PubMed

Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L).

Yang D, Wang MT, Tang Y, Chen Y, Jiang H, Jones TT, Rao K, Brewer GJ, Singh KK, Nie D.

Cancer Biol Ther. 2010 Feb 21;9(2). [Epub ahead of print]PMID: 19923925 [PubMed - as supplied by publisher]Related articles

Why Vitamin E Therapy Fails for Treatment of Alzheimer's Disease.

Brewer GJ.

J Alzheimers Dis. 2009 Oct 8. [Epub ahead of print] No abstract available. PMID: 19815983 [PubMed - as supplied by publisher]Related articles

Age-related deficiencies in complex I endogenous substrate availability and reserve capacity of complex IV in cortical neuron electron transport.

Jones TT, Brewer GJ.

Biochim Biophys Acta. 2009 Sep 30. [Epub ahead of print]PMID: 19799853 [PubMed - as supplied by publisher]Related articles

Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin II. The denture cream is a primary source of excessive zinc.

Hedera P, Peltier A, Fink JK, Wilcock S, London Z, Brewer GJ.

Neurotoxicology. 2009 Sep 2. [Epub ahead of print]PMID: 19732792 [PubMed - as supplied by publisher]Related articles

Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates.

Brewer GJ, Boehler MD, Ide AN, Wheeler BC.

J Neurosci Methods. 2009 Oct 30;184(1):104-9. Epub 2009 Aug 8.PMID: 19666055 [PubMed - in process]Related articles

Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine.

Brewer GJ, Askari F, Dick RB, Sitterly J, Fink JK, Carlson M, Kluin KJ, Lorincz MT.

Transl Res. 2009 Aug;154(2):70-7. Epub 2009 Jun 6.PMID: 19595438 [PubMed - indexed for MEDLINE]Related articles

Diagnosis of Wilson's disease.

Brewer GJ.

Neth J Med. 2009 May;67(5):195; author reply 196. No abstract available. PMID: 19581671 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of tetrathiomolybdate in the R6/2 model of Huntington disease.

Tallaksen-Greene SJ, Janiszewska A, Benton K, Hou G, Dick R, Brewer GJ, Albin RL.

Neurosci Lett. 2009 Mar 6;452(1):60-2. Epub 2009 Jan 21.PMID: 19429000 [PubMed - indexed for MEDLINE]Related articles

Improvement in dissolution of liver fibrosis in an animal model by tetrathiomolybdate.

Hou G, Dick R, Brewer GJ.

Exp Biol Med (Maywood). 2009 Jun;234(6):662-5. Epub 2009 Mar 23.PMID: 19307461 [PubMed - indexed for MEDLINE]Related articles

Neuron network activity scales exponentially with synapse density.

Brewer GJ, Boehler MD, Pearson RA, DeMaris AA, Ide AN, Wheeler BC.

J Neural Eng. 2009 Feb;6(1):014001. Epub 2008 Dec 22.PMID: 19104141 [PubMed - indexed for MEDLINE]Related articlesFree article

The use of copper-lowering therapy with tetrathiomolybdate in medicine.

Brewer GJ.

Expert Opin Investig Drugs. 2009 Jan;18(1):89-97. Review.PMID: 19053885 [PubMed - indexed for MEDLINE]Related articles

Efficacy of tetrathiomolybdate in a mouse model of multiple sclerosis.

Hou G, Abrams GD, Dick R, Brewer GJ.

Transl Res. 2008 Nov;152(5):239-44. Epub 2008 Oct 11.PMID: 19010295 [PubMed - indexed for MEDLINE]Related articles

Critical age-related loss of cofactors of neuron cytochrome C oxidase reversed by estrogen.

Jones TT, Brewer GJ.

Exp Neurol. 2009 Feb;215(2):212-9. Epub 2008 Sep 30.PMID: 18930048 [PubMed - indexed for MEDLINE]Related articles

The risks of free copper in the body and the development of useful anticopper drugs.

Brewer GJ.

Curr Opin Clin Nutr Metab Care. 2008 Nov;11(6):727-32. Review.PMID: 18827576 [PubMed - indexed for MEDLINE]Related articles

A pilot trial of the anti-angiogenic copper lowering agent tetrathiomolybdate in combination with irinotecan, 5-flurouracil, and leucovorin for metastatic colorectal cancer.

Gartner EM, Griffith KA, Pan Q, Brewer GJ, Henja GF, Merajver SD, Zalupski MM.

Invest New Drugs. 2009 Apr;27(2):159-65. Epub 2008 Aug 20.PMID: 18712502 [PubMed - indexed for MEDLINE]Related articles

A phase II trial of tetrathiomolybdate after surgery for malignant mesothelioma: final results.

Pass HI, Brewer GJ, Dick R, Carbone M, Merajver S.

Ann Thorac Surg. 2008 Aug;86(2):383-9; discussion 390.PMID: 18640301 [PubMed - indexed for MEDLINE]Related articles

Age-related differences in NFkappaB translocation and Bcl-2/Bax ratio caused by TNFalpha and Abeta42 promote survival in middle-age neurons and death in old neurons.

