PubMed

What is the status of gene therapy for primary immunodeficiency?

Blaese RM.

Immunol Res. 2007;38(1-3):274-84.PMID: 17917032 [PubMed - indexed for MEDLINE]Related articles

Preferential survival of CD4+ T lymphocytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infected individuals.

Morgan RA, Walker R, Carter CS, Natarajan V, Tavel JA, Bechtel C, Herpin B, Muul L, Zheng Z, Jagannatha S, Bunnell BA, Fellowes V, Metcalf JA, Stevens R, Baseler M, Leitman SF, Read EJ, Blaese RM, Lane HC.

Hum Gene Ther. 2005 Sep;16(9):1065-74.PMID: 16149905 [PubMed - indexed for MEDLINE]Related articles

In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo.

Okada T, Caplen NJ, Ramsey WJ, Onodera M, Shimazaki K, Nomoto T, Ajalli R, Wildner O, Morris J, Kume A, Hamada H, Blaese RM, Ozawa K.

J Gene Med. 2004 Mar;6(3):288-99.PMID: 15026990 [PubMed - indexed for MEDLINE]Related articles

Induction of an antitumor immunological response by an intratumoral injection of dendritic cells pulsed with genetically engineered Semliki Forest virus to produce interleukin-18 combined with the systemic administration of interleukin-12.

Yamanaka R, Tsuchiya N, Yajima N, Honma J, Hasegawa H, Tanaka R, Ramsey J, Blaese RM, Xanthopoulos KG.

J Neurosurg. 2003 Oct;99(4):746-53.PMID: 14567611 [PubMed - indexed for MEDLINE]Related articles

Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial.

Muul LM, Tuschong LM, Soenen SL, Jagadeesh GJ, Ramsey WJ, Long Z, Carter CS, Garabedian EK, Alleyne M, Brown M, Bernstein W, Schurman SH, Fleisher TA, Leitman SF, Dunbar CE, Blaese RM, Candotti F.

Blood. 2003 Apr 1;101(7):2563-9. Epub 2002 Nov 27.PMID: 12456496 [PubMed - indexed for MEDLINE]Related articlesFree article

Immune response to fetal calf serum by two adenosine deaminase-deficient patients after T cell gene therapy.

Tuschong L, Soenen SL, Blaese RM, Candotti F, Muul LM.

Hum Gene Ther. 2002 Sep 1;13(13):1605-10.PMID: 12228015 [PubMed - indexed for MEDLINE]Related articles

A novel approach using transcomplementing adenoviral vectors for gene therapy of adrenocortical cancer.

Wolkersdörfer GW, Bornstein SR, Higginbotham JN, Hiroi N, Vaquero JJ, Green MV, Blaese RM, Aguilera G, Chrousos GP, Ramsey WJ.

Horm Metab Res. 2002 Jun;34(6):279-87. Erratum in: Horm Metab Res. 2002 Oct;34(10):604.. PMID: 12173067 [PubMed - indexed for MEDLINE]Related articles

The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid.

Higginbotham JN, Seth P, Blaese RM, Ramsey WJ.

Hum Gene Ther. 2002 Jan 1;13(1):129-41.PMID: 11779417 [PubMed - indexed for MEDLINE]Related articles

Biosynthetic ganciclovir triphosphate: its isolation and characterization from ganciclovir-treated herpes simplex thymidine kinase-transduced murine cells.

Agbaria R, Candotti F, Kelley JA, Hao Z, Johns DG, Cooney DA, Blaese RM, Ford H Jr.

Biochem Biophys Res Commun. 2001 Nov 30;289(2):525-30.PMID: 11716505 [PubMed - indexed for MEDLINE]Related articles

AV.TK-mediated killing of subcutaneous tumors in situ results in effective immunization against established secondary intracranial tumor deposits.

Okada T, Shah M, Higginbotham JN, Li Q, Wildner O, Walbridge S, Oldfield E, Blaese RM, Ramsey WJ.

Gene Ther. 2001 Sep;8(17):1315-22.PMID: 11571568 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of a skin-based metabolic sink for phenylalanine by overexpression of phenylalanine hydroxylase and GTP cyclohydrolase in primary human keratinocytes.

Christensen R, Kolvraa S, Blaese RM, Jensen TG.

Gene Ther. 2000 Dec;7(23):1971-8.PMID: 11175307 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection.

