PubMed

Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta.

Frangioudakis G, Burchfield JG, Narasimhan S, Cooney GJ, Leitges M, Biden TJ, Schmitz-Peiffer C.

Diabetologia. 2009 Oct 7. [Epub ahead of print]PMID: 19809797 [PubMed - as supplied by publisher]Related articles

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload.

Preston AM, Gurisik E, Bartley C, Laybutt DR, Biden TJ.

Diabetologia. 2009 Aug 29. [Epub ahead of print]PMID: 19727664 [PubMed - as supplied by publisher]Related articles

Bad news for beta-cell apoptosis.

Thomas HE, Biden TJ.

Diabetes. 2009 Aug;58(8):1725-7. No abstract available. PMID: 19638530 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells.

Cantley J, Burchfield JG, Pearson GL, Schmitz-Peiffer C, Leitges M, Biden TJ.

Diabetes. 2009 Aug;58(8):1826-34. Epub 2009 Apr 28.PMID: 19401415 [PubMed - indexed for MEDLINE]Related articlesFree article

The diverse roles of protein kinase C in pancreatic beta-cell function.

Biden TJ, Schmitz-Peiffer C, Burchfield JG, Gurisik E, Cantley J, Mitchell CJ, Carpenter L.

Biochem Soc Trans. 2008 Oct;36(Pt 5):916-9.PMID: 18793161 [PubMed - indexed for MEDLINE]Related articles

Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

Akerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM, King C, Biden TJ, Laybutt DR.

Diabetes. 2008 Nov;57(11):3034-44. Epub 2008 Jun 30.PMID: 18591394 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes.

Schmitz-Peiffer C, Biden TJ.

Diabetes. 2008 Jul;57(7):1774-83. Review. No abstract available. PMID: 18586909 [PubMed - indexed for MEDLINE]Related articlesFree article

Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism.

Roberts CG, Gurisik E, Biden TJ, Sutherland RL, Butt AJ.

Mol Cancer Ther. 2007 Oct;6(10):2777-85. Epub 2007 Oct 3.PMID: 17913853 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

Schmitz-Peiffer C, Laybutt DR, Burchfield JG, Gurisik E, Narasimhan S, Mitchell CJ, Pedersen DJ, Braun U, Cooney GJ, Leitges M, Biden TJ.

Cell Metab. 2007 Oct;6(4):320-8.PMID: 17908560 [PubMed - indexed for MEDLINE]Related articles

Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle.

Cazzolli R, Mitchell TW, Burchfield JG, Pedersen DJ, Turner N, Biden TJ, Schmitz-Peiffer C.

Diabetologia. 2007 Aug;50(8):1732-42. Epub 2007 Jun 26.PMID: 17593346 [PubMed - indexed for MEDLINE]Related articles

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes.

Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV, Biden TJ.

Diabetologia. 2007 Apr;50(4):752-63. Epub 2007 Feb 1.PMID: 17268797 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation of nonmuscle myosin heavy chain IIA on Ser1917 is mediated by protein kinase C beta II and coincides with the onset of stimulated degranulation of RBL-2H3 mast cells.

Ludowyke RI, Elgundi Z, Kranenburg T, Stehn JR, Schmitz-Peiffer C, Hughes WE, Biden TJ.

J Immunol. 2006 Aug 1;177(3):1492-9.PMID: 16849455 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

Busch AK, Gurisik E, Cordery DV, Sudlow M, Denyer GS, Laybutt DR, Hughes WE, Biden TJ.

Diabetes. 2005 Oct;54(10):2917-24.PMID: 16186393 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.

Kjørholt C, Akerfeldt MC, Biden TJ, Laybutt DR.

Diabetes. 2005 Sep;54(9):2755-63.PMID: 16123366 [PubMed - indexed for MEDLINE]Related articlesFree article

Phospholipase D1 regulates secretagogue-stimulated insulin release in pancreatic beta-cells.

Hughes WE, Elgundi Z, Huang P, Frohman MA, Biden TJ.

J Biol Chem. 2004 Jun 25;279(26):27534-41. Epub 2004 Apr 14.PMID: 15087463 [PubMed - indexed for MEDLINE]Related articlesFree article

Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C theta.

Burchfield JG, Lennard AJ, Narasimhan S, Hughes WE, Wasinger VC, Corthals GL, Okuda T, Kondoh H, Biden TJ, Schmitz-Peiffer C.

J Biol Chem. 2004 Apr 30;279(18):18623-32. Epub 2004 Feb 24.PMID: 14985363 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice.

Cooney GJ, Lyons RJ, Crew AJ, Jensen TE, Molero JC, Mitchell CJ, Biden TJ, Ormandy CJ, James DE, Daly RJ.

