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    Results: 35

    1.

    Akt and PTEN: beta-cell mass and pancreas plasticity.

    Elghazi L, Bernal-Mizrachi E.

    Trends Endocrinol Metab. 2009 Jul;20(5):243-51. Epub 2009 Jun 21. Review.PMID: 19541499 [PubMed - indexed for MEDLINE]Related articles

    2.

    mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability.

    Balcazar N, Sathyamurthy A, Elghazi L, Gould A, Weiss A, Shiojima I, Walsh K, Bernal-Mizrachi E.

    J Biol Chem. 2009 Mar 20;284(12):7832-42. Epub 2009 Jan 14.PMID: 19144649 [PubMed - indexed for MEDLINE]Related articles

    3.

    Regulation of pancreas plasticity and malignant transformation by Akt signaling.

    Elghazi L, Weiss AJ, Barker DJ, Callaghan J, Staloch L, Sandgren EP, Gannon M, Adsay VN, Bernal-Mizrachi E.

    Gastroenterology. 2009 Mar;136(3):1091-103. Epub 2008 Nov 27.PMID: 19121634 [PubMed - indexed for MEDLINE]Related articles

    4.

    Beta-cell failure as a complication of diabetes.

    Chang-Chen KJ, Mullur R, Bernal-Mizrachi E.

    Rev Endocr Metab Disord. 2008 Dec;9(4):329-43. Review.PMID: 18777097 [PubMed - indexed for MEDLINE]Related articles

    5.

    Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.

    Rachdi L, Balcazar N, Osorio-Duque F, Elghazi L, Weiss A, Gould A, Chang-Chen KJ, Gambello MJ, Bernal-Mizrachi E.

    Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9250-5. Epub 2008 Jun 27.PMID: 18587048 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Generation of a reporter mouse line expressing Akt and EGFP upon Cre-mediated recombination.

    Elghazi L, Weiss AJ, Gould AP, Hegedus B, Gutmann DH, Bernal-Mizrachi E.

    Genesis. 2008 May;46(5):256-64.PMID: 18442046 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.

    Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH.

    Cell Stem Cell. 2007 Oct 11;1(4):443-57.PMID: 18371380 [PubMed - indexed for MEDLINE]Related articles

    8.

    Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.

    Tanabe K, Liu Z, Patel S, Doble BW, Li L, Cras-Méneur C, Martinez SC, Welling CM, White MF, Bernal-Mizrachi E, Woodgett JR, Permutt MA.

    PLoS Biol. 2008 Feb;6(2):e37.PMID: 18288891 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation.

    Liu Z, Tanabe K, Bernal-Mizrachi E, Permutt MA.

    Diabetologia. 2008 Apr;51(4):623-31. Epub 2008 Jan 25.PMID: 18219478 [PubMed - indexed for MEDLINE]Related articles

    10.

    Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.

    Martinez SC, Tanabe K, Cras-Méneur C, Abumrad NA, Bernal-Mizrachi E, Permutt MA.

    Diabetes. 2008 Apr;57(4):846-59. Epub 2008 Jan 3.PMID: 18174526 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Regulation of beta-cell mass and function by the Akt/protein kinase B signalling pathway.

    Elghazi L, Rachdi L, Weiss AJ, Cras-Méneur C, Bernal-Mizrachi E.

    Diabetes Obes Metab. 2007 Nov;9 Suppl 2:147-57. Review.PMID: 17919189 [PubMed - indexed for MEDLINE]Related articles

    12.

    Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis.

    McDunn JE, Muenzer JT, Rachdi L, Chang KC, Davis CG, Dunne WM, Piwnica-Worms D, Bernal-Mizrachi E, Hotchkiss RS.

    FASEB J. 2008 Feb;22(2):561-8. Epub 2007 Sep 13.PMID: 17855622 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.

    Johnson JD, Bernal-Mizrachi E, Alejandro EU, Han Z, Kalynyak TB, Li H, Beith JL, Gross J, Warnock GL, Townsend RR, Permutt MA, Polonsky KS.

    Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19575-80. Epub 2006 Dec 8.PMID: 17158802 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Differential effects of p27 in regulation of beta-cell mass during development, neonatal period, and adult life.

    Rachdi L, Balcazar N, Elghazi L, Barker DJ, Krits I, Kiyokawa H, Bernal-Mizrachi E.

    Diabetes. 2006 Dec;55(12):3520-8.PMID: 17130500 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Suppressed insulin signaling and increased apoptosis in CD38-null islets.

    Johnson JD, Ford EL, Bernal-Mizrachi E, Kusser KL, Luciani DS, Han Z, Tran H, Randall TD, Lund FE, Polonsky KS.

    Diabetes. 2006 Oct;55(10):2737-46.PMID: 17003338 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cell.

    Martinez SC, Cras-Méneur C, Bernal-Mizrachi E, Permutt MA.

    Diabetes. 2006 Jun;55(6):1581-91.PMID: 16731820 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity.

    Fatrai S, Elghazi L, Balcazar N, Cras-Méneur C, Krits I, Kiyokawa H, Bernal-Mizrachi E.

    Diabetes. 2006 Feb;55(2):318-25.PMID: 16443763 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.

    Riggs AC, Bernal-Mizrachi E, Ohsugi M, Wasson J, Fatrai S, Welling C, Murray J, Schmidt RE, Herrera PL, Permutt MA.

    Diabetologia. 2005 Nov;48(11):2313-21. Epub 2005 Oct 8.PMID: 16215705 [PubMed - indexed for MEDLINE]Related articles

    19.

