PubMed

Risk factors for incident type 2 diabetes in individuals with a BMI of <27 kg/m(2): the role of gamma-glutamyltransferase. Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR).

Gautier A, Balkau B, Lange C, Tichet J, Bonnet F; for the DESIR Study Group.

Diabetologia. 2009 Nov 20. [Epub ahead of print]PMID: 19936701 [PubMed - as supplied by publisher]

Birth weight, body silhouette over the life course and incident diabetes in 91,453 middle-aged women from the French E3N cohort.

de Lauzon-Guillain B, Balkau B, Charles MA, Romieu I, Boutron-Ruault MC, Clavel-Chapelon F.

Diabetes Care. 2009 Nov 16. [Epub ahead of print]PMID: 19918011 [PubMed - as supplied by publisher]Related articles

HOMA insulin sensitivity index and the risk of all-cause mortality and cardiovascular disease events in the general population: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab) study.

Barr EL, Cameron AJ, Balkau B, Zimmet PZ, Welborn TA, Tonkin AM, Shaw JE.

Diabetologia. 2009 Nov 7. [Epub ahead of print]PMID: 19894029 [PubMed - as supplied by publisher]Related articles

Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.

Fontaine-Bisson B, Alessi MC, Saut N, Fumeron F, Marre M, Dutour A, Badens C, Levy N, Tichet J, Juhan-Vague I, Trégouët DA, Balkau B, Morange PE.

J Mol Med. 2009 Oct 16. [Epub ahead of print]PMID: 19841875 [PubMed - as supplied by publisher]Related articles

Insulin pump failures are still frequent: a prospective study over 6 years from 2001 to 2007.

Guilhem I, Balkau B, Lecordier F, Malécot JM, Elbadii S, Leguerrier AM, Poirier JY, Derrien C, Bonnet F.

Diabetologia. 2009 Oct 16. [Epub ahead of print] No abstract available. PMID: 19834687 [PubMed - as supplied by publisher]Related articles

Prevalence of loss of function FTO mutations in lean and obese individuals.

Meyre D, Proulx K, Kawagoe-Takaki H, Vatin V, Gutiérrez-Aguilar R, Lyon D, Ma M, Choquet H, Horber F, Van Hul W, Van Gaal L, Balkau B, Visvikis-Siest S, Pattou F, Farooqi IS, Saudek V, O'Rahilly S, Froguel P, Sedgwick B, Yeo GS.

Diabetes. 2009 Oct 15. [Epub ahead of print]PMID: 19833892 [PubMed - as supplied by publisher]Related articles

Relationship of abdominal obesity with cardiovascular disease, diabetes and hyperlipidaemia in Spain.

Casanueva FF, Moreno B, Rodríguez-Azeredo R, Massien C, Conthe P, Formiguera X, Barrios V, Balkau B.

Clin Endocrinol (Oxf). 2009 Oct 15. [Epub ahead of print]PMID: 19832855 [PubMed - as supplied by publisher]Related articles

Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals.

Finucane FM, Luan J, Wareham NJ, Sharp SJ, O'Rahilly S, Balkau B, Flyvbjerg A, Walker M, Højlund K, Nolan JJ; (on behalf of the European Group for the Study of Insulin Resistance: Relationship between Insulin Sensitivity and Cardiovascular Disease Risk Study Group), Savage DB.

Diabetologia. 2009 Sep 12. [Epub ahead of print]PMID: 19756488 [PubMed - as supplied by publisher]Related articlesFree article

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proença C, Bacot F, Balkau B, Belisle A, Borch-Johnsen K, Charpentier G, Dina C, Durand E, Elliott P, Hadjadj S, Järvelin MR, Laitinen J, Lauritzen T, Marre M, Mazur A, Meyre D, Montpetit A, Pisinger C, Posner B, Poulsen P, Pouta A, Prentki M, Ribel-Madsen R, Ruokonen A, Sandbaek A, Serre D, Tichet J, Vaxillaire M, Wojtaszewski JF, Vaag A, Hansen T, Polychronakos C, Pedersen O, Froguel P, Sladek R.

Nat Genet. 2009 Oct;41(10):1110-5. Epub 2009 Sep 6. Erratum in: Nat Genet. 2009 Oct;41(10):1156. PMID: 19734900 [PubMed - indexed for MEDLINE]Related articles

Ten-year's change in blood pressure levels and prevalence of hypertension in urban and rural Cameroon.

Fezeu L, Kengne AP, Balkau B, Awah PK, Mbanya JC.