EMBO J. 2004 Feb 11;23(3):582-93. Epub 2004 Jan 29.PMID: 14749734 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic effects of fatty acids on pancreatic beta-cell function: new insights from functional genomics.

Biden TJ, Robinson D, Cordery D, Hughes WE, Busch AK.

Diabetes. 2004 Feb;53 Suppl 1:S159-65. Review.PMID: 14749282 [PubMed - indexed for MEDLINE]Related articlesFree article

PKC alpha is activated but not required during glucose-induced insulin secretion from rat pancreatic islets.

Carpenter L, Mitchell CJ, Xu ZZ, Poronnik P, Both GW, Biden TJ.

Diabetes. 2004 Jan;53(1):53-60.PMID: 14693697 [PubMed - indexed for MEDLINE]Related articlesFree article

Phospholipase Cdelta(1) does not mediate Ca(2+) responses in neonatal rat cardiomyocytes.

Woodcock EA, Mitchell CJ, Biden TJ.

FEBS Lett. 2003 Jul 10;546(2-3):325-8.PMID: 12832062 [PubMed - indexed for MEDLINE]Related articles

Inhibition of PKCalpha induces a PKCdelta-dependent apoptotic program in salivary epithelial cells.

Matassa AA, Kalkofen RL, Carpenter L, Biden TJ, Reyland ME.

Cell Death Differ. 2003 Mar;10(3):269-77.PMID: 12700627 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of glycogen synthesis by fatty acid in C(2)C(12) muscle cells is independent of PKC-alpha, -epsilon, and -theta.

Cazzolli R, Craig DL, Biden TJ, Schmitz-Peiffer C.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1204-13.PMID: 12006349 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function.

Busch AK, Cordery D, Denyer GS, Biden TJ.

Diabetes. 2002 Apr;51(4):977-87.PMID: 11916915 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of protein kinase C delta protects rat INS-1 cells against interleukin-1beta and streptozotocin-induced apoptosis.

Carpenter L, Cordery D, Biden TJ.

Diabetes. 2002 Feb;51(2):317-24.PMID: 11812738 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.

Buteau J, Foisy S, Rhodes CJ, Carpenter L, Biden TJ, Prentki M.

Diabetes. 2001 Oct;50(10):2237-43.PMID: 11574404 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate.

Cazzolli R, Carpenter L, Biden TJ, Schmitz-Peiffer C.

Diabetes. 2001 Oct;50(10):2210-8.PMID: 11574400 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for selective coupling of alpha 1-adrenergic receptors to phospholipase C-beta 1 in rat neonatal cardiomyocytes.

Arthur JF, Matkovich SJ, Mitchell CJ, Biden TJ, Woodcock EA.

J Biol Chem. 2001 Oct 5;276(40):37341-6. Epub 2001 Aug 6.PMID: 11489909 [PubMed - indexed for MEDLINE]Related articlesFree article

PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells.

Matassa AA, Carpenter L, Biden TJ, Humphries MJ, Reyland ME.

J Biol Chem. 2001 Aug 10;276(32):29719-28. Epub 2001 May 21.PMID: 11369761 [PubMed - indexed for MEDLINE]Related articlesFree article

Phospholipase C-gamma mediates the hydrolysis of phosphatidylinositol, but not of phosphatidylinositol 4,5-bisphoshate, in carbamylcholine-stimulated islets of langerhans.

Mitchell CJ, Kelly MM, Blewitt M, Wilson JR, Biden TJ.

J Biol Chem. 2001 Jun 1;276(22):19072-7. Epub 2001 Mar 27.PMID: 11274217 [PubMed - indexed for MEDLINE]Related articlesFree article

A redistribution of actin and myosin IIA accompanies Ca(2+)-dependent insulin secretion.

Wilson JR, Ludowyke RI, Biden TJ.

FEBS Lett. 2001 Mar 9;492(1-2):101-6.PMID: 11248245 [PubMed - indexed for MEDLINE]Related articles

Protein kinase Cdelta activation by interleukin-1beta stabilizes inducible nitric-oxide synthase mRNA in pancreatic beta-cells.

Carpenter L, Cordery D, Biden TJ.

J Biol Chem. 2001 Feb 16;276(7):5368-74. Epub 2000 Nov 21.PMID: 11087760 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-theta localization.

Bell KS, Schmitz-Peiffer C, Lim-Fraser M, Biden TJ, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2000 Nov;279(5):E1196-201.PMID: 11052977 [PubMed - indexed for MEDLINE]Related articlesFree article

An antisense of protein kinase C-zeta inhibits proliferation of human airway smooth muscle cells.

Carlin S, Poronnik P, Cook DI, Carpenter L, Biden TJ, Johnson PR, Black JL.

Am J Respir Cell Mol Biol. 2000 Oct;23(4):555-9.PMID: 11017922 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative and functional characterization of muscarinic receptor subtypes in insulin-secreting cell lines and rat pancreatic islets.

