PubMed

Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.

Oriente F, Iovino S, Cassese A, Romano C, Miele C, Troncone G, Balletta M, Perfetti A, Santulli G, Iaccarino G, Valentino R, Beguinot F, Formisano P.

Diabetologia. 2009 Sep 30. [Epub ahead of print]PMID: 19789852 [PubMed - as supplied by publisher]Related articles

Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism.

Fiory F, Formisano P, Perruolo G, Beguinot F.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E592-601. Epub 2009 Jun 16. Review.PMID: 19531639 [PubMed - indexed for MEDLINE]Related articles

Peptide antagonists of the PED-hPLD1 binding.

Viparelli F, Doti N, Monti SM, Marasco D, Dathan N, Pedone C, Miele C, Formisano P, Beguinot F, Ruvo M.

Adv Exp Med Biol. 2009;611:445-6. No abstract available. PMID: 19400259 [PubMed - indexed for MEDLINE]Related articles

Leptin-stimulated endothelial nitric-oxide synthase via an adenosine 5'-monophosphate-activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein.

Procopio C, Andreozzi F, Laratta E, Cassese A, Beguinot F, Arturi F, Hribal ML, Perticone F, Sesti G.

Endocrinology. 2009 Aug;150(8):3584-93. Epub 2009 Apr 9.PMID: 19359389 [PubMed - indexed for MEDLINE]Related articles

In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.

Cassese A, Esposito I, Fiory F, Barbagallo AP, Paturzo F, Mirra P, Ulianich L, Giacco F, Iadicicco C, Lombardi A, Oriente F, Van Obberghen E, Beguinot F, Formisano P, Miele C.

J Biol Chem. 2008 Dec 26;283(52):36088-99. Epub 2008 Oct 27.PMID: 18955497 [PubMed - indexed for MEDLINE]Related articles

The cannabinoid CB1 receptor antagonist rimonabant stimulates 2-deoxyglucose uptake in skeletal muscle cells by regulating the expression of phosphatidylinositol-3-kinase.

Esposito I, Proto MC, Gazzerro P, Laezza C, Miele C, Alberobello AT, D'Esposito V, Beguinot F, Formisano P, Bifulco M.

Mol Pharmacol. 2008 Dec;74(6):1678-86. Epub 2008 Sep 18.PMID: 18801918 [PubMed - indexed for MEDLINE]Related articles

Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.

Ungaro P, Teperino R, Mirra P, Cassese A, Fiory F, Perruolo G, Miele C, Laakso M, Formisano P, Beguinot F.

J Biol Chem. 2008 Nov 7;283(45):30970-9. Epub 2008 Sep 2.PMID: 18765665 [PubMed - indexed for MEDLINE]Related articlesFree article

Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.

Oriente F, Fernandez Diaz LC, Miele C, Iovino S, Mori S, Diaz VM, Troncone G, Cassese A, Formisano P, Blasi F, Beguinot F.

Mol Cell Biol. 2008 Sep;28(18):5634-45. Epub 2008 Jul 21.PMID: 18644868 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.

Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M.

J Biol Chem. 2008 Aug 1;283(31):21769-78. Epub 2008 Jun 9.PMID: 18541525 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15.

Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M.

Protein Expr Purif. 2008 Jun;59(2):302-8. Epub 2008 Feb 29.PMID: 18420420 [PubMed - indexed for MEDLINE]Related articles

Atypical protein kinase C dysfunction and the metabolic syndrome.

Beguinot F, Formisano P.

Trends Endocrinol Metab. 2008 Mar;19(2):39-41. Epub 2008 Feb 21.PMID: 18294863 [PubMed - indexed for MEDLINE]Related articles

ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells.

Ulianich L, Garbi C, Treglia AS, Punzi D, Miele C, Raciti GA, Beguinot F, Consiglio E, Di Jeso B.

J Cell Sci. 2008 Feb 15;121(Pt 4):477-86. Epub 2008 Jan 22.PMID: 18211961 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization.

Miele C, Paturzo F, Teperino R, Sakane F, Fiory F, Oriente F, Ungaro P, Valentino R, Beguinot F, Formisano P.

