PubMed

Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt.

Wegiel B, Baty CJ, Gallo D, Csizmadia E, Scott JR, Akhavan A, Chin BY, Kaczmarek E, Alam J, Bach FH, Zuckerbraun BS, Otterbein LE.

J Biol Chem. 2009 Aug 7;284(32):21369-78. Epub 2009 Jun 9.PMID: 19509285 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-1: from biology to therapeutic potential.

Soares MP, Bach FH.

Trends Mol Med. 2009 Feb;15(2):50-8. Epub 2009 Jan 21.PMID: 19162549 [PubMed - indexed for MEDLINE]Related articles

Blockade of p38 MAPK inhibits chronic allograft vasculopathy.

Ollinger R, Thomas M, Kogler P, Hermann M, Weiss H, Mark W, Bilban M, Troppmair J, Bach FH, Margreiter R.

Transplantation. 2008 Jan 27;85(2):293-7.PMID: 18212636 [PubMed - indexed for MEDLINE]Related articles

Bilirubin inhibits tumor cell growth via activation of ERK.

Ollinger R, Kogler P, Troppmair J, Hermann M, Wurm M, Drasche A, Königsrainer I, Amberger A, Weiss H, Ofner D, Bach FH, Margreiter R.

Cell Cycle. 2007 Dec 15;6(24):3078-85. Epub 2007 Sep 7.PMID: 18073533 [PubMed - indexed for MEDLINE]Related articles

Therapeutic applications of bilirubin and biliverdin in transplantation.

Ollinger R, Wang H, Yamashita K, Wegiel B, Thomas M, Margreiter R, Bach FH.

Antioxid Redox Signal. 2007 Dec;9(12):2175-85. Review.PMID: 17919067 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-1 in organ transplantation.

Soares MP, Bach FH.

Front Biosci. 2007 Sep 1;12:4932-45. Review.PMID: 17569621 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells.

Lee SS, Gao W, Mazzola S, Thomas MN, Csizmadia E, Otterbein LE, Bach FH, Wang H.

FASEB J. 2007 Nov;21(13):3450-7. Epub 2007 Jun 5.PMID: 17551098 [PubMed - indexed for MEDLINE]Related articlesFree article

Toll-like receptor 4 suppression leads to islet allograft survival.

Goldberg A, Parolini M, Chin BY, Czismadia E, Otterbein LE, Bach FH, Wang H.

FASEB J. 2007 Sep;21(11):2840-8. Epub 2007 May 2.PMID: 17475921 [PubMed - indexed for MEDLINE]Related articlesFree article

Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages.

Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE.

J Immunol. 2007 May 1;178(9):5921-9.PMID: 17442976 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning.

Chin BY, Jiang G, Wegiel B, Wang HJ, Macdonald T, Zhang XC, Gallo D, Cszimadia E, Bach FH, Lee PJ, Otterbein LE.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5109-14. Epub 2007 Mar 12.PMID: 17360382 [PubMed - indexed for MEDLINE]Related articlesFree article

Bilirubin and biliverdin treatment of atherosclerotic diseases.

Ollinger R, Yamashita K, Bilban M, Erat A, Kogler P, Thomas M, Csizmadia E, Usheva A, Margreiter R, Bach FH.

Cell Cycle. 2007 Jan 1;6(1):39-43. Epub 2007 Jan 11.PMID: 17245120 [PubMed - indexed for MEDLINE]Related articles

Inhaled carbon monoxide prevents graft-induced intimal hyperplasia in swine.

Ramlawi B, Scott JR, Feng J, Mieno S, Raman KG, Gallo D, Csizmadia E, Yoke Chin B, Bach FH, Otterbein LE, Sellke FW.

J Surg Res. 2007 Mar;138(1):121-7. Epub 2006 Dec 29.PMID: 17196991 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes.

Drechsler Y, Dolganiuc A, Norkina O, Romics L, Li W, Kodys K, Bach FH, Mandrekar P, Szabo G.

J Immunol. 2006 Aug 15;177(4):2592-600.PMID: 16888021 [PubMed - indexed for MEDLINE]Related articlesFree article

Carbon monoxide: from the origin of life to molecular medicine.

