PubMed

TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action.

Villareal DT, Robertson H, Bell GI, Patterson BW, Tran H, Wice B, Polonsky KS.

Diabetes. 2009 Nov 23. [Epub ahead of print]PMID: 19934000 [PubMed - as supplied by publisher]

A brief perspective on insulin production.

Steiner DF, Park SY, Støy J, Philipson LH, Bell GI.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:189-96.PMID: 19817801 [PubMed - in process]Related articles

Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.

Kawai T, Ng MC, Hayes MG, Yoshiuchi I, Tsuchiya T, Robertson H, Cox NJ, Polonsky KS, Bell GI, Ehrmann DA.

Diabetes Res Clin Pract. 2009 Dec;86(3):186-92. Epub 2009 Sep 25.PMID: 19782423 [PubMed - in process]Related articles

Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.

Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS.

Diabetes. 2009 Aug;58(8):1869-78. Epub 2009 Jun 2.PMID: 19491206 [PubMed - indexed for MEDLINE]Related articlesFree article

Calpain-10 is a component of the obesity-related quantitative trait locus, Adip1.

Cheverud JM, Fawcett GL, Jarvis JP, Norgard EA, Pavlicev M, Pletscher LS, Polonsky KS, Ye H, Bell GI, Semenkovich CF.

J Lipid Res. 2009 May 12. [Epub ahead of print]PMID: 19436065 [PubMed - as supplied by publisher]Related articlesFree article

Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity.

Capoccia BJ, Robson DL, Levac KD, Maxwell DJ, Hohm SA, Neelamkavil MJ, Bell GI, Xenocostas A, Link DC, Piwnica-Worms D, Nolta JA, Hess DA.

Blood. 2009 May 21;113(21):5340-51. Epub 2009 Mar 26.PMID: 19324906 [PubMed - indexed for MEDLINE]Related articles

Noninvasive monitoring of changes in pancreatic beta-cell mass by bioluminescent imaging in MIP-luc transgenic mice.

Park SY, Bell GI.

Horm Metab Res. 2009 Jan;41(1):1-4. Epub 2008 Oct 23. Erratum in: Horm Metab Res. 2009 Jan;41(1):71. PMID: 18949679 [PubMed - indexed for MEDLINE]Related articlesFree article

Diagnosis and treatment of neonatal diabetes: a United States experience.

Støy J, Greeley SA, Paz VP, Ye H, Pastore AN, Skowron KB, Lipton RB, Cogen FR, Bell GI, Philipson LH; United States Neonatal Diabetes Working Group.

Pediatr Diabetes. 2008 Oct;9(5):450-9. Epub 2008 Jul 25.PMID: 18662362 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.

Molven A, Ringdal M, Nordbø AM, Raeder H, Støy J, Lipkind GM, Steiner DF, Philipson LH, Bergmann I, Aarskog D, Undlien DE, Joner G, Søvik O; Norwegian Childhood Diabetes Study Group, Bell GI, Njølstad PR.

Diabetes. 2008 Apr;57(4):1131-5. Epub 2008 Jan 11.PMID: 18192540 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.

Edghill EL, Flanagan SE, Patch AM, Boustred C, Parrish A, Shields B, Shepherd MH, Hussain K, Kapoor RR, Malecki M, MacDonald MJ, Støy J, Steiner DF, Philipson LH, Bell GI; Neonatal Diabetes International Collaborative Group, Hattersley AT, Ellard S.

Diabetes. 2008 Apr;57(4):1034-42. Epub 2007 Dec 27.PMID: 18162506 [PubMed - indexed for MEDLINE]Related articlesFree article

Calpain-10 gene and protein expression in human skeletal muscle: effect of acute lipid-induced insulin resistance and type 2 diabetes.

Norton L, Parr T, Chokkalingam K, Bardsley RG, Ye H, Bell GI, Pelsers MM, van Loon LJ, Tsintzas K.

J Clin Endocrinol Metab. 2008 Mar;93(3):992-8. Epub 2007 Dec 18.PMID: 18089694 [PubMed - indexed for MEDLINE]Related articlesFree article

Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis.

Hara M, Shen J, Pugh W, Polonsky KS, Le Beau MM, Bell GI.

Exp Clin Endocrinol Diabetes. 2007 Nov;115(10):654-61.PMID: 18058600 [PubMed - indexed for MEDLINE]Related articles

Macrosomia and neonatal hypoglycaemia in RW pedigree subjects with a mutation (Q268X) in the gene encoding hepatocyte nuclear factor 4alpha (HNF4A).

Fajans SS, Bell GI.