J Biol Chem. 2007 Nov 2;282(44):31835-43. Epub 2007 Aug 3.PMID: 17675299 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of the phosphoprotein enriched in diabetes gene product (Ped/pea-15) in women with polycystic ovary syndrome.

Savastano S, Orio F Jr, Palomba S, Cascella T, Manguso F, Lupoli GA, Formisano P, Lombardi G, Colao A, Beguinot F, Valentino R.

Clin Endocrinol (Oxf). 2007 Oct;67(4):557-62. Epub 2007 Jun 21.PMID: 17590172 [PubMed - indexed for MEDLINE]Related articles

AP20187-mediated activation of a chimeric insulin receptor results in insulin-like actions in skeletal muscle and liver of diabetic mice.

Cotugno G, Formisano P, Giacco F, Colella P, Beguinot F, Auricchio A.

Hum Gene Ther. 2007 Feb;18(2):106-17.PMID: 17328681 [PubMed - indexed for MEDLINE]Related articles

PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells.

Miele C, Raciti GA, Cassese A, Romano C, Giacco F, Oriente F, Paturzo F, Andreozzi F, Zabatta A, Troncone G, Bosch F, Pujol A, Chneiweiss H, Formisano P, Beguinot F.

Diabetes. 2007 Mar;56(3):622-33.PMID: 17327429 [PubMed - indexed for MEDLINE]Related articlesFree article

Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

Perfetti A, Oriente F, Iovino S, Alberobello AT, Barbagallo AP, Esposito I, Fiory F, Teperino R, Ungaro P, Miele C, Formisano P, Beguinot F.

J Biol Chem. 2007 Mar 23;282(12):8648-57. Epub 2007 Jan 16.PMID: 17227770 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutamic acid decarboxylase antibodies in idiopathic generalized epilepsy and type 1 diabetes.

Striano P, Perruolo G, Errichiello L, Formisano P, Beguinot F, Zara F, Striano S.

Ann Neurol. 2008 Jan;63(1):127-8. No abstract available. PMID: 17167787 [PubMed - indexed for MEDLINE]Related articles

PTEN targeting: the search for novel insulin sensitisers provides new insight into obesity research.

Beguinot F.

Diabetologia. 2007 Feb;50(2):247-9. No abstract available. PMID: 17136390 [PubMed - indexed for MEDLINE]Related articles

The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes.

Valentino R, Lupoli GA, Raciti GA, Oriente F, Farinaro E, Della Valle E, Salomone M, Riccardi G, Vaccaro O, Donnarumma G, Sesti G, Hribal ML, Cardellini M, Miele C, Formisano P, Beguinot F.

Diabetologia. 2006 Dec;49(12):3058-66. Epub 2006 Oct 5.PMID: 17021921 [PubMed - indexed for MEDLINE]Related articles

Thrombin-activated platelets induce proliferation of human skin fibroblasts by stimulating autocrine production of insulin-like growth factor-1.

Giacco F, Perruolo G, D'Agostino E, Fratellanza G, Perna E, Misso S, Saldalamacchia G, Oriente F, Fiory F, Miele C, Formisano S, Beguinot F, Formisano P.

FASEB J. 2006 Nov;20(13):2402-4. Epub 2006 Oct 2.PMID: 17015410 [PubMed - indexed for MEDLINE]Related articlesFree article

Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.

Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F.

Mol Cell Biol. 2005 Dec;25(24):10803-14.PMID: 16314505 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase C-alpha regulates insulin action and degradation by interacting with insulin receptor substrate-1 and 14-3-3 epsilon.

Oriente F, Andreozzi F, Romano C, Perruolo G, Perfetti A, Fiory F, Miele C, Beguinot F, Formisano P.

J Biol Chem. 2005 Dec 9;280(49):40642-9. Epub 2005 Oct 10.PMID: 16216880 [PubMed - indexed for MEDLINE]Related articlesFree article

Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.

Formisano P, Perruolo G, Libertini S, Santopietro S, Troncone G, Raciti GA, Oriente F, Portella G, Miele C, Beguinot F.

Oncogene. 2005 Oct 27;24(47):7012-21.PMID: 16044159 [PubMed - indexed for MEDLINE]Related articles

Pharmacological regulation of the insulin receptor signaling pathway mimics insulin action in cells transduced with viral vectors.

