PubMed

Epitope-specific immunotherapy of rheumatoid arthritis: Clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial.

Koffeman EC, Genovese M, Amox D, Keogh E, Santana E, Matteson EL, Kavanaugh A, Molitor JA, Schiff MH, Posever JO, Bathon JM, Kivitz AJ, Samodal R, Belardi F, Dennehey C, van den Broek T, van Wijk F, Zhang X, Zieseniss P, Le T, Prakken BA, Cutter GC, Albani S.

Arthritis Rheum. 2009 Nov;60(11):3207-16.PMID: 19877047 [PubMed - in process]Related articles

Golimumab.

Pappas DA, Bathon JM, Hanicq D, Yasothan U, Kirkpatrick P.

Nat Rev Drug Discov. 2009 Sep;8(9):695-6. No abstract available. PMID: 19721444 [PubMed - indexed for MEDLINE]Related articles

Adiponectin is a mediator of the inverse association of adiposity with radiographic damage in rheumatoid arthritis.

Giles JT, Allison M, Bingham CO 3rd, Scott WM Jr, Bathon JM.

Arthritis Rheum. 2009 Sep 15;61(9):1248-56.PMID: 19714593 [PubMed - indexed for MEDLINE]Related articlesFree article

Proposal for levels of evidence schema for validation of a soluble biomarker reflecting damage endpoints in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, and recommendations for study design.

Maksymowych WP, Fitzgerald O, Wells GA, Gladman DD, Landewé R, Ostergaard M, Taylor WJ, Christensen R, Tak PP, Boers M, Syversen SW, Bathon JM, Ritchlin CJ, Mease PJ, Bykerk VP, Garnero P, Geusens P, El-Gabalawy H, Aletaha D, Inman RD, Kraus VB, Kvien TK, van der Heijde D.

J Rheumatol. 2009 Aug;36(8):1792-9.PMID: 19671814 [PubMed - indexed for MEDLINE]Related articles

Reappraisal of OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage endpoints in rheumatoid arthritis, psoriatic arthritis, and spondyloarthritis: the OMERACT 9 v2 criteria.

Maksymowych WP, Landewé R, Tak PP, Ritchlin CJ, Ostergaard M, Mease PJ, El-Gabalawy H, Garnero P, Gladman DD, Fitzgerald O, Aletaha D, Bykerk VP, Bathon JM, Syversen SW, Boers M, Geusens P, Inman RD, Kraus VB, Kvien TK, Taylor WJ, Wells GA, van der Heijde D.

J Rheumatol. 2009 Aug;36(8):1785-91.PMID: 19671813 [PubMed - indexed for MEDLINE]Related articles

Testing of the OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage in rheumatoid arthritis: a systematic literature search on 5 candidate biomarkers.

Syversen SW, Landewe R, van der Heijde D, Bathon JM, Boers M, Bykerk VP, Fitzgerald O, Gladman DD, Garnero P, Geusens P, El-Gabalawy H, Inman RD, Kraus V, Kvien TK, Mease PJ, Ostergaard M, Ritchlin CJ, Tak PP, Taylor WJ, Maksymowych WP.

J Rheumatol. 2009 Aug;36(8):1769-84. Review.PMID: 19671812 [PubMed - indexed for MEDLINE]Related articles

Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis.

Giles JT, Szklo M, Post W, Petri M, Blumenthal RS, Lam G, Gelber AC, Detrano R, Scott WW Jr, Kronmal RA, Bathon JM.

Arthritis Res Ther. 2009;11(2):R36. Epub 2009 Mar 10.PMID: 19284547 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of body composition with disability in rheumatoid arthritis: impact of appendicular fat and lean tissue mass.

Giles JT, Bartlett SJ, Andersen RE, Fontaine KR, Bathon JM.

Arthritis Rheum. 2008 Oct 15;59(10):1407-15.PMID: 18821641 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of body fat with C-reactive protein in rheumatoid arthritis.

Giles JT, Bartlett SJ, Andersen R, Thompson R, Fontaine KR, Bathon JM.

Arthritis Rheum. 2008 Sep;58(9):2632-41.PMID: 18759279 [PubMed - in process]Related articlesFree article

Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: the impacts of remission and tumour necrosis factor blockade.

Smolen JS, Han C, van der Heijde DM, Emery P, Bathon JM, Keystone E, Maini RN, Kalden JR, Aletaha D, Baker D, Han J, Bala M, St Clair EW; Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset (ASPIRE) Study Group.

Ann Rheum Dis. 2009 Jun;68(6):823-7. Epub 2008 Jul 1.PMID: 18593759 [PubMed - indexed for MEDLINE]Related articles

Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.

Harris ML, Darrah E, Lam GK, Bartlett SJ, Giles JT, Grant AV, Gao P, Scott WW Jr, El-Gabalawy H, Casciola-Rosen L, Barnes KC, Bathon JM, Rosen A.

Arthritis Rheum. 2008 Jul;58(7):1958-67.PMID: 18576335 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum protein signatures detect early radiographic osteoarthritis.

Ling SM, Patel DD, Garnero P, Zhan M, Vaduganathan M, Muller D, Taub D, Bathon JM, Hochberg M, Abernethy DR, Metter EJ, Ferrucci L.

Osteoarthritis Cartilage. 2009 Jan;17(1):43-8. Epub 2008 Jun 20.PMID: 18571442 [PubMed - indexed for MEDLINE]Related articles

A 73-year-old woman with rheumatoid arthritis and shortness of breath.

Pappas DA, Taube JM, Bathon JM, Giles JT.

Arthritis Rheum. 2008 Jun 15;59(6):892-9. No abstract available. PMID: 18512726 [PubMed - indexed for MEDLINE]Related articlesFree article

The 2008 American College of Rheumatology recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis: where the rubber meets the road.

Bathon JM, Cohen SB.

Arthritis Rheum. 2008 Jun 15;59(6):757-9. No abstract available. PMID: 18512712 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal body composition phenotypes in older rheumatoid arthritis patients: association with disease characteristics and pharmacotherapies.

Giles JT, Ling SM, Ferrucci L, Bartlett SJ, Andersen RE, Towns M, Muller D, Fontaine KR, Bathon JM.

Arthritis Rheum. 2008 Jun 15;59(6):807-15.PMID: 18512711 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of anemia and physical disability among patients with rheumatoid arthritis.

Han C, Rahman MU, Doyle MK, Bathon JM, Smolen J, Kavanaugh A, Westhovens R, St Clair EW, Baker D, Bala M.

J Rheumatol. 2007 Nov;34(11):2177-82. Epub 2007 Oct 15.PMID: 17937474 [PubMed - indexed for MEDLINE]Related articles

Combination versus monotherapy for patients with RA--are initial clinical benefits maintained over time?

Haque UJ, Bathon JM.

Nat Clin Pract Rheumatol. 2007 Nov;3(11):602-3. Epub 2007 Sep 25. No abstract available. PMID: 17895876 [PubMed]Related articles

Therapy Insight: managing cardiovascular risk in patients with rheumatoid arthritis.

Giles JT, Post W, Blumenthal RS, Bathon JM.

Nat Clin Pract Rheumatol. 2006 Jun;2(6):320-9. Review.PMID: 16932711 [PubMed - indexed for MEDLINE]Related articles

Transitions to mobility difficulty associated with lower extremity osteoarthritis in high functioning older women: longitudinal data from the Women's Health and Aging Study II.

Ling SM, Xue QL, Simonsick EM, Tian J, Bandeen-Roche K, Fried LP, Bathon JM.

Arthritis Rheum. 2006 Apr 15;55(2):256-63.PMID: 16583416 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor inhibitor therapy and risk of serious postoperative orthopedic infection in rheumatoid arthritis.

Giles JT, Bartlett SJ, Gelber AC, Nanda S, Fontaine K, Ruffing V, Bathon JM.

Arthritis Rheum. 2006 Apr 15;55(2):333-7. No abstract available. PMID: 16583385 [PubMed - indexed for MEDLINE]Related articlesFree article

Infliximab treatment maintains employability in patients with early rheumatoid arthritis.

Smolen JS, Han C, van der Heijde D, Emery P, Bathon JM, Keystone E, Kalden JR, Schiff M, Bala M, Baker D, Han J, Maini RN, St Clair EW.

Arthritis Rheum. 2006 Mar;54(3):716-22.PMID: 16508932 [PubMed - indexed for MEDLINE]Related articlesFree article

Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab: results from the ASPIRE trial.

Smolen JS, Van Der Heijde DM, St Clair EW, Emery P, Bathon JM, Keystone E, Maini RN, Kalden JR, Schiff M, Baker D, Han C, Han J, Bala M; Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset (ASPIRE) Study Group.

Arthritis Rheum. 2006 Mar;54(3):702-10.PMID: 16508926 [PubMed - indexed for MEDLINE]Related articlesFree article

Safety and efficacy of etanercept treatment in elderly subjects with rheumatoid arthritis.

Bathon JM, Fleischmann RM, Van der Heijde D, Tesser JR, Peloso PM, Chon Y, White B.

J Rheumatol. 2006 Feb;33(2):234-43.PMID: 16465653 [PubMed - indexed for MEDLINE]Related articles

Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis.

Giles JT, Fernandes V, Lima JA, Bathon JM.

Arthritis Res Ther. 2005;7(5):195-207. Epub 2005 Aug 24. Review.PMID: 16207349 [PubMed - indexed for MEDLINE]Related articlesFree article

Longterm safety, efficacy, and radiographic outcome with etanercept treatment in patients with early rheumatoid arthritis.

Genovese MC, Bathon JM, Fleischmann RM, Moreland LW, Martin RW, Whitmore JB, Tsuji WH, Leff JA.

J Rheumatol. 2005 Jul;32(7):1232-42.PMID: 15996057 [PubMed - indexed for MEDLINE]Related articles

The role of biologicals in early rheumatoid arthritis.

Haque UJ, Bathon JM.

Best Pract Res Clin Rheumatol. 2005 Feb;19(1):179-89. Review.PMID: 15588978 [PubMed - indexed for MEDLINE]Related articles

Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial.

St Clair EW, van der Heijde DM, Smolen JS, Maini RN, Bathon JM, Emery P, Keystone E, Schiff M, Kalden JR, Wang B, Dewoody K, Weiss R, Baker D; Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset Study Group.

Arthritis Rheum. 2004 Nov;50(11):3432-43.PMID: 15529377 [PubMed - indexed for MEDLINE]Related articlesFree article

Serious infections associated with anticytokine therapies in the rheumatic diseases.

Giles JT, Bathon JM.

J Intensive Care Med. 2004 Nov-Dec;19(6):320-34. Review.PMID: 15523118 [PubMed - indexed for MEDLINE]Related articles

Etanercept: a clinical review of current and emerging indications.

Nanda S, Bathon JM.

Expert Opin Pharmacother. 2004 May;5(5):1175-86. Review.PMID: 15155116 [PubMed - indexed for MEDLINE]Related articles

The Early Rheumatoid Arthritis (ERA) trial comparing the efficacy and safety of etanercept and methotrexate.

Bathon JM, Genovese MC.

Clin Exp Rheumatol. 2003 Sep-Oct;21(5 Suppl 31):S195-7. Review.PMID: 14969076 [PubMed - indexed for MEDLINE]Related articles

Spirituality, well-being, and quality of life in people with rheumatoid arthritis.

Bartlett SJ, Piedmont R, Bilderback A, Matsumoto AK, Bathon JM.

Arthritis Rheum. 2003 Dec 15;49(6):778-83.PMID: 14673963 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship between body weight gain and significant knee, hip, and back pain in older Americans.

Andersen RE, Crespo CJ, Bartlett SJ, Bathon JM, Fontaine KR.

Obes Res. 2003 Oct;11(10):1159-62.PMID: 14569039 [PubMed - indexed for MEDLINE]Related articles

Knee osteoarthritis compromises early mobility function: The Women's Health and Aging Study II.

Ling SM, Fried LP, Garrett ES, Fan MY, Rantanen T, Bathon JM.

J Rheumatol. 2003 Jan;30(1):114-20.PMID: 12508399 [PubMed - indexed for MEDLINE]Related articles

Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial.

Kremer JM, Genovese MC, Cannon GW, Caldwell JR, Cush JJ, Furst DE, Luggen ME, Keystone E, Weisman MH, Bensen WM, Kaine JL, Ruderman EM, Coleman P, Curtis DL, Kopp EJ, Kantor SM, Waltuck J, Lindsley HB, Markenson JA, Strand V, Crawford B, Fernando I, Simpson K, Bathon JM.

Ann Intern Med. 2002 Nov 5;137(9):726-33.PMID: 12416946 [PubMed - indexed for MEDLINE]Related articlesFree article

Etanercept versus methotrexate in patients with early rheumatoid arthritis: two-year radiographic and clinical outcomes.

Genovese MC, Bathon JM, Martin RW, Fleischmann RM, Tesser JR, Schiff MH, Keystone EC, Wasko MC, Moreland LW, Weaver AL, Markenson J, Cannon GW, Spencer-Green G, Finck BK.

Arthritis Rheum. 2002 Jun;46(6):1443-50.PMID: 12115173 [PubMed - indexed for MEDLINE]Related articlesFree article

How common is hip pain among older adults? Results from the Third National Health and Nutrition Examination Survey.

Christmas C, Crespo CJ, Franckowiak SC, Bathon JM, Bartlett SJ, Andersen RE.

J Fam Pract. 2002 Apr;51(4):345-8.PMID: 11978258 [PubMed - indexed for MEDLINE]Related articles

A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis.

Bathon JM, Martin RW, Fleischmann RM, Tesser JR, Schiff MH, Keystone EC, Genovese MC, Wasko MC, Moreland LW, Weaver AL, Markenson J, Finck BK.

