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Adenoviral expression of human lecithin-cholesterol acyltransferase in nonhuman primates leads to an antiatherogenic lipoprotein phenotype by increasing high-density lipoprotein and lowering low-density lipoprotein.

Amar MJ, Shamburek RD, Vaisman B, Knapper CL, Foger B, Hoyt RF Jr, Santamarina-Fojo S, Brewer HB Jr, Remaley AT.

Metabolism. 2009 Apr;58(4):568-75.PMID: 19303980 [PubMed - indexed for MEDLINE]Related articles

Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo.

Sacks FM, Rudel LL, Conner A, Akeefe H, Kostner G, Baki T, Rothblat G, de la Llera-Moya M, Asztalos B, Perlman T, Zheng C, Alaupovic P, Maltais JA, Brewer HB.

J Lipid Res. 2009 May;50(5):894-907. Epub 2009 Jan 14.PMID: 19144994 [PubMed - indexed for MEDLINE]Related articles

Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides.

Sethi AA, Stonik JA, Thomas F, Demosky SJ, Amar M, Neufeld E, Brewer HB, Davidson WS, D'Souza W, Sviridov D, Remaley AT.

J Biol Chem. 2008 Nov 21;283(47):32273-82. Epub 2008 Sep 19.PMID: 18805791 [PubMed - indexed for MEDLINE]Related articlesFree article

HDL metabolism and the role of HDL in the treatment of high-risk patients with cardiovascular disease.

Brewer HB Jr.

Curr Cardiol Rep. 2007 Nov;9(6):486-92. Review.PMID: 17999874 [PubMed - indexed for MEDLINE]Related articles

The editor's roundtable: high-density lipoprotein cholesterol.

Friedewald VE Jr, Brewer HB Jr, Grundy SM, Rader DJ, Roberts WC.

Am J Cardiol. 2007 Jun 15;99(12):1698-705. Epub 2007 May 8. No abstract available. PMID: 17560878 [PubMed - indexed for MEDLINE]Related articles

Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mice.

Freeman L, Amar MJ, Shamburek R, Paigen B, Brewer HB Jr, Santamarina-Fojo S, González-Navarro H.

J Lipid Res. 2007 Jan;48(1):104-13. Epub 2006 Oct 27.PMID: 17071916 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited.

Basso F, Freeman LA, Ko C, Joyce C, Amar MJ, Shamburek RD, Tansey T, Thomas F, Wu J, Paigen B, Remaley AT, Santamarina-Fojo S, Brewer HB Jr.

J Lipid Res. 2007 Jan;48(1):114-26. Epub 2006 Oct 23.PMID: 17060690 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of low high-density lipoproteins on in-hospital events and one-year clinical outcomes in patients with non-ST-elevation myocardial infarction acute coronary syndrome treated with drug-eluting stent implantation.

Wolfram RM, Brewer HB, Xue Z, Satler LF, Pichard AD, Kent KM, Waksman R.

Am J Cardiol. 2006 Sep 15;98(6):711-7. Epub 2006 Jul 17.PMID: 16950168 [PubMed - indexed for MEDLINE]Related articles

ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis.

Joyce CW, Wagner EM, Basso F, Amar MJ, Freeman LA, Shamburek RD, Knapper CL, Syed J, Wu J, Vaisman BL, Fruchart-Najib J, Billings EM, Paigen B, Remaley AT, Santamarina-Fojo S, Brewer HB Jr.

J Biol Chem. 2006 Nov 3;281(44):33053-65. Epub 2006 Aug 23.PMID: 16928680 [PubMed - indexed for MEDLINE]Related articlesFree article

Hollis Bryan Brewer, Jr., MD: a conversation with the editor.

Brewer HB.

Am J Cardiol. 2006 Jun 15;97(12):1791-804. Epub 2006 May 3. No abstract available. PMID: 16765137 [PubMed - indexed for MEDLINE]Related articles

Effect of ACAT inhibition on the progression of coronary atherosclerosis.

Nissen SE, Tuzcu EM, Brewer HB, Sipahi I, Nicholls SJ, Ganz P, Schoenhagen P, Waters DD, Pepine CJ, Crowe TD, Davidson MH, Deanfield JE, Wisniewski LM, Hanyok JJ, Kassalow LM; ACAT Intravascular Atherosclerosis Treatment Evaluation (ACTIVATE) Investigators.

