PubMed

How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets.

Feuerer M, Shen Y, Littman DR, Benoist C, Mathis D.

Immunity. 2009 Oct 16;31(4):654-64. Epub 2009 Oct 8.PMID: 19818653 [PubMed - indexed for MEDLINE]Related articles

The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms.

Binstadt BA, Hebert JL, Ortiz-Lopez A, Bronson R, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16758-63. Epub 2009 Sep 15.PMID: 19805369 [PubMed - in process]Related articles

A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis.

Monach PA, Hueber W, Kessler B, Tomooka BH, BenBarak M, Simmons BP, Wright J, Thornhill TS, Monestier M, Ploegh H, Robinson WH, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15867-72. Epub 2009 Aug 31.PMID: 19720992 [PubMed - indexed for MEDLINE]Related articles

Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.

Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U.

Arthritis Rheum. 2009 Aug;60(8):2314-24.PMID: 19644878 [PubMed - indexed for MEDLINE]Related articles

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters.

Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D.

Nat Med. 2009 Aug;15(8):930-9. Epub 2009 Jul 26.PMID: 19633656 [PubMed - indexed for MEDLINE]Related articles

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes.

Feuerer M, Hill JA, Mathis D, Benoist C.

Nat Immunol. 2009 Jul;10(7):689-95. Review.PMID: 19536194 [PubMed - indexed for MEDLINE]Related articles

Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity.

Guerau-de-Arellano M, Martinic M, Benoist C, Mathis D.

J Exp Med. 2009 Jun 8;206(6):1245-52. Epub 2009 Jun 1.PMID: 19487417 [PubMed - indexed for MEDLINE]Related articles

Aire.

Mathis D, Benoist C.

Annu Rev Immunol. 2009;27:287-312. Review.PMID: 19302042 [PubMed - indexed for MEDLINE]Related articles

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors.

D'Alise AM, Auyeung V, Feuerer M, Nishio J, Fontenot J, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19857-62. Epub 2008 Dec 10.PMID: 19073938 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.

Hill JA, Hall JA, Sun CM, Cai Q, Ghyselinck N, Chambon P, Belkaid Y, Mathis D, Benoist C.

Immunity. 2008 Nov 14;29(5):758-70.PMID: 19006694 [PubMed - indexed for MEDLINE]Related articles

Genetic inversion in mast cell-deficient (W(sh)) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy.

Nigrovic PA, Gray DH, Jones T, Hallgren J, Kuo FC, Chaletzky B, Gurish M, Mathis D, Benoist C, Lee DM.

Am J Pathol. 2008 Dec;173(6):1693-701. Epub 2008 Nov 6.PMID: 18988802 [PubMed - indexed for MEDLINE]Related articlesFree article

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.

Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15878-83. Epub 2008 Oct 7.PMID: 18840680 [PubMed - indexed for MEDLINE]Related articlesFree article

The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.

Venanzi ES, Melamed R, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15860-5. Epub 2008 Oct 6.PMID: 18838677 [PubMed - indexed for MEDLINE]Related articlesFree article

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated.

Villaseñor J, Besse W, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15854-9. Epub 2008 Oct 3.PMID: 18836079 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional impact of Aire varies with cell type.

Guerau-de-Arellano M, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14011-6. Epub 2008 Sep 9.PMID: 18780794 [PubMed - indexed for MEDLINE]Related articlesFree article

B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients.

Gavanescu I, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13009-14. Epub 2008 Aug 28.PMID: 18755889 [PubMed - indexed for MEDLINE]Related articlesFree article

A broad analysis of IL1 polymorphism and rheumatoid arthritis.

Johnsen AK, Plenge RM, Butty V, Campbell C, Dieguez-Gonzalez R, Gomez-Reino JJ, Shadick N, Weinblatt M, Gonzalez A, Gregersen PK, Benoist C, Mathis D.

Arthritis Rheum. 2008 Jul;58(7):1947-57.PMID: 18576312 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).

Butty V, Campbell C, Mathis D, Benoist C; DPT-1 Study Group.