Diabetologia. 2007 Dec;50(12):2600-1. Epub 2007 Sep 22. No abstract available. PMID: 17891372 [PubMed - indexed for MEDLINE]Related articles

Insulin gene mutations as a cause of permanent neonatal diabetes.

Støy J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM, Lipton RB, Greeley SA, Patch AM, Ellard S, Steiner DF, Hattersley AT, Philipson LH, Bell GI; Neonatal Diabetes International Collaborative Group.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15040-4. Epub 2007 Sep 12.PMID: 17855560 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies.

Hayes MG, Pluzhnikov A, Miyake K, Sun Y, Ng MC, Roe CA, Below JE, Nicolae RI, Konkashbaev A, Bell GI, Cox NJ, Hanis CL.

Diabetes. 2007 Dec;56(12):3033-44. Epub 2007 Sep 10.PMID: 17846124 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses.

Tsuchiya T, Schwarz PE, Bosque-Plata LD, Geoffrey Hayes M, Dina C, Froguel P, Wayne Towers G, Fischer S, Temelkova-Kurktschiev T, Rietzsch H, Graessler J, Vcelák J, Palyzová D, Selisko T, Bendlová B, Schulze J, Julius U, Hanefeld M, Weedon MN, Evans JC, Frayling TM, Hattersley AT, Orho-Melander M, Groop L, Malecki MT, Hansen T, Pedersen O, Fingerlin TE, Boehnke M, Hanis CL, Cox NJ, Bell GI.

Mol Genet Metab. 2006 Sep-Oct;89(1-2):174-84. Epub 2006 Jul 11.PMID: 16837224 [PubMed - indexed for MEDLINE]Related articles

Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes.

Pihlajamäki J, Salmenniemi U, Vänttinen M, Ruotsalainen E, Kuusisto J, Vauhkonen I, Kainulainen S, Ng MC, Cox NJ, Bell GI, Laakso M.

Diabetologia. 2006 Jul;49(7):1560-6. Epub 2006 May 12.PMID: 16752174 [PubMed - indexed for MEDLINE]Related articles

Core transcriptional regulatory circuitry in human hepatocytes.

Odom DT, Dowell RD, Jacobsen ES, Nekludova L, Rolfe PA, Danford TW, Gifford DK, Fraenkel E, Bell GI, Young RA.

Mol Syst Biol. 2006;2:2006.0017. Epub 2006 May 2.PMID: 16738562 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of hyperglycemia in a 7-year-old child diagnosed with neonatal diabetes.

Hathout E, Mace J, Bell GI, Njølstad PR.

Diabetes Care. 2006 Jun;29(6):1458. No abstract available. PMID: 16732049 [PubMed - indexed for MEDLINE]Related articlesFree article

From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.

Sagen JV, Odili S, Bjørkhaug L, Zelent D, Buettger C, Kwagh J, Stanley C, Dahl-Jørgensen K, de Beaufort C, Bell GI, Han Y, Grimsby J, Taub R, Molven A, Søvik O, Njølstad PR, Matschinsky FM.

Diabetes. 2006 Jun;55(6):1713-22.PMID: 16731834 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenotypic heterogeneity between different mutations of MODY subtypes and within MODY pedigrees.

Fajans SS, Bell GI.

Diabetologia. 2006 May;49(5):1106-8. Epub 2006 Feb 25. No abstract available. PMID: 16502298 [PubMed - indexed for MEDLINE]Related articles

Patterns of linkage disequilibrium in the type 2 diabetes gene calpain-10.

Hayes MG, del Bosque-Plata L, Tsuchiya T, Hanis CL, Bell GI, Cox NJ.

Diabetes. 2005 Dec;54(12):3573-6.PMID: 16306378 [PubMed - indexed for MEDLINE]Related articlesFree article

The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population.

Ng MC, Miyake K, So WY, Poon EW, Lam VK, Li JK, Cox NJ, Bell GI, Chan JC.

Diabetologia. 2005 Oct;48(10):2018-24. Epub 2005 Aug 26.PMID: 16132950 [PubMed - indexed for MEDLINE]Related articles

Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene.

Park SY, Wang X, Chen Z, Powers AC, Magnuson MA, Head WS, Piston DW, Bell GI.

Genesis. 2005 Oct;43(2):80-6.PMID: 16108006 [PubMed - indexed for MEDLINE]Related articles

Gene symbol: IPF1. Disease: MODY 4.

Cockburn BN, Bermano G, Boodram LL, Teelucksingh S, Tsuchiya T, Mahabir D, Allan AB, Stein R, Docherty K, Bell GI.

Hum Genet. 2005 May;116(6):538. No abstract available. PMID: 15991313 [PubMed - indexed for MEDLINE]Related articles

Anti-diabetic effect of ginsenoside Re in ob/ob mice.

