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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 2
2007 1
2009 2
2010 5
2011 3
2012 3
2013 2
2014 6
2015 4
2016 7
2017 6
2018 5
2019 8
2020 18
2021 12
2022 8
2023 15
2024 6

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98 results

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Page 1
Past, present and future of therapeutic strategies against amyloid-beta peptides in Alzheimer's disease: a systematic review.
Jeremic D, Jiménez-Díaz L, Navarro-López JD. Jeremic D, et al. Ageing Res Rev. 2021 Dec;72:101496. doi: 10.1016/j.arr.2021.101496. Epub 2021 Oct 21. Ageing Res Rev. 2021. PMID: 34687956 Free article. Review.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing, affecting around 46 million people worldwide but few treatments are currently available. ...Therefore, many amyloid-targeted therapies have been investigated. Here, we will sy …
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing, affecting around 46 million people worldwi …
Efficacy of innovative therapies in myasthenia gravis: A systematic review, meta-analysis and network meta-analysis.
Saccà F, Pane C, Espinosa PE, Sormani MP, Signori A. Saccà F, et al. Eur J Neurol. 2023 Dec;30(12):3854-3867. doi: 10.1111/ene.15872. Epub 2023 May 30. Eur J Neurol. 2023. PMID: 37204031
The aim of this study was to perform a meta-analysis and network meta-analysis of randomized and placebo-controlled trials of innovative therapies in MG with available efficacy data. METHODS: We assessed statistical heterogeneity across trials based on the Cochrane Q test …
The aim of this study was to perform a meta-analysis and network meta-analysis of randomized and placebo-controlled trials of innovative …
New biologics and targeted therapies in systemic lupus: From new molecular targets to new indications. A systematic review.
Felten R, Scherlinger M, Mertz P, Chasset F, Arnaud L. Felten R, et al. Joint Bone Spine. 2023 Mar;90(2):105523. doi: 10.1016/j.jbspin.2023.105523. Epub 2023 Jan 7. Joint Bone Spine. 2023. PMID: 36623799
For each investigational drug, we considered only the study at the most advanced stage of clinical development. ...CONCLUSION: The pipeline of investigational drugs in SLE is highly diversified and will hopefully enable more optimal Treat-To-Target with the goal of …
For each investigational drug, we considered only the study at the most advanced stage of clinical development. ...CONCLUSION: The pi …
Recent Antifungal Pipeline Developments against Candida auris: A Systematic Review.
Treviño-Rangel RJ, González GM, Montoya AM, Rojas OC, Elizondo-Zertuche M, Álvarez-Villalobos NA. Treviño-Rangel RJ, et al. J Fungi (Basel). 2022 Oct 28;8(11):1144. doi: 10.3390/jof8111144. J Fungi (Basel). 2022. PMID: 36354911 Free PMC article. Review.
A systematic search in MEDLINE, EMBASE, Web of Science, and Scopus up to 27 June 2022 was conducted to find relevant articles reporting data of in vitro activity and in vivo efficacy of investigational antifungals against C. auris. These included new additions to existing …
A systematic search in MEDLINE, EMBASE, Web of Science, and Scopus up to 27 June 2022 was conducted to find relevant articles reporting data …
Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies.
Suraev AS, Marshall NS, Vandrey R, McCartney D, Benson MJ, McGregor IS, Grunstein RR, Hoyos CM. Suraev AS, et al. Sleep Med Rev. 2020 Oct;53:101339. doi: 10.1016/j.smrv.2020.101339. Epub 2020 May 16. Sleep Med Rev. 2020. PMID: 32603954
Promising preliminary evidence provides the rationale for future randomised controlled trials of cannabinoid therapies in individuals with sleep apnea, insomnia, post-traumatic stress disorder-related nightmares, restless legs syndrome, rapid eye movement sleep beha …
Promising preliminary evidence provides the rationale for future randomised controlled trials of cannabinoid therapies in indi …
Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake-up stroke.
