PubMed

Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure.

D'Apolito M, Du X, Zong H, Catucci A, Maiuri L, Trivisano T, Pettoello-Mantovani M, Campanozzi A, Raia V, Pessin JE, Brownlee M, Giardino I.

J Clin Invest. 2009 Dec 1. pii: 37672. doi: 10.1172/JCI37672. [Epub ahead of print]PMID: 19955654 [PubMed - as supplied by publisher]Related articlesFree article

Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of RAGE and RAGE Ligands.

Yao D, Brownlee M.

Diabetes. 2009 Oct 15. [Epub ahead of print]PMID: 19833897 [PubMed - as supplied by publisher]Related articles

C. elegans as model for the study of high glucose- mediated life span reduction.

Schlotterer A, Kukudov G, Bozorgmehr F, Hutter H, Du X, Oikonomou D, Ibrahim Y, Pfisterer F, Rabbani N, Thornalley P, Sayed A, Fleming T, Humpert P, Schwenger V, Zeier M, Hamann A, Stern D, Brownlee M, Bierhaus A, Nawroth P, Morcos M.

Diabetes. 2009 Nov;58(11):2450-6. Epub 2009 Aug 12.PMID: 19675139 [PubMed - in process]Related articles

The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.

Thangarajah H, Yao D, Chang EI, Shi Y, Jazayeri L, Vial IN, Galiano RD, Du XL, Grogan R, Galvez MG, Januszyk M, Brownlee M, Gurtner GC.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13505-10. Epub 2009 Jul 28.PMID: 19666581 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) upregulation contribute to the onset of diabetic cardiomyopathy.

Ma H, Li SY, Xu P, Babcock SA, Dolence EK, Brownlee M, Li J, Ren J.

J Cell Mol Med. 2008 Oct 13. [Epub ahead of print]PMID: 19602045 [PubMed - as supplied by publisher]Related articles

Putting patient safety first.

Brownlee MA.

Provider. 2009 Apr;35(4):39, 41-3. No abstract available. PMID: 19402380 [PubMed - indexed for MEDLINE]Related articles

Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.

Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S.

Endocrinology. 2009 Jul;150(7):3040-8. Epub 2009 Feb 26.PMID: 19246534 [PubMed - indexed for MEDLINE]Related articles

Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.

Brasacchio D, Okabe J, Tikellis C, Balcerczyk A, George P, Baker EK, Calkin AC, Brownlee M, Cooper ME, El-Osta A.

Diabetes. 2009 May;58(5):1229-36. Epub 2009 Feb 10.PMID: 19208907 [PubMed - indexed for MEDLINE]Related articlesFree article

RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes.

Coughlan MT, Thorburn DR, Penfold SA, Laskowski A, Harcourt BE, Sourris KC, Tan AL, Fukami K, Thallas-Bonke V, Nawroth PP, Brownlee M, Bierhaus A, Cooper ME, Forbes JM.

J Am Soc Nephrol. 2009 Apr;20(4):742-52. Epub 2009 Jan 21.PMID: 19158353 [PubMed - indexed for MEDLINE]Related articles

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia.

El-Osta A, Brasacchio D, Yao D, Pocai A, Jones PL, Roeder RG, Cooper ME, Brownlee M.

J Exp Med. 2008 Sep 29;205(10):2409-17. Epub 2008 Sep 22. Erratum in: J Exp Med. 2008 Oct 27;205(11):2683. PMID: 18809715 [PubMed - indexed for MEDLINE]Related articlesFree article

Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.

Du X, Edelstein D, Brownlee M.

Diabetologia. 2008 Oct;51(10):1930-2. Epub 2008 Jul 29.PMID: 18663426 [PubMed - indexed for MEDLINE]Related articles

PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation.

Wang ZV, Mu J, Schraw TD, Gautron L, Elmquist JK, Zhang BB, Brownlee M, Scherer PE.

Diabetes. 2008 Aug;57(8):2137-48. Epub 2008 May 9.PMID: 18469203 [PubMed - indexed for MEDLINE]Related articlesFree article

A Delphi study investigating consensus among expert physiotherapists in relation to the management of low back pain.

