PubMed

In vivo neurochemical profiling of rat brain by (1)H-[(13)C] NMR spectroscopy: cerebral energetics and glutamatergic/GABAergic neurotransmission.

van Eijsden P, Behar KL, Mason GF, Braun KP, de Graaf RA.

J Neurochem. 2009 Oct 10. [Epub ahead of print]PMID: 19818103 [PubMed - as supplied by publisher]Related articles

Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy.

Boumezbeur F, Mason GF, de Graaf RA, Behar KL, Cline GW, Shulman GI, Rothman DL, Petersen KF.

J Cereb Blood Flow Metab. 2009 Sep 30. [Epub ahead of print]PMID: 19794401 [PubMed - as supplied by publisher]Related articles

Recurrent antecedent hypoglycemia alters neuronal oxidative metabolism in vivo.

Jiang L, Herzog RI, Mason GF, de Graaf RA, Rothman DL, Sherwin RS, Behar KL.

Diabetes. 2009 Jun;58(6):1266-74. Epub 2009 Mar 10.PMID: 19276443 [PubMed - indexed for MEDLINE]Related articlesFree article

Concentration-dependent effects on intracellular and surface pH of exposing Xenopus oocytes to solutions containing NH3/NH4(+).

Musa-Aziz R, Jiang L, Chen LM, Behar KL, Boron WF.

J Membr Biol. 2009 Mar;228(1):15-31. Epub 2009 Feb 26.PMID: 19242745 [PubMed - indexed for MEDLINE]Related articles

In situ 3D magnetic resonance metabolic imaging of microwave-irradiated rodent brain: a new tool for metabolomics research.

de Graaf RA, Chowdhury GM, Brown PB, Rothman DL, Behar KL.

J Neurochem. 2009 Apr;109(2):494-501. Epub 2009 Feb 7.PMID: 19200336 [PubMed - indexed for MEDLINE]Related articles

Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole.

Banasr M, Chowdhury GM, Terwilliger R, Newton SS, Duman RS, Behar KL, Sanacora G.

Mol Psychiatry. 2008 Sep 30. [Epub ahead of print]PMID: 18825147 [PubMed - as supplied by publisher]Related articles

Determination of the glutamate-glutamine cycling flux using two-compartment dynamic metabolic modeling is sensitive to astroglial dilution.

Shen J, Rothman DL, Behar KL, Xu S.

J Cereb Blood Flow Metab. 2009 Jan;29(1):108-18. Epub 2008 Sep 3.PMID: 18766194 [PubMed - indexed for MEDLINE]Related articles

Chronic riluzole treatment increases glucose metabolism in rat prefrontal cortex and hippocampus.

Chowdhury GM, Banasr M, de Graaf RA, Rothman DL, Behar KL, Sanacora G.

J Cereb Blood Flow Metab. 2008 Dec;28(12):1892-7. Epub 2008 Jul 16.PMID: 18628780 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons.

Malthankar-Phatak GH, Patel AB, Xia Y, Hong S, Chowdhury GM, Behar KL, Orina IA, Lai JC.

Brain Res. 2008 Sep 10;1229:147-54. Epub 2008 Jun 28.PMID: 18621040 [PubMed - indexed for MEDLINE]Related articlesFree article

Natural abundance (17)O NMR spectroscopy of rat brain in vivo.

de Graaf RA, Brown PB, Rothman DL, Behar KL.

J Magn Reson. 2008 Jul;193(1):63-7. Epub 2008 May 5.PMID: 18456525 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling.

Chowdhury GM, Gupta M, Gibson KM, Patel AB, Behar KL.

J Neurochem. 2007 Dec;103(5):2077-91. Epub 2007 Sep 13.PMID: 17854388 [PubMed - indexed for MEDLINE]Related articles

High resolution NMR spectroscopy of rat brain in vivo through indirect zero-quantum-coherence detection.

de Graaf RA, Rothman DL, Behar KL.

J Magn Reson. 2007 Aug;187(2):320-6. Epub 2007 Jun 10.PMID: 17587617 [PubMed - indexed for MEDLINE]Related articles

Glutamatergic and GABAergic neurotransmitter cycling and energy metabolism in rat cerebral cortex during postnatal development.

Chowdhury GM, Patel AB, Mason GF, Rothman DL, Behar KL.

J Cereb Blood Flow Metab. 2007 Dec;27(12):1895-907. Epub 2007 Apr 18.PMID: 17440492 [PubMed - indexed for MEDLINE]Related articles

Regional whole body fat quantification in mice.

Papademetris X, Shkarin P, Staib LH, Behar KL.

Inf Process Med Imaging. 2005;19:369-80.PMID: 17354710 [PubMed - indexed for MEDLINE]Related articles

Differential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy.

Malthankar-Phatak GH, de Lanerolle N, Eid T, Spencer DD, Behar KL, Spencer SS, Kim JH, Lai JC.

Epilepsia. 2006 Aug;47(8):1292-9.PMID: 16922873 [PubMed - indexed for MEDLINE]Related articles

High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo.

de Graaf RA, Brown PB, McIntyre S, Nixon TW, Behar KL, Rothman DL.