Bach FH.

Trends Mol Med. 2006 Aug;12(8):348-50. Epub 2006 Jul 10.PMID: 16829200 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-1 and transplantation tolerance.

Bach FH.

Hum Immunol. 2006 Jun;67(6):430-2. Epub 2006 Apr 24. Review.PMID: 16728265 [PubMed - indexed for MEDLINE]Related articles

Carbon monoxide orchestrates a protective response through PPARgamma.

Bilban M, Bach FH, Otterbein SL, Ifedigbo E, d'Avila JC, Esterbauer H, Chin BY, Usheva A, Robson SC, Wagner O, Otterbein LE.

Immunity. 2006 May;24(5):601-10.PMID: 16713977 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs.

Yamashita K, Ollinger R, McDaid J, Sakahama H, Wang H, Tyagi S, Csizmadia E, Smith NR, Soares MP, Bach FH.

FASEB J. 2006 Apr;20(6):776-8. Epub 2006 Feb 10.PMID: 16473885 [PubMed - indexed for MEDLINE]Related articlesFree article

Bilirubin can induce tolerance to islet allografts.

Wang H, Lee SS, Dell'Agnello C, Tchipashvili V, d'Avila JC, Czismadia E, Chin BY, Bach FH.

Endocrinology. 2006 Feb;147(2):762-8. Epub 2005 Oct 27. Erratum in: Endocrinology. 2006 Oct;147(10):4842. D'Avilla, Joanna [corrected to d'Avila, Joana Costa Pinto]. PMID: 16254033 [PubMed - indexed for MEDLINE]Related articlesFree article

Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs.

Mazzola S, Forni M, Albertini M, Bacci ML, Zannoni A, Gentilini F, Lavitrano M, Bach FH, Otterbein LE, Clement MG.

FASEB J. 2005 Dec;19(14):2045-7. Epub 2005 Oct 13.PMID: 16223783 [PubMed - indexed for MEDLINE]Related articlesFree article

Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation.

Ollinger R, Bilban M, Erat A, Froio A, McDaid J, Tyagi S, Csizmadia E, Graça-Souza AV, Liloia A, Soares MP, Otterbein LE, Usheva A, Yamashita K, Bach FH.

Circulation. 2005 Aug 16;112(7):1030-9. Epub 2005 Aug 8.PMID: 16087796 [PubMed - indexed for MEDLINE]Related articlesFree article

Heme oxygenase-1: a therapeutic amplification funnel.

Bach FH.

FASEB J. 2005 Aug;19(10):1216-9. No abstract available. PMID: 16051687 [PubMed - indexed for MEDLINE]Related articlesFree article

Donor treatment with carbon monoxide can yield islet allograft survival and tolerance.

Wang H, Lee SS, Gao W, Czismadia E, McDaid J, Ollinger R, Soares MP, Yamashita K, Bach FH.

Diabetes. 2005 May;54(5):1400-6.PMID: 15855326 [PubMed - indexed for MEDLINE]Related articlesFree article

Heme oxygenase-1-generated biliverdin ameliorates experimental murine colitis.

Berberat PO, A-Rahim YI, Yamashita K, Warny MM, Csizmadia E, Robson SC, Bach FH.

Inflamm Bowel Dis. 2005 Apr;11(4):350-9.PMID: 15803024 [PubMed - indexed for MEDLINE]Related articles

Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both.

Nakao A, Neto JS, Kanno S, Stolz DB, Kimizuka K, Liu F, Bach FH, Billiar TR, Choi AM, Otterbein LE, Murase N.

Am J Transplant. 2005 Feb;5(2):282-91.PMID: 15643987 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells.

McDaid J, Yamashita K, Chora A, Ollinger R, Strom TB, Li XC, Bach FH, Soares MP.

FASEB J. 2005 Mar;19(3):458-60. Epub 2005 Jan 7.PMID: 15640283 [PubMed - indexed for MEDLINE]Related articlesFree article

Biliverdin therapy protects rat livers from ischemia and reperfusion injury.

Fondevila C, Shen XD, Tsuchiyashi S, Yamashita K, Csizmadia E, Lassman C, Busuttil RW, Kupiec-Weglinski JW, Bach FH.