Ferguson FC, Brownlee M, Webster V.

Musculoskeletal Care. 2008 Dec;6(4):197-210.PMID: 18311847 [PubMed - indexed for MEDLINE]Related articles

Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice.

Ceradini DJ, Yao D, Grogan RH, Callaghan MJ, Edelstein D, Brownlee M, Gurtner GC.

J Biol Chem. 2008 Apr 18;283(16):10930-8. Epub 2008 Jan 28.PMID: 18227068 [PubMed - indexed for MEDLINE]Related articlesFree article

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans.

Morcos M, Du X, Pfisterer F, Hutter H, Sayed AA, Thornalley P, Ahmed N, Baynes J, Thorpe S, Kukudov G, Schlotterer A, Bozorgmehr F, El Baki RA, Stern D, Moehrlen F, Ibrahim Y, Oikonomou D, Hamann A, Becker C, Zeier M, Schwenger V, Miftari N, Humpert P, Hammes HP, Buechler M, Bierhaus A, Brownlee M, Nawroth PP.

Aging Cell. 2008 Mar;7(2):260-9. Epub 2008 Jan 21.PMID: 18221415 [PubMed - indexed for MEDLINE]Related articles

Preventing kidney cell suicide.

Brownlee M.

Nat Med. 2007 Nov;13(11):1284-5. No abstract available. PMID: 17987021 [PubMed - indexed for MEDLINE]Related articles

High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.

Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, Suske G, Rabbani N, Thornalley PJ, Sarthy VP, Hammes HP, Brownlee M.

J Biol Chem. 2007 Oct 19;282(42):31038-45. Epub 2007 Aug 1.PMID: 17670746 [PubMed - indexed for MEDLINE]Related articlesFree article

Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages.

Yano M, Matsumura T, Senokuchi T, Ishii N, Murata Y, Taketa K, Motoshima H, Taguchi T, Sonoda K, Kukidome D, Takuwa Y, Kawada T, Brownlee M, Nishikawa T, Araki E.

Circ Res. 2007 May 25;100(10):1442-51. Epub 2007 Apr 26.PMID: 17463321 [PubMed - indexed for MEDLINE]Related articlesFree article

Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.

Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, Suske G, Ahmed N, Thornalley PJ, Sarthy VP, Hammes HP, Brownlee M.

Cell. 2007 Feb 9;128(3):625. No abstract available. PMID: 17387784 [PubMed - indexed for MEDLINE]Related articles

Method for chronological recording of antigen appearance in human head-hair shafts and its use for monitoring glycation products in diabetes.

Nissimov J, Elchalal U, Bakala H, Brownlee M, Berry E, Phillip M, Milner Y.

J Immunol Methods. 2007 Mar 30;320(1-2):1-17. Epub 2006 Nov 27.PMID: 17210162 [PubMed - indexed for MEDLINE]Related articles

The effect of glucose variability on the risk of microvascular complications in type 1 diabetes.

Hirsch IB, Brownlee M.

Diabetes Care. 2007 Jan;30(1):186-7; author reply 188-9. No abstract available. PMID: 17192365 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycemic variability: a hemoglobin A1c-independent risk factor for diabetic complications.

Brownlee M, Hirsch IB.

JAMA. 2006 Apr 12;295(14):1707-8. No abstract available. PMID: 16609094 [PubMed - indexed for MEDLINE]Related articles

Tenilsetam prevents early diabetic retinopathy without correcting pericyte loss.

Hoffmann J, Alt A, Lin J, Lochnit G, Schubert U, Schleicher E, Chavakis T, Brownlee M, Van der Woude FJ, Preissner KT, Hammes HP.

Thromb Haemost. 2006 Apr;95(4):689-95.PMID: 16601840 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation.

Du X, Edelstein D, Obici S, Higham N, Zou MH, Brownlee M.

J Clin Invest. 2006 Apr;116(4):1071-80. Epub 2006 Mar 9.PMID: 16528409 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy.