Diabetes. 2008 Sep;57(9):2348-59. Epub 2008 Jun 12.PMID: 18556337 [PubMed - indexed for MEDLINE]Related articlesFree article

The K/BxN arthritis model.

Monach PA, Mathis D, Benoist C.

Curr Protoc Immunol. 2008 May;Chapter 15:Unit 15.22.PMID: 18491295 [PubMed - indexed for MEDLINE]Related articles

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells.

Haxhinasto S, Mathis D, Benoist C.

J Exp Med. 2008 Mar 17;205(3):565-74. Epub 2008 Feb 18.PMID: 18283119 [PubMed - indexed for MEDLINE]Related articlesFree article

Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.

Hill JA, Feuerer M, Tash K, Haxhinasto S, Perez J, Melamed R, Mathis D, Benoist C.

Immunity. 2007 Nov;27(5):786-800.PMID: 18024188 [PubMed - indexed for MEDLINE]Related articles

Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes.

Feuerer M, Jiang W, Holler PD, Satpathy A, Campbell C, Bogue M, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18181-6. Epub 2007 Nov 8.PMID: 17991775 [PubMed - indexed for MEDLINE]Related articlesFree article

Danger-free autoimmune disease in Aire-deficient mice.

Gray DH, Gavanescu I, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18193-8. Epub 2007 Nov 8.PMID: 17991771 [PubMed - indexed for MEDLINE]Related articlesFree article

The K/BxN mouse model of inflammatory arthritis: theory and practice.

Monach P, Hattori K, Huang H, Hyatt E, Morse J, Nguyen L, Ortiz-Lopez A, Wu HJ, Mathis D, Benoist C.

Methods Mol Med. 2007;136:269-82.PMID: 17983155 [PubMed - indexed for MEDLINE]Related articles

Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected.

Venanzi ES, Gray DH, Benoist C, Mathis D.

J Immunol. 2007 Nov 1;179(9):5693-700.PMID: 17947641 [PubMed - indexed for MEDLINE]Related articlesFree article

Yes, it does.

Mathis D, Benoist C.

Nat Rev Immunol. 2007 Oct 12;7(10):1. [Epub ahead of print] No abstract available. PMID: 17932494 [PubMed - as supplied by publisher]Related articles

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire.

Gray D, Abramson J, Benoist C, Mathis D.

J Exp Med. 2007 Oct 29;204(11):2521-8. Epub 2007 Oct 1.PMID: 17908938 [PubMed - indexed for MEDLINE]Related articlesFree article

Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation.

Obst R, van Santen HM, Melamed R, Kamphorst AO, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15460-5. Epub 2007 Sep 19.PMID: 17881563 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model.

Monach PA, Verschoor A, Jacobs JP, Carroll MC, Wagers AJ, Benoist C, Mathis D.

Arthritis Rheum. 2007 Sep;56(9):2968-74.PMID: 17763447 [PubMed - indexed for MEDLINE]Related articlesFree article

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets.

Wong J, Mathis D, Benoist C.

J Exp Med. 2007 Sep 3;204(9):2039-45. Epub 2007 Aug 27.PMID: 17724131 [PubMed - indexed for MEDLINE]Related articlesFree article

Hippocampal MMP-3 elevation is associated with passive avoidance conditioning.

Olson ML, Meighan PC, Brown TE, Asay AL, Benoist CC, Harding JW, Wright JW.

Regul Pept. 2008 Feb 7;146(1-3):19-25. Epub 2007 Jul 19.PMID: 17698214 [PubMed - indexed for MEDLINE]Related articles

Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk.

Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D.

J Exp Med. 2007 Aug 6;204(8):1911-22. Epub 2007 Jul 23.PMID: 17646407 [PubMed - indexed for MEDLINE]Related articlesFree article

A decade of AIRE.

Mathis D, Benoist C.

Nat Rev Immunol. 2007 Aug;7(8):645-50. Epub 2007 Jul 20. Review.PMID: 17641664 [PubMed - indexed for MEDLINE]Related articles

Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells.

Wong J, Obst R, Correia-Neves M, Losyev G, Mathis D, Benoist C.

J Immunol. 2007 Jun 1;178(11):7032-41.PMID: 17513752 [PubMed - indexed for MEDLINE]Related articlesFree article

The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice.