Xie JT, Mehendale SR, Li X, Quigg R, Wang X, Wang CZ, Wu JA, Aung HH, A Rue P, Bell GI, Yuan CS.

Biochim Biophys Acta. 2005 Jun 10;1740(3):319-25. Epub 2004 Nov 5.PMID: 15949698 [PubMed - indexed for MEDLINE]Related articles

Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells.

Gunawardana SC, Hara M, Bell GI, Head WS, Magnuson MA, Piston DW.

In Vitro Cell Dev Biol Anim. 2005 Jan-Feb;41(1-2):7-11.PMID: 15926862 [PubMed - indexed for MEDLINE]Related articles

Subcellular recruitment by TSG118 and TSPYL implicates a role for zinc finger protein 106 in a novel developmental pathway.

Grasberger H, Bell GI.

Int J Biochem Cell Biol. 2005 Jul;37(7):1421-37.PMID: 15833274 [PubMed - indexed for MEDLINE]Related articles

5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.

Wang CZ, Wang Y, Di A, Magnuson MA, Ye H, Roe MW, Nelson DJ, Bell GI, Philipson LH.

Biochem Biophys Res Commun. 2005 May 20;330(4):1073-9.PMID: 15823553 [PubMed - indexed for MEDLINE]Related articles

Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population.

Iwasaki N, Horikawa Y, Tsuchiya T, Kitamura Y, Nakamura T, Tanizawa Y, Oka Y, Hara K, Kadowaki T, Awata T, Honda M, Yamashita K, Oda N, Yu L, Yamada N, Ogata M, Kamatani N, Iwamoto Y, Del Bosque-Plata L, Hayes MG, Cox NJ, Bell GI.

J Hum Genet. 2005;50(2):92-8. Epub 2005 Feb 5.PMID: 15696376 [PubMed - indexed for MEDLINE]Related articles

Dual promoter structure of ZFP106: regulation by myogenin and nuclear respiratory factor-1.

Grasberger H, Ye H, Mashima H, Bell GI.

Gene. 2005 Jan 3;344:143-59. Epub 2004 Nov 19.PMID: 15656981 [PubMed - indexed for MEDLINE]Related articles

Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy.

Sagen JV, Raeder H, Hathout E, Shehadeh N, Gudmundsson K, Baevre H, Abuelo D, Phornphutkul C, Molnes J, Bell GI, Gloyn AL, Hattersley AT, Molven A, Søvik O, Njølstad PR.

Diabetes. 2004 Oct;53(10):2713-8.PMID: 15448106 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25.

Ng MC, So WY, Lam VK, Cockram CS, Bell GI, Cox NJ, Chan JC.

Diabetes. 2004 Oct;53(10):2676-83.PMID: 15448100 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome.

Alcoser SY, Hara M, Bell GI, Ehrmann DA.

J Clin Endocrinol Metab. 2004 Jun;89(6):2973-6.PMID: 15181086 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide scan for type 2 diabetes loci in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25.

Ng MC, So WY, Cox NJ, Lam VK, Cockram CS, Critchley JA, Bell GI, Chan JC.

Diabetes. 2004 Jun;53(6):1609-13.PMID: 15161769 [PubMed - indexed for MEDLINE]Related articlesFree article

RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.

Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS.

J Biol Chem. 2004 Jun 4;279(23):24794-802. Epub 2004 Mar 25.PMID: 15044459 [PubMed - indexed for MEDLINE]Related articlesFree article

Calpain system regulates muscle mass and glucose transporter GLUT4 turnover.

Otani K, Han DH, Ford EL, Garcia-Roves PM, Ye H, Horikawa Y, Bell GI, Holloszy JO, Polonsky KS.

J Biol Chem. 2004 May 14;279(20):20915-20. Epub 2004 Mar 9.PMID: 15014085 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of pancreas and liver gene expression by HNF transcription factors.

Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA.

Science. 2004 Feb 27;303(5662):1378-81.PMID: 14988562 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin promoter factor-1 mutations and diabetes in Trinidad: identification of a novel diabetes-associated mutation (E224K) in an Indo-Trinidadian family.

Cockburn BN, Bermano G, Boodram LL, Teelucksingh S, Tsuchiya T, Mahabir D, Allan AB, Stein R, Docherty K, Bell GI.

J Clin Endocrinol Metab. 2004 Feb;89(2):971-8.PMID: 14764823 [PubMed - indexed for MEDLINE]Related articlesFree article

Linkage of calpain 10 to type 2 diabetes: the biological rationale.