Walker RE, Bechtel CM, Natarajan V, Baseler M, Hege KM, Metcalf JA, Stevens R, Hazen A, Blaese RM, Chen CC, Leitman SF, Palensky J, Wittes J, Davey RT Jr, Falloon J, Polis MA, Kovacs JA, Broad DF, Levine BL, Roberts MR, Masur H, Lane HC.

Blood. 2000 Jul 15;96(2):467-74.PMID: 10887107 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene transfer.

Candotti F, Agbaria R, Mullen CA, Touraine R, Balzarini J, Johns DG, Blaese RM.

Cancer Gene Ther. 2000 Apr;7(4):574-80.PMID: 10811475 [PubMed - indexed for MEDLINE]Related articlesFree article

Human gene marker/therapy clinical protocols.

Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley FD, Lotze MT, Wilson JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell SR, Brenner M, Oldfield E, Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA, Crystal RG, Welsh MJ, Culver K, Heslop HE, Simons J, Wilmott RW, Boucher RC, Siegler HF, Barranger JA, Karlsson S, Kohn D, Galpin JE, Raffel C, Hesdorffer C, Ilan J, Cassileth P, O'Shaughnessy J, Kun LE, Das TK, Wong-Staal F, Sobol RE, Haubrich R, Sznol M, Rubin J, Sorcher EJ, Rosenblatt J, Walker R, Brigham K, Vogelzang N, Hersh E, Eck SL.

Hum Gene Ther. 2000 Apr 10;11(6):919-79. No abstract available. PMID: 10779168 [PubMed - indexed for MEDLINE]Related articles

Optimism regarding the use of RNA/DNA hybrids to repair genes at high efficiency.

Blaese RM.

J Gene Med. 1999 Mar-Apr;1(2):144-7. No abstract available. PMID: 10738578 [PubMed - indexed for MEDLINE]Related articles

A phase I study of intralesional administration of an adenovirus vector expressing the HSV-1 thymidine kinase gene (AdV.RSV-TK) in combination with escalating doses of ganciclovir in patients with cutaneous metastatic malignant melanoma.

Morris JC, Ramsey WJ, Wildner O, Muslow HA, Aguilar-Cordova E, Blaese RM.

Hum Gene Ther. 2000 Feb 10;11(3):487-503. No abstract available. PMID: 10697123 [PubMed - indexed for MEDLINE]Related articles

Human gene marker/therapy clinical protocols.

Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley FD, Lotze MT, Wilson JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell SR, Oldfield E, Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA, Crystal RG, Welsh MJ, Culver K, Heslop HE, Simons J, Wilmott RW, Habib NA, et al.

Hum Gene Ther. 1999 Dec 10;10(18):3067-123. No abstract available. PMID: 10609664 [PubMed - indexed for MEDLINE]Related articles

Synergy between the herpes simplex virus tk/ganciclovir prodrug suicide system and the topoisomerase I inhibitor topotecan.

Wildner O, Blaese RM, Morris JC.

Hum Gene Ther. 1999 Nov 1;10(16):2679-87.PMID: 10566896 [PubMed - indexed for MEDLINE]Related articles

Gene therapy: lessons learnt from the past decade. Interview by Clare Thompson.

Morgan RA, Blaese RM.

BMJ. 1999 Nov 13;319(7220):1310. No abstract available. PMID: 10559061 [PubMed - indexed for MEDLINE]Related articlesFree article

Enzyme prodrug gene therapy: synergistic use of the herpes simplex virus-cellular thymidine kinase/ganciclovir system and thymidylate synthase inhibitors for the treatment of colon cancer.

Wildner O, Blaese RM, Candotti F.

Cancer Res. 1999 Oct 15;59(20):5233-8.PMID: 10537302 [PubMed - indexed for MEDLINE]Related articlesFree article

Retrovirus-mediated WASP gene transfer corrects defective actin polymerization in B cell lines from Wiskott-Aldrich syndrome patients carrying 'null' mutations.

Candotti F, Facchetti F, Blanzuoli L, Stewart DM, Nelson DL, Blaese RM.

Gene Ther. 1999 Jun;6(6):1170-4.PMID: 10455421 [PubMed - indexed for MEDLINE]Related articlesFree article

Adeno-retroviral chimeric viruses as in vivo transducing agents.

Caplen NJ, Higginbotham JN, Scheel JR, Vahanian N, Yoshida Y, Hamada H, Blaese RM, Ramsey WJ.

