PubMed

Synergistic Electrophysiologic and Antiarrhythmic Effects of the Combination of Ranolazine and Chronic Amiodarone in Canine Atria.

Sicouri S, Burashnikov A, Belardinelli L, Antzelevitch C.

Circ Arrhythm Electrophysiol. 2009 Dec 1. [Epub ahead of print]PMID: 19952329 [PubMed - as supplied by publisher]Related articles

A study of the effects of ranolazine using automated quantitative analysis of serial myocardial perfusion images.

Venkataraman R, Belardinelli L, Blackburn B, Heo J, Iskandrian AE.

JACC Cardiovasc Imaging. 2009 Nov;2(11):1301-9.PMID: 19909934 [PubMed - in process]Related articles

Use-dependent block of cardiac late Na(+) current by ranolazine.

Rajamani S, El-Bizri N, Shryock JC, Makielski JC, Belardinelli L.

Heart Rhythm. 2009 Nov;6(11):1625-31. Epub 2009 Jul 28.PMID: 19879541 [PubMed - in process]Related articles

Abnormal left ventricular relaxation in patients with long QT syndrome.

Belardinelli L, Dhalla A, Shryock J.

Eur Heart J. 2009 Nov;30(22):2813-4; author reply 2814-5. Epub 2009 Oct 20. No abstract available. PMID: 19843555 [PubMed - in process]Related articles

Effects of adenosine and a selective A2A adenosine receptor agonist on hemodynamic and thallium-201 and technetium-99m-sestaMIBI biodistribution and kinetics.

Mekkaoui C, Jadbabaie F, Dione DP, Meoli DF, Purushothaman K, Belardinelli L, Sinusas AJ.

JACC Cardiovasc Imaging. 2009 Oct;2(10):1198-208.PMID: 19833310 [PubMed - in process]Related articles

Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts.

Hwang H, Arcidi JM Jr, Hale SL, Simkhovich BZ, Belardinelli L, Dhalla AK, Shryock JC, Kloner RA.

Circulation. 2009 Sep 15;120(11 Suppl):S16-21.PMID: 19752362 [PubMed - indexed for MEDLINE]Related articles

Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion.

Dhalla AK, Wang WQ, Dow J, Shryock JC, Belardinelli L, Bhandari A, Kloner RA.

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1923-9. Epub 2009 Sep 18.PMID: 19767532 [PubMed - indexed for MEDLINE]Related articles

LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte apoptosis, cardiac fibrosis and contractile dysfunction in mice.

Zhang T, Yong SL, Drinko JK, Popović ZB, Shryock JC, Belardinelli L, Wang QK.

Int J Cardiol. 2009 Sep 16. [Epub ahead of print]PMID: 19762097 [PubMed - as supplied by publisher]Related articles

A slowly inactivating sodium current contributes to spontaneous diastolic depolarization of atrial myocytes.

Song Y, Shryock JC, Belardinelli L.

Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1254-62. Epub 2009 Aug 21.PMID: 19700626 [PubMed - indexed for MEDLINE]Related articles

Ranolazine antagonizes the effects of increased late sodium current on intracellular calcium cycling in rat isolated intact heart.

Wasserstrom JA, Sharma R, O'Toole MJ, Zheng J, Kelly JE, Shryock J, Belardinelli L, Aistrup GL.

J Pharmacol Exp Ther. 2009 Nov;331(2):382-91. Epub 2009 Aug 12.PMID: 19675298 [PubMed - in process]Related articles

A1 adenosine receptor: role in diabetes and obesity.

Dhalla AK, Chisholm JW, Reaven GM, Belardinelli L.

Handb Exp Pharmacol. 2009;(193):271-95. Review.PMID: 19639285 [PubMed - indexed for MEDLINE]Related articles

Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart.

Wu L, Rajamani S, Li H, January CT, Shryock JC, Belardinelli L.

Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1048-57. Epub 2009 Jul 10.PMID: 19592609 [PubMed - indexed for MEDLINE]Related articles

The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular diastolic dysfunction.

Wu Y, Song Y, Belardinelli L, Shryock JC.

J Pharmacol Exp Ther. 2009 Aug;330(2):550-7. Epub 2009 Apr 29.PMID: 19403851 [PubMed - indexed for MEDLINE]Related articles

Sinus node dysfunction in ATX-II-induced in-vitro murine model of long QT3 syndrome and rescue effect of ranolazine.