N Engl J Med. 2006 Mar 23;354(12):1253-63. Erratum in: N Engl J Med. 2006 Aug 10;355(6):638. PMID: 16554527 [PubMed - indexed for MEDLINE]Related articlesFree article

Human lecithin:cholesterol acyltransferase deficiency: in vivo kinetics of low-density lipoprotein and lipoprotein-X.

Nishiwaki M, Ikewaki K, Bader G, Nazih H, Hannuksela M, Remaley AT, Shamburek RD, Brewer HB Jr.

Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1370-5. Epub 2006 Mar 16.PMID: 16543491 [PubMed - indexed for MEDLINE]Related articlesFree article

The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver.

Sabol SL, Brewer HB Jr, Santamarina-Fojo S.

J Lipid Res. 2005 Oct;46(10):2151-67. Epub 2005 Jul 16.PMID: 16024918 [PubMed - indexed for MEDLINE]Related articlesFree article

Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells.

Lalanne F, Lambert G, Amar MJ, Chétiveaux M, Zaïr Y, Jarnoux AL, Ouguerram K, Friburg J, Seidah NG, Brewer HB Jr, Krempf M, Costet P.

J Lipid Res. 2005 Jun;46(6):1312-9. Epub 2005 Mar 1.PMID: 15741654 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum amyloid A promotes ABCA1-dependent and ABCA1-independent lipid efflux from cells.

Stonik JA, Remaley AT, Demosky SJ, Neufeld EB, Bocharov A, Brewer HB.

Biochem Biophys Res Commun. 2004 Sep 3;321(4):936-41.PMID: 15358117 [PubMed - indexed for MEDLINE]Related articles

Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines.

Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ; Coordinating Committee of the National Cholesterol Education Program.

J Am Coll Cardiol. 2004 Aug 4;44(3):720-32. Review.PMID: 15358046 [PubMed - indexed for MEDLINE]Related articles

Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice.

Matsusue K, Gavrilova O, Lambert G, Brewer HB Jr, Ward JM, Inoue Y, LeRoith D, Gonzalez FJ.

Mol Endocrinol. 2004 Nov;18(11):2751-64. Epub 2004 Aug 19.PMID: 15319454 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of plasma high-density lipoprotein levels by the ABCA1 transporter and the emerging role of high-density lipoprotein in the treatment of cardiovascular disease.

Brewer HB Jr, Remaley AT, Neufeld EB, Basso F, Joyce C.

Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1755-60. Epub 2004 Aug 19. Review.PMID: 15319263 [PubMed - indexed for MEDLINE]Related articlesFree article

The ligand-binding function of hepatic lipase modulates the development of atherosclerosis in transgenic mice.

González-Navarro H, Nong Z, Amar MJ, Shamburek RD, Najib-Fruchart J, Paigen BJ, Brewer HB Jr, Santamarina-Fojo S.

J Biol Chem. 2004 Oct 29;279(44):45312-21. Epub 2004 Aug 10.PMID: 15304509 [PubMed - indexed for MEDLINE]Related articlesFree article

Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines.

Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ; Coordinating Committee of the National Cholesterol Education Program.

Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):e149-61. Review.PMID: 15297292 [PubMed - indexed for MEDLINE]Related articlesFree article

A summary of implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines.

Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ; Coordinating Committee of the National Cholesterol Education Program.

Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1329-30. No abstract available. PMID: 15297284 [PubMed - indexed for MEDLINE]Related articlesFree article

Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines.

Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ; National Heart, Lung, and Blood Institute; American College of Cardiology Foundation; American Heart Association.

Circulation. 2004 Jul 13;110(2):227-39. Review. Erratum in: Circulation. 2004 Aug 10;110(6):763. PMID: 15249516 [PubMed - indexed for MEDLINE]Related articlesFree article

Focus on high-density lipoproteins in reducing cardiovascular risk.

Brewer HB Jr.

Am Heart J. 2004 Jul;148(1 Suppl):S14-8.PMID: 15211328 [PubMed - indexed for MEDLINE]Related articles

A new dawn in the treatment of dyslipidemia: cardiovascular risk reduction through emerging science and proven clinical results. Introduction.

Brewer HB Jr.