Cotugno G, Pollock R, Formisano P, Linher K, Beguinot F, Auricchio A.

Hum Gene Ther. 2004 Nov;15(11):1101-8.PMID: 15610610 [PubMed - indexed for MEDLINE]Related articles

Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15.

Trencia A, Fiory F, Maitan MA, Vito P, Barbagallo AP, Perfetti A, Miele C, Ungaro P, Oriente F, Cilenti L, Zervos AS, Formisano P, Beguinot F.

J Biol Chem. 2004 Nov 5;279(45):46566-72. Epub 2004 Aug 24.PMID: 15328349 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action.

Vigliotta G, Miele C, Santopietro S, Portella G, Perfetti A, Maitan MA, Cassese A, Oriente F, Trencia A, Fiory F, Romano C, Tiveron C, Tatangelo L, Troncone G, Formisano P, Beguinot F.

Mol Cell Biol. 2004 Jun;24(11):5005-15.PMID: 15143191 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting.

Fiory F, Oriente F, Miele C, Romano C, Trencia A, Alberobello AT, Esposito I, Valentino R, Beguinot F, Formisano P.

J Biol Chem. 2004 Mar 19;279(12):11137-45. Epub 2004 Jan 6.PMID: 14711831 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular mechanisms involved in GnRH analogue-related apoptosis for uterine leiomyomas.

Bifulco G, Miele C, Pellicano M, Trencia A, Ferraioli M, Paturzo F, Tommaselli GA, Beguinot F, Nappi C.

Mol Hum Reprod. 2004 Jan;10(1):43-8.PMID: 14665705 [PubMed - in process]Related articlesFree article

Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.

Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E.

J Biol Chem. 2003 Nov 28;278(48):47376-87. Epub 2003 Sep 11.PMID: 12970360 [PubMed - indexed for MEDLINE]Related articlesFree article

Vanadate regulates the insulin mitogenic effect by modulating SHP-2 association with insulin receptor substrate 1 in JAr human choriocarcinoma cells.

Bifulco G, Caruso M, Di Carlo C, Acunzo G, Votino C, Pellicano M, Beguinot F, Nappi C.

Gynecol Endocrinol. 2003 Jun;17(3):239-45.PMID: 12857432 [PubMed - indexed for MEDLINE]Related articles

Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action.

Trencia A, Perfetti A, Cassese A, Vigliotta G, Miele C, Oriente F, Santopietro S, Giacco F, Condorelli G, Formisano P, Beguinot F.

Mol Cell Biol. 2003 Jul;23(13):4511-21.PMID: 12808093 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase.

Andreozzi F, Melillo RM, Carlomagno F, Oriente F, Miele C, Fiory F, Santopietro S, Castellone MD, Beguinot F, Santoro M, Formisano P.

Oncogene. 2003 May 15;22(19):2942-9.PMID: 12771945 [PubMed - indexed for MEDLINE]Related articles

Leptin induces mitogenic effect on human choriocarcinoma cell line (JAr) via MAP kinase activation in a glucose-dependent fashion.

Bifulco G, Trencia A, Caruso M, Tommaselli GA, Miele C, di Carlo C, Beguinot F, Nappi C.

Placenta. 2003 Apr;24(4):385-91.PMID: 12657513 [PubMed - indexed for MEDLINE]Related articles

Glucose regulates insulin mitogenic effect by modulating SHP-2 activation and localization in JAr cells.

Bifulco G, Di Carlo C, Caruso M, Oriente F, Di Spiezio Sardo A, Formisano P, Beguinot F, Nappi C.

J Biol Chem. 2002 Jul 5;277(27):24306-14. Epub 2002 Apr 30.PMID: 11983706 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells.

Xiao C, Yang BF, Asadi N, Beguinot F, Hao C.

J Biol Chem. 2002 Jul 12;277(28):25020-5. Epub 2002 Apr 25.PMID: 11976344 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function.

Condorelli G, Trencia A, Vigliotta G, Perfetti A, Goglia U, Cassese A, Musti AM, Miele C, Santopietro S, Formisano P, Beguinot F.