J Epidemiol Community Health. 2009 Aug 26. [Epub ahead of print]PMID: 19692732 [PubMed - as supplied by publisher]Related articles

Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits.

Bonnefond A, Vaxillaire M, Labrune Y, Lecoeur C, Chèvre JC, Bouatia-Naji N, Cauchi S, Balkau B, Marre M, Tichet J, Riveline JP, Hadjadj S, Gallois Y, Czernichow S, Hercberg S, Kaakinen M, Wiesner S, Charpentier G, Lévy-Marchal C, Elliott P, Jarvelin MR, Horber F, Dina C, Pedersen O, Sladek R, Meyre D, Froguel P.

Diabetes. 2009 Nov;58(11):2687-97. Epub 2009 Aug 3.PMID: 19651813 [PubMed - in process]Related articles

Menopausal hormone therapy and new-onset diabetes in the French Etude Epidemiologique de Femmes de la Mutuelle Générale de l'Education Nationale (E3N) cohort.

de Lauzon-Guillain B, Fournier A, Fabre A, Simon N, Mesrine S, Boutron-Ruault MC, Balkau B, Clavel-Chapelon F.

Diabetologia. 2009 Oct;52(10):2092-100. Epub 2009 Jul 23.PMID: 19629429 [PubMed - in process]Related articles

Sex hormone-binding globulin predicts the incidence of hyperglycemia in women: interactions with adiponectin levels.

Bonnet F, Balkau B, Malécot JM, Picard P, Lange C, Fumeron F, Aubert R, Raverot V, Déchaud H, Tichet J, Lecomte P, Pugeat M; DESIR Study Group.

Eur J Endocrinol. 2009 Jul;161(1):81-5. Epub 2009 May 8.PMID: 19429700 [PubMed - indexed for MEDLINE]Related articles

Center effect on ankle-brachial index measurement when using the reference method (Doppler and manometer): results from a large cohort study.

Vierron E, Halimi JM, Tichet J, Balkau B, Cogneau J, Giraudeau B; DESIR Study Group.

Am J Hypertens. 2009 Jul;22(7):718-22. Epub 2009 Apr 30.PMID: 19407803 [PubMed - indexed for MEDLINE]Related articles

The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects.

Choquet H, Cavalcanti-Proença C, Lecoeur C, Dina C, Cauchi S, Vaxillaire M, Hadjadj S, Horber F, Potoczna N, Charpentier G, Ruiz J, Hercberg S, Maimaitiming S, Roussel R, Boenhnke M, Jackson AU, Patsch W, Krempler F, Voight BF, Altshuler D, Groop L, Thorleifsson G, Steinthorsdottir V, Stefansson K, Balkau B, Froguel P, Meyre D.

Hum Mol Genet. 2009 Jul 1;18(13):2495-501. Epub 2009 Apr 18.PMID: 19377085 [PubMed - indexed for MEDLINE]Related articles

Noninvasive measurement of carotid extra-media thickness: associations with cardiovascular risk factors and intima-media thickness.

Skilton MR, Sérusclat A, Sethu AH, Brun S, Bernard S, Balkau B, Moulin P, Bonnet F.

JACC Cardiovasc Imaging. 2009 Feb;2(2):176-82.PMID: 19356553 [PubMed - indexed for MEDLINE]Related articles

G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.

Sparsø T, Bonnefond A, Andersson E, Bouatia-Naji N, Holmkvist J, Wegner L, Grarup N, Gjesing AP, Banasik K, Cavalcanti-Proença C, Marchand M, Vaxillaire M, Charpentier G, Jarvelin MR, Tichet J, Balkau B, Marre M, Lévy-Marchal C, Faerch K, Borch-Johnsen K, Jørgensen T, Madsbad S, Poulsen P, Vaag A, Dina C, Hansen T, Pedersen O, Froguel P.

Diabetes. 2009 Jun;58(6):1450-6. Epub 2009 Mar 26.PMID: 19324940 [PubMed - indexed for MEDLINE]Related articlesFree article

A rare variant in the visfatin gene (NAMPT/PBEF1) is associated with protection from obesity.

Blakemore AI, Meyre D, Delplanque J, Vatin V, Lecoeur C, Marre M, Tichet J, Balkau B, Froguel P, Walley AJ.

Obesity (Silver Spring). 2009 Aug;17(8):1549-53. Epub 2009 Mar 19.PMID: 19300429 [PubMed - indexed for MEDLINE]Related articles

Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population.