Gene Ther. 1999 Mar;6(3):454-9.PMID: 10435096 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer.

Wildner O, Morris JC, Vahanian NN, Ford H Jr, Ramsey WJ, Blaese RM.

Gene Ther. 1999 Jan;6(1):57-62.PMID: 10341876 [PubMed - indexed for MEDLINE]Related articlesFree article

Retroviral-mediated transfer and expression of the common gamma chain into human hematopoietic progenitors.

Candotti F, Onodera M, Knazek RA, Blaese RM.

Acta Haematol. 1999;101(2):106-10.PMID: 10202241 [PubMed - indexed for MEDLINE]Related articles

Gene therapy for severe combined immunodeficiency caused by adenosine deaminase deficiency: improved retroviral vectors for clinical trials.

Onodera M, Nelson DM, Sakiyama Y, Candotti F, Blaese RM.

Acta Haematol. 1999;101(2):89-96. Review.PMID: 10202239 [PubMed - indexed for MEDLINE]Related articles

Anti-tumor immunity generated by tumor cells engineered to express B7-1 via retroviral or adenoviral gene transfer.

Felzmann T, Ramsey WJ, Blaese RM.

Cancer Lett. 1999 Jan 8;135(1):1-10.PMID: 10077215 [PubMed - indexed for MEDLINE]Related articles

The bystander effect in the HSVtk/ganciclovir system and its relationship to gap junctional communication.

Touraine RL, Ishii-Morita H, Ramsey WJ, Blaese RM.

Gene Ther. 1998 Dec;5(12):1705-11.PMID: 10023450 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase.

Wildner O, Blaese RM, Morris JC.

Cancer Res. 1999 Jan 15;59(2):410-3.PMID: 9927055 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions.

Touraine RL, Vahanian N, Ramsey WJ, Blaese RM.

Hum Gene Ther. 1998 Nov 1;9(16):2385-91.PMID: 9829537 [PubMed - indexed for MEDLINE]Related articles

Generation of a conditionally neo(r)-containing retroviral producer cell line: effects of neo(r) on retroviral titer and transgene expression.

Wildner O, Candotti F, Krecko EG, Xanthopoulos KG, Ramsey WJ, Blaese RM.

Gene Ther. 1998 May;5(5):684-91.PMID: 9797874 [PubMed - indexed for MEDLINE]Related articlesFree article

Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults.

Walker RE, Carter CS, Muul L, Natarajan V, Herpin BR, Leitman SF, Klein HG, Mullen CA, Metcalf JA, Baseler M, Falloon J, Davey RT Jr, Kovacs JA, Polis MA, Masur H, Blaese RM, Lane HC.

Nat Med. 1998 Jul;4(7):852-6.PMID: 9662381 [PubMed - indexed for MEDLINE]Related articles

T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates.

Kohn DB, Hershfield MS, Carbonaro D, Shigeoka A, Brooks J, Smogorzewska EM, Barsky LW, Chan R, Burotto F, Annett G, Nolta JA, Crooks G, Kapoor N, Elder M, Wara D, Bowen T, Madsen E, Snyder FF, Bastian J, Muul L, Blaese RM, Weinberg K, Parkman R.

Nat Med. 1998 Jul;4(7):775-80.PMID: 9662367 [PubMed - indexed for MEDLINE]Related articles

Gene therapy of primary immunodeficiencies.

Candotti F, Blaese RM.

Springer Semin Immunopathol. 1998;19(4):493-508. Review. No abstract available. PMID: 9618770 [PubMed - indexed for MEDLINE]Related articles

Adenovirus vectors as transcomplementing templates for the production of replication defective retroviral vectors.

Ramsey WJ, Caplen NJ, Li Q, Higginbotham JN, Shah M, Blaese RM.

Biochem Biophys Res Commun. 1998 May 29;246(3):912-9.PMID: 9618311 [PubMed - indexed for MEDLINE]Related articles

Efficient directional cloning of recombinant adenovirus vectors using DNA-protein complex.

Okada T, Ramsey WJ, Munir J, Wildner O, Blaese RM.

Nucleic Acids Res. 1998 Apr 15;26(8):1947-50.PMID: 9518487 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of improved adenosine deaminase retroviral vectors.

Onodera M, Nelson DM, Yachie A, Jagadeesh GJ, Bunnell BA, Morgan RA, Blaese RM.