Roaldsen MB, Lindekleiv H, Mathiesen EB. Roaldsen MB, et al. Cochrane Database Syst Rev. 2021 Dec 1;12(12):CD010995. doi: 10.1002/14651858.CD010995.pub3. Cochrane Database Syst Rev. 2021. PMID: 34850380 Free PMC article. Review.
However, recent studies suggest benefit from recanalisation therapies in selected patients. OBJECTIVES: To assess the effects of intravenous thrombolysis and endovascular thrombectomy versus control in people with acute ischaemic stroke presenting on awakening from sleep. …
However, recent studies suggest benefit from recanalisation therapies in selected patients. OBJECTIVES: To assess the effects of intr …
Behavioral and psychological treatments for chronic insomnia disorder in adults: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.
Edinger JD, Arnedt JT, Bertisch SM, Carney CE, Harrington JJ, Lichstein KL, Sateia MJ, Troxel WM, Zhou ES, Kazmi U, Heald JL, Martin JL. Edinger JD, et al. J Clin Sleep Med. 2021 Feb 1;17(2):263-298. doi: 10.5664/jcsm.8988. J Clin Sleep Med. 2021. PMID: 33164741 Free PMC article.
Evidence for the following interventions is presented in this review: cognitive-behavioral therapy for insomnia, brief therapies for insomnia, stimulus control, sleep restriction therapy, relaxation training, sleep hygiene, biofeedback, paradoxical intention, intensive sle …
Evidence for the following interventions is presented in this review: cognitive-behavioral therapy for insomnia, brief therapies for …
Funding breakthrough therapies: A systematic review and recommendation.
Hanna E, Toumi M, Dussart C, Borissov B, Dabbous O, Badora K, Auquier P. Hanna E, et al. Health Policy. 2018 Mar;122(3):217-229. doi: 10.1016/j.healthpol.2017.11.012. Epub 2017 Dec 2. Health Policy. 2018. PMID: 29223847 Review.
BACKGROUND: Advanced therapy medicinal products (ATMPs) are innovative therapies likely associated with high prices. Payers need guidance to create a balance between ensuring patient access to breakthrough therapies and maintaining the financial sustainability of th …
BACKGROUND: Advanced therapy medicinal products (ATMPs) are innovative therapies likely associated with high prices. Payers need guid …
Effectiveness of Medical Treatment of Cushing's Disease: A Systematic Review and Meta-Analysis.
Simões Corrêa Galendi J, Correa Neto ANS, Demetres M, Boguszewski CL, Nogueira VDSN. Simões Corrêa Galendi J, et al. Front Endocrinol (Lausanne). 2021 Sep 17;12:732240. doi: 10.3389/fendo.2021.732240. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34603209 Free PMC article.
CONCLUSION: The superiority of one drug over another could not be determined due to lack of controlled studies, but the proportion of disease control identified in our meta-analysis may support clinical decision. New therapeutic options should be investigated due to the li …
CONCLUSION: The superiority of one drug over another could not be determined due to lack of controlled studies, but the proportion of dis …
Emerging Therapies for the Management of Pain and Vaso-Occlusive Crises in Patients With Sickle Cell Disease: A Systematic Review of Randomized Controlled Trials.
Lowe M, Bambhroliya Z, Patel H, Patel VJ, Vudugula SA, Cheruvu NP, Raza S, Okunlola OI. Lowe M, et al. Cureus. 2023 Apr 23;15(4):e38014. doi: 10.7759/cureus.38014. eCollection 2023 Apr. Cureus. 2023. PMID: 37223201 Free PMC article. Review.
All other therapies are investigational only in nature. Several studies included measurement of biomarker endpoints as well as clinical outcomes. ...It can be concluded that there exists a specific opportunity to design, fund, and execute investigations that both co …
All other therapies are investigational only in nature. Several studies included measurement of biomarker endpoints as well as …
98 results