Cox NJ, Hayes MG, Roe CA, Tsuchiya T, Bell GI.

Diabetes. 2004 Feb;53 Suppl 1:S19-25. Review.PMID: 14749261 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population.

del Bosque-Plata L, Aguilar-Salinas CA, Tusié-Luna MT, Ramírez-Jiménez S, Rodríguez-Torres M, Aurón-Gómez M, Ramírez E, Velasco-Pérez ML, Ramírez-Silva A, Gómez-Pérez F, Hanis CL, Tsuchiya T, Yoshiuchi I, Cox NJ, Bell GI.

Mol Genet Metab. 2004 Feb;81(2):122-6.PMID: 14741193 [PubMed - indexed for MEDLINE]Related articles

Genetic variants of hepatocyte nuclear factor-1beta in Chinese young-onset diabetic patients with nephropathy.

So WY, Ng MC, Horikawa Y, Njølstad PR, Li JK, Ma RC, Bell GI, Chan JC.

J Diabetes Complications. 2003 Nov-Dec;17(6):369-73.PMID: 14583183 [PubMed - indexed for MEDLINE]Related articles

Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.

Weedon MN, Schwarz PE, Horikawa Y, Iwasaki N, Illig T, Holle R, Rathmann W, Selisko T, Schulze J, Owen KR, Evans J, Del Bosque-Plata L, Hitman G, Walker M, Levy JC, Sampson M, Bell GI, McCarthy MI, Hattersley AT, Frayling TM.

Am J Hum Genet. 2003 Nov;73(5):1208-12. No abstract available. PMID: 14574648 [PubMed - indexed for MEDLINE]Related articlesFree article

Confirmed locus on chromosome 11p and candidate loci on 6q and 8p for the triglyceride and cholesterol traits of combined hyperlipidemia.

Naoumova RP, Bonney SA, Eichenbaum-Voline S, Patel HN, Jones B, Jones EL, Amey J, Colilla S, Neuwirth CK, Allotey R, Seed M, Betteridge DJ, Galton DJ, Cox NJ, Bell GI, Scott J, Shoulders CC.

Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2070-7. Epub 2003 Sep 18.PMID: 14500288 [PubMed - indexed for MEDLINE]Related articlesFree article

A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin.

Zhou YP, Sreenan S, Pan CY, Currie KP, Bindokas VP, Horikawa Y, Lee JP, Ostrega D, Ahmed N, Baldwin AC, Cox NJ, Fox AP, Miller RJ, Bell GI, Polonsky KS.

Metabolism. 2003 May;52(5):528-34.PMID: 12759879 [PubMed - indexed for MEDLINE]Related articles

Organ alchemy: producing insulin in the liver.

Polonsky KS, Bell GI.

Nat Med. 2003 May;9(5):504-5. No abstract available. PMID: 12724755 [PubMed - indexed for MEDLINE]Related articles

Locus on chromosome 6p linked to elevated HDL cholesterol serum levels and to protection against premature atherosclerosis in a kindred with familial hypercholesterolemia.

Canizales-Quinteros S, Aguilar-Salinas CA, Reyes-Rodríguez E, Riba L, Rodríguez-Torres M, Ramírez-Jiménez S, Huertas-Vázquez A, Fragoso-Ontiveros V, Zentella-Dehesa A, Ventura-Gallegos JL, Vega-Hernández G, López-Estrada A, Aurón-Gómez M, Gómez-Pérez F, Rull J, Cox NJ, Bell GI, Tusié-Luna MT.

Circ Res. 2003 Mar 21;92(5):569-76. Epub 2003 Feb 27.PMID: 12609970 [PubMed - indexed for MEDLINE]Related articlesFree article

Mapping genes influencing type 2 diabetes risk and BMI in Japanese subjects.

Iwasaki N, Cox NJ, Wang YQ, Schwarz PE, Bell GI, Honda M, Imura M, Ogata M, Saito M, Kamatani N, Iwamoto Y.

Diabetes. 2003 Jan;52(1):209-13.PMID: 12502515 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians.

Rasmussen SK, Urhammer SA, Berglund L, Jensen JN, Hansen L, Echwald SM, Borch-Johnsen K, Horikawa Y, Mashima H, Lithell H, Cox NJ, Hansen T, Bell GI, Pedersen O.

Diabetes. 2002 Dec;51(12):3561-7.PMID: 12453914 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells.

Hara M, Wang X, Kawamura T, Bindokas VP, Dizon RF, Alcoser SY, Magnuson MA, Bell GI.

Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E177-83. Epub 2002 Sep 17.PMID: 12388130 [PubMed - indexed for MEDLINE]Related articlesFree article