PubMed

Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry.

Bielawski J, Pierce JS, Snider J, Rembiesa B, Szulc ZM, Bielawska A.

Methods Mol Biol. 2009;579:443-67.PMID: 19763489 [PubMed - in process]Related articles

Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.

Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B.

FASEB J. 2009 Sep 1. [Epub ahead of print]PMID: 19723703 [PubMed - as supplied by publisher]Related articles

Reconciling ecological and genomic divergence among lineages of listeria under an "extended mosaic genome concept".

Dunn KA, Bielawski JP, Ward TJ, Urquhart C, Gu H.

Mol Biol Evol. 2009 Nov;26(11):2605-15. Epub 2009 Aug 10.PMID: 19666992 [PubMed - in process]Related articles

Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism.

Gustafsson K, Sander B, Bielawski J, Hannun YA, Flygare J.

Mol Cancer Res. 2009 Jul;7(7):1086-98.PMID: 19609004 [PubMed - in process]Related articles

AMPK inhibitor compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.

Jin J, Mullen TD, Hou Q, Bielawski J, Bielawska A, Zhang X, Obeid LM, Hannun YA, Hsu YT.

J Lipid Res. 2009 Jun 15. [Epub ahead of print]PMID: 19528633 [PubMed - as supplied by publisher]Related articlesFree article

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome.

Yang G, Badeanlou L, Bielawski J, Roberts AJ, Hannun YA, Samad F.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E211-24. Epub 2009 May 12.PMID: 19435851 [PubMed - indexed for MEDLINE]Related articles

Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.

Hu W, Bielawski J, Samad F, Merrill AH Jr, Cowart LA.

J Lipid Res. 2009 Apr 15. [Epub ahead of print]PMID: 19369694 [PubMed - as supplied by publisher]Related articlesFree article

Trade-offs between efficiency and robustness in bacterial metabolic networks are associated with niche breadth.

Morine MJ, Gu H, Myers RA, Bielawski JP.

J Mol Evol. 2009 May;68(5):506-15. Epub 2009 Apr 14.PMID: 19365645 [PubMed - indexed for MEDLINE]Related articles

Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas.

Separovic D, Bielawski J, Pierce JS, Merchant S, Tarca AL, Ogretmen B, Korbelik M.

Br J Cancer. 2009 Feb 24;100(4):626-32.PMID: 19223911 [PubMed - indexed for MEDLINE]Related articles

Synthesis and bioevaluation of omega-N-amino analogs of B13.

Bai A, Szulc ZM, Bielawski J, Mayroo N, Liu X, Norris J, Hannun YA, Bielawska A.

Bioorg Med Chem. 2009 Mar 1;17(5):1840-8. Epub 2009 Jan 31.PMID: 19217788 [PubMed - indexed for MEDLINE]Related articles

Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.

Mahdy AE, Cheng JC, Li J, Elojeimy S, Meacham WD, Turner LS, Bai A, Gault CR, McPherson AS, Garcia N, Beckham TH, Saad A, Bielawska A, Bielawski J, Hannun YA, Keane TE, Taha MI, Hammouda HM, Norris JS, Liu X.

Mol Ther. 2009 Mar;17(3):430-8. Epub 2008 Dec 23.PMID: 19107118 [PubMed - indexed for MEDLINE]Related articles

Multilocus genotyping assays for single nucleotide polymorphism-based subtyping of Listeria monocytogenes isolates.

Ward TJ, Ducey TF, Usgaard T, Dunn KA, Bielawski JP.

Appl Environ Microbiol. 2008 Dec;74(24):7629-42. Epub 2008 Oct 17.PMID: 18931295 [PubMed - indexed for MEDLINE]Related articlesFree article

Role for sphingosine kinase 1 in colon carcinogenesis.

Kawamori T, Kaneshiro T, Okumura M, Maalouf S, Uflacker A, Bielawski J, Hannun YA, Obeid LM.

FASEB J. 2009 Feb;23(2):405-14. Epub 2008 Sep 29.PMID: 18824518 [PubMed - indexed for MEDLINE]Related articles

Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function.