Holler PD, Yamagata T, Jiang W, Feuerer M, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7187-92. Epub 2007 Apr 16.PMID: 17438291 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.

Gavanescu I, Kessler B, Ploegh H, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4583-7. Epub 2007 Mar 6.PMID: 17360567 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of Foxp3 function and expression in the thymic epithelium.

Liston A, Farr AG, Chen Z, Benoist C, Mathis D, Manley NR, Rudensky AY.

J Exp Med. 2007 Mar 19;204(3):475-80. Epub 2007 Mar 12.PMID: 17353370 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory T-cell differentiation: Committed to control: a precocious choice?

Haxhinasto S, Benoist C, Mathis D.

Immunol Cell Biol. 2007 Apr-May;85(3):175-6. Epub 2007 Feb 20. No abstract available. PMID: 17310224 [PubMed - indexed for MEDLINE]Related articles

Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1.

Nigrovic PA, Binstadt BA, Monach PA, Johnsen A, Gurish M, Iwakura Y, Benoist C, Mathis D, Lee DM.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2325-30. Epub 2007 Feb 2.PMID: 17277081 [PubMed - indexed for MEDLINE]Related articlesFree article

Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis.

Nguyen LT, Jacobs J, Mathis D, Benoist C.

Arthritis Rheum. 2007 Feb;56(2):509-20.PMID: 17265486 [PubMed - indexed for MEDLINE]Related articlesFree article

Treg cells: guardians for life.

Hill JA, Benoist C, Mathis D.

Nat Immunol. 2007 Feb;8(2):124-5.PMID: 17242683 [PubMed - indexed for MEDLINE]Related articles

Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.

Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):570-5. Epub 2006 Dec 29.PMID: 17197413 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered natural killer cells in type 1 diabetic patients.

Rodacki M, Svoren B, Butty V, Besse W, Laffel L, Benoist C, Mathis D.

Diabetes. 2007 Jan;56(1):177-85.PMID: 17192480 [PubMed - indexed for MEDLINE]Related articlesFree article

Modeling CTLA4-linked autoimmunity with RNA interference in mice.

Chen Z, Stockton J, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16400-5. Epub 2006 Oct 23.PMID: 17060611 [PubMed - indexed for MEDLINE]Related articlesFree article

Habituation of the head-shake response induces changes in brain matrix metalloproteinases-3 (MMP-3) and -9.

Wright JW, Meighan SE, Murphy ES, Holtfreter KL, Davis CJ, Olson ML, Benoist CC, Muhunthan K, Harding JW.

Behav Brain Res. 2006 Nov 1;174(1):78-85. Epub 2006 Aug 17.PMID: 16916548 [PubMed - indexed for MEDLINE]Related articles

FOXP3 controls regulatory T cell function through cooperation with NFAT.

Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L, Rao A.

Cell. 2006 Jul 28;126(2):375-87.PMID: 16873067 [PubMed - indexed for MEDLINE]Related articles

Gene expression microarrays: glimpses of the immunological genome.

Hyatt G, Melamed R, Park R, Seguritan R, Laplace C, Poirot L, Zucchelli S, Obst R, Matos M, Venanzi E, Goldrath A, Nguyen L, Luckey J, Yamagata T, Herman A, Jacobs J, Mathis D, Benoist C.

Nat Immunol. 2006 Jul;7(7):686-91.PMID: 16785882 [PubMed - indexed for MEDLINE]Related articles

A plaidoyer for 'systems immunology'.

Benoist C, Germain RN, Mathis D.

Immunol Rev. 2006 Apr;210:229-34. Review.PMID: 16623774 [PubMed - indexed for MEDLINE]Related articles

A shared gene-expression signature in innate-like lymphocytes.

Yamagata T, Benoist C, Mathis D.

Immunol Rev. 2006 Apr;210:52-66. Review.PMID: 16623764 [PubMed - indexed for MEDLINE]Related articles

Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution.

Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D.

Science. 2006 Mar 24;311(5768):1775-8.PMID: 16556845 [PubMed - indexed for MEDLINE]Related articlesFree article