Iismaa TP, Kerr EA, Wilson JR, Carpenter L, Sims N, Biden TJ.

Diabetes. 2000 Mar;49(3):392-8.PMID: 10868960 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat.

Laybutt DR, Schmitz-Peiffer C, Saha AK, Ruderman NB, Biden TJ, Kraegen EW.

Am J Physiol. 1999 Dec;277(6 Pt 1):E1070-6.PMID: 10600797 [PubMed - indexed for MEDLINE]Related articlesFree article

Increases in phosphorylation of the myosin II heavy chain, but not regulatory light chains, correlate with insulin secretion in rat pancreatic islets and RINm5F cells.

Wilson JR, Biden TJ, Ludowyke RI.

Diabetes. 1999 Dec;48(12):2383-9.PMID: 10580427 [PubMed - indexed for MEDLINE]Related articlesFree article

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate.

Schmitz-Peiffer C, Craig DL, Biden TJ.

J Biol Chem. 1999 Aug 20;274(34):24202-10.PMID: 10446195 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis.

Jamieson L, Carpenter L, Biden TJ, Fields AP.

J Biol Chem. 1999 Feb 12;274(7):3927-30.PMID: 9933579 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutrient stimulation results in a rapid Ca2+-dependent threonine phosphorylation of myosin heavy chain in rat pancreatic islets and RINm5F cells.

Wilson JR, Ludowyke RI, Biden TJ.

J Biol Chem. 1998 Aug 28;273(35):22729-37.PMID: 9712904 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated protein kinase C alpha associates with annexin VI from skeletal muscle.

Schmitz-Peiffer C, Browne CL, Walker JH, Biden TJ.

Biochem J. 1998 Mar 1;330 ( Pt 2):675-81.PMID: 9480874 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653.

Schmitz-Peiffer C, Oakes ND, Browne CL, Kraegen EW, Biden TJ.

Am J Physiol. 1997 Nov;273(5 Pt 1):E915-21.PMID: 9374677 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat.

Schmitz-Peiffer C, Browne CL, Oakes ND, Watkinson A, Chisholm DJ, Kraegen EW, Biden TJ.

Diabetes. 1997 Feb;46(2):169-78.PMID: 9000691 [PubMed - indexed for MEDLINE]Related articles

Characterization of two forms of protein kinase C alpha, with different substrate specificities, from skeletal muscle.

Schmitz-Peiffer C, Browne CL, Biden TJ.

Biochem J. 1996 Nov 15;320 ( Pt 1):207-14.PMID: 8947489 [PubMed - indexed for MEDLINE]Related articlesFree article

Synergistic interaction of Y1-neuropeptide Y and alpha 1b-adrenergic receptors in the regulation of phospholipase C, protein kinase C, and arachidonic acid production.

Selbie LA, Darby K, Schmitz-Peiffer C, Browne CL, Herzog H, Shine J, Biden TJ.

J Biol Chem. 1995 May 19;270(20):11789-96.PMID: 7744827 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural and biochemical studies of human galanin: NMR evidence for nascent helical structures in aqueous solution.

Morris MB, Ralston GB, Biden TJ, Browne CL, King GF, Iismaa TP.

Biochemistry. 1995 Apr 11;34(14):4538-45.PMID: 7536469 [PubMed - indexed for MEDLINE]Related articles

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

Selbie LA, Schmitz-Peiffer C, Sheng Y, Biden TJ.

J Biol Chem. 1993 Nov 15;268(32):24296-302.PMID: 8226978 [PubMed - indexed for MEDLINE]Related articlesFree article

Cross-talk between muscarinic- and adenosine-receptor signalling in the regulation of cytosolic free Ca2+ and insulin secretion.

Biden TJ, Browne CL.

Biochem J. 1993 Aug 1;293 ( Pt 3):721-8.PMID: 7688958 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation by membrane potential of phosphatidylinositol hydrolysis in pancreatic islets.

Biden TJ, Davison AG, Prugue ML.

J Biol Chem. 1993 May 25;268(15):11065-72.PMID: 8496168 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for phosphatidylinositol hydrolysis in pancreatic islets stimulated with carbamoylcholine. Kinetic analysis of inositol polyphosphate metabolism.

Biden TJ, Prugue ML, Davison AG.

Biochem J. 1992 Jul 15;285 ( Pt 2):541-9.PMID: 1637344 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural subtypes of the dopamine D2 receptor are functionally distinct: expression of the cloned D2A and D2B subtypes in a heterologous cell line.

Hayes G, Biden TJ, Selbie LA, Shine J.

Mol Endocrinol. 1992 Jun;6(6):920-6.PMID: 1323056 [PubMed - indexed for MEDLINE]Related articles