PubMed

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.

Zhang Y, Ikeno Y, Qi W, Chaudhuri A, Li Y, Bokov A, Thorpe SR, Baynes JW, Epstein C, Richardson A, Van Remmen H.

J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1212-20. Epub 2009 Sep 23.PMID: 19776219 [PubMed - in process]Related articles

Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin.

Frizzell N, Rajesh M, Jepson MJ, Nagai R, Carson JA, Thorpe SR, Baynes JW.

J Biol Chem. 2009 Sep 18;284(38):25772-81. Epub 2009 Jul 10.PMID: 19592500 [PubMed - indexed for MEDLINE]Related articles

Glycation of wood frog (Rana sylvatica) hemoglobin and blood proteins: in vivo and in vitro studies.

MacDonald JA, Degenhardt T, Baynes JW, Storey KB.

Cryobiology. 2009 Oct;59(2):223-5. Epub 2009 Jun 18.PMID: 19540217 [PubMed - indexed for MEDLINE]Related articles

The metal chelators, trientine and citrate, inhibit the development of cardiac pathology in the Zucker diabetic rat.

Baynes JW, Murray DB.

Exp Diabetes Res. 2009;2009:696378. Epub 2009 Apr 15.PMID: 19390595 [PubMed - indexed for MEDLINE]Related articlesFree article

A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic disease.

Zhang Q, Ames JM, Smith RD, Baynes JW, Metz TO.

J Proteome Res. 2009 Feb;8(2):754-69. Review.PMID: 19093874 [PubMed - indexed for MEDLINE]Related articles

Improved methods for the enrichment and analysis of glycated peptides.

Zhang Q, Schepmoes AA, Brock JW, Wu S, Moore RJ, Purvine SO, Baynes JW, Smith RD, Metz TO.

Anal Chem. 2008 Dec 15;80(24):9822-9.PMID: 18989935 [PubMed - indexed for MEDLINE]Related articlesFree article

Succination of proteins by fumarate: mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in diabetes.

Blatnik M, Thorpe SR, Baynes JW.

Ann N Y Acad Sci. 2008 Apr;1126:272-5.PMID: 18448829 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutaraldehyde is an effective cross-linker for production of antibodies against advanced glycation end-products.

Mera K, Nagai M, Brock JW, Fujiwara Y, Murata T, Maruyama T, Baynes JW, Otagiri M, Nagai R.

J Immunol Methods. 2008 May 20;334(1-2):82-90. Epub 2008 Mar 5.PMID: 18353354 [PubMed - indexed for MEDLINE]Related articles

Increased methionine sulfoxide content of apoA-I in type 1 diabetes.

Brock JW, Jenkins AJ, Lyons TJ, Klein RL, Yim E, Lopes-Virella M, Carter RE; (DCCT/EDIC) Research Group, Thorpe SR, Baynes JW.

J Lipid Res. 2008 Apr;49(4):847-55. Epub 2008 Jan 17.PMID: 18202432 [PubMed - indexed for MEDLINE]Related articlesFree article

Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress.

Blatnik M, Frizzell N, Thorpe SR, Baynes JW.

Diabetes. 2008 Jan;57(1):41-9. Epub 2007 Oct 12.PMID: 17934141 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary ALEs are a risk to human health--NOT!

Baynes JW.

Mol Nutr Food Res. 2007 Sep;51(9):1102-6.PMID: 17854007 [PubMed - indexed for MEDLINE]Related articles

Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress.

Nagai R, Brock JW, Blatnik M, Baatz JE, Bethard J, Walla MD, Thorpe SR, Baynes JW, Frizzell N.

J Biol Chem. 2007 Nov 23;282(47):34219-28. Epub 2007 Aug 28.PMID: 17726021 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation end products and the absence of premature atherosclerosis in glycogen storage disease Ia.

den Hollander NC, Mulder DJ, Graaff R, Thorpe SR, Baynes JW, Smit GP, Smit AJ.

J Inherit Metab Dis. 2007 Nov;30(6):916-23. Epub 2007 Jun 14.PMID: 17570077 [PubMed - indexed for MEDLINE]Related articles

Enrichment and analysis of nonenzymatically glycated peptides: boronate affinity chromatography coupled with electron-transfer dissociation mass spectrometry.