Gastaldelli A, Kozakova M, Højlund K, Flyvbjerg A, Favuzzi A, Mitrakou A, Balkau B; RISC Investigators.

Hepatology. 2009 May;49(5):1537-44.PMID: 19291789 [PubMed - indexed for MEDLINE]Related articles

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.

Cauchi S, Stutzmann F, Cavalcanti-Proença C, Durand E, Pouta A, Hartikainen AL, Marre M, Vol S, Tammelin T, Laitinen J, Gonzalez-Izquierdo A, Blakemore AI, Elliott P, Meyre D, Balkau B, Järvelin MR, Froguel P.

J Mol Med. 2009 May;87(5):537-46. Epub 2009 Mar 3.PMID: 19255736 [PubMed - indexed for MEDLINE]Related articles

Evaluating the association of common APOA2 variants with type 2 diabetes.

Duesing K, Charpentier G, Marre M, Tichet J, Hercberg S, Balkau B, Froguel P, Gibson F.

BMC Med Genet. 2009 Feb 13;10:13.PMID: 19216768 [PubMed - indexed for MEDLINE]Related articlesFree article

Common genetic variation near MC4R is associated with eating behaviour patterns in European populations.

Stutzmann F, Cauchi S, Durand E, Calvacanti-Proença C, Pigeyre M, Hartikainen AL, Sovio U, Tichet J, Marre M, Weill J, Balkau B, Potoczna N, Laitinen J, Elliott P, Järvelin MR, Horber F, Meyre D, Froguel P.

Int J Obes (Lond). 2009 Mar;33(3):373-8. Epub 2009 Jan 20.PMID: 19153581 [PubMed - in process]Related articles

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

Meyre D, Delplanque J, Chèvre JC, Lecoeur C, Lobbens S, Gallina S, Durand E, Vatin V, Degraeve F, Proença C, Gaget S, Körner A, Kovacs P, Kiess W, Tichet J, Marre M, Hartikainen AL, Horber F, Potoczna N, Hercberg S, Levy-Marchal C, Pattou F, Heude B, Tauber M, McCarthy MI, Blakemore AI, Montpetit A, Polychronakos C, Weill J, Coin LJ, Asher J, Elliott P, Järvelin MR, Visvikis-Siest S, Balkau B, Sladek R, Balding D, Walley A, Dina C, Froguel P.

Nat Genet. 2009 Feb;41(2):157-9. Epub 2009 Jan 18.PMID: 19151714 [PubMed - indexed for MEDLINE]Related articles

Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height.

Bouatia-Naji N, Marchand M, Cavalcanti-Proença C, Daghmoun S, Durand E, Tichet J, Marre M, Balkau B, Froguel P, Lévy-Marchal C.

Eur J Endocrinol. 2009 Apr;160(4):557-60. Epub 2009 Jan 12.PMID: 19139030 [PubMed - indexed for MEDLINE]Related articles

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.

Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, Sparsø T, Holmkvist J, Marchand M, Delplanque J, Lobbens S, Rocheleau G, Durand E, De Graeve F, Chèvre JC, Borch-Johnsen K, Hartikainen AL, Ruokonen A, Tichet J, Marre M, Weill J, Heude B, Tauber M, Lemaire K, Schuit F, Elliott P, Jørgensen T, Charpentier G, Hadjadj S, Cauchi S, Vaxillaire M, Sladek R, Visvikis-Siest S, Balkau B, Lévy-Marchal C, Pattou F, Meyre D, Blakemore AI, Jarvelin MR, Walley AJ, Hansen T, Dina C, Pedersen O, Froguel P.

Nat Genet. 2009 Jan;41(1):89-94. Epub 2008 Dec 7.PMID: 19060909 [PubMed - indexed for MEDLINE]Related articles

Urinary albumin excretion is a risk factor for diabetes mellitus in men, independently of initial metabolic profile and development of insulin resistance. The DESIR Study.

Halimi JM, Bonnet F, Lange C, Balkau B, Tichet J, Marre M; DESIR Study Group.

J Hypertens. 2008 Nov;26(11):2198-206.PMID: 18854761 [PubMed - indexed for MEDLINE]Related articles

The Data from an Epidemiologic Study on the Insulin Resistance Syndrome Study: the change and the rate of change of the age-blood pressure relationship.

Safar ME, Lange C, Tichet J, Blacher J, Eschwège E, Balkau B; D.E.S.I.R. Study Group, France.

J Hypertens. 2008 Oct;26(10):1903-11.PMID: 18806613 [PubMed - indexed for MEDLINE]Related articles

Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).