Lin J, Bierhaus A, Bugert P, Dietrich N, Feng Y, Vom Hagen F, Nawroth P, Brownlee M, Hammes HP.

Diabetologia. 2006 May;49(5):1089-96. Epub 2006 Mar 7.PMID: 16520919 [PubMed - indexed for MEDLINE]Related articles

Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.

Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, Suske G, Ahmed N, Thornalley PJ, Sarthy VP, Hammes HP, Brownlee M.

Cell. 2006 Jan 27;124(2):275-86. Epub 2006 Jan 12. Retraction in: Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, Suske G, Ahmed N, Thornalley PJ, Sarthy VP, Hammes HP, Brownlee M. Cell. 2007 Feb 9;128(3):625. PMID: 16413606 [PubMed - indexed for MEDLINE]Related articles

Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.

Nascimento NR, Lessa LM, Kerntopf MR, Sousa CM, Alves RS, Queiroz MG, Price J, Heimark DB, Larner J, Du X, Brownlee M, Gow A, Davis C, Fonteles MC.

Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):218-23. Epub 2005 Dec 22.PMID: 16373499 [PubMed - indexed for MEDLINE]Related articlesFree article

The pathobiology of diabetic complications: a unifying mechanism.

Brownlee M.

Diabetes. 2005 Jun;54(6):1615-25. No abstract available. PMID: 15919781 [PubMed - indexed for MEDLINE]Related articlesFree article

Should minimal blood glucose variability become the gold standard of glycemic control?

Hirsch IB, Brownlee M.

J Diabetes Complications. 2005 May-Jun;19(3):178-81. Review.PMID: 15866065 [PubMed - indexed for MEDLINE]Related articles

The effects of progressive resistance training for children with cerebral palsy.

Morton JF, Brownlee M, McFadyen AK.

Clin Rehabil. 2005 May;19(3):283-9.PMID: 15859529 [PubMed - indexed for MEDLINE]Related articles

Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation.

Rosca MG, Mustata TG, Kinter MT, Ozdemir AM, Kern TS, Szweda LI, Brownlee M, Monnier VM, Weiss MF.

Am J Physiol Renal Physiol. 2005 Aug;289(2):F420-30. Epub 2005 Apr 5.PMID: 15814529 [PubMed - indexed for MEDLINE]Related articlesFree article

Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking.

Mustata GT, Rosca M, Biemel KM, Reihl O, Smith MA, Viswanathan A, Strauch C, Du Y, Tang J, Kern TS, Lederer MO, Brownlee M, Weiss MF, Monnier VM.

Diabetes. 2005 Feb;54(2):517-26.PMID: 15677510 [PubMed - indexed for MEDLINE]Related articlesFree article

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.

Lin Y, Berg AH, Iyengar P, Lam TK, Giacca A, Combs TP, Rajala MW, Du X, Rollman B, Li W, Hawkins M, Barzilai N, Rhodes CJ, Fantus IG, Brownlee M, Scherer PE.

J Biol Chem. 2005 Feb 11;280(6):4617-26. Epub 2004 Nov 9.PMID: 15536073 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells.

Srinivasan S, Hatley ME, Bolick DT, Palmer LA, Edelstein D, Brownlee M, Hedrick CC.

Diabetologia. 2004 Oct;47(10):1727-34. Epub 2004 Oct 13.PMID: 15490108 [PubMed - indexed for MEDLINE]Related articles

A novel action of minocycline: inhibition of human immunodeficiency virus type 1 infection in microglia.

Si Q, Cosenza M, Kim MO, Zhao ML, Brownlee M, Goldstein H, Lee S.

J Neurovirol. 2004 Oct;10(5):284-92.PMID: 15385251 [PubMed - indexed for MEDLINE]Related articles

Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.

Valverde AM, Mur C, Brownlee M, Benito M.

Mol Biol Cell. 2004 Nov;15(11):5101-17. Epub 2004 Sep 8.PMID: 15356271 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species.

Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WG 4th, Schlattner U, Neumann D, Brownlee M, Freeman MB, Goldman MH.