Am Heart J. 2004 Jul;148(1 Suppl):S1-2. No abstract available. PMID: 15211325 [PubMed - indexed for MEDLINE]Related articles

The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter.

Freeman LA, Kennedy A, Wu J, Bark S, Remaley AT, Santamarina-Fojo S, Brewer HB Jr.

J Lipid Res. 2004 Jul;45(7):1197-206. Epub 2004 May 1.PMID: 15121760 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal in vivo metabolism of apoB-containing lipoproteins in human apoE deficiency.

Ikewaki K, Cain W, Thomas F, Shamburek R, Zech LA, Usher D, Brewer HB Jr, Rader DJ.

J Lipid Res. 2004 Jul;45(7):1302-11. Epub 2004 Apr 21.PMID: 15102883 [PubMed - indexed for MEDLINE]Related articlesFree article

Increasing HDL Cholesterol Levels.

Brewer HB Jr.

N Engl J Med. 2004 Apr 8;350(15):1491-4. No abstract available. PMID: 15071124 [PubMed - indexed for MEDLINE]Related articles

Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice.

Wu JE, Basso F, Shamburek RD, Amar MJ, Vaisman B, Szakacs G, Joyce C, Tansey T, Freeman L, Paigen BJ, Thomas F, Brewer HB Jr, Santamarina-Fojo S.

J Biol Chem. 2004 May 28;279(22):22913-25. Epub 2004 Mar 25.PMID: 15044450 [PubMed - indexed for MEDLINE]Related articlesFree article

High-density lipoproteins: a new potential therapeutic target for the prevention of cardiovascular disease.

Brewer HB Jr.

Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):387-91. No abstract available. PMID: 15003970 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet.

Akiyama TE, Lambert G, Nicol CJ, Matsusue K, Peters JM, Brewer HB Jr, Gonzalez FJ.

J Biol Chem. 2004 May 14;279(20):20874-81. Epub 2004 Mar 4.PMID: 15001574 [PubMed - indexed for MEDLINE]Related articlesFree article

Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition.

Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C; National Heart, Lung, and Blood Institute; American Heart Association.

Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):e13-8. Review. No abstract available. PMID: 14766739 [PubMed - indexed for MEDLINE]Related articlesFree article

The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease.

Neufeld EB, Stonik JA, Demosky SJ Jr, Knapper CL, Combs CA, Cooney A, Comly M, Dwyer N, Blanchette-Mackie J, Remaley AT, Santamarina-Fojo S, Brewer HB Jr.

J Biol Chem. 2004 Apr 9;279(15):15571-8. Epub 2004 Jan 27.PMID: 14747463 [PubMed - indexed for MEDLINE]Related articlesFree article

Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition.

Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C; American Heart Association; National Heart, Lung, and Blood Institute.

Circulation. 2004 Jan 27;109(3):433-8. Review. No abstract available. PMID: 14744958 [PubMed - indexed for MEDLINE]Related articlesFree article

Benefit-risk assessment of Rosuvastatin 10 to 40 milligrams.

Brewer HB Jr.

Am J Cardiol. 2003 Aug 21;92(4B):23K-29K. Review.PMID: 12948873 [PubMed - indexed for MEDLINE]Related articles

Clinical significance of high-density lipoproteins and the development of atherosclerosis: focus on the role of the adenosine triphosphate-binding cassette protein A1 transporter.

Brewer HB Jr, Santamarina-Fojo S.

Am J Cardiol. 2003 Aug 21;92(4B):10K-16K. Review.PMID: 12948871 [PubMed - indexed for MEDLINE]Related articles

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.

Guo GL, Lambert G, Negishi M, Ward JM, Brewer HB Jr, Kliewer SA, Gonzalez FJ, Sinal CJ.

J Biol Chem. 2003 Nov 14;278(46):45062-71. Epub 2003 Aug 15.PMID: 12923173 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-density lipoprotein receptor and apolipoprotein A-I and B expression in human enterocytes.

Sviridov D, Hoeg JM, Eggerman T, Demosky SJ, Safonova IG, Brewer HB.

Digestion. 2003;67(1-2):67-70.PMID: 12743443 [PubMed - indexed for MEDLINE]Related articles

New features of the National Cholesterol Education Program Adult Treatment Panel III lipid-lowering guidelines.

Brewer HB Jr.