Patel JR, Brewer GJ.

Exp Neurol. 2008 Sep;213(1):93-100. Epub 2008 May 22.PMID: 18625500 [PubMed - indexed for MEDLINE]Related articlesFree article

Using banded sunflower moth (Lepidoptera: Tortricidae) egg density to estimate damage and economic distance in oilseed sunflower.

Mundal KD, Brewer GJ.

J Econ Entomol. 2008 Jun;101(3):969-75.PMID: 18613601 [PubMed - indexed for MEDLINE]Related articles

Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetes.

Zeng C, Hou G, Dick R, Brewer GJ.

Exp Biol Med (Maywood). 2008 Aug;233(8):1021-5. Epub 2008 May 14.PMID: 18480419 [PubMed - indexed for MEDLINE]Related articlesFree article

Age-related decreases in NAD(P)H and glutathione cause redox declines before ATP loss during glutamate treatment of hippocampal neurons.

Parihar MS, Kunz EA, Brewer GJ.

J Neurosci Res. 2008 Aug 1;86(10):2339-52.PMID: 18438923 [PubMed - indexed for MEDLINE]Related articles

SU-8 2000 rendered cytocompatible for neuronal bioMEMS applications.

Vernekar VN, Cullen DK, Fogleman N, Choi Y, García AJ, Allen MG, Brewer GJ, LaPlaca MC.

J Biomed Mater Res A. 2009 Apr;89(1):138-51.PMID: 18431778 [PubMed - indexed for MEDLINE]Related articles

Age-related changes to tumor necrosis factor receptors affect neuron survival in the presence of beta-amyloid.

Patel JR, Brewer GJ.

J Neurosci Res. 2008 Aug 1;86(10):2303-13.PMID: 18418902 [PubMed - indexed for MEDLINE]Related articlesFree article

Comment on: "High concentration of zinc in sub-retinal pigment epithelial deposits" (Lengyel et al.) (Exp. Eye Res. 772-780, 84/4, 2007).

Newsome D, Brewer GJ.

Exp Eye Res. 2008 May;86(5):860-1; author reply 862-3. Epub 2008 Feb 8. No abstract available. PMID: 18346731 [PubMed - indexed for MEDLINE]Related articles

Added astroglia promote greater synapse density and higher activity in neuronal networks.

Boehler MD, Wheeler BC, Brewer GJ.

Neuron Glia Biol. 2007;3:127-140.PMID: 18345351 [PubMed]Related articlesFree article

How reliable and robust are current biomarkers for copper status?--comments by Brewer and Althaus.

Brewer GJ, Althaus J.

Br J Nutr. 2008 Dec;100(6):1341-2; discussion 1343-4. Epub 2008 Mar 17. No abstract available. PMID: 18341759 [PubMed - indexed for MEDLINE]Related articles

NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays.

Brewer GJ, Boehler MD, Jones TT, Wheeler BC.

J Neurosci Methods. 2008 May 30;170(2):181-7. Epub 2008 Jan 20.PMID: 18308400 [PubMed - indexed for MEDLINE]Related articlesFree article

Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis.

Song M, Song Z, Barve S, Zhang J, Chen T, Liu M, Arteel GE, Brewer GJ, McClain CJ.

J Pharmacol Exp Ther. 2008 May;325(2):409-16. Epub 2008 Feb 25. Erratum in: J Pharmacol Exp Ther. 2008 Jun;325(3):1062. PMID: 18299419 [PubMed - indexed for MEDLINE]Related articlesFree article

Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C.

Jajoo S, Mukherjea D, Brewer GJ, Ramkumar V.

Neuroscience. 2008 Jan 24;151(2):525-32. Epub 2007 Nov 17.PMID: 18093742 [PubMed - indexed for MEDLINE]Related articles

Causes and diagnosis of copper deficiency.

Brewer GJ.

Am J Hematol. 2008 Jan;83(1):87-8. No abstract available. PMID: 17724702 [PubMed - indexed for MEDLINE]Related articles

Development of astroglial cells in patterned neuronal cultures.

Nam Y, Brewer GJ, Wheeler BC.

J Biomater Sci Polym Ed. 2007;18(8):1091-100.PMID: 17706000 [PubMed - indexed for MEDLINE]Related articles

A brand new mechanism for copper toxicity.

Brewer GJ.

J Hepatol. 2007 Oct;47(4):621-2. Epub 2007 Jul 23. No abstract available. PMID: 17697726 [PubMed]Related articles

Dopamine and Abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract.

Joseph JA, Carey A, Brewer GJ, Lau FC, Fisher DR.

J Alzheimers Dis. 2007 Jul;11(4):433-46.PMID: 17656822 [PubMed - indexed for MEDLINE]Related articles

Isolation and culture of adult neurons and neurospheres.

Brewer GJ, Torricelli JR.

Nat Protoc. 2007;2(6):1490-8.PMID: 17545985 [PubMed - indexed for MEDLINE]Related articles

Human primary brain tumor cell growth inhibition in serum-free medium optimized for neuron survival.

Brewer GJ, LeRoux PD.