Zhang Q, Tang N, Brock JW, Mottaz HM, Ames JM, Baynes JW, Smith RD, Metz TO.

J Proteome Res. 2007 Jun;6(6):2323-30. Epub 2007 May 9.PMID: 17488106 [PubMed - indexed for MEDLINE]Related articlesFree article

Skin autofluorescence is a strong predictor of cardiac mortality in diabetes.

Meerwaldt R, Lutgers HL, Links TP, Graaff R, Baynes JW, Gans RO, Smit AJ.

Diabetes Care. 2007 Jan;30(1):107-12.PMID: 17192342 [PubMed - indexed for MEDLINE]Related articlesFree article

Detection and identification of arginine modifications on methylglyoxal-modified ribonuclease by mass spectrometric analysis.

Brock JW, Cotham WE, Thorpe SR, Baynes JW, Ames JM.

J Mass Spectrom. 2007 Jan;42(1):89-100.PMID: 17143934 [PubMed - indexed for MEDLINE]Related articles

Formation of methionine sulfoxide during glycoxidation and lipoxidation of ribonuclease A.

Brock JW, Ames JM, Thorpe SR, Baynes JW.

Arch Biochem Biophys. 2007 Jan 15;457(2):170-6. Epub 2006 Nov 2.PMID: 17141728 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes.

Yu Y, Thorpe SR, Jenkins AJ, Shaw JN, Sochaski MA, McGee D, Aston CE, Orchard TJ, Silvers N, Peng YG, McKnight JA, Baynes JW, Lyons TJ; DCCT/EDIC Research Group.

Diabetologia. 2006 Oct;49(10):2488-98. Epub 2006 Aug 29.PMID: 16955213 [PubMed - indexed for MEDLINE]Related articles

Cadmium and mercury cause an oxidative stress-induced endothelial dysfunction.

Wolf MB, Baynes JW.

Biometals. 2007 Feb;20(1):73-81. Epub 2006 Jun 4.PMID: 16752219 [PubMed - indexed for MEDLINE]Related articles

S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate.

Alderson NL, Wang Y, Blatnik M, Frizzell N, Walla MD, Lyons TJ, Alt N, Carson JA, Nagai R, Thorpe SR, Baynes JW.

Arch Biochem Biophys. 2006 Jun 1;450(1):1-8. Epub 2006 Mar 22.PMID: 16624247 [PubMed - indexed for MEDLINE]Related articles

What is the future of diabetic wound care?

Sweitzer SM, Fann SA, Borg TK, Baynes JW, Yost MJ.

Diabetes Educ. 2006 Mar-Apr;32(2):197-210. Review.PMID: 16554422 [PubMed - indexed for MEDLINE]Related articles

The anti-cancer drug, doxorubicin, causes oxidant stress-induced endothelial dysfunction.

Wolf MB, Baynes JW.

Biochim Biophys Acta. 2006 Feb;1760(2):267-71. Epub 2005 Nov 28.PMID: 16337743 [PubMed - indexed for MEDLINE]Related articles

Elements of diabetic nephropathy in a patient with GLUT 2 deficiency.

Berry GT, Baynes JW, Wells-Knecht KJ, Szwergold BS, Santer R.

Mol Genet Metab. 2005 Dec;86(4):473-7. Epub 2005 Nov 8.PMID: 16288895 [PubMed - indexed for MEDLINE]Related articles

Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients.

Meerwaldt R, Hartog JW, Graaff R, Huisman RJ, Links TP, den Hollander NC, Thorpe SR, Baynes JW, Navis G, Gans RO, Smit AJ.

J Am Soc Nephrol. 2005 Dec;16(12):3687-93. Epub 2005 Nov 9.PMID: 16280473 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific variation in glycation of proteins in diabetes: evidence for a functional role of amadoriase enzymes.

Brown SM, Smith DM, Alt N, Thorpe SR, Baynes JW.

Ann N Y Acad Sci. 2005 Jun;1043:817-23. Review.PMID: 16037309 [PubMed - indexed for MEDLINE]Related articles

Dietary bread crust advanced glycation end products bind to the receptor for AGEs in HEK-293 kidney cells but are rapidly excreted after oral administration to healthy and subtotally nephrectomized rats.