    Emerging role of protein kinase B/Akt signaling in pancreatic beta-cell mass and function.

    Elghazi L, Balcazar N, Bernal-Mizrachi E.

    Int J Biochem Cell Biol. 2006 Feb;38(2):157-63. Epub 2005 Sep 23. Review.PMID: 16213777 [PubMed - indexed for MEDLINE]Related articles

    20.

    Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.

    Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Méneur C, Permutt MA, Imai S.

    Cell Metab. 2005 Aug;2(2):105-17.PMID: 16098828 [PubMed - indexed for MEDLINE]Related articles

    21.

    Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells.

    Srinivasan S, Ohsugi M, Liu Z, Fatrai S, Bernal-Mizrachi E, Permutt MA.

    Diabetes. 2005 Apr;54(4):968-75.PMID: 15793234 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.

    Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA.

    J Biol Chem. 2005 Feb 11;280(6):4992-5003. Epub 2004 Nov 15.PMID: 15546857 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.

    Bernal-Mizrachi E, Fatrai S, Johnson JD, Ohsugi M, Otani K, Han Z, Polonsky KS, Permutt MA.

    J Clin Invest. 2004 Oct;114(7):928-36.PMID: 15467831 [PubMed - indexed for MEDLINE]Related articlesFree article

    24.

    Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes.

    Ohsugi M, Cras-Méneur C, Zhou Y, Warren W, Bernal-Mizrachi E, Permutt MA.

    Diabetes. 2004 Jun;53(6):1496-508.PMID: 15161754 [PubMed - indexed for MEDLINE]Related articlesFree article

    25.

    An expression profile of human pancreatic islet mRNAs by Serial Analysis of Gene Expression (SAGE).

    Cras-Méneur C, Inoue H, Zhou Y, Ohsugi M, Bernal-Mizrachi E, Pape D, Clifton SW, Permutt MA.

    Diabetologia. 2004 Feb;47(2):284-99. Epub 2004 Jan 13.PMID: 14722648 [PubMed - indexed for MEDLINE]Related articles

    26.

    Gene expression profiling in islet biology and diabetes research.

    Bernal-Mizrachi E, Cras-Méneur C, Ohsugi M, Permutt MA.

    Diabetes Metab Res Rev. 2003 Jan-Feb;19(1):32-42. Review.PMID: 12592642 [PubMed - indexed for MEDLINE]Related articles

    27.

    Activation of nuclear factor-kappaB by depolarization and Ca(2+) influx in MIN6 insulinoma cells.

    Bernal-Mizrachi E, Wen W, Shornick M, Permutt MA.

    Diabetes. 2002 Dec;51 Suppl 3:S484-8.PMID: 12475794 [PubMed - indexed for MEDLINE]Related articlesFree article

    28.

    Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway.

    Srinivasan S, Bernal-Mizrachi E, Ohsugi M, Permutt MA.

    Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E784-93.PMID: 12217896 [PubMed - indexed for MEDLINE]Related articlesFree article

    29.

    Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia.

    Bernal-Mizrachi E, Wen W, Stahlhut S, Welling CM, Permutt MA.

    J Clin Invest. 2001 Dec;108(11):1631-8.PMID: 11733558 [PubMed - indexed for MEDLINE]Related articlesFree article

    30.

    Activation of Elk-1, an Ets transcription factor, by glucose and EGF treatment of insulinoma cells.

    Bernal-Mizrachi E, Wen W, Srinivasan S, Klenk A, Cohen D, Permutt MA.

    Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1286-99.PMID: 11701445 [PubMed - indexed for MEDLINE]Related articlesFree article

    31.

    Glucose and other insulin secretagogues induce, rather than inhibit, expression of Id-1 and Id-3 in pancreatic islet beta cells.

    Wice BM, Bernal-Mizrachi E, Permutt MA.

    Diabetologia. 2001 Apr;44(4):453-63.PMID: 11357476 [PubMed - indexed for MEDLINE]Related articles

    32.

    Calpain 10: the first positional cloning of a gene for type 2 diabetes?

    Permutt MA, Bernal-Mizrachi E, Inoue H.

    J Clin Invest. 2000 Oct;106(7):819-21. No abstract available. PMID: 11018067 [PubMed - indexed for MEDLINE]Related articlesFree article

    33.

    Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet beta-cells.

    Bernal-Mizrachi E, Wice B, Inoue H, Permutt MA.

    J Biol Chem. 2000 Aug 18;275(33):25681-9.PMID: 10829028 [PubMed - indexed for MEDLINE]Related articlesFree article

    34.

    A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome).

    Inoue H, Tanizawa Y, Wasson J, Behn P, Kalidas K, Bernal-Mizrachi E, Mueckler M, Marshall H, Donis-Keller H, Crock P, Rogers D, Mikuni M, Kumashiro H, Higashi K, Sobue G, Oka Y, Permutt MA.

    Nat Genet. 1998 Oct;20(2):143-8.PMID: 9771706 [PubMed - indexed for MEDLINE]Related articles

    35.

    Isolation and characterization of the human PAX4 gene.

    Tao T, Wasson J, Bernal-Mizrachi E, Behn PS, Chayen S, Duprat L, Meyer J, Glaser B, Permutt MA.

    Diabetes. 1998 Oct;47(10):1650-3. No abstract available. PMID: 9753306 [PubMed - indexed for MEDLINE]Related articlesFree article

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