Wu J, Cheng L, Lammers WJ, Wu L, Wang X, Shryock JC, Belardinelli L, Lei M.

Prog Biophys Mol Biol. 2008 Oct-Nov;98(2-3):198-207. Epub 2009 Jan 25.PMID: 19351514 [PubMed - indexed for MEDLINE]Related articles

Differences in heart rate response to adenosine and regadenoson in patients with and without diabetes mellitus.

Hage FG, Heo J, Franks B, Belardinelli L, Blackburn B, Wang W, Iskandrian AE.

Am Heart J. 2009 Apr;157(4):771-6. Epub 2009 Mar 6.PMID: 19332209 [PubMed - indexed for MEDLINE]Related articles

Ranolazine as an adjunct to cardioplegia: a potential new therapeutic application.

Hwang H, Arcidi JM Jr, Hale SL, Simkhovich BZ, Belardinelli L, Dhalla AK, Shryock JC, Kloner RA.

J Cardiovasc Pharmacol Ther. 2009 Jun;14(2):125-33. Epub 2009 Mar 27.PMID: 19329672 [PubMed - indexed for MEDLINE]Related articles

Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart.

Kumar K, Nearing BD, Carvas M, Nascimento BC, Acar M, Belardinelli L, Verrier RL.

J Cardiovasc Electrophysiol. 2009 Jul;20(7):796-802. Epub 2009 Feb 27.PMID: 19298570 [PubMed - indexed for MEDLINE]Related articles

Potent antiarrhythmic effects of chronic amiodarone in canine pulmonary vein sleeve preparations.

Sicouri S, Belardinelli L, Carlsson L, Antzelevitch C.

J Cardiovasc Electrophysiol. 2009 Jul;20(7):803-10. Epub 2009 Feb 27.PMID: 19298559 [PubMed - indexed for MEDLINE]Related articles

Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine.

Wu L, Guo D, Li H, Hackett J, Yan GX, Jiao Z, Antzelevitch C, Shryock JC, Belardinelli L.

Heart Rhythm. 2008 Dec;5(12):1726-34. Epub 2008 Sep 6.PMID: 19084812 [PubMed - indexed for MEDLINE]Related articlesFree article

Block of tetrodotoxin-sensitive, Na(V)1.7 and tetrodotoxin-resistant, Na(V)1.8, Na+ channels by ranolazine.

Rajamani S, Shryock JC, Belardinelli L.

Channels (Austin). 2008 Nov-Dec;2(6):449-60. Epub 2008 Nov 7.PMID: 19077543 [PubMed - indexed for MEDLINE]Related articles

Regadenoson, a novel pharmacologic stress agent for use in myocardial perfusion imaging, does not have a direct effect on the QT interval in conscious dogs.

Zhao G, Serpllion S, Shryock J, Messina E, Xu X, Ochoa M, Belardinelli L, Hintze TH.

J Cardiovasc Pharmacol. 2008 Nov;52(5):467-73.PMID: 19033827 [PubMed - indexed for MEDLINE]Related articles

Partial A1 adenosine receptor agonist regulates cardiac substrate utilization in insulin-resistant rats in vivo.

Shearer J, Severson DL, Su L, Belardinelli L, Dhalla AK.

J Pharmacol Exp Ther. 2009 Jan;328(1):306-11. Epub 2008 Oct 24.PMID: 18952888 [PubMed - indexed for MEDLINE]Related articles

Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure.

Rastogi S, Sharov VG, Mishra S, Gupta RC, Blackburn B, Belardinelli L, Stanley WC, Sabbah HN.

Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2149-55. Epub 2008 Sep 26.PMID: 18820026 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathophysiology and pharmacology of the cardiac "late sodium current.".

Zaza A, Belardinelli L, Shryock JC.

Pharmacol Ther. 2008 Sep;119(3):326-39. Epub 2008 Jul 1. Review.PMID: 18662720 [PubMed - indexed for MEDLINE]Related articles

Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations.

Sicouri S, Glass A, Belardinelli L, Antzelevitch C.