Somoza V, Lindenmeier M, Hofmann T, Frank O, Erbersdobler HF, Baynes JW, Thorpe SR, Heidland A, Zill H, Bek S, Huber J, Weigle T, Scheidler S, Busch AE, Sebeková K.

Ann N Y Acad Sci. 2005 Jun;1043:492-500.PMID: 16037271 [PubMed - indexed for MEDLINE]Related articles

Renal effects of oral maillard reaction product load in the form of bread crusts in healthy and subtotally nephrectomized rats.

Sebeková K, Hofmann T, Boor P, Sebeková K Jr, Ulicná O, Erbersdobler HF, Baynes JW, Thorpe SR, Heidland A, Somoza V.

Ann N Y Acad Sci. 2005 Jun;1043:482-91.PMID: 16037270 [PubMed - indexed for MEDLINE]Related articles

Lipid-derived modifications of plasma proteins in experimental and human diabetes.

Januszewski AS, Jenkins AJ, Baynes JW, Thorpe SR.

Ann N Y Acad Sci. 2005 Jun;1043:404-12.PMID: 16037262 [PubMed - indexed for MEDLINE]Related articles

Glycation does not alter LDL-induced secretion of tissue plasminogen activator and plasminogen activator inhibitor-1 from human aortic endothelial cells.

Klein RL, Semler AJ, Baynes JW, Thorpe SR, Lyons TJ, Jenkins AJ.

Ann N Y Acad Sci. 2005 Jun;1043:379-89.PMID: 16037259 [PubMed - indexed for MEDLINE]Related articles

Simple noninvasive measurement of skin autofluorescence.

Meerwaldt R, Links T, Graaff R, Thorpe SR, Baynes JW, Hartog J, Gans R, Smit A.

Ann N Y Acad Sci. 2005 Jun;1043:290-8.PMID: 16037251 [PubMed - indexed for MEDLINE]Related articles

Proteomic method for the quantification of methionine sulfoxide.

Brock JW, Cotham WC, Ames JM, Thorpe SR, Baynes JW.

Ann N Y Acad Sci. 2005 Jun;1043:284-9.PMID: 16037250 [PubMed - indexed for MEDLINE]Related articles

Effect of glucose concentration on formation of AGEs in erythrocytes in vitro.

Nagai R, Deemer EK, Brock JW, Thorpe SR, Baynes JW.

Ann N Y Acad Sci. 2005 Jun;1043:146-50.PMID: 16037233 [PubMed - indexed for MEDLINE]Related articles

The role of AGEs and AGE inhibitors in diabetic cardiovascular disease.

Thomas MC, Baynes JW, Thorpe SR, Cooper ME.

Curr Drug Targets. 2005 Jun;6(4):453-74. Review.PMID: 16026265 [PubMed - indexed for MEDLINE]Related articles

Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy.

Meerwaldt R, Links TP, Graaff R, Hoogenberg K, Lefrandt JD, Baynes JW, Gans RO, Smit AJ.

Diabetologia. 2005 Aug;48(8):1637-44. Epub 2005 Jul 14.PMID: 16021416 [PubMed - indexed for MEDLINE]Related articles

Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: effect of angiotensin-converting enzyme and vasopeptidase inhibition.

Wihler C, Schäfer S, Schmid K, Deemer EK, Münch G, Bleich M, Busch AE, Dingermann T, Somoza V, Baynes JW, Huber J.

Diabetologia. 2005 Aug;48(8):1645-53. Epub 2005 Jul 12.PMID: 16010524 [PubMed - indexed for MEDLINE]Related articles

Renal accumulation of pentosidine in non-diabetic proteinuria-induced renal damage in rats.

Waanders F, Greven WL, Baynes JW, Thorpe SR, Kramer AB, Nagai R, Sakata N, van Goor H, Navis G.

Nephrol Dial Transplant. 2005 Oct;20(10):2060-70. Epub 2005 Jun 14.PMID: 15956058 [PubMed - indexed for MEDLINE]Related articlesFree article

Chemical modification of proteins during peroxidation of phospholipids.

Januszewski AS, Alderson NL, Jenkins AJ, Thorpe SR, Baynes JW.