J Biol Chem. 2004 Oct 15;279(42):43940-51. Epub 2004 Jul 19.PMID: 15265871 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.

Hammes HP, Lin J, Wagner P, Feng Y, Vom Hagen F, Krzizok T, Renner O, Breier G, Brownlee M, Deutsch U.

Diabetes. 2004 Apr;53(4):1104-10.PMID: 15047628 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death.

Vincent AM, Olzmann JA, Brownlee M, Sivitz WI, Russell JW.

Diabetes. 2004 Mar;53(3):726-34.PMID: 14988258 [PubMed - indexed for MEDLINE]Related articlesFree article

15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB.

Matsuo T, Matsumura T, Sakai M, Senokuchi T, Yano M, Kiritoshi S, Sonoda K, Kukidome D, Pestell RG, Brownlee M, Nishikawa T, Araki E.

Biochem Biophys Res Commun. 2004 Feb 13;314(3):817-23.PMID: 14741709 [PubMed - indexed for MEDLINE]Related articles

A radical explanation for glucose-induced beta cell dysfunction.

Brownlee M.

J Clin Invest. 2003 Dec;112(12):1788-90.PMID: 14679173 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells.

Du X, Matsumura T, Edelstein D, Rossetti L, Zsengellér Z, Szabó C, Brownlee M.

J Clin Invest. 2003 Oct;112(7):1049-57.PMID: 14523042 [PubMed - indexed for MEDLINE]Related articlesFree article

Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy.

Kiritoshi S, Nishikawa T, Sonoda K, Kukidome D, Senokuchi T, Matsuo T, Matsumura T, Tokunaga H, Brownlee M, Araki E.

Diabetes. 2003 Oct;52(10):2570-7.PMID: 14514642 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation.

Wang C, Pattabiraman N, Zhou JN, Fu M, Sakamaki T, Albanese C, Li Z, Wu K, Hulit J, Neumeister P, Novikoff PM, Brownlee M, Scherer PE, Jones JG, Whitney KD, Donehower LA, Harris EL, Rohan T, Johns DC, Pestell RG.

Mol Cell Biol. 2003 Sep;23(17):6159-73.PMID: 12917338 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes.

Kilhovd BK, Giardino I, Torjesen PA, Birkeland KI, Berg TJ, Thornalley PJ, Brownlee M, Hanssen KF.

Metabolism. 2003 Feb;52(2):163-7.PMID: 12601626 [PubMed - indexed for MEDLINE]Related articles

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.

Hammes HP, Du X, Edelstein D, Taguchi T, Matsumura T, Ju Q, Lin J, Bierhaus A, Nawroth P, Hannak D, Neumaier M, Bergfeld R, Giardino I, Brownlee M.

Nat Med. 2003 Mar;9(3):294-9. Epub 2003 Feb 18.PMID: 12592403 [PubMed - indexed for MEDLINE]Related articles

Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity.

Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE.

J Biol Chem. 2003 Mar 14;278(11):9073-85. Epub 2002 Dec 20.PMID: 12496257 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells.

Sakai K, Matsumoto K, Nishikawa T, Suefuji M, Nakamaru K, Hirashima Y, Kawashima J, Shirotani T, Ichinose K, Brownlee M, Araki E.

Biochem Biophys Res Commun. 2003 Jan 3;300(1):216-22.PMID: 12480546 [PubMed - indexed for MEDLINE]Related articles

Pericytes and the pathogenesis of diabetic retinopathy.

Hammes HP, Lin J, Renner O, Shani M, Lundqvist A, Betsholtz C, Brownlee M, Deutsch U.

Diabetes. 2002 Oct;51(10):3107-12.PMID: 12351455 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer.

Casper D, Engstrom SJ, Mirchandani GR, Pidel A, Palencia D, Cho PH, Brownlee M, Edelstein D, Federoff HJ, Sonstein WJ.

Cell Transplant. 2002;11(4):331-49.PMID: 12162374 [PubMed - indexed for MEDLINE]Related articles