

Receptor for advanced glycation end product expression in experimental diabetic retinopathy.

Wang Y, Vom Hagen F, Pfister F, Bierhaus A, Feng Y, Gans R, Hammes HP.

Ann N Y Acad Sci. 2008 Apr;1126:42-5.PMID: 18448794 [PubMed - indexed for MEDLINE]Related articles

Impact of autonomic neuropathy on left ventricular function in normotensive type 1 diabetic patients: a tissue Doppler echocardiographic study: response to Karamitsos et al.

Humpert PM, Oikonomou D, Morcos M, Kuecherer H, Schilling T, Bierhaus A, Nawroth PP, Katus HA, Korosoglou G.

Diabetes Care. 2008 May;31(5):e40; author reply e41. No abstract available. PMID: 18445720 [PubMed - indexed for MEDLINE]Related articlesFree article

Inactivation of AP1 proteins by a nuclear serine protease precedes the onset of radiation-induced fibrosing alveolitis.

Haase MG, Klawitter A, Bierhaus A, Yokoyama KK, Kasper M, Geyer P, Baumann M, Baretton GB.

Radiat Res. 2008 May;169(5):531-42.PMID: 18439036 [PubMed - indexed for MEDLINE]Related articles

Insulin stimulates the clonogenic potential of angiogenic endothelial progenitor cells by IGF-1 receptor-dependent signaling.

Humpert PM, Djuric Z, Zeuge U, Oikonomou D, Seregin Y, Laine K, Eckstein V, Nawroth PP, Bierhaus A.

Mol Med. 2008 May-Jun;14(5-6):301-8.PMID: 18309377 [PubMed - indexed for MEDLINE]Related articlesFree article

Maturing dendritic cells depend on RAGE for in vivo homing to lymph nodes.

Manfredi AA, Capobianco A, Esposito A, De Cobelli F, Canu T, Monno A, Raucci A, Sanvito F, Doglioni C, Nawroth PP, Bierhaus A, Bianchi ME, Rovere-Querini P, Del Maschio A.

J Immunol. 2008 Feb 15;180(4):2270-5.PMID: 18250435 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis.

Englert JM, Hanford LE, Kaminski N, Tobolewski JM, Tan RJ, Fattman CL, Ramsgaard L, Richards TJ, Loutaev I, Nawroth PP, Kasper M, Bierhaus A, Oury TD.

Am J Pathol. 2008 Mar;172(3):583-91. Epub 2008 Feb 2.PMID: 18245812 [PubMed - indexed for MEDLINE]Related articlesFree article

Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis.

Bopp C, Bierhaus A, Hofer S, Bouchon A, Nawroth PP, Martin E, Weigand MA.

Crit Care. 2008;12(1):201. Epub 2008 Jan 9. Review.PMID: 18226173 [PubMed - indexed for MEDLINE]Related articlesFree article

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans.

Morcos M, Du X, Pfisterer F, Hutter H, Sayed AA, Thornalley P, Ahmed N, Baynes J, Thorpe S, Kukudov G, Schlotterer A, Bozorgmehr F, El Baki RA, Stern D, Moehrlen F, Ibrahim Y, Oikonomou D, Hamann A, Becker C, Zeier M, Schwenger V, Miftari N, Humpert P, Hammes HP, Buechler M, Bierhaus A, Brownlee M, Nawroth PP.

Aging Cell. 2008 Mar;7(2):260-9. Epub 2008 Jan 21.PMID: 18221415 [PubMed - indexed for MEDLINE]Related articles

RAGE signaling sustains inflammation and promotes tumor development.

Gebhardt C, Riehl A, Durchdewald M, Németh J, Fürstenberger G, Müller-Decker K, Enk A, Arnold B, Bierhaus A, Nawroth PP, Hess J, Angel P.

J Exp Med. 2008 Feb 18;205(2):275-85. Epub 2008 Jan 21.PMID: 18208974 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical benefit of a short term dietary oatmeal intervention in patients with type 2 diabetes and severe insulin resistance: a pilot study.

Lammert A, Kratzsch J, Selhorst J, Humpert PM, Bierhaus A, Birck R, Kusterer K, Hammes HP.

Exp Clin Endocrinol Diabetes. 2008 Feb;116(2):132-4. Epub 2007 Dec 20.PMID: 18095234 [PubMed - indexed for MEDLINE]Related articles

Pharmacologic cholinesterase inhibition improves survival in experimental sepsis.

Hofer S, Eisenbach C, Lukic IK, Schneider L, Bode K, Brueckmann M, Mautner S, Wente MN, Encke J, Werner J, Dalpke AH, Stremmel W, Nawroth PP, Martin E, Krammer PH, Bierhaus A, Weigand MA.

Crit Care Med. 2008 Feb;36(2):404-8.PMID: 18091537 [PubMed - indexed for MEDLINE]Related articles

The DG10S478 variant in the TCF7L2 gene is not associated with microvascular complications in type 2 diabetes.

Buchbinder S, Rudofsky G Jr, Humpert PM, Schilling T, Zorn M, Bierhaus A, Nawroth PP.

Exp Clin Endocrinol Diabetes. 2008 Apr;116(4):211-4. Epub 2007 Dec 10.PMID: 18072015 [PubMed - indexed for MEDLINE]Related articles