Hepatology. 2004 Dec;40(6):1333-41.PMID: 15565657 [PubMed - indexed for MEDLINE]Related articles

Looking back 25 years.

Bach FH.

Trends Immunol. 2004 Dec;25(12):619-20. No abstract available. PMID: 15530827 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-1 as a protective gene.

Bach FH.

Wien Klin Wochenschr. 2002;114 Suppl 4:1-3. Review.PMID: 15499991 [PubMed - indexed for MEDLINE]Related articles

Biliverdin protects the functional integrity of a transplanted syngeneic small bowel.

Nakao A, Otterbein LE, Overhaus M, Sarady JK, Tsung A, Kimizuka K, Nalesnik MA, Kaizu T, Uchiyama T, Liu F, Murase N, Bauer AJ, Bach FH.

Gastroenterology. 2004 Aug;127(2):595-606.PMID: 15300591 [PubMed - indexed for MEDLINE]Related articles

Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs.

Lavitrano M, Smolenski RT, Musumeci A, Maccherini M, Slominska E, Di Florio E, Bracco A, Mancini A, Stassi G, Patti M, Giovannoni R, Froio A, Simeone F, Forni M, Bacci ML, D'Alise G, Cozzi E, Otterbein LE, Yacoub MH, Bach FH, Calise F.

FASEB J. 2004 Jul;18(10):1093-5. Epub 2004 May 7.PMID: 15132974 [PubMed - indexed for MEDLINE]Related articlesFree article

Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor.

Schillinger M, Exner M, Minar E, Mlekusch W, Müllner M, Mannhalter C, Bach FH, Wagner O.

J Am Coll Cardiol. 2004 Mar 17;43(6):950-7.PMID: 15028349 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation.

Soares MP, Seldon MP, Gregoire IP, Vassilevskaia T, Berberat PO, Yu J, Tsui TY, Bach FH.

J Immunol. 2004 Mar 15;172(6):3553-63.PMID: 15004156 [PubMed - indexed for MEDLINE]Related articlesFree article

Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury.

Akamatsu Y, Haga M, Tyagi S, Yamashita K, Graça-Souza AV, Ollinger R, Czismadia E, May GA, Ifedigbo E, Otterbein LE, Bach FH, Soares MP.

FASEB J. 2004 Apr;18(6):771-2. Epub 2004 Feb 20.PMID: 14977880 [PubMed - indexed for MEDLINE]Related articlesFree article

Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts.

Yamashita K, McDaid J, Ollinger R, Tsui TY, Berberat PO, Usheva A, Csizmadia E, Smith RN, Soares MP, Bach FH.

FASEB J. 2004 Apr;18(6):765-7. Epub 2004 Feb 20.PMID: 14977878 [PubMed - indexed for MEDLINE]Related articlesFree article

Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1.

Zuckerbraun BS, Billiar TR, Otterbein SL, Kim PK, Liu F, Choi AM, Bach FH, Otterbein LE.

J Exp Med. 2003 Dec 1;198(11):1707-16.PMID: 14657222 [PubMed - indexed for MEDLINE]Related articlesFree article

Biliverdin protects rat livers from ischemia/reperfusion injury.

Fondevila C, Katori M, Lassman C, Carmody I, Busuttil RW, Bach FH, Kupiec-Weglinski JW.

Transplant Proc. 2003 Aug;35(5):1798-9.PMID: 12962799 [PubMed - indexed for MEDLINE]Related articles

Heavy chain ferritin acts as an antiapoptotic gene that protects livers from ischemia reperfusion injury.

Berberat PO, Katori M, Kaczmarek E, Anselmo D, Lassman C, Ke B, Shen X, Busuttil RW, Yamashita K, Csizmadia E, Tyagi S, Otterbein LE, Brouard S, Tobiasch E, Bach FH, Kupiec-Weglinski JW, Soares MP.

FASEB J. 2003 Sep;17(12):1724-6. Epub 2003 Jul 18.PMID: 12958189 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunomodulatory effects of inhaled carbon monoxide on rat syngeneic small bowel graft motility.