Ponnusamy S, Alderson NL, Hama H, Bielawski J, Jiang JC, Bhandari R, Snyder SH, Jazwinski SM, Ogretmen B.

J Biol Chem. 2008 Oct 10;283(41):27514-24. Epub 2008 Aug 11.PMID: 18694931 [PubMed - indexed for MEDLINE]Related articlesFree article

Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells.

Jin J, Hou Q, Mullen TD, Zeidan YH, Bielawski J, Kraveka JM, Bielawska A, Obeid LM, Hannun YA, Hsu YT.

J Biol Chem. 2008 Sep 26;283(39):26509-17. Epub 2008 Aug 1.PMID: 18676372 [PubMed - indexed for MEDLINE]Related articlesFree article

Portal protein diversity and phage ecology.

Sullivan MB, Coleman ML, Quinlivan V, Rosenkrantz JE, Defrancesco AS, Tan G, Fu R, Lee JA, Waterbury JB, Bielawski JP, Chisholm SW.

Environ Microbiol. 2008 Oct;10(10):2810-23. Epub 2008 Jul 31.PMID: 18673386 [PubMed - indexed for MEDLINE]Related articlesFree article

Likelihood-based clustering (LiBaC) for codon models, a method for grouping sites according to similarities in the underlying process of evolution.

Bao L, Gu H, Dunn KA, Bielawski JP.

Mol Biol Evol. 2008 Sep;25(9):1995-2007. Epub 2008 Jun 26.PMID: 18586695 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice.

Pata MO, Wu BX, Bielawski J, Xiong TC, Hannun YA, Ng CK.

Plant J. 2008 Sep;55(6):1000-9. Epub 2008 Jun 10.PMID: 18547394 [PubMed - indexed for MEDLINE]Related articles

Modulation of total ceramide and constituent ceramide species in the acutely and chronically hypoxic mouse heart at different ages.

Noureddine L, Azzam R, Nemer G, Bielawski J, Nasser M, Bitar F, Dbaibo GS.

Prostaglandins Other Lipid Mediat. 2008 Jun;86(1-4):49-55. Epub 2008 Mar 4.PMID: 18400538 [PubMed - indexed for MEDLINE]Related articles

De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.

Panjarian S, Kozhaya L, Arayssi S, Yehia M, Bielawski J, Bielawska A, Usta J, Hannun YA, Obeid LM, Dbaibo GS.

Prostaglandins Other Lipid Mediat. 2008 Jun;86(1-4):41-8. Epub 2008 Mar 4.PMID: 18400537 [PubMed - indexed for MEDLINE]Related articles

Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage.

Separovic D, Semaan L, Tarca AL, Awad Maitah MY, Hanada K, Bielawski J, Villani M, Luberto C.

Exp Cell Res. 2008 May 1;314(8):1860-8. Epub 2008 Feb 29.PMID: 18374917 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.

Shah C, Yang G, Lee I, Bielawski J, Hannun YA, Samad F.

J Biol Chem. 2008 May 16;283(20):13538-48. Epub 2008 Mar 22.PMID: 18359942 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis.

Shi L, Bielawski J, Mu J, Dong H, Teng C, Zhang J, Yang X, Tomishige N, Hanada K, Hannun YA, Zuo J.

Cell Res. 2007 Dec;17(12):1030-40. Erratum in: Cell Res. 2008 Feb;18(2):324. PMID: 18059378 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthetic triterpenoids have cytotoxicity in pediatric acute lymphoblastic leukemia cell lines but cytotoxicity is independent of induced ceramide increase in MOLT-4 cells.

Kong G, Wang D, Wang H, Wu J, Bielawski J, Konopleva M, Andreeff M, Ruvolo PP, Maurer BJ.

Leukemia. 2008 Jun;22(6):1258-62. Epub 2007 Nov 22. No abstract available. PMID: 18033322 [PubMed - indexed for MEDLINE]Related articles

Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice.

Dahm F, Bielawska A, Nocito A, Georgiev P, Szulc ZM, Bielawski J, Jochum W, Dindo D, Hannun YA, Clavien PA.

Br J Cancer. 2008 Jan 15;98(1):98-105. Epub 2007 Nov 20.PMID: 18026195 [PubMed - indexed for MEDLINE]Related articlesFree article

Acid ceramidase inhibition: a novel target for cancer therapy.