Clin Cardiol. 2003 Apr;26(4 Suppl 3):III19-24.PMID: 12708635 [PubMed - indexed for MEDLINE]Related articles

New insights into the role of the adenosine triphosphate-binding cassette transporters in high-density lipoprotein metabolism and reverse cholesterol transport.

Brewer HB Jr, Santamarina-Fojo S.

Am J Cardiol. 2003 Apr 3;91(7A):3E-11E. Review.PMID: 12679197 [PubMed - indexed for MEDLINE]Related articles

Study of ABCA1 function in transgenic mice.

Joyce C, Freeman L, Brewer HB Jr, Santamarina-Fojo S.

Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):965-71. Epub 2003 Jan 2. Review.PMID: 12615681 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis.

Barter PJ, Brewer HB Jr, Chapman MJ, Hennekens CH, Rader DJ, Tall AR.

Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):160-7. Review.PMID: 12588754 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations.

Basso F, Freeman L, Knapper CL, Remaley A, Stonik J, Neufeld EB, Tansey T, Amar MJ, Fruchart-Najib J, Duverger N, Santamarina-Fojo S, Brewer HB Jr.

J Lipid Res. 2003 Feb;44(2):296-302. Epub 2002 Nov 4.PMID: 12576511 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthetic amphipathic helical peptides promote lipid efflux from cells by an ABCA1-dependent and an ABCA1-independent pathway.

Remaley AT, Thomas F, Stonik JA, Demosky SJ, Bark SE, Neufeld EB, Bocharov AV, Vishnyakova TG, Patterson AP, Eggerman TL, Santamarina-Fojo S, Brewer HB.

J Lipid Res. 2003 Apr;44(4):828-36. Epub 2003 Jan 16.PMID: 12562845 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental regulation of apolipoprotein B mRNA editing is an autonomous function of small intestine involving homeobox gene Cdx1.

Patterson AP, Chen Z, Rubin DC, Moucadel V, Iovanna JL, Brewer HB Jr, Eggerman TL.

J Biol Chem. 2003 Feb 28;278(9):7600-6. Epub 2002 Dec 18.PMID: 12493769 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative in vivo metabolism of apolipoproteins E2 and E4 in heterozygous apoE2/4 subjects.

Ikewaki K, Zech LA, Brewer HB Jr, Rader DJ.

J Lab Clin Med. 2002 Nov;140(5):369-74.PMID: 12434139 [PubMed - indexed for MEDLINE]Related articles

The farnesoid X-receptor is an essential regulator of cholesterol homeostasis.

Lambert G, Amar MJ, Guo G, Brewer HB Jr, Gonzalez FJ, Sinal CJ.

J Biol Chem. 2003 Jan 24;278(4):2563-70. Epub 2002 Nov 5.PMID: 12421815 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo metabolism of apolipoprotein E within the HDL subpopulations LpE, LpE:A-I, LpE:A-II and LpE:A-I:A-II.

Hannuksela ML, Brousseau ME, Meyn SM, Nazih H, Bader G, Shamburek RD, Alaupovic P, Brewer HB Jr.

Atherosclerosis. 2002 Dec;165(2):205-20.PMID: 12417271 [PubMed - indexed for MEDLINE]Related articles

The ABCA1 transporter functions on the basolateral surface of hepatocytes.

Neufeld EB, Demosky SJ Jr, Stonik JA, Combs C, Remaley AT, Duverger N, Santamarina-Fojo S, Brewer HB Jr.

Biochem Biophys Res Commun. 2002 Oct 4;297(4):974-9.PMID: 12359250 [PubMed - indexed for MEDLINE]Related articles

Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster.

Remaley AT, Bark S, Walts AD, Freeman L, Shulenin S, Annilo T, Elgin E, Rhodes HE, Joyce C, Dean M, Santamarina-Fojo S, Brewer HB Jr.

Biochem Biophys Res Commun. 2002 Jul 12;295(2):276-82.PMID: 12150943 [PubMed - indexed for MEDLINE]Related articles

Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux.

Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, Lee YH, Ricote M, Glass CK, Brewer HB Jr, Gonzalez FJ.

Mol Cell Biol. 2002 Apr;22(8):2607-19.PMID: 11909955 [PubMed - indexed for MEDLINE]Related articlesFree article