PubMed

Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians.

Atzmon G, Cho M, Cawthon RM, Budagov T, Katz M, Yang X, Siegel G, Bergman A, Huffman DM, Schechter CB, Wright WE, Shay JW, Barzilai N, Govindaraju DR, Suh Y.

Proc Natl Acad Sci U S A. 2009 Nov 13. [Epub ahead of print]PMID: 19915151 [PubMed - as supplied by publisher]Related articles

Genetic Predisposition to Elevated Serum Thyrotropin Is Associated with Exceptional Longevity.

Atzmon G, Barzilai N, Surks MI, Gabriely I.

J Clin Endocrinol Metab. 2009 Oct 16. [Epub ahead of print]PMID: 19837933 [PubMed - as supplied by publisher]Related articles

Statin therapy and risk of developing type 2 diabetes: a meta-analysis.

Rajpathak SN, Kumbhani DJ, Crandall J, Barzilai N, Alderman M, Ridker PM.

Diabetes Care. 2009 Oct;32(10):1924-9.PMID: 19794004 [PubMed - in process]Related articles

Comparison between Surrogate Indexes of Insulin Sensitivity/Resistance and Hyperinsulinemic Euglycemic Clamp Estimates in Rats.

Muniyappa R, Chen H, Muzumdar R, Einstein FH, Yan X, Yue LQ, Barzilai N, Quon MJ.

Am J Physiol Endocrinol Metab. 2009 Aug 25. [Epub ahead of print]PMID: 19706785 [PubMed - as supplied by publisher]Related articles

Humanin: a novel central regulator of peripheral insulin action.

Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P.

PLoS One. 2009 Jul 22;4(7):e6334.PMID: 19623253 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.

Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, Chen J, Joyner AH, Schork NJ, Hsueh WC, Reiner AP, Psaty BM, Atzmon G, Barzilai N, Cummings SR, Browner WS, Kwok PY, Ziv E; Study of Osteoporotic Fractures.

Aging Cell. 2009 Aug;8(4):460-72. Epub 2009 May 31.PMID: 19489743 [PubMed - indexed for MEDLINE]Related articles

Role of visceral adipose tissue in aging.

Huffman DM, Barzilai N.

Biochim Biophys Acta. 2009 Oct;1790(10):1117-23. Epub 2009 Jan 31. Review.PMID: 19364483 [PubMed - in process]Related articles

Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.

Walston JD, Matteini AM, Nievergelt C, Lange LA, Fallin DM, Barzilai N, Ziv E, Pawlikowska L, Kwok P, Cummings SR, Kooperberg C, LaCroix A, Tracy RP, Atzmon G, Lange EM, Reiner AP.

Exp Gerontol. 2009 May;44(5):350-5. Epub 2009 Feb 26.PMID: 19249341 [PubMed - in process]Related articles

Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones.

Barzilai N, Bartke A.

J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):187-91. Epub 2009 Feb 19. Review.PMID: 19228789 [PubMed - indexed for MEDLINE]Related articles

Post-challenge hyperglycemia in older adults is associated with increased cardiovascular risk profile.

Crandall JP, Shamoon H, Cohen HW, Reid M, Gajavelli S, Trandafirescu G, Tabatabaie V, Barzilai N.

J Clin Endocrinol Metab. 2009 May;94(5):1595-601. Epub 2009 Feb 10.PMID: 19208733 [PubMed - indexed for MEDLINE]Related articles

Extreme longevity is associated with increased serum thyrotropin.

Atzmon G, Barzilai N, Hollowell JG, Surks MI, Gabriely I.

J Clin Endocrinol Metab. 2009 Apr;94(4):1251-4. Epub 2009 Jan 21.PMID: 19158193 [PubMed - indexed for MEDLINE]Related articles

Ashkenazi Jewish centenarians do not demonstrate enrichment in mitochondrial haplogroup J.

Shlush LI, Atzmon G, Weisshof R, Behar D, Yudkovsky G, Barzilai N, Skorecki K.

PLoS One. 2008;3(10):e3425. Epub 2008 Oct 16.PMID: 18923645 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance.

Einstein FH, Fishman S, Bauman J, Thompson RF, Huffman DM, Atzmon G, Barzilai N, Muzumdar RH.

FASEB J. 2008 Oct;22(10):3450-7. Epub 2008 Jun 19.PMID: 18566293 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin levels and genotype: a potential regulator of life span in humans.

Atzmon G, Pollin TI, Crandall J, Tanner K, Schechter CB, Scherer PE, Rincon M, Siegel G, Katz M, Lipton RB, Shuldiner AR, Barzilai N.

J Gerontol A Biol Sci Med Sci. 2008 May;63(5):447-53.PMID: 18511746 [PubMed - indexed for MEDLINE]Related articles

Visceral adipose tissue modulates mammalian longevity.

Muzumdar R, Allison DB, Huffman DM, Ma X, Atzmon G, Einstein FH, Fishman S, Poduval AD, McVei T, Keith SW, Barzilai N.

Aging Cell. 2008 Jun;7(3):438-40. Epub 2008 Mar 18.PMID: 18363902 [PubMed - indexed for MEDLINE]Related articlesFree article

Functionally significant insulin-like growth factor I receptor mutations in centenarians.

Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3438-42. Epub 2008 Mar 3.PMID: 18316725 [PubMed - indexed for MEDLINE]Related articlesFree article

Accretion of visceral fat and hepatic insulin resistance in pregnant rats.

Einstein FH, Fishman S, Muzumdar RH, Yang XM, Atzmon G, Barzilai N.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E451-5. Epub 2007 Dec 11.PMID: 18073320 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies.

Hwang JH, Stein DT, Barzilai N, Cui MH, Tonelli J, Kishore P, Hawkins M.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1663-9. Epub 2007 Oct 2.PMID: 17911339 [PubMed - indexed for MEDLINE]Related articlesFree article

Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging.

Bergman A, Atzmon G, Ye K, MacCarthy T, Barzilai N.

PLoS Comput Biol. 2007 Aug;3(8):e170. Epub 2007 Jul 18.PMID: 17784782 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic determinants of human health span and life span: progress and new opportunities.

Martin GM, Bergman A, Barzilai N.

PLoS Genet. 2007 Jul;3(7):e125. Review.PMID: 17677003 [PubMed - indexed for MEDLINE]Related articlesFree article

Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians.

Iwata N, Zhang J, Atzmon G, Leanza S, Cho J, Chomyn A, Burk RD, Barzilai N, Attardi G.

Mitochondrion. 2007 Jul;7(4):267-72. Epub 2007 Mar 12.PMID: 17452024 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo.

Kim HS, Ali O, Shim M, Lee KW, Vuguin P, Muzumdar R, Barzilai N, Cohen P.

Pediatr Res. 2007 Feb;61(2):159-64.PMID: 17237715 [PubMed - indexed for MEDLINE]Related articles

A genotype of exceptional longevity is associated with preservation of cognitive function.

Barzilai N, Atzmon G, Derby CA, Bauman JM, Lipton RB.

Neurology. 2006 Dec 26;67(12):2170-5.PMID: 17190939 [PubMed - indexed for MEDLINE]Related articles

Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo.

Fishman S, Muzumdar RH, Atzmon G, Ma X, Yang X, Einstein FH, Barzilai N.

FASEB J. 2007 Jan;21(1):53-60. Epub 2006 Nov 10.PMID: 17099068 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum heat shock protein 70 level as a biomarker of exceptional longevity.

Terry DF, Wyszynski DF, Nolan VG, Atzmon G, Schoenhofen EA, Pennington JY, Andersen SL, Wilcox MA, Farrer LA, Barzilai N, Baldwin CT, Asea A.

Mech Ageing Dev. 2006 Nov;127(11):862-8. Epub 2006 Oct 6.PMID: 17027907 [PubMed - indexed for MEDLINE]Related articlesFree article

Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action.

Muzumdar RH, Ma X, Fishman S, Yang X, Atzmon G, Vuguin P, Einstein FH, Hwang D, Cohen P, Barzilai N.

Diabetes. 2006 Oct;55(10):2788-96.PMID: 17003344 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoprotein genotype and conserved pathway for exceptional longevity in humans.

Atzmon G, Rincon M, Schechter CB, Shuldiner AR, Lipton RB, Bergman A, Barzilai N.

PLoS Biol. 2006 Apr;4(4):e113. Epub 2006 Apr 4.PMID: 16602826 [PubMed - indexed for MEDLINE]Related articlesFree article

The insulin/IGF-1 signaling in mammals and its relevance to human longevity.

Rincon M, Rudin E, Barzilai N.

Exp Gerontol. 2005 Nov;40(11):873-7. Epub 2005 Sep 15. Review.PMID: 16168602 [PubMed - indexed for MEDLINE]Related articles

Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with aging.

Muzumdar RH, Ma X, Yang X, Atzmon G, Barzilai N.

Neurobiol Aging. 2006 Sep;27(9):1308-14. Epub 2005 Aug 24.PMID: 16122839 [PubMed - indexed for MEDLINE]Related articles

Differential responses of visceral and subcutaneous fat depots to nutrients.

Einstein FH, Atzmon G, Yang XM, Ma XH, Rincon M, Rudin E, Muzumdar R, Barzilai N.

Diabetes. 2005 Mar;54(3):672-8.PMID: 15734842 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammatory peptides derived from adipose tissue.

Rudin E, Barzilai N.

Immun Ageing. 2005 Jan 21;2(1):1.PMID: 15679897 [PubMed - as supplied by publisher]Related articlesFree article

Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity.

Arking DE, Atzmon G, Arking A, Barzilai N, Dietz HC.

Circ Res. 2005 Mar 4;96(4):412-8. Epub 2005 Jan 27.PMID: 15677572 [PubMed - indexed for MEDLINE]Related articlesFree article

Biological evidence for inheritance of exceptional longevity.

Atzmon G, Rincon M, Rabizadeh P, Barzilai N.

Mech Ageing Dev. 2005 Feb;126(2):341-5.PMID: 15621216 [PubMed - indexed for MEDLINE]Related articles

The voyage to healthy longevity: from experimental models to the ultimate goal.

Globerson A, Barzilai N.

Mech Ageing Dev. 2005 Feb;126(2):225-9. Review.PMID: 15621200 [PubMed - indexed for MEDLINE]Related articles

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.

Lin Y, Berg AH, Iyengar P, Lam TK, Giacca A, Combs TP, Rajala MW, Du X, Rollman B, Li W, Hawkins M, Barzilai N, Rhodes CJ, Fantus IG, Brownlee M, Scherer PE.

J Biol Chem. 2005 Feb 11;280(6):4617-26. Epub 2004 Nov 9.PMID: 15536073 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation.

Vuguin P, Raab E, Liu B, Barzilai N, Simmons R.

Diabetes. 2004 Oct;53(10):2617-22.PMID: 15448092 [PubMed - indexed for MEDLINE]Related articlesFree article

The paradox of the insulin/IGF-1 signaling pathway in longevity.

Rincon M, Muzumdar R, Atzmon G, Barzilai N.

Mech Ageing Dev. 2004 Jun;125(6):397-403. Review.PMID: 15272501 [PubMed - indexed for MEDLINE]Related articles

Einstein's Institute for Aging Research: collaborative and programmatic approaches in the search for successful aging.

Barzilai N, Rossetti L, Lipton RB.

Exp Gerontol. 2004 Feb;39(2):151-7.PMID: 15036407 [PubMed - indexed for MEDLINE]Related articles

Caloric restriction, body fat and ageing in experimental models.

Das M, Gabriely I, Barzilai N.

Obes Rev. 2004 Feb;5(1):13-9. Review.PMID: 14969503 [PubMed - indexed for MEDLINE]Related articles

Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action.

Muzumdar R, Ma X, Atzmon G, Vuguin P, Yang X, Barzilai N.

Diabetes. 2004 Feb;53(2):441-6.PMID: 14747296 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical phenotype of families with longevity.

Atzmon G, Schechter C, Greiner W, Davidson D, Rennert G, Barzilai N.

J Am Geriatr Soc. 2004 Feb;52(2):274-7.PMID: 14728640 [PubMed - indexed for MEDLINE]Related articles

Pennington scientific symposium on mechanisms and retardation of aging.

Atwood CS, Barzilai N, Bowen RL, Brown-Borg HM, Jarrard DF, Fu VX, Heilbronn LK, Ingram DK, Ravussin E, Schwartz RS, Weindruch R.

Exp Gerontol. 2003 Oct;38(10):1217-26. No abstract available. PMID: 14580876 [PubMed - indexed for MEDLINE]Related articles

Unique lipoprotein phenotype and genotype associated with exceptional longevity.

Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton R, Cheng S, Shuldiner AR.

JAMA. 2003 Oct 15;290(15):2030-40.PMID: 14559957 [PubMed - indexed for MEDLINE]Related articlesFree article

Longevity genes: from primitive organisms to humans.

Butler RN, Austad SN, Barzilai N, Braun A, Helfand S, Larsen PL, McCormick AM, Perls TT, Shuldiner AR, Sprott RL, Warner HR.

J Gerontol A Biol Sci Med Sci. 2003 Jul;58(7):581-4. No abstract available. PMID: 12865472 [PubMed - indexed for MEDLINE]Related articles

Surgical removal of visceral adipose tissue: effects on insulin action.

Gabriely I, Barzilai N.

Curr Diab Rep. 2003 Jun;3(3):201-6. Review.PMID: 12762966 [PubMed - indexed for MEDLINE]Related articles

Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms.

Muzumdar R, Ma X, Yang X, Atzmon G, Bernstein J, Karkanias G, Barzilai N.

FASEB J. 2003 Jun;17(9):1130-2. Epub 2003 Apr 22.PMID: 12709405 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential gene expression between visceral and subcutaneous fat depots.

Atzmon G, Yang XM, Muzumdar R, Ma XH, Gabriely I, Barzilai N.

Horm Metab Res. 2002 Nov-Dec;34(11-12):622-8.PMID: 12660871 [PubMed - indexed for MEDLINE]Related articles

Discovering the secrets of successful longevity.

Barzilai N.

J Gerontol A Biol Sci Med Sci. 2003 Mar;58(3):225-6. No abstract available. PMID: 12634287 [PubMed - indexed for MEDLINE]Related articles

Treatment of diabetes mellitus in older people: oral therapy options.

Crandall J, Barzilai N.

J Am Geriatr Soc. 2003 Feb;51(2):272-4. No abstract available. PMID: 12558728 [PubMed - indexed for MEDLINE]Related articles

Plasma HDL levels highly correlate with cognitive function in exceptional longevity.

Atzmon G, Gabriely I, Greiner W, Davidson D, Schechter C, Barzilai N.

J Gerontol A Biol Sci Med Sci. 2002 Nov;57(11):M712-5.PMID: 12403798 [PubMed - indexed for MEDLINE]Related articles