Liu X, Elojeimy S, Turner LS, Mahdy AE, Zeidan YH, Bielawska A, Bielawski J, Dong JY, El-Zawahry AM, Guo GW, Hannun YA, Holman DH, Rubinchik S, Szulc Z, Keane TE, Tavassoli M, Norris JS.

Front Biosci. 2008 Jan 1;13:2293-8. Review.PMID: 17981711 [PubMed - indexed for MEDLINE]Related articles

Combination of C(17) sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism.

Spassieva S, Bielawski J, Anelli V, Obeid LM.

Methods Enzymol. 2007;434:233-41.PMID: 17954250 [PubMed - indexed for MEDLINE]Related articles

Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice.

Mizugishi K, Li C, Olivera A, Bielawski J, Bielawska A, Deng CX, Proia RL.

J Clin Invest. 2007 Oct;117(10):2993-3006.PMID: 17885683 [PubMed - indexed for MEDLINE]Related articlesFree article

The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy.

Saad AF, Meacham WD, Bai A, Anelli V, Elojeimy S, Mahdy AE, Turner LS, Cheng J, Bielawska A, Bielawski J, Keane TE, Obeid LM, Hannun YA, Norris JS, Liu X.

Cancer Biol Ther. 2007 Sep;6(9):1455-60. Epub 2007 Jun 23.PMID: 17881906 [PubMed - indexed for MEDLINE]Related articles

Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids.

Bielawska A, Bielawski J, Szulc ZM, Mayroo N, Liu X, Bai A, Elojeimy S, Rembiesa B, Pierce J, Norris JS, Hannun YA.

Bioorg Med Chem. 2008 Jan 15;16(2):1032-45. Epub 2007 Aug 24. Erratum in: Bioorg Med Chem. 2008 Apr 1;16(7):4187. PMID: 17881234 [PubMed - indexed for MEDLINE]Related articlesFree article

Isc1 regulates sphingolipid metabolism in yeast mitochondria.

Kitagaki H, Cowart LA, Matmati N, Vaena de Avalos S, Novgorodov SA, Zeidan YH, Bielawski J, Obeid LM, Hannun YA.

Biochim Biophys Acta. 2007 Nov;1768(11):2849-61. Epub 2007 Aug 10.PMID: 17880915 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.

Szulc ZM, Mayroo N, Bai A, Bielawski J, Liu X, Norris JS, Hannun YA, Bielawska A.

Bioorg Med Chem. 2008 Jan 15;16(2):1015-31. Epub 2007 Aug 24. Erratum in: Bioorg Med Chem. 2008 Apr 1;16(7):4186. PMID: 17869115 [PubMed - indexed for MEDLINE]Related articlesFree article

Phylogenomic analysis of natural selection pressure in Streptococcus genomes.

Anisimova M, Bielawski J, Dunn K, Yang Z.

BMC Evol Biol. 2007 Aug 30;7:154.PMID: 17760998 [PubMed - indexed for MEDLINE]Related articlesFree article

Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes.

Sun W, Xu R, Hu W, Jin J, Crellin HA, Bielawski J, Szulc ZM, Thiers BH, Obeid LM, Mao C.

J Invest Dermatol. 2008 Feb;128(2):389-97. Epub 2007 Aug 23.PMID: 17713573 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.

D'Angelo G, Polishchuk E, Di Tullio G, Santoro M, Di Campli A, Godi A, West G, Bielawski J, Chuang CC, van der Spoel AC, Platt FM, Hannun YA, Polishchuk R, Mattjus P, De Matteis MA.

Nature. 2007 Sep 6;449(7158):62-7. Epub 2007 Aug 8.PMID: 17687330 [PubMed - indexed for MEDLINE]Related articles

Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis.

Karahatay S, Thomas K, Koybasi S, Senkal CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D, Norris JS, Hannun YA, Ogretmen B.

Cancer Lett. 2007 Oct 18;256(1):101-11. Epub 2007 Jul 9.PMID: 17619081 [PubMed - indexed for MEDLINE]Related articlesFree article

JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction.