J Virol. 1998 Mar;72(3):1769-74.PMID: 9499026 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the antitumor immune response generated by treatment of murine tumors with recombinant adenoviruses expressing HSVtk, IL-2, IL-6 or B7-1.

Felzmann T, Ramsey WJ, Blaese RM.

Gene Ther. 1997 Dec;4(12):1322-9.PMID: 9472556 [PubMed - indexed for MEDLINE]Related articlesFree article

Successful peripheral T-lymphocyte-directed gene transfer for a patient with severe combined immune deficiency caused by adenosine deaminase deficiency.

Onodera M, Ariga T, Kawamura N, Kobayashi I, Ohtsu M, Yamada M, Tame A, Furuta H, Okano M, Matsumoto S, Kotani H, McGarrity GJ, Blaese RM, Sakiyama Y.

Blood. 1998 Jan 1;91(1):30-6.PMID: 9414266 [PubMed - indexed for MEDLINE]Related articlesFree article

Human gene marker/therapy clinical protocols.

Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley FD, Lotze MT, Wilson JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell SR, Oldfield E, Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA, Crystal RG, Welsh MJ, Culver K, Heslop HE, Simons J, Wilmott RW, Boucher RC, et al.

Hum Gene Ther. 1997 Dec 10;8(18):2301-38. No abstract available. PMID: 9449381 [PubMed - indexed for MEDLINE]Related articles

Retrovirus-mediated gene transfer of ornithine-delta-aminotransferase into keratinocytes from gyrate atrophy patients.

Jensen TG, Sullivan DM, Morgan RA, Taichman LB, Nussenblatt RB, Blaese RM, Csaky KG.

Hum Gene Ther. 1997 Nov 20;8(17):2125-32.PMID: 9414260 [PubMed - indexed for MEDLINE]Related articles

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells.

Ram Z, Culver KW, Oshiro EM, Viola JJ, DeVroom HL, Otto E, Long Z, Chiang Y, McGarrity GJ, Muul LM, Katz D, Blaese RM, Oldfield EH.

Nat Med. 1997 Dec;3(12):1354-61.PMID: 9396605 [PubMed - indexed for MEDLINE]Related articles

Structural and functional basis for JAK3-deficient severe combined immunodeficiency.

Candotti F, Oakes SA, Johnston JA, Giliani S, Schumacher RF, Mella P, Fiorini M, Ugazio AG, Badolato R, Notarangelo LD, Bozzi F, Macchi P, Strina D, Vezzoni P, Blaese RM, O'Shea JJ, Villa A.

Blood. 1997 Nov 15;90(10):3996-4003.PMID: 9354668 [PubMed - indexed for MEDLINE]Related articlesFree article

Wiskott-Aldrich syndrome/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotype.

Zhu Q, Watanabe C, Liu T, Hollenbaugh D, Blaese RM, Kanner SB, Aruffo A, Ochs HD.

Blood. 1997 Oct 1;90(7):2680-9.PMID: 9326235 [PubMed - indexed for MEDLINE]Related articlesFree article

Retroviral transfer of acid alpha-glucosidase cDNA to enzyme-deficient myoblasts results in phenotypic spread of the genotypic correction by both secretion and fusion.

Zaretsky JZ, Candotti F, Boerkoel C, Adams EM, Yewdell JW, Blaese RM, Plotz PH.

Hum Gene Ther. 1997 Sep 1;8(13):1555-63. Erratum in: Hum Gene Ther 1998 Apr 10;9(6):930. PMID: 9322088 [PubMed - indexed for MEDLINE]Related articles

A simple and reliable method for screening retroviral producer clones without selectable markers.

Onodera M, Yachie A, Nelson DM, Welchlin H, Morgan RA, Blaese RM.

Hum Gene Ther. 1997 Jul 1;8(10):1189-94.PMID: 9215736 [PubMed - indexed for MEDLINE]Related articles

Gene therapy for cancer.

Blaese RM.

Sci Am. 1997 Jun;276(6):111-5. No abstract available. PMID: 9163943 [PubMed - indexed for MEDLINE]Related articles

Keratinocyte gene therapy for adenosine deaminase deficiency: a model approach for inherited metabolic disorders.

Fenjves ES, Schwartz PM, Blaese RM, Taichman LB.

Hum Gene Ther. 1997 May 20;8(8):911-7.PMID: 9195213 [PubMed - indexed for MEDLINE]Related articles

Mechanism of 'bystander effect' killