PubMed

Expression of Uncoupling Protein 1 in Mouse Brown Adipose Tissue Is Thyroid Hormone Receptor-{beta} Isoform Specific and Required for Adaptive Thermogenesis.

Ribeiro MO, Bianco SD, Kaneshige M, Schultz JJ, Cheng SY, Bianco AC, Brent GA.

Endocrinology. 2009 Nov 11. [Epub ahead of print]PMID: 19906816 [PubMed - as supplied by publisher]Related articles

Activation of the PI3 kinase pathway by retinoic acid mediates sodium/iodide symporter induction and iodide transport in MCF-7 breast cancer cells.

Ohashi E, Kogai T, Kagechika H, Brent GA.

Cancer Res. 2009 Apr 15;69(8):3443-50. Epub 2009 Apr 7.PMID: 19351850 [PubMed - indexed for MEDLINE]Related articles

Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cells.

Kogai T, Sajid-Crockett S, Newmarch LS, Liu YY, Brent GA.

J Endocrinol. 2008 Nov;199(2):243-52. Epub 2008 Sep 1. Erratum in: J Endocrinol. 2008 Dec;199(3):500. PMID: 18762555 [PubMed - indexed for MEDLINE]Related articlesFree article

Stealth sequences in reporter gene vectors confound studies of T3-regulated negative gene expression.

Liu YY, Brent GA.

Thyroid. 2008 Jun;18(6):593-5. No abstract available. PMID: 18578606 [PubMed - indexed for MEDLINE]Related articles

Clinical practice. Graves' disease.

Brent GA.

N Engl J Med. 2008 Jun 12;358(24):2594-605. Review. No abstract available. PMID: 18550875 [PubMed - indexed for MEDLINE]Related articles

Thyroid hormone receptor gene knockouts.

Hsu JH, Brent GA.

Trends Endocrinol Metab. 1998 Apr;9(3):103-12.PMID: 18406250 [PubMed - in process]Related articles

Retinoic acid stimulation of the sodium/iodide symporter in MCF-7 breast cancer cells is mediated by the insulin growth factor-I/phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase signaling pathways.

Kogai T, Ohashi E, Jacobs MS, Sajid-Crockett S, Fisher ML, Kanamoto Y, Brent GA.

J Clin Endocrinol Metab. 2008 May;93(5):1884-92. Epub 2008 Mar 4.PMID: 18319322 [PubMed - indexed for MEDLINE]Related articlesFree article

Thyroid health and the environment.

Brent GA, Braverman LE, Zoeller RT.

Thyroid. 2007 Sep;17(9):807-9. No abstract available. PMID: 17956154 [PubMed - indexed for MEDLINE]Related articles

Diagnosing thyroid dysfunction in pregnant women: Is case finding enough?

Brent GA.

J Clin Endocrinol Metab. 2007 Jan;92(1):39-41. No abstract available. PMID: 17209222 [PubMed - indexed for MEDLINE]Related articlesFree article

Thyroid hormone regulates endogenous amyloid-beta precursor protein gene expression and processing in both in vitro and in vivo models.

O'Barr SA, Oh JS, Ma C, Brent GA, Schultz JJ.

Thyroid. 2006 Dec;16(12):1207-13.PMID: 17199430 [PubMed - indexed for MEDLINE]Related articles

A mutant thyroid hormone receptor alpha antagonizes peroxisome proliferator-activated receptor alpha signaling in vivo and impairs fatty acid oxidation.

Liu YY, Heymann RS, Moatamed F, Schultz JJ, Sobel D, Brent GA.

Endocrinology. 2007 Mar;148(3):1206-17. Epub 2006 Nov 22.PMID: 17122078 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of sodium/iodide symporter expression in thyroid and breast cancer.

Kogai T, Taki K, Brent GA.

Endocr Relat Cancer. 2006 Sep;13(3):797-826. Review.PMID: 16954431 [PubMed - indexed for MEDLINE]Related articlesFree article

Iodide sensitizes genetically modified non-small cell lung cancer cells to ionizing radiation.

Zhang L, Sharma S, Hershman JM, Brent GA, Dubinett SM, Huang M.

Cancer Gene Ther. 2006 Jan 1;13(1):74-81.PMID: 16052231 [PubMed - indexed for MEDLINE]Related articles

Anaplastic thyroid carcinoma with thyrotoxicosis and hypoparathyroidism.

Heymann RS, Brent GA, Hershman JM.

Endocr Pract. 2005 Jul-Aug;11(4):281-4.PMID: 16006301 [PubMed - indexed for MEDLINE]Related articles

Rapid progression from subclinical to symptomatic overt hypothyroidism.

Heymann R, Brent GA.

Endocr Pract. 2005 Mar-Apr;11(2):115-9.PMID: 15901527 [PubMed - indexed for MEDLINE]Related articles

Differential regulation of sodium/iodide symporter gene expression by nuclear receptor ligands in MCF-7 breast cancer cells.

Kogai T, Kanamoto Y, Li AI, Che LH, Ohashi E, Taki K, Chandraratna RA, Saito T, Brent GA.

Endocrinology. 2005 Jul;146(7):3059-69. Epub 2005 Apr 7.PMID: 15817668 [PubMed - indexed for MEDLINE]Related articlesFree article

Resistance to thyroid hormone in Hashimoto's thyroiditis.

Fukata S, Brent GA, Sugawara M.

N Engl J Med. 2005 Feb 3;352(5):517-8. No abstract available. PMID: 15689599 [PubMed - indexed for MEDLINE]Related articles

Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter.

Shen X, Li QL, Brent GA, Friedman TC.

Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E236-45.PMID: 15585599 [PubMed - indexed for MEDLINE]Related articlesFree article

Thyroid hormone-dependent gene expression in differentiated embryonic stem cells and embryonal carcinoma cells: identification of novel thyroid hormone target genes by deoxyribonucleic acid microarray analysis.

Liu YY, Brent GA.

Endocrinology. 2005 Feb;146(2):776-83. Epub 2004 Nov 18.PMID: 15550503 [PubMed - indexed for MEDLINE]Related articlesFree article

Thyroid hormone regulation of prohormone convertase 1 (PC1): regional expression in rat brain and in vitro characterization of negative thyroid hormone response elements.

Shen X, Li QL, Brent GA, Friedman TC.

J Mol Endocrinol. 2004 Aug;33(1):21-33.PMID: 15291740 [PubMed - indexed for MEDLINE]Related articlesFree article

Systemic retinoic acid treatment induces sodium/iodide symporter expression and radioiodide uptake in mouse breast cancer models.

Kogai T, Kanamoto Y, Che LH, Taki K, Moatamed F, Schultz JJ, Brent GA.

Cancer Res. 2004 Jan 1;64(1):415-22.PMID: 14729653 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells.

Xu J, Moatamed F, Caldwell JS, Walker JR, Kraiem Z, Taki K, Brent GA, Hershman JM.

J Clin Endocrinol Metab. 2003 Oct;88(10):4990-6.PMID: 14557485 [PubMed - indexed for MEDLINE]Related articlesFree article

Follow-up of newborns with elevated screening T4 concentrations.

Lafranchi SH, Snyder DB, Sesser DE, Skeels MR, Singh N, Brent GA, Nelson JC.

J Pediatr. 2003 Sep;143(3):296-301.PMID: 14517508 [PubMed - indexed for MEDLINE]Related articles

Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1.

Freitas FR, Moriscot AS, Jorgetti V, Soares AG, Passarelli M, Scanlan TS, Brent GA, Bianco AC, Gouveia CH.

Am J Physiol Endocrinol Metab. 2003 Nov;285(5):E1135-41. Epub 2003 Sep 9.PMID: 12965872 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells.

Zhang L, Sharma S, Zhu LX, Kogai T, Hershman JM, Brent GA, Dubinett SM, Huang M.

Cancer Res. 2003 Aug 15;63(16):5065-72.PMID: 12941836 [PubMed - indexed for MEDLINE]Related articlesFree article

A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice.

Liu YY, Schultz JJ, Brent GA.

J Biol Chem. 2003 Oct 3;278(40):38913-20. Epub 2003 Jul 16.PMID: 12869545 [PubMed - indexed for MEDLINE]Related articlesFree article

The modified firefly luciferase reporter gene (luc+) but not Renilla luciferase is induced by all-trans retinoic acid in MCF-7 breast cancer cells.

Kogai T, Kanamoto Y, Brent GA.

Breast Cancer Res Treat. 2003 Mar;78(1):119-26.PMID: 12611464 [PubMed - indexed for MEDLINE]Related articles

A complex deoxyribonucleic acid response element in the rat Ca(2+)/calmodulin-dependent protein kinase IV gene 5'-flanking region mediates thyroid hormone induction and chicken ovalbumin upstream promoter transcription factor 1 repression.

Liu YY, Brent GA.

Mol Endocrinol. 2002 Nov;16(11):2439-51.PMID: 12403833 [PubMed - indexed for MEDLINE]Related articlesFree article

A thyroid-specific far-upstream enhancer in the human sodium/iodide symporter gene requires Pax-8 binding and cyclic adenosine 3',5'-monophosphate response element-like sequence binding proteins for full activity and is differentially regulated in normal and thyroid cancer cells.

Taki K, Kogai T, Kanamoto Y, Hershman JM, Brent GA.

Mol Endocrinol. 2002 Oct;16(10):2266-82.PMID: 12351692 [PubMed - indexed for MEDLINE]Related articlesFree article

Thyroid hormone gene targets in ROS 17/2.8 osteoblast-like cells identified by differential display analysis.

Gouveia CH, Schultz JJ, Jackson DJ, Williams GR, Brent GA.

Thyroid. 2002 Aug;12(8):663-71.PMID: 12225634 [PubMed - indexed for MEDLINE]Related articles

A targeted thyroid hormone receptor alpha gene dominant-negative mutation (P398H) selectively impairs gene expression in differentiated embryonic stem cells.

Liu YY, Tachiki KH, Brent GA.

