PubMed

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.

Gibson GE, Starkov A, Blass JP, Ratan RR, Beal MF.

Biochim Biophys Acta. 2009 Aug 26. [Epub ahead of print]PMID: 19715758 [PubMed - as supplied by publisher]Related articles

A new approach to treating Alzheimer's disease.

Blass JP.

Ann N Y Acad Sci. 2008 Dec;1147:122-8. Review.PMID: 19076437 [PubMed - indexed for MEDLINE]Related articles

Intensive nutritional supplements can improve outcomes in stroke rehabilitation.

Rabadi MH, Coar PL, Lukin M, Lesser M, Blass JP.

Neurology. 2008 Dec 2;71(23):1856-61. Epub 2008 Oct 22.PMID: 18946003 [PubMed - indexed for MEDLINE]Related articles

Admission C-reactive protein does not predict functional outcomes in patients with strokes in a subacute rehabilitation unit.

Rabadi MH, Coar PL, Lukin M, Lesser M, Blass JP.

Am J Phys Med Rehabil. 2008 Sep;87(9):731-9.PMID: 18716485 [PubMed - indexed for MEDLINE]Related articles

Increased levels of gamma-glutamylamines in Huntington disease CSF.

Jeitner TM, Matson WR, Folk JE, Blass JP, Cooper AJ.

J Neurochem. 2008 Jul;106(1):37-44. Epub 2008 Jul 1.PMID: 18422943 [PubMed - indexed for MEDLINE]Related articlesFree article

Randomized clinical stroke trials in 2006.

Rabadi MH, Blass JP.

Curr Vasc Pharmacol. 2008 Jan;6(1):61-6. Review.PMID: 18220941 [PubMed - indexed for MEDLINE]Related articles

Randomized clinical stroke trials in 2007.

Rabadi MH, Blass JP.

Open Neurol J. 2008 Oct 31;2:55-65.PMID: 19452012 [PubMed]Related articlesFree article

Thiamine-dependent processes and treatment strategies in neurodegeneration.

Gibson GE, Blass JP.

Antioxid Redox Signal. 2007 Oct;9(10):1605-19. Review.PMID: 17685850 [PubMed - indexed for MEDLINE]Related articles

Testing for linkage and association across the dihydrolipoyl dehydrogenase gene region with Alzheimer's disease in three sample populations.

Brown AM, Gordon D, Lee H, Wavrant-De Vrièze F, Cellini E, Bagnoli S, Nacmias B, Sorbi S, Hardy J, Blass JP.

Neurochem Res. 2007 Apr-May;32(4-5):857-69. Epub 2007 Mar 7.PMID: 17342416 [PubMed - indexed for MEDLINE]Related articles

Correlations of disability and biologic alterations in Alzheimer brain and test of significance by a therapeutic trial in humans.

Blass JP, Gibson GE.

J Alzheimers Dis. 2006 Jul;9(2):207-18.PMID: 16873967 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.

Kim SY, Marekov L, Bubber P, Browne SE, Stavrovskaya I, Lee J, Steinert PM, Blass JP, Beal MF, Gibson GE, Cooper AJ.

Neurochem Res. 2005 Oct;30(10):1245-55.PMID: 16341586 [PubMed - indexed for MEDLINE]Related articles

Commentary on "Diagnosis of Alzheimer's disease: Two decades of progress." Perspectives on "Perspectives".

Blass JP.

Alzheimers Dement. 2005 Oct;1(2):124-5. No abstract available. PMID: 19595844 [PubMed - in process]Related articles

What is aging? What is its role in Alzheimer's disease? What can we do about it?

Ashford JW, Atwood CS, Blass JP, Bowen RL, Finch CE, Iqbal K, Joseph JA, Perry G.

J Alzheimers Dis. 2005 Jun;7(3):247-53; discussion 255-62. No abstract available. PMID: 16006669 [PubMed - indexed for MEDLINE]Related articles

The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration.

Gibson GE, Blass JP, Beal MF, Bunik V.

Mol Neurobiol. 2005;31(1-3):43-63. Review.PMID: 15953811 [PubMed - indexed for MEDLINE]Related articles

Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria.

Krasnikov BF, Kim SY, McConoughey SJ, Ryu H, Xu H, Stavrovskaya I, Iismaa SE, Mearns BM, Ratan RR, Blass JP, Gibson GE, Cooper AJ.

Biochemistry. 2005 May 31;44(21):7830-43.PMID: 15909997 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial abnormalities in Alzheimer brain: mechanistic implications.

Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE.

Ann Neurol. 2005 May;57(5):695-703.PMID: 15852400 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial enzymes in schizophrenia.

Bubber P, Tang J, Haroutunian V, Xu H, Davis KL, Blass JP, Gibson GE.

J Mol Neurosci. 2004;24(2):315-21.PMID: 15456945 [PubMed - indexed for MEDLINE]Related articles

Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population.

