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1,169 results

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BGN/FAP/STAT3 positive feedback loop mediated mutual interaction between tumor cells and mesothelial cells contributes to peritoneal metastasis of gastric cancer.
Wu H, Xiang Z, Huang G, He Q, Song J, Dou R, Yang C, Wang S, Xiong B. Wu H, et al. Int J Biol Sci. 2023 Jan 1;19(2):465-483. doi: 10.7150/ijbs.72218. eCollection 2023. Int J Biol Sci. 2023. PMID: 36632455 Free PMC article.
Microarray sequencing of GC focus and PM lesions was performed, and biglycan (BGN) was screened for further study. Clinically, BGN expression was higher in GC tissues than adjacent normal tissues, and high expression correlated with poor prognosis. ...CAFLCs-derived …
Microarray sequencing of GC focus and PM lesions was performed, and biglycan (BGN) was screened for further study. Clinically, BGN …
The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells.
Brina D, Ponzoni A, Troiani M, Calì B, Pasquini E, Attanasio G, Mosole S, Mirenda M, D'Ambrosio M, Colucci M, Guccini I, Revandkar A, Alajati A, Tebaldi T, Donzel D, Lauria F, Parhizgari N, Valdata A, Maddalena M, Calcinotto A, Bolis M, Rinaldi A, Barry S, Rüschoff JH, Sabbadin M, Sumanasuriya S, Crespo M, Sharp A, Yuan W, Grinu M, Boyle A, Miller C, Trotman L, Delaleu N, Fassan M, Moch H, Viero G, de Bono J, Alimonti A. Brina D, et al. Nat Cancer. 2023 Aug;4(8):1102-1121. doi: 10.1038/s43018-023-00594-z. Epub 2023 Jul 17. Nat Cancer. 2023. PMID: 37460872
Among different secreted proteins released by prostate tumor cells, we identified Hgf, Spp1 and Bgn as the key factors that regulate MDSC migration. Mechanistically, we found that the coordinated loss of Pdcd4 and activation of the MNK/eIF4E pathways regulate the mRNAs tra …
Among different secreted proteins released by prostate tumor cells, we identified Hgf, Spp1 and Bgn as the key factors that regulate …
Identification of BGN and THBS2 as metastasis-specific biomarkers and poor survival key regulators in human colon cancer by integrated analysis.
He Z, Lin J, Chen C, Chen Y, Yang S, Cai X, He Y, Liu S. He Z, et al. Clin Transl Med. 2022 Nov;12(11):e973. doi: 10.1002/ctm2.973. Clin Transl Med. 2022. PMID: 36377223 Free PMC article.
The most significant signatures associated with colon cancer metastasis were determined to be BGN and THBS2. Furthermore, highly expression of BGN and THBS2 in tumours was linked to a worse survival rate. ...CONCLUSIONS: CRC metastatic progression, EMT phenotypic tr …
The most significant signatures associated with colon cancer metastasis were determined to be BGN and THBS2. Furthermore, highly expr …
BGN May be a Potential Prognostic Biomarker and Associated With Immune Cell Enrichment of Gastric Cancer.
Zhang S, Yang H, Xiang X, Liu L, Huang H, Tang G. Zhang S, et al. Front Genet. 2022 Jan 26;13:765569. doi: 10.3389/fgene.2022.765569. eCollection 2022. Front Genet. 2022. PMID: 35154268 Free PMC article.
BGN-related differentially expressed genes (DEGs) were identified. ...BGN expression was also significantly correlated with histologic grade (GI&G2 vs. ...
BGN-related differentially expressed genes (DEGs) were identified. ...BGN expression was also significantly correlated with hi …
BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells.
Huang HC, Cai BH, Suen CS, Lee HY, Hwang MJ, Liu FT, Kannagi R. Huang HC, et al. Cells. 2020 Feb 9;9(2):397. doi: 10.3390/cells9020397. Cells. 2020. PMID: 32050430 Free PMC article.
Suppression of BGN expression substantially downregulated NF-B activity and the marker H3K27me3 in the promoter regions of the SLC26A2 and ST6GalNAc6 genes, which are involved in the synthesis of those glycans, and restored expression of normal glycans as well as Siglec-7 …
Suppression of BGN expression substantially downregulated NF-B activity and the marker H3K27me3 in the promoter regions of the SLC26A …
Biglycan neo-epitope (BGN(262)), a novel biomarker for screening early changes in equine osteoarthritic subchondral bone.