Endocrinology. 2002 Jul;143(7):2664-72.PMID: 12072400 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonthyroidal illness syndrome: evaluation of thyroid function in sick patients.

Langton JE, Brent GA.

Endocrinol Metab Clin North Am. 2002 Mar;31(1):159-72. Review.PMID: 12055987 [PubMed - indexed for MEDLINE]Related articles

A GC box in the human sodium iodide symporter gene promoter is essential for full activity.

Xu J, Kogai T, Brent GA, Hershman JM.

Thyroid. 2002 Feb;12(2):107-14.PMID: 11916279 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific actions of thyroid hormone: insights from animal models.

Brent GA.

Rev Endocr Metab Disord. 2000 Jan;1(1-2):27-33. Review.PMID: 11704989 [PubMed - indexed for MEDLINE]Related articles

Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non-small cell lung cancer.

Huang M, Batra RK, Kogai T, Lin YQ, Hershman JM, Lichtenstein A, Sharma S, Zhu LX, Brent GA, Dubinett SM.

Cancer Gene Ther. 2001 Aug;8(8):612-8.PMID: 11571539 [PubMed - indexed for MEDLINE]Related articlesFree article

Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanisms.

Gouveia CH, Schultz JJ, Bianco AC, Brent GA.

J Endocrinol. 2001 Sep;170(3):667-75.PMID: 11524248 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of the human sodium/iodide symporter gene promoter in papillary thyroid carcinoma cell lines and normal thyroid cells.

Kogai T, Hershman JM, Motomura K, Endo T, Onaya T, Brent GA.

Endocrinology. 2001 Aug;142(8):3369-79.PMID: 11459780 [PubMed - indexed for MEDLINE]Related articlesFree article

Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific.

Ribeiro MO, Carvalho SD, Schultz JJ, Chiellini G, Scanlan TS, Bianco AC, Brent GA.

J Clin Invest. 2001 Jul;108(1):97-105.PMID: 11435461 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of prohormone convertase 1 (PC1) by thyroid hormone.

Li QL, Jansen E, Brent GA, Friedman TC.

Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E160-70.PMID: 11120670 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of follicle formation in long-term cultured normal human thyroid cells treated with thyrotropin stimulates iodide uptake but not sodium/iodide symporter messenger RNA and protein expression.

Kogai T, Curcio F, Hyman S, Cornford EM, Brent GA, Hershman JM.

J Endocrinol. 2000 Oct;167(1):125-35.PMID: 11018760 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions between the prohormone convertase 2 promoter and the thyroid hormone receptor.

Li QL, Jansen E, Brent GA, Naqvi S, Wilber JF, Friedman TC.

Endocrinology. 2000 Sep;141(9):3256-66.PMID: 10965896 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line.

Kogai T, Schultz JJ, Johnson LS, Huang M, Brent GA.

Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8519-24.PMID: 10890895 [PubMed - indexed for MEDLINE]Related articlesFree article

Maternal hypothyroidism: recognition and management.

Brent GA.

Thyroid. 1999 Jul;9(7):661-5. Review.PMID: 10447011 [PubMed - indexed for MEDLINE]Related articles

Thyroid hormone action: down novel paths. Focus on "thyroid hormone induces activation of mitogen-activated protein kinase in cultured cells".

Brent GA.

Am J Physiol. 1999 May;276(5 Pt 1):C1012-3. Review. No abstract available. PMID: 10329947 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of thyroid hormone action. Implications for the clinical manifestation of thyrotoxicosis.

Motomura K, Brent GA.

Endocrinol Metab Clin North Am. 1998 Mar;27(1):1-23. Review.PMID: 9534024 [PubMed - indexed for MEDLINE]Related articles

Maternal thyroid function: interpretation of thyroid function tests in pregnancy.

Brent GA.

Clin Obstet Gynecol. 1997 Mar;40(1):3-15. Review.PMID: 9103946 [PubMed - indexed for MEDLINE]Related articles

Characterization of the promoter of the rat sarcoplasmic endoplasmic reticulum Ca2+-ATPase 1 gene and analysis of thyroid hormone responsiveness.

Simonides WS, Brent GA, Thelen MH, van der Linden CG, Larsen PR, van Hardeveld C.

J Biol Chem. 1996 Dec 13;271(50):32048-56.PMID: 8943255 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor.

Zavacki AM, Harney JW, Brent GA, Larsen PR.

Endocrinology. 1996 Jul;137(7):2833-41.PMID: 8770904 [PubMed - indexed for MEDLINE]Related articles

Prospective studies of thyroid function in patients receiving gold therapy.

Mandel SJ, Brent GA, Weinblatt M, Larsen PR.

Thyroid. 1995 Apr;5(2):113-6.PMID: 7647570 [PubMed - indexed for MEDLINE]Related articles

Retinoid-X receptor (RXR) differentially augments thyroid hormone response in cell lines as a function of the response element and endogenous RXR content.

Hsu JH, Zavacki AM, Harney JW, Brent GA.

Endocrinology. 1995 Feb;136(2):421-30.PMID: 7835272 [PubMed - indexed for MEDLINE]Related articles