Brown AM, Gordon D, Lee H, Caudy M, Hardy J, Haroutunian V, Blass JP.

Am J Med Genet B Neuropsychiatr Genet. 2004 Nov 15;131B(1):60-6.PMID: 15389771 [PubMed - indexed for MEDLINE]Related articles

Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology.

Stavrovskaya IG, Narayanan MV, Zhang W, Krasnikov BF, Heemskerk J, Young SS, Blass JP, Brown AM, Beal MF, Friedlander RM, Kristal BS.

J Exp Med. 2004 Jul 19;200(2):211-22.PMID: 15263028 [PubMed - indexed for MEDLINE]Related articlesFree article

Substantial linkage disequilibrium across the dihydrolipoyl succinyltransferase gene region without Alzheimer's disease association.

Brown AM, Gordon D, Lee H, Caudy M, Haroutunian V, Blass JP.

Neurochem Res. 2004 Mar;29(3):629-35.PMID: 15038610 [PubMed - indexed for MEDLINE]Related articles

Cerebrometabolic abnormalities in Alzheimer's disease.

Blass JP.

Neurol Res. 2003 Sep;25(6):556-66. Review.PMID: 14503009 [PubMed - indexed for MEDLINE]Related articles

"Silent" strokes and dementia.

Blass JP, Ratan RR.

N Engl J Med. 2003 Mar 27;348(13):1277-8. No abstract available. PMID: 12660392 [PubMed - indexed for MEDLINE]Related articles

Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson's disease.

Gibson GE, Kingsbury AE, Xu H, Lindsay JG, Daniel S, Foster OJ, Lees AJ, Blass JP.

Neurochem Int. 2003 Jul;43(2):129-35.PMID: 12620281 [PubMed - indexed for MEDLINE]Related articles

Alzheimer's disease and Alzheimer's dementia: distinct but overlapping entities.

Blass JP.

Neurobiol Aging. 2002 Nov-Dec;23(6):1077-84.PMID: 12470805 [PubMed - indexed for MEDLINE]Related articles

Glucose/mitochondria in neurological conditions.

Blass JP.

Int Rev Neurobiol. 2002;51:325-76. Review.PMID: 12420364 [PubMed - indexed for MEDLINE]Related articles

Cyclin towards, or away from, dementia?

Blass JP.

J Alzheimers Dis. 2002 Jun;4(3):241-2. No abstract available. PMID: 12226543 [PubMed - indexed for MEDLINE]Related articles

The role of the metabolic lesion in Alzheimer's disease.

Blass JP, Gibson GE, Hoyer S.

J Alzheimers Dis. 2002 Jun;4(3):225-32. Review.PMID: 12226541 [PubMed - indexed for MEDLINE]Related articles

Potential for a specific neuroradiologic diagnosis of Alzheimer's disease.

Blass JP.

J Nucl Med. 2002 Aug;43(8):1052-3. No abstract available. PMID: 12163631 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression in Escherichia coli and purification of hexahistidine-tagged human tissue transglutaminase.

Shi Q, Kim SY, Blass JP, Cooper AJ.

Protein Expr Purif. 2002 Apr;24(3):366-73.PMID: 11922752 [PubMed - indexed for MEDLINE]Related articles

Selective loss of KGDHC-enriched neurons in Alzheimer temporal cortex: does mitochondrial variation contribute to selective vulnerability?

Ko LW, Sheu KF, Thaler HT, Markesbery WR, Blass JP.

J Mol Neurosci. 2001 Dec;17(3):361-9.PMID: 11859932 [PubMed - indexed for MEDLINE]Related articles

Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia?

Blass JP.

J Neurosci Res. 2001 Dec 1;66(5):851-6. Review.PMID: 11746411 [PubMed - indexed for MEDLINE]Related articles

N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease.

Jeitner TM, Bogdanov MB, Matson WR, Daikhin Y, Yudkoff M, Folk JE, Steinman L, Browne SE, Beal MF, Blass JP, Cooper AJ.

J Neurochem. 2001 Dec;79(5):1109-12.PMID: 11739625 [PubMed - indexed for MEDLINE]Related articles

Cross linking of polyglutamine domains catalyzed by tissue transglutaminase is greatly favored with pathological-length repeats: does transglutaminase activity play a role in (CAG)(n)/Q(n)-expansion diseases?

Cooper AJ, Jeitner TM, Gentile V, Blass JP.

Neurochem Int. 2002 Jan;40(1):53-67. Review.PMID: 11738472 [PubMed - indexed for MEDLINE]Related articles

The role of transglutaminases in neurodegenerative diseases: overview.

Cooper AJ, Jeitner TM, Blass JP.

Neurochem Int. 2002 Jan;40(1):1-5. Review. No abstract available. PMID: 11738467 [PubMed - indexed for MEDLINE]Related articles

A sensitive fluorometric assay for tissue transglutaminase.