Magn Reson Med. 2006 Aug;56(2):386-94.PMID: 16767752 [PubMed - indexed for MEDLINE]Related articles

Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo.

Patel AB, de Graaf RA, Martin DL, Battaglioli G, Behar KL.

J Neurochem. 2006 Apr;97(2):385-96. Epub 2006 Mar 15.PMID: 16539672 [PubMed - indexed for MEDLINE]Related articles

Acute regulation of steady-state GABA levels following GABA-transaminase inhibition in rat cerebral cortex.

de Graaf RA, Patel AB, Rothman DL, Behar KL.

Neurochem Int. 2006 May-Jun;48(6-7):508-14. Epub 2006 Mar 3.PMID: 16517019 [PubMed - indexed for MEDLINE]Related articles

Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.

Hyder F, Patel AB, Gjedde A, Rothman DL, Behar KL, Shulman RG.

J Cereb Blood Flow Metab. 2006 Jul;26(7):865-77. Epub 2006 Jan 11. Review.PMID: 16407855 [PubMed - indexed for MEDLINE]Related articles

Lamotrigine suppresses neurophysiological responses to somatosensory stimulation in the rodent.

Kida I, Smith AJ, Blumenfeld H, Behar KL, Hyder F.

Neuroimage. 2006 Jan 1;29(1):216-24. Epub 2005 Aug 19.PMID: 16112588 [PubMed - indexed for MEDLINE]Related articles

The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo.

Patel AB, de Graaf RA, Mason GF, Rothman DL, Shulman RG, Behar KL.

Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5588-93. Epub 2005 Apr 4.PMID: 15809416 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder.

Goddard AW, Mason GF, Appel M, Rothman DL, Gueorguieva R, Behar KL, Krystal JH.

Am J Psychiatry. 2004 Dec;161(12):2186-93.PMID: 15569888 [PubMed - indexed for MEDLINE]Related articlesFree article

Cerebral pyruvate carboxylase flux is unaltered during bicuculline-seizures.

Patel AB, Chowdhury GM, de Graaf RA, Rothman DL, Shulman RG, Behar KL.

J Neurosci Res. 2005 Jan 1-15;79(1-2):128-38. Erratum in: J Neurosci Res. 2005 Jun 1;80(5):738. PMID: 15562501 [PubMed - indexed for MEDLINE]Related articles

Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activation.

Patel AB, de Graaf RA, Mason GF, Kanamatsu T, Rothman DL, Shulman RG, Behar KL.

J Cereb Blood Flow Metab. 2004 Sep;24(9):972-85.PMID: 15356418 [PubMed - indexed for MEDLINE]Related articles

Regional glucose metabolism and glutamatergic neurotransmission in rat brain in vivo.

de Graaf RA, Mason GF, Patel AB, Rothman DL, Behar KL.

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12700-5. Epub 2004 Aug 13.PMID: 15310848 [PubMed - indexed for MEDLINE]Related articlesFree article

Energetic basis of brain activity: implications for neuroimaging.

Shulman RG, Rothman DL, Behar KL, Hyder F.

Trends Neurosci. 2004 Aug;27(8):489-95. Review.PMID: 15271497 [PubMed - indexed for MEDLINE]Related articles

Family psychopathology and magnitude of reductions in occipital cortex GABA levels in panic disorder.

Goddard AW, Mason GF, Rothman DL, Behar KL, Petroff OA, Krystal JH.

Neuropsychopharmacology. 2004 Mar;29(3):639-40. No abstract available. PMID: 14973435 [PubMed - indexed for MEDLINE]Related articlesFree article

Determination of liposomal encapsulation efficiency using proton NMR spectroscopy.

Zhang XM, Patel AB, de Graaf RA, Behar KL.

Chem Phys Lipids. 2004 Jan;127(1):113-20.PMID: 14706745 [PubMed - indexed for MEDLINE]Related articles

Coupling of glutamatergic neurotransmission and neuronal glucose oxidation over the entire range of cerebral cortex activity.

Patel AB, De Graaf RA, Mason GF, Rothman DL, Shulman RG, Behar KL.

Ann N Y Acad Sci. 2003 Nov;1003:452-3. No abstract available. PMID: 14684486 [PubMed - indexed for MEDLINE]Related articles

In vivo 1H-[13C]-NMR spectroscopy of cerebral metabolism.

de Graaf RA, Mason GF, Patel AB, Behar KL, Rothman DL.

NMR Biomed. 2003 Oct-Nov;16(6-7):339-57. Review.PMID: 14679499 [PubMed - indexed for MEDLINE]Related articles

Dominant events that modulate mass transfer coefficient of oxygen in cerebral cortex.

Hyder F, Kida I, Behar KL, Kennan RP, Rothman DL.

Adv Exp Med Biol. 2003;530:401-11.PMID: 14562735 [PubMed - indexed for MEDLINE]Related articles

Mapping cerebral glutamate 13C turnover and oxygen consumption by in vivo NMR.

Hyder F, Brown P, Nixon TW, Behar KL.