J Biol Chem. 2002 Mar 29;277(13):11013-8. Epub 2002 Jan 14.PMID: 11790785 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation and mitochondrial translocation of protein kinase Cdelta are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells.

Caruso M, Maitan MA, Bifulco G, Miele C, Vigliotta G, Oriente F, Formisano P, Beguinot F.

J Biol Chem. 2001 Nov 30;276(48):45088-97. Epub 2001 Sep 27.PMID: 11577086 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor substrate-2 phosphorylation is necessary for protein kinase C zeta activation by insulin in L6hIR cells.

Oriente F, Formisano P, Miele C, Fiory F, Maitan MA, Vigliotta G, Trencia A, Santopietro S, Caruso M, Van Obberghen E, Beguinot F.

J Biol Chem. 2001 Oct 5;276(40):37109-19. Epub 2001 Jul 31.PMID: 11481324 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of protein kinase C isoforms in insulin action.

Formisano P, Beguinot F.

J Endocrinol Invest. 2001 Jun;24(6):460-7. Review.PMID: 11434672 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells.

Condorelli G, Vigliotta G, Trencia A, Maitan MA, Caruso M, Miele C, Oriente F, Santopietro S, Formisano P, Beguinot F.

Diabetes. 2001 Jun;50(6):1244-52.PMID: 11375323 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells.

Hao C, Beguinot F, Condorelli G, Trencia A, Van Meir EG, Yong VW, Parney IF, Roa WH, Petruk KC.

Cancer Res. 2001 Feb 1;61(3):1162-70.PMID: 11221847 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-activated protein kinase Cbeta bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells.

Formisano P, Oriente F, Fiory F, Caruso M, Miele C, Maitan MA, Andreozzi F, Vigliotta G, Condorelli G, Beguinot F.

Mol Cell Biol. 2000 Sep;20(17):6323-33.PMID: 10938109 [PubMed - indexed for MEDLINE]Related articlesFree article

The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver.

Caruso M, Miele C, Oliva A, Condorelli G, Oriente F, Riccardi G, Capaldo B, Fiory F, Accili D, Formisano P, Beguinot F.

Diabetes. 2000 Jul;49(7):1194-202.PMID: 10909978 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-stimulated cardiac glucose uptake is impaired in spontaneously hypertensive rats: role of early steps of insulin signalling.

Morisco C, Condorelli G, Orzi F, Vigliotta G, Di Grezia R, Beguinot F, Trimarco B, Lembo G.

J Hypertens. 2000 Apr;18(4):465-73.PMID: 10779099 [PubMed - indexed for MEDLINE]Related articles

PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes.

Smith U, Carvalho E, Mosialou E, Beguinot F, Formisano P, Rondinone C.

Biochem Biophys Res Commun. 2000 Feb 16;268(2):315-20.PMID: 10679201 [PubMed - indexed for MEDLINE]Related articles

In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-alpha and trans-activates the insulin receptor kinase.

Caruso M, Miele C, Oriente F, Maitan A, Bifulco G, Andreozzi F, Condorelli G, Formisano P, Beguinot F.

J Biol Chem. 1999 Oct 1;274(40):28637-44.PMID: 10497232 [PubMed - indexed for MEDLINE]Related articlesFree article

PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis.

Condorelli G, Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F.

Oncogene. 1999 Aug 5;18(31):4409-15.PMID: 10442631 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential role of insulin receptor substrate (IRS)-1 and IRS-2 in L6 skeletal muscle cells expressing the Arg1152 --> Gln insulin receptor.

Miele C, Caruso M, Calleja V, Auricchio R, Oriente F, Formisano P, Condorelli G, Cafieri A, Sawka-Verhelle D, Van Obberghen E, Beguinot F.

J Biol Chem. 1999 Jan 29;274(5):3094-102.PMID: 9915848 [PubMed - indexed for MEDLINE]Related articlesFree article

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.

Condorelli G, Vigliotta G, Iavarone C, Caruso M, Tocchetti CG, Andreozzi F, Cafieri A, Tecce MF, Formisano P, Beguinot L, Beguinot F.

EMBO J. 1998 Jul 15;17(14):3858-66.PMID: 9670003 [PubMed - indexed for MEDLINE]Related articlesFree article