Jeitner TM, Fuchsbauer HL, Blass JP, Cooper AJ.

Anal Biochem. 2001 May 15;292(2):198-206.PMID: 11355851 [PubMed - indexed for MEDLINE]Related articles

Correlation of the clinical severity of Alzheimer's disease with an aberration in mitochondrial DNA (mtDNA).

Brown AM, Sheu RK, Mohs R, Haroutunian V, Blass JP.

J Mol Neurosci. 2001 Feb;16(1):41-8.PMID: 11345519 [PubMed - indexed for MEDLINE]Related articles

The mitochondrial spiral. An adequate cause of dementia in the Alzheimer's syndrome.

Blass JP.

Ann N Y Acad Sci. 2000;924:170-83. Review.PMID: 11193795 [PubMed - indexed for MEDLINE]Related articles

Lysine-rich histone (H1) is a lysyl substrate of tissue transglutaminase: possible involvement of transglutaminase in the formation of nuclear aggregates in (CAG)(n)/Q(n) expansion diseases.

Cooper AJ, Wang J, Pasternack R, Fuchsbauer HL, Sheu RK, Blass JP.

Dev Neurosci. 2000 Sep-Dec;22(5-6):404-17.PMID: 11111157 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype.

Gibson GE, Haroutunian V, Zhang H, Park LC, Shi Q, Lesser M, Mohs RC, Sheu RK, Blass JP.

Ann Neurol. 2000 Sep;48(3):297-303.PMID: 10976635 [PubMed - indexed for MEDLINE]Related articles

Inherent abnormalities in energy metabolism in Alzheimer disease. Interaction with cerebrovascular compromise.

Blass JP, Sheu RK, Gibson GE.

Ann N Y Acad Sci. 2000 Apr;903:204-21. Review.PMID: 10818509 [PubMed - indexed for MEDLINE]Related articles

Zn2+ inhibits alpha-ketoglutarate-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate dehydrogenase complex.

Brown AM, Kristal BS, Effron MS, Shestopalov AI, Ullucci PA, Sheu KF, Blass JP, Cooper AJ.

J Biol Chem. 2000 May 5;275(18):13441-7.PMID: 10788456 [PubMed - indexed for MEDLINE]Related articlesFree article

Randomized, double-blind, placebo-controlled, multicenter study to evaluate the safety and tolerability of metrifonate in patients with probable Alzheimer disease. The Metrifonate Study Group.

Blass JP, Cyrus PA, Bieber F, Gulanski B.

Alzheimer Dis Assoc Disord. 2000 Jan-Mar;14(1):39-45.PMID: 10718203 [PubMed - indexed for MEDLINE]Related articles

Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resuscitation.

Bogaert YE, Sheu KF, Hof PR, Brown AM, Blass JP, Rosenthal RE, Fiskum G.

Exp Neurol. 2000 Jan;161(1):115-26.PMID: 10683278 [PubMed - indexed for MEDLINE]Related articles

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration.

Gibson GE, Park LC, Sheu KF, Blass JP, Calingasan NY.

Neurochem Int. 2000 Feb;36(2):97-112. Review.PMID: 10676873 [PubMed - indexed for MEDLINE]Related articles

Mitochondria, neurodegenerative diseases, and selective neuronal vulnerability.

Blass JP.

Ann N Y Acad Sci. 1999;893:434-9. No abstract available. PMID: 10672284 [PubMed - indexed for MEDLINE]Related articles

The alpha-ketoglutarate dehydrogenase complex.

Sheu KF, Blass JP.

Ann N Y Acad Sci. 1999;893:61-78. Review.PMID: 10672230 [PubMed - indexed for MEDLINE]Related articles

Immunologic treatment of Alzheimer's disease.

Blass JP.

N Engl J Med. 1999 Nov 25;341(22):1694-5. No abstract available. PMID: 10572162 [PubMed - indexed for MEDLINE]Related articles

Cerebrometabolic aspects of delirium in relationship to dementia.

Blass JP, Gibson GE.

Dement Geriatr Cogn Disord. 1999 Sep-Oct;10(5):335-8. Review.PMID: 10473934 [PubMed - indexed for MEDLINE]Related articles

A DLST genotype associated with reduced risk for Alzheimer's disease.

Sheu KF, Brown AM, Kristal BS, Kalaria RN, Lilius L, Lannfelt L, Blass JP.

Neurology. 1999 Apr 22;52(7):1505-7.PMID: 10227647 [PubMed - indexed for MEDLINE]Related articles

Pathogenesis of inclusion bodies in (CAG)n/Qn-expansion diseases with special reference to the role of tissue transglutaminase and to selective vulnerability.

Cooper AJ, Sheu KF, Burke JR, Strittmatter WJ, Gentile V, Peluso G, Blass JP.

J Neurochem. 1999 Mar;72(3):889-99. Review.PMID: 10037459 [PubMed - indexed for MEDLINE]Related articles