Balkau B, Lange C, Fezeu L, Tichet J, de Lauzon-Guillain B, Czernichow S, Fumeron F, Froguel P, Vaxillaire M, Cauchi S, Ducimetière P, Eschwège E.

Diabetes Care. 2008 Oct;31(10):2056-61. Epub 2008 Aug 8.PMID: 18689695 [PubMed - indexed for MEDLINE]Related articlesFree article

Common nonsynonymous variants in PCSK1 confer risk of obesity.

Benzinou M, Creemers JW, Choquet H, Lobbens S, Dina C, Durand E, Guerardel A, Boutin P, Jouret B, Heude B, Balkau B, Tichet J, Marre M, Potoczna N, Horber F, Le Stunff C, Czernichow S, Sandbaek A, Lauritzen T, Borch-Johnsen K, Andersen G, Kiess W, Körner A, Kovacs P, Jacobson P, Carlsson LM, Walley AJ, Jørgensen T, Hansen T, Pedersen O, Meyre D, Froguel P.

Nat Genet. 2008 Aug;40(8):943-5. Epub 2008 Jul 6.PMID: 18604207 [PubMed - indexed for MEDLINE]Related articles

Physical activity and insulin sensitivity: the RISC study.

Balkau B, Mhamdi L, Oppert JM, Nolan J, Golay A, Porcellati F, Laakso M, Ferrannini E; EGIR-RISC Study Group.

Diabetes. 2008 Oct;57(10):2613-8. Epub 2008 Jun 30.PMID: 18591396 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.

Stutzmann F, Tan K, Vatin V, Dina C, Jouret B, Tichet J, Balkau B, Potoczna N, Horber F, O'Rahilly S, Farooqi IS, Froguel P, Meyre D.

Diabetes. 2008 Sep;57(9):2511-8. Epub 2008 Jun 16.PMID: 18559663 [PubMed - indexed for MEDLINE]Related articlesFree article

The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.

Vaxillaire M, Cavalcanti-Proença C, Dechaume A, Tichet J, Marre M, Balkau B, Froguel P; DESIR Study Group.

Diabetes. 2008 Aug;57(8):2253-7. Epub 2008 Jun 12.PMID: 18556336 [PubMed - indexed for MEDLINE]Related articlesFree article

The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.

Cauchi S, Nead KT, Choquet H, Horber F, Potoczna N, Balkau B, Marre M, Charpentier G, Froguel P, Meyre D.

BMC Med Genet. 2008 May 22;9:45.PMID: 18498634 [PubMed - indexed for MEDLINE]Related articlesFree article

Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.

Cauchi S, Meyre D, Durand E, Proença C, Marre M, Hadjadj S, Choquet H, De Graeve F, Gaget S, Allegaert F, Delplanque J, Permutt MA, Wasson J, Blech I, Charpentier G, Balkau B, Vergnaud AC, Czernichow S, Patsch W, Chikri M, Glaser B, Sladek R, Froguel P.

PLoS One. 2008 May 7;3(5):e2031.PMID: 18461161 [PubMed - indexed for MEDLINE]Related articlesFree article

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.

Bouatia-Naji N, Rocheleau G, Van Lommel L, Lemaire K, Schuit F, Cavalcanti-Proença C, Marchand M, Hartikainen AL, Sovio U, De Graeve F, Rung J, Vaxillaire M, Tichet J, Marre M, Balkau B, Weill J, Elliott P, Jarvelin MR, Meyre D, Polychronakos C, Dina C, Sladek R, Froguel P.

Science. 2008 May 23;320(5879):1085-8. Epub 2008 May 1.PMID: 18451265 [PubMed - indexed for MEDLINE]Related articlesFree article

Screening for diabetes.

Balkau B.

Diabetes Care. 2008 May;31(5):1084-5. No abstract available. PMID: 18445732 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians.

Duesing K, Fatemifar G, Charpentier G, Marre M, Tichet J, Hercberg S, Balkau B, Froguel P, Gibson F.

Diabetes. 2008 Jul;57(7):1992-6. Epub 2008 Apr 22.PMID: 18430866 [PubMed - indexed for MEDLINE]Related articlesFree article

The burden of diabetes-related mortality in France in 2002: an analysis using both underlying and multiple causes of death.

Romon I, Jougla E, Balkau B, Fagot-Campagna A.

Eur J Epidemiol. 2008;23(5):327-34.PMID: 18386133 [PubMed - indexed for MEDLINE]Related articles

Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations.