Brain Res. 2007 Jul 9;1157:156-66. Epub 2007 Apr 30.PMID: 17537410 [PubMed - indexed for MEDLINE]Related articles

Antitumor and antiinflammatory effects of tetrathiotungstate in comparison with tetrathiomolybdate.

Hou G, Dick R, Zeng C, Brewer GJ.

Transl Res. 2007 May;149(5):260-4.PMID: 17466925 [PubMed - indexed for MEDLINE]Related articles

Active 3-D microscaffold system with fluid perfusion for culturing in vitro neuronal networks.

Rowe L, Almasri M, Lee K, Fogleman N, Brewer GJ, Nam Y, Wheeler BC, Vukasinovic J, Glezer A, Frazier AB.

Lab Chip. 2007 Apr;7(4):475-82. Epub 2007 Mar 1.PMID: 17389964 [PubMed - indexed for MEDLINE]Related articles

Simultaneous age-related depolarization of mitochondrial membrane potential and increased mitochondrial reactive oxygen species production correlate with age-related glutamate excitotoxicity in rat hippocampal neurons.

Parihar MS, Brewer GJ.

J Neurosci Res. 2007 Apr;85(5):1018-32.PMID: 17335078 [PubMed - indexed for MEDLINE]Related articles

Patterning to influence in vitro neuronal interfaces.

Wheeler BC, Nam Y, Brewer GJ.

Conf Proc IEEE Eng Med Biol Soc. 2004;7:5337-9.PMID: 17271547 [PubMed]Related articles

Iron and copper toxicity in diseases of aging, particularly atherosclerosis and Alzheimer's disease.

Brewer GJ.

Exp Biol Med (Maywood). 2007 Feb;232(2):323-35. Review.PMID: 17259340 [PubMed - indexed for MEDLINE]Related articlesFree article

Fundamental problems lie ahead in the drug discovery and commercialization process: restructuring of the pharmaceutical industry and an improved partnership with academia are required.

Brewer GJ.

J Investig Med. 2006 Sep;54(6):291-302. No abstract available. PMID: 17191351 [PubMed - indexed for MEDLINE]Related articles

Comparison of lowering copper levels with tetrathiomolybdate and zinc on mouse tumor and doxorubicin models.

Hou G, Dick R, Zeng C, Brewer GJ.

Transl Res. 2006 Dec;148(6):309-14.PMID: 17162252 [PubMed - indexed for MEDLINE]Related articles

Tetrathiomolybdate is effective in a mouse model of arthritis.

McCubbin MD, Hou G, Abrams GD, Dick R, Zhang Z, Brewer GJ.

J Rheumatol. 2006 Dec;33(12):2501-6. Epub 2006 Oct 15.PMID: 17143984 [PubMed - indexed for MEDLINE]Related articles

Neuronal network structuring induces greater neuronal activity through enhanced astroglial development.

Chang JC, Brewer GJ, Wheeler BC.

J Neural Eng. 2006 Sep;3(3):217-26. Epub 2006 Jul 5.PMID: 16921205 [PubMed - indexed for MEDLINE]Related articles

Rediscovery of the susceptibility of G6PD deficient persons to methemoglobinemia from oxidant drugs, and to hemolysis from methylene blue.

Brewer GJ.

Am J Hematol. 2007 Jan;82(1):87-8. No abstract available. PMID: 16917918 [PubMed - indexed for MEDLINE]Related articles

Mitoenergetic failure in Alzheimer disease.

Parihar MS, Brewer GJ.

Am J Physiol Cell Physiol. 2007 Jan;292(1):C8-23. Epub 2006 Jun 28. Review.PMID: 16807300 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease.

Brewer GJ, Askari F, Lorincz MT, Carlson M, Schilsky M, Kluin KJ, Hedera P, Moretti P, Fink JK, Tankanow R, Dick RB, Sitterly J.

Arch Neurol. 2006 Apr;63(4):521-7.PMID: 16606763 [PubMed - indexed for MEDLINE]Related articlesFree article

XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders.

Mufti AR, Burstein E, Csomos RA, Graf PC, Wilkinson JC, Dick RD, Challa M, Son JK, Bratton SB, Su GL, Brewer GJ, Jakob U, Duckett CS.

Mol Cell. 2006 Mar 17;21(6):775-85.PMID: 16543147 [PubMed - indexed for MEDLINE]Related articles

Patterning to enhance activity of cultured neuronal networks.

Nam Y, Chang J, Khatami D, Brewer GJ, Wheeler BC.

IEE Proc Nanobiotechnol. 2004 Jun;151(3):109-15.PMID: 16475852 [PubMed]Related articles

Novel therapeutic approaches to the treatment of Wilson's disease.

Brewer GJ.

Expert Opin Pharmacother. 2006 Feb;7(3):317-24. Review.PMID: 16448326 [PubMed - indexed for MEDLINE]Related articles

Connectivity patterns in neuronal networks of experimentally defined geometry.

Vogt AK, Brewer GJ, Offenhäusser A.

Tissue Eng. 2005 Nov-Dec;11(11-12):1757-67.PMID: 16411821 [PubMed - indexed for MEDLINE]Related articles