Heart Rhythm. 2008 Jul;5(7):1019-26. Epub 2008 Mar 21.PMID: 18598958 [PubMed - indexed for MEDLINE]Related articlesFree article

The first second-generation adenosine drug enters the US market.

Pelleg A, Belardinelli L.

Purinergic Signal. 2008 Dec;4(4):407-8. No abstract available. PMID: 18566916 [PubMed - in process]Related articlesFree article

Rapid kinetic interactions of ranolazine with HERG K+ current.

Rajamani S, Shryock JC, Belardinelli L.

J Cardiovasc Pharmacol. 2008 Jun;51(6):581-9.PMID: 18520952 [PubMed - indexed for MEDLINE]Related articles

Comparison of the antilipolytic effects of an A1 adenosine receptor partial agonist in normal and diabetic rats.

Dhalla AK, Santikul M, Chisholm JW, Belardinelli L, Reaven GM.

Diabetes Obes Metab. 2009 Feb;11(2):95-101. Epub 2008 May 20.PMID: 18494808 [PubMed - indexed for MEDLINE]Related articles

Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart.

Kumar K, Nearing BD, Bartoli CR, Kwaku KF, Belardinelli L, Verrier RL.

J Cardiovasc Electrophysiol. 2008 Oct;19(10):1073-9. Epub 2008 May 9.PMID: 18479333 [PubMed - indexed for MEDLINE]Related articles

Late sodium current inhibition as a new cardioprotective approach.

Hale SL, Shryock JC, Belardinelli L, Sweeney M, Kloner RA.

J Mol Cell Cardiol. 2008 Jun;44(6):954-67. Epub 2008 Apr 8. Review.PMID: 18462746 [PubMed - indexed for MEDLINE]Related articles

Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation.

Sossalla S, Wagner S, Rasenack EC, Ruff H, Weber SL, Schöndube FA, Tirilomis T, Tenderich G, Hasenfuss G, Belardinelli L, Maier LS.

J Mol Cell Cardiol. 2008 Jul;45(1):32-43. Epub 2008 Mar 14.PMID: 18439620 [PubMed - indexed for MEDLINE]Related articles

A novel partial fatty acid oxidation inhibitor decreases myocardial oxygen consumption and improves cardiac efficiency in demand-induced ischemic heart.

Wu L, Belardinelli L, Fraser H.

J Cardiovasc Pharmacol. 2008 Apr;51(4):372-9.PMID: 18427280 [PubMed - indexed for MEDLINE]Related articles

Atrial-selective sodium channel block as a strategy for suppression of atrial fibrillation.

Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C.

Ann N Y Acad Sci. 2008 Mar;1123:105-12.PMID: 18375582 [PubMed - indexed for MEDLINE]Related articlesFree article

Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits.

Wang WQ, Robertson C, Dhalla AK, Belardinelli L.

J Pharmacol Exp Ther. 2008 Jun;325(3):875-81. Epub 2008 Mar 5.PMID: 18322148 [PubMed - indexed for MEDLINE]Related articlesFree article

An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes.

Song Y, Shryock JC, Belardinelli L.

Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2031-9. Epub 2008 Feb 29.PMID: 18310511 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium.

Shryock JC, Belardinelli L.

Br J Pharmacol. 2008 Mar;153(6):1128-32. Epub 2007 Dec 10.PMID: 18071302 [PubMed - indexed for MEDLINE]Related articlesFree article

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

Wu L, Rajamani S, Shryock JC, Li H, Ruskin J, Antzelevitch C, Belardinelli L.

Cardiovasc Res. 2008 Feb 1;77(3):481-8. Epub 2007 Nov 13.PMID: 18006430 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenosine versus regadenoson comparative evaluation in myocardial perfusion imaging: results of the ADVANCE phase 3 multicenter international trial.

Iskandrian AE, Bateman TM, Belardinelli L, Blackburn B, Cerqueira MD, Hendel RC, Lieu H, Mahmarian JJ, Olmsted A, Underwood SR, Vitola J, Wang W; ADVANCE MPI Investigators.

J Nucl Cardiol. 2007 Sep-Oct;14(5):645-58.PMID: 17826318 [PubMed - indexed for MEDLINE]Related articles

Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial.