Yu J, Novgorodov SA, Chudakova D, Zhu H, Bielawska A, Bielawski J, Obeid LM, Kindy MS, Gudz TI.

J Biol Chem. 2007 Aug 31;282(35):25940-9. Epub 2007 Jul 3.PMID: 17609208 [PubMed - indexed for MEDLINE]Related articlesFree article

Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage.

Separovic D, Hanada K, Maitah MY, Nagy B, Hang I, Tainsky MA, Kraniak JM, Bielawski J.

Biochem Biophys Res Commun. 2007 Jun 22;358(1):196-202. Epub 2007 Apr 23.PMID: 17467659 [PubMed - indexed for MEDLINE]Related articlesFree article

Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells.

Holman DH, Turner LS, El-Zawahry A, Elojeimy S, Liu X, Bielawski J, Szulc ZM, Norris K, Zeidan YH, Hannun YA, Bielawska A, Norris JS.

Cancer Chemother Pharmacol. 2008 Feb;61(2):231-42. Epub 2007 Apr 12.PMID: 17429631 [PubMed - indexed for MEDLINE]Related articles

Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells.

Baran Y, Salas A, Senkal CE, Gunduz U, Bielawski J, Obeid LM, Ogretmen B.

J Biol Chem. 2007 Apr 13;282(15):10922-34. Epub 2007 Feb 15.PMID: 17303574 [PubMed - indexed for MEDLINE]Related articlesFree article

Methods for selecting fixed-effect models for heterogeneous codon evolution, with comments on their application to gene and genome data.

Bao L, Gu H, Dunn KA, Bielawski JP.

BMC Evol Biol. 2007 Feb 8;7 Suppl 1:S5.PMID: 17288578 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.

Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A.

J Biol Chem. 2007 Jun 8;282(23):16718-28. Epub 2007 Feb 5.PMID: 17283068 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration.

Novgorodov AS, El-Alwani M, Bielawski J, Obeid LM, Gudz TI.

FASEB J. 2007 May;21(7):1503-14. Epub 2007 Jan 25.PMID: 17255471 [PubMed - indexed for MEDLINE]Related articlesFree article

Proposed standard nomenclature for the alpha- and beta-globin gene families.

Aguileta G, Bielawski JP, Yang Z.

Genes Genet Syst. 2006 Oct;81(5):367-71.PMID: 17159299 [PubMed - indexed for MEDLINE]Related articlesFree article

[News in treatments of bone fractures on the beginning of XXI century]

Bielawski J.

Chir Narzadow Ruchu Ortop Pol. 2006;71(1):77. Polish. No abstract available. PMID: 17128779 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha TA, Jenkins RW, Senkal CE, Ogretmen B, Obeid LM, Hannun YA.

J Biol Chem. 2006 Dec 1;281(48):36793-802. Epub 2006 Oct 9.PMID: 17030510 [PubMed - indexed for MEDLINE]Related articlesFree article

Distribution and dynamic changes of sphingolipids in blood in response to platelet activation.

Dahm F, Nocito A, Bielawska A, Lang KS, Georgiev P, Asmis LM, Bielawski J, Madon J, Hannun YA, Clavien PA.

J Thromb Haemost. 2006 Dec;4(12):2704-9. Epub 2006 Sep 28.PMID: 17010150 [PubMed - indexed for MEDLINE]Related articles

Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity.

Spassieva S, Seo JG, Jiang JC, Bielawski J, Alvarez-Vasquez F, Jazwinski SM, Hannun YA, Obeid LM.

J Biol Chem. 2006 Nov 10;281(45):33931-8. Epub 2006 Sep 1.PMID: 16951403 [PubMed - indexed for MEDLINE]Related articlesFree article

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P.

Xu R, Jin J, Hu W, Sun W, Bielawski J, Szulc Z, Taha T, Obeid LM, Mao C.

FASEB J. 2006 Sep;20(11):1813-25.PMID: 16940153 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk.

Samad F, Hester KD, Yang G, Hannun YA, Bielawski J.

Diabetes. 2006 Sep;55(9):2579-87.PMID: 16936207 [PubMed - indexed for MEDLINE]Related articlesFree article