Adv Exp Med Biol. 2003;530:29-39.PMID: 14562702 [PubMed - indexed for MEDLINE]Related articles

Expression of Drosophila trehalose-phosphate synthase in HEK-293 cells increases hypoxia tolerance.

Chen Q, Behar KL, Xu T, Fan C, Haddad GG.

J Biol Chem. 2003 Dec 5;278(49):49113-8. Epub 2003 Sep 16.PMID: 13129920 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative 1H NMR spectroscopy of blood plasma metabolites.

de Graaf RA, Behar KL.

Anal Chem. 2003 May 1;75(9):2100-4.PMID: 12720347 [PubMed - indexed for MEDLINE]Related articles

Chronic hypoxia in development selectively alters the activities of key enzymes of glucose oxidative metabolism in brain regions.

Lai JC, White BK, Buerstatte CR, Haddad GG, Novotny EJ Jr, Behar KL.

Neurochem Res. 2003 Jun;28(6):933-40.PMID: 12718448 [PubMed - indexed for MEDLINE]Related articles

Adiabatic RARE imaging.

de Graaf RA, Rothman DL, Behar KL.

NMR Biomed. 2003 Feb;16(1):29-35.PMID: 12577295 [PubMed - indexed for MEDLINE]Related articles

In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function.

Rothman DL, Behar KL, Hyder F, Shulman RG.

Annu Rev Physiol. 2003;65:401-27. Epub 2002 May 1. Review.PMID: 12524459 [PubMed - indexed for MEDLINE]Related articles

Detection of [1,6-13C2]-glucose metabolism in rat brain by in vivo 1H-[13C]-NMR spectroscopy.

de Graaf RA, Brown PB, Mason GF, Rothman DL, Behar KL.

Magn Reson Med. 2003 Jan;49(1):37-46.PMID: 12509818 [PubMed - indexed for MEDLINE]Related articles

Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI.

Smith AJ, Blumenfeld H, Behar KL, Rothman DL, Shulman RG, Hyder F.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10765-70. Epub 2002 Jul 19.PMID: 12134056 [PubMed - indexed for MEDLINE]Related articlesFree article

Continuous-wave near-infrared spectroscopy using pathlength-independent hypoxia normalization.

Kennan RP, Behar KL.

J Biomed Opt. 2002 Apr;7(2):228-35.PMID: 11966308 [PubMed - indexed for MEDLINE]Related articles

Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism.

Lebon V, Petersen KF, Cline GW, Shen J, Mason GF, Dufour S, Behar KL, Shulman GI, Rothman DL.

J Neurosci. 2002 Mar 1;22(5):1523-31.PMID: 11880482 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI.

Hyder F, Kida I, Behar KL, Kennan RP, Maciejewski PK, Rothman DL.

NMR Biomed. 2001 Nov-Dec;14(7-8):413-31.PMID: 11746934 [PubMed - indexed for MEDLINE]Related articles

Role of trehalose phosphate synthase in anoxia tolerance and development in Drosophila melanogaster.

Chen Q, Ma E, Behar KL, Xu T, Haddad GG.

J Biol Chem. 2002 Feb 1;277(5):3274-9. Epub 2001 Nov 21.PMID: 11719513 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition.

Patel AB, Rothman DL, Cline GW, Behar KL.

Brain Res. 2001 Nov 23;919(2):207-20.PMID: 11701133 [PubMed - indexed for MEDLINE]Related articles

Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD(67) protein.

Mason GF, Martin DL, Martin SB, Manor D, Sibson NR, Patel A, Rothman DL, Behar KL.

Brain Res. 2001 Sep 28;914(1-2):81-91.PMID: 11578600 [PubMed - indexed for MEDLINE]Related articles

In vivo nuclear magnetic resonance studies of glutamate-gamma-aminobutyric acid-glutamine cycling in rodent and human cortex: the central role of glutamine.

Behar KL, Rothman DL.

J Nutr. 2001 Sep;131(9 Suppl):2498S-504S; discussion 2523S-4S. Review.PMID: 11533301 [PubMed - indexed for MEDLINE]Related articlesFree article

Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy.

Goddard AW, Mason GF, Almai A, Rothman DL, Behar KL, Petroff OA, Charney DS, Krystal JH.

Arch Gen Psychiatry. 2001 Jun;58(6):556-61.PMID: 11386984 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of voltage-dependent sodium channels suppresses the functional magnetic resonance imaging response to forepaw somatosensory activation in the rodent.

Kida I, Hyder F, Behar KL.

J Cereb Blood Flow Metab. 2001 May;21(5):585-91.PMID: 11333369 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during.

Sibson NR, Mason GF, Shen J, Cline GW, Herskovits AZ, Wall JE, Behar KL, Rothman DL, Shulman RG.

J Neurochem. 2001 Feb;76(4):975-89.PMID: 11181817 [PubMed - indexed for MEDLINE]Related articles

Brain regional development of the activity of alpha-ketoglutarate dehydrogenase complex in the rat.

Buerstatte CR, Behar KL, Novotny EJ, Lai JC.

Brain Res Dev Brain Res. 2000 Dec 29;125(1-2):139-45.PMID: 11154769 [PubMed - indexed for MEDLINE]Related articles