Scirica BM, Morrow DA, Hod H, Murphy SA, Belardinelli L, Hedgepeth CM, Molhoek P, Verheugt FW, Gersh BJ, McCabe CH, Braunwald E.

Circulation. 2007 Oct 9;116(15):1647-52. Epub 2007 Sep 5.PMID: 17804441 [PubMed - indexed for MEDLINE]Related articlesFree article

Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine.

Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C.

Circulation. 2007 Sep 25;116(13):1449-57. Epub 2007 Sep 4.PMID: 17785620 [PubMed - indexed for MEDLINE]Related articlesFree article

Regadenoson, a selective A2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans.

Lieu HD, Shryock JC, von Mering GO, Gordi T, Blackburn B, Olmsted AW, Belardinelli L, Kerensky RA.

J Nucl Cardiol. 2007 Jul;14(4):514-20.PMID: 17679059 [PubMed - indexed for MEDLINE]Related articles

Caffeine attenuates the duration of coronary vasodilation and changes in hemodynamics induced by regadenoson (CVT-3146), a novel adenosine A2A receptor agonist.

Zhao G, Messina E, Xu X, Ochoa M, Sun HL, Leung K, Shryock J, Belardinelli L, Hintze TH.

J Cardiovasc Pharmacol. 2007 Jun;49(6):369-75.PMID: 17577101 [PubMed - indexed for MEDLINE]Related articles

Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: effects of ranolazine.

Sicouri S, Timothy KW, Zygmunt AC, Glass A, Goodrow RJ, Belardinelli L, Antzelevitch C.

Heart Rhythm. 2007 May;4(5):638-47. Epub 2007 Jan 7.PMID: 17467634 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists.

Yang M, Soohoo D, Soelaiman S, Kalla R, Zablocki J, Chu N, Leung K, Yao L, Diamond I, Belardinelli L, Shryock JC.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Apr;375(2):133-44. Epub 2007 Feb 20.PMID: 17310264 [PubMed - indexed for MEDLINE]Related articles

A1 adenosine receptor partial agonist lowers plasma FFA and improves insulin resistance induced by high-fat diet in rodents.

Dhalla AK, Wong MY, Voshol PJ, Belardinelli L, Reaven GM.

Am J Physiol Endocrinol Metab. 2007 May;292(5):E1358-63. Epub 2007 Jan 16.PMID: 17227958 [PubMed - indexed for MEDLINE]Related articlesFree article

Antilipolytic activity of a novel partial A1 adenosine receptor agonist devoid of cardiovascular effects: comparison with nicotinic acid.

Dhalla AK, Santikul M, Smith M, Wong MY, Shryock JC, Belardinelli L.

J Pharmacol Exp Ther. 2007 Apr;321(1):327-33. Epub 2007 Jan 4.PMID: 17204748 [PubMed - indexed for MEDLINE]Related articlesFree article

A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion.

Wang P, Fraser H, Lloyd SG, McVeigh JJ, Belardinelli L, Chatham JC.

J Pharmacol Exp Ther. 2007 Apr;321(1):213-20. Epub 2007 Jan 3.PMID: 17202401 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of a specific and selective A(2B) adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma.

Mustafa SJ, Nadeem A, Fan M, Zhong H, Belardinelli L, Zeng D.

J Pharmacol Exp Ther. 2007 Mar;320(3):1246-51. Epub 2006 Dec 11.PMID: 17159162 [PubMed - indexed for MEDLINE]Related articlesFree article

CVT-4325 inhibits myocardial fatty acid uptake and improves left ventricular systolic function without increasing myocardial oxygen consumption in dogs with chronic heart failure.

Imai M, Rastogi S, Sharma N, Chandler MP, Sharov VG, Blackburn B, Belardinelli L, Stanley WC, Sabbah HN.

Cardiovasc Drugs Ther. 2007 Feb;21(1):9-15.PMID: 17119875 [PubMed - indexed for MEDLINE]Related articles

A population pharmacokinetic/pharmacodynamic analysis of regadenoson, an adenosine A2A-receptor agonist, in healthy male volunteers.

Gordi T, Frohna P, Sun HL, Wolff A, Belardinelli L, Lieu H.

Clin Pharmacokinet. 2006;45(12):1201-12.PMID: 17112296 [PubMed - indexed for MEDLINE]Related articles