Adepu S, Ekman S, Leth J, Johansson U, Lindahl A, Skiöldebrand E. Adepu S, et al. Osteoarthritis Cartilage. 2022 Oct;30(10):1328-1336. doi: 10.1016/j.joca.2022.07.005. Epub 2022 Jul 21. Osteoarthritis Cartilage. 2022. PMID: 35870736 Free article.
This study aimed to delineate the specific cleavage fragment, a neo-epitope for BGN (BGN(262)), in synovial fluid (SF) from young racehorses in training, osteoarthritic (OA) joints with subchondral bone sclerosis (SCBS), and chip fracture joints. ...Cohort 2: BGN …
This study aimed to delineate the specific cleavage fragment, a neo-epitope for BGN (BGN(262)), in synovial fluid (SF) from yo …
Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer.
Zhou Y, Bian S, Zhou X, Cui Y, Wang W, Wen L, Guo L, Fu W, Tang F. Zhou Y, et al. Cancer Cell. 2020 Dec 14;38(6):818-828.e5. doi: 10.1016/j.ccell.2020.09.015. Epub 2020 Oct 22. Cancer Cell. 2020. PMID: 33096021 Free article.
Moreover, the proportions of fibroblasts with SCNAs in tumors (11.1%-47.7%) are much higher than those in adjacent normal tissues (1.1%-10.6%), with gain of chromosome 7 strongly enriched in the TME, clearly indicating clonal expansion. Furthermore, five genes (BGN, RCN3, …
Moreover, the proportions of fibroblasts with SCNAs in tumors (11.1%-47.7%) are much higher than those in adjacent normal tissues (1.1%-10.6 …
BGN Mutations in X-Linked Spondyloepimetaphyseal Dysplasia.
Cho SY, Bae JS, Kim NKD, Forzano F, Girisha KM, Baldo C, Faravelli F, Cho TJ, Kim D, Lee KY, Ikegawa S, Shim JS, Ko AR, Miyake N, Nishimura G, Superti-Furga A, Spranger J, Kim OH, Park WY, Jin DK. Cho SY, et al. Am J Hum Genet. 2016 Jun 2;98(6):1243-1248. doi: 10.1016/j.ajhg.2016.04.004. Epub 2016 May 26. Am J Hum Genet. 2016. PMID: 27236923 Free PMC article.
We have been able to restudy this family together with a second family from Korea by segregating a severe SEMD in an X-linked pattern. Exome sequencing showed missense mutations in BGN c.439A>G (p.Lys147Glu) in the Korean family and c.776G>T (p.Gly259Val) in the Ital …
We have been able to restudy this family together with a second family from Korea by segregating a severe SEMD in an X-linked pattern. Exome …
Prognostic and Predictive Value of BGN in Colon Cancer Outcomes and Response to Immunotherapy.
He ZX, Zhao SB, Fang X, E JF, Fu HY, Song YH, Wu JY, Pan P, Gu L, Xia T, Liu YL, Li ZS, Wang SL, Bai Y. He ZX, et al. Front Oncol. 2022 Jan 11;11:761030. doi: 10.3389/fonc.2021.761030. eCollection 2021. Front Oncol. 2022. PMID: 35096572 Free PMC article.
Finally, we predicted the immunotherapeutic response rates in the subgroups of low and high BGN expression by TIS score, ImmuCellAI and TIDE algorithms. RESULTS: BGN expression demonstrated a statistically significant upregulation in colon cancer tissues than in nor …
Finally, we predicted the immunotherapeutic response rates in the subgroups of low and high BGN expression by TIS score, ImmuCellAI a …
Expression and prognostic analysis of BGN in head and neck squamous cell carcinoma.
Zhao L, Liang J, Zhong W, Han C, Liu D, Chen X. Zhao L, et al. Gene. 2022 Jun 15;827:146461. doi: 10.1016/j.gene.2022.146461. Epub 2022 Mar 28. Gene. 2022. PMID: 35358652 Free article.
However, the detailed role of BGN remains unclear in Head and neck squamous cell carcinoma (HNSC). ...RESULTS: We found that the expression of BGN is higher in patients with HNSC than in control tissues. Pathologically, high BGN expression was significantly c …
However, the detailed role of BGN remains unclear in Head and neck squamous cell carcinoma (HNSC). ...RESULTS: We found that the expr …
1,169 results