Benzinou M, Chèvre JC, Ward KJ, Lecoeur C, Dina C, Lobbens S, Durand E, Delplanque J, Horber FF, Heude B, Balkau B, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O, Meyre D, Froguel P.

Hum Mol Genet. 2008 Jul 1;17(13):1916-21. Epub 2008 Mar 28.PMID: 18375449 [PubMed - indexed for MEDLINE]Related articlesFree article

Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids.

Duesing K, Fatemifar G, Charpentier G, Marre M, Tichet J, Hercberg S, Balkau B, Froguel P, Gibson F.

Diabetologia. 2008 May;51(5):821-6. Epub 2008 Mar 27.PMID: 18368387 [PubMed - indexed for MEDLINE]Related articles

Ten-year changes in central obesity and BMI in rural and urban Cameroon.

Fezeu LK, Assah FK, Balkau B, Mbanya DS, Kengne AP, Awah PK, Mbanya JC.

Obesity (Silver Spring). 2008 May;16(5):1144-7. Epub 2008 Mar 6.PMID: 18356839 [PubMed - indexed for MEDLINE]Related articles

R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population.

Meyre D, Farge M, Lecoeur C, Proenca C, Durand E, Allegaert F, Tichet J, Marre M, Balkau B, Weill J, Delplanque J, Froguel P.

Hum Mol Genet. 2008 Jun 15;17(12):1798-802. Epub 2008 Mar 5.PMID: 18325908 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluating the association of common PBX1 variants with type 2 diabetes.

Duesing K, Charpentier G, Marre M, Tichet J, Hercberg S, Balkau B, Froguel P, Gibson F.

BMC Med Genet. 2008 Feb 29;9:14.PMID: 18312624 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of TCF7L2 polymorphisms on obesity in European populations.

Cauchi S, Choquet H, Gutiérrez-Aguilar R, Capel F, Grau K, Proença C, Dina C, Duval A, Balkau B, Marre M, Potoczna N, Langin D, Horber F, Sørensen TI, Charpentier G, Meyre D, Froguel P.

Obesity (Silver Spring). 2008 Feb;16(2):476-82.PMID: 18239663 [PubMed - indexed for MEDLINE]Related articles

Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects.

Bonnet F, Patel S, Laville M, Balkau B, Favuzzi A, Monti LD, Lalic N, Walker M; European Group for the Study of Insulin Resistance Relationship Between Insulin Sensitivity and Cardiovascular Disease Risk Study Group.

Diabetes Care. 2008 Apr;31(4):789-94. Epub 2008 Jan 30.PMID: 18235053 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.

Cauchi S, Proença C, Choquet H, Gaget S, De Graeve F, Marre M, Balkau B, Tichet J, Meyre D, Vaxillaire M, Froguel P; D.E.S.I.R. Study Group.

J Mol Med. 2008 Mar;86(3):341-8. Epub 2008 Jan 22.PMID: 18210030 [PubMed - indexed for MEDLINE]Related articles

A review of the metabolic syndrome.

Balkau B, Valensi P, Eschwège E, Slama G.

Diabetes Metab. 2007 Dec;33(6):405-13. Epub 2007 Nov 5. Review.PMID: 17981485 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study.

Vaxillaire M, Veslot J, Dina C, Proença C, Cauchi S, Charpentier G, Tichet J, Fumeron F, Marre M, Meyre D, Balkau B, Froguel P; DESIR Study Group.

Diabetes. 2008 Jan;57(1):244-54. Epub 2007 Oct 31.PMID: 17977958 [PubMed - indexed for MEDLINE]Related articlesFree article

International Day for the Evaluation of Abdominal Obesity (IDEA): a study of waist circumference, cardiovascular disease, and diabetes mellitus in 168,000 primary care patients in 63 countries.

Balkau B, Deanfield JE, Després JP, Bassand JP, Fox KA, Smith SC Jr, Barter P, Tan CE, Van Gaal L, Wittchen HU, Massien C, Haffner SM.

Circulation. 2007 Oct 23;116(17):1942-51.PMID: 17965405 [PubMed - indexed for MEDLINE]Related articlesFree article

Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes.

Gutierrez-Aguilar R, Benmezroua Y, Balkau B, Marre M, Helbecque N, Charpentier G, Polychronakos C, Sladek R, Froguel P, Neve B.

Diabetes Metab. 2007 Nov;33(5):372-8. Epub 2007 Oct 10.PMID: 17931948 [PubMed - indexed for MEDLINE]Related articlesFree article