J Lipid Res. 2005 Jul;46(7):1440-9. Epub 2005 Apr 1.PMID: 15805546 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteomic analysis of arginine adducts on glyoxal-modified ribonuclease.

Cotham WE, Metz TO, Ferguson PL, Brock JW, Hinton DJ, Thorpe SR, Baynes JW, Ames JM.

Mol Cell Proteomics. 2004 Dec;3(12):1145-53. Epub 2004 Sep 17.PMID: 15377717 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat.

Alderson NL, Chachich ME, Frizzell N, Canning P, Metz TO, Januszewski AS, Youssef NN, Stitt AW, Baynes JW, Thorpe SR.

Diabetologia. 2004 Aug;47(8):1385-95. Epub 2004 Jul 28.PMID: 15309289 [PubMed - indexed for MEDLINE]Related articles

Simple non-invasive assessment of advanced glycation endproduct accumulation.

Meerwaldt R, Graaff R, Oomen PH, Links TP, Jager JJ, Alderson NL, Thorpe SR, Baynes JW, Gans RO, Smit AJ.

Diabetologia. 2004 Jul;47(7):1324-30. Epub 2004 Jul 9.PMID: 15243705 [PubMed - indexed for MEDLINE]Related articles

The clinical chemome: a tool for the diagnosis and management of chronic disease.

Baynes JW.

Clin Chem. 2004 Jul;50(7):1116-7. No abstract available. PMID: 15229147 [PubMed - indexed for MEDLINE]Related articlesFree article

Chemical modification of muscle protein in diabetes.

Alt N, Carson JA, Alderson NL, Wang Y, Nagai R, Henle T, Thorpe SR, Baynes JW.

Arch Biochem Biophys. 2004 May 15;425(2):200-6.PMID: 15111128 [PubMed - indexed for MEDLINE]Related articles

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging.

Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, Alderson NL, Baynes JW, Epstein CJ, Huang TT, Nelson J, Strong R, Richardson A.

Physiol Genomics. 2003 Dec 16;16(1):29-37.PMID: 14679299 [PubMed - indexed for MEDLINE]Related articles

Maillard reaction products in tissue proteins: new products and new perspectives.

Thorpe SR, Baynes JW.

Amino Acids. 2003 Dec;25(3-4):275-81. Epub 2003 Jul 29. Review.PMID: 14661090 [PubMed - indexed for MEDLINE]Related articles

Mass spectrometric analysis of glucose-modified ribonuclease.

Cotham WE, Hinton DJ, Metz TO, Brock JW, Thorpe SR, Baynes JW, Ames JM.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1426-7.PMID: 14641080 [PubMed - indexed for MEDLINE]Related articles

Role of lipids in chemical modification of proteins and development of complications in diabetes.

Januszewski AS, Alderson NL, Metz TO, Thorpe SR, Baynes JW.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1413-6. Review.PMID: 14641077 [PubMed - indexed for MEDLINE]Related articles

Chemical modification of proteins by lipids in diabetes.

Baynes JW.

Clin Chem Lab Med. 2003 Sep;41(9):1159-65. Review.PMID: 14598865 [PubMed - indexed for MEDLINE]Related articles

Proteomic analysis of the site specificity of glycation and carboxymethylation of ribonuclease.

Brock JW, Hinton DJ, Cotham WE, Metz TO, Thorpe SR, Baynes JW, Ames JM.

J Proteome Res. 2003 Sep-Oct;2(5):506-13.PMID: 14582647 [PubMed - indexed for MEDLINE]Related articles

Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications.

Metz TO, Alderson NL, Thorpe SR, Baynes JW.

Arch Biochem Biophys. 2003 Nov 1;419(1):41-9. Review.PMID: 14568007 [PubMed - indexed for MEDLINE]Related articles

Pyridoxamine traps intermediates in lipid peroxidation reactions in vivo: evidence on the role of lipids in chemical modification of protein and development of diabetic complications.

Metz TO, Alderson NL, Chachich ME, Thorpe SR, Baynes JW.

J Biol Chem. 2003 Oct 24;278(43):42012-9. Epub 2003 Aug 15.PMID: 12923193 [PubMed - indexed for MEDLINE]Related articlesFree article