N Engl J Med. 2000 Nov 30;343(22):1586-93. Erratum in: N Engl J Med 2001 Jan 18;344(3):240. N Engl J Med 2001 Jan 4;344(1):76. PMID: 11096165 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of the responses of B1 and B2 kinin receptors to agonist stimulation.

Faussner A, Bathon JM, Proud D.

Immunopharmacology. 1999 Dec;45(1-3):13-20.PMID: 10614984 [PubMed - indexed for MEDLINE]Related articles

Prevalence of significant knee pain among older Americans: results from the Third National Health and Nutrition Examination Survey.

Andersen RE, Crespo CJ, Ling SM, Bathon JM, Bartlett SJ.

J Am Geriatr Soc. 1999 Dec;47(12):1435-8.PMID: 10591238 [PubMed - indexed for MEDLINE]Related articles

Coupling of the PTH/PTHrP receptor to multiple G-proteins. Direct demonstration of receptor activation of Gs, Gq/11, and Gi(1) by [alpha-32P]GTP-gamma-azidoanilide photoaffinity labeling.

Schwindinger WF, Fredericks J, Watkins L, Robinson H, Bathon JM, Pines M, Suva LJ, Levine MA.

Endocrine. 1998 Apr;8(2):201-9.PMID: 9704578 [PubMed - indexed for MEDLINE]Related articles

Soluble recombinant neutral endopeptidase (CD10) as a potential antiinflammatory agent.

Solan NJ, Ward PE, Sanders SP, Towns MC, Bathon JM.

Inflammation. 1998 Feb;22(1):107-21.PMID: 9484654 [PubMed - indexed for MEDLINE]Related articles

Influence of the cytosolic carboxyl termini of human B1 and B2 kinin receptors on receptor sequestration, ligand internalization, and signal transduction.

Faussner A, Proud D, Towns M, Bathon JM.

J Biol Chem. 1998 Jan 30;273(5):2617-23.PMID: 9446564 [PubMed - indexed for MEDLINE]Related articlesFree article

Osteoarthritis in older adults.

Ling SM, Bathon JM.

J Am Geriatr Soc. 1998 Feb;46(2):216-25. Review.PMID: 9475453 [PubMed - indexed for MEDLINE]Related articles

Stable expression of the human kinin B1 receptor in Chinese hamster ovary cells. Characterization of ligand binding and effector pathways.

Austin CE, Faussner A, Robinson HE, Chakravarty S, Kyle DJ, Bathon JM, Proud D.

J Biol Chem. 1997 Apr 25;272(17):11420-5.PMID: 9111052 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of prostanoid synthesis in human synovial cells: cytokine-peptide synergism.

Bathon JM, Chilton FH, Hubbard WC, Towns MC, Solan NJ, Proud D.

Inflammation. 1996 Oct;20(5):537-54.PMID: 8894717 [PubMed - indexed for MEDLINE]Related articles

Inhibition of the response to nasal provocation with bradykinin by HOE-140: efficacy and duration of action.

Proud D, Bathon JM, Togias AG, Naclerio RM.

Can J Physiol Pharmacol. 1995 Jul;73(7):820-6.PMID: 8846415 [PubMed - indexed for MEDLINE]Related articles

Bradykinin is a potent and relatively selective stimulus for cytosolic calcium elevation in human synovial cells.

Bathon JM, Croghan JC, MacGlashan DW Jr, Proud D.

J Immunol. 1994 Sep 15;153(6):2600-8.PMID: 8077670 [PubMed - indexed for MEDLINE]Related articles

Type VI collagen-specific messenger RNA is expressed constitutively by cultured human synovial fibroblasts and is suppressed by interleukin-1.

Bathon JM, Hwang JJ, Shin LH, Precht PA, Towns MC, Horton WE Jr.

Arthritis Rheum. 1994 Sep;37(9):1350-6.PMID: 7945500 [PubMed - indexed for MEDLINE]Related articles

Bradykinin effects in guinea pig tracheal epithelial cells are mediated through a B2 kinin receptor and can be inhibited by the selective antagonist Hoe 140.

Proud D, Reynolds CJ, Broomfield J, Goldman DW, Bathon JM.

J Pharmacol Exp Ther. 1993 Mar;264(3):1124-31.PMID: 8383737 [PubMed - indexed for MEDLINE]Related articles

Cultured human synovial fibroblasts rapidly metabolize kinins and neuropeptides.

Bathon JM, Proud D, Mizutani S, Ward PE.

J Clin Invest. 1992 Sep;90(3):981-91.PMID: 1381726 [PubMed - indexed for MEDLINE]Related articlesFree article