Nakao A, Moore BA, Murase N, Liu F, Zuckerbraun BS, Bach FH, Choi AM, Nalesnik MA, Otterbein LE, Bauer AJ.

Gut. 2003 Sep;52(9):1278-85.PMID: 12912858 [PubMed - indexed for MEDLINE]Related articlesFree article

Heme oxygenase-1: unleashing the protective properties of heme.

Otterbein LE, Soares MP, Yamashita K, Bach FH.

Trends Immunol. 2003 Aug;24(8):449-55. Review.PMID: 12909459 [PubMed - indexed for MEDLINE]Related articles

Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury.

Otterbein LE, Zuckerbraun BS, Haga M, Liu F, Song R, Usheva A, Stachulak C, Bodyak N, Smith RN, Csizmadia E, Tyagi S, Akamatsu Y, Flavell RJ, Billiar TR, Tzeng E, Bach FH, Choi AM, Soares MP.

Nat Med. 2003 Feb;9(2):183-90. Epub 2003 Jan 21.PMID: 12539038 [PubMed - indexed for MEDLINE]Related articles

Induction of xenograft accommodation by modulation of elicited antibody responses1 2.

Wang N, Lee JM, Tobiasch E, Csizmadia E, Smith NR, Gollackes B, Robson SC, Bach FH, Lin Y.

Transplantation. 2002 Aug 15;74(3):334-45.PMID: 12177611 [PubMed - indexed for MEDLINE]Related articles

The xenotransplantation question: public consultation is an important part of the answer.

Ivinson AJ, Bach FH.

CMAJ. 2002 Jul 9;167(1):42-3. No abstract available. PMID: 12137078 [PubMed - indexed for MEDLINE]Related articlesFree article

Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs.

Soares MP, Brouard S, Smith RN, Bach FH.

Immunol Rev. 2001 Dec;184:275-85. Review.PMID: 12086318 [PubMed - indexed for MEDLINE]Related articles

A 50-year retrospective: cell-mediated immunity and the major histocompatibility complex.

Bach FH.

Transplant Proc. 2002 Jun;34(4):1071-2. No abstract available. PMID: 12072279 [PubMed - indexed for MEDLINE]Related articles

Modulation of endothelial cell apoptosis by heme oxygenase-1-derived carbon monoxide.

Soares MP, Usheva A, Brouard S, Berberat PO, Gunther L, Tobiasch E, Bach FH.

Antioxid Redox Signal. 2002 Apr;4(2):321-9. Review.PMID: 12006183 [PubMed - indexed for MEDLINE]Related articles

Carbon monoxide protects pancreatic beta-cells from apoptosis and improves islet function/survival after transplantation.

Günther L, Berberat PO, Haga M, Brouard S, Smith RN, Soares MP, Bach FH, Tobiasch E.

Diabetes. 2002 Apr;51(4):994-9.PMID: 11916917 [PubMed - indexed for MEDLINE]Related articlesFree article

Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis.

Brouard S, Berberat PO, Tobiasch E, Seldon MP, Bach FH, Soares MP.

J Biol Chem. 2002 May 17;277(20):17950-61. Epub 2002 Mar 5.PMID: 11880364 [PubMed - indexed for MEDLINE]Related articlesFree article

A shrewd and ethical approach to xenotransplantation.

Bach FH, Ivinson AJ.

Trends Biotechnol. 2002 Mar;20(3):129-31.PMID: 11841865 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-1 protects pancreatic beta cells from apoptosis caused by various stimuli.

Tobiasch E, Günther L, Bach FH.

J Investig Med. 2001 Nov;49(6):566-71.PMID: 11730093 [PubMed - indexed for MEDLINE]Related articles

"Haemoxygenase-1 induction and exhaled markers of oxidative stress in lung diseases", summary of the ERS Research Seminar in Budapest, Hungary, September, 1999.

Horváth I, MacNee W, Kelly FJ, Dekhuijzen PN, Phillips M, Döring G, Choi AM, Yamaya M, Bach FH, Willis D, Donnelly LE, Chung KF, Barnes PJ.

Eur Respir J. 2001 Aug;18(2):420-30.PMID: 11529303 [PubMed - indexed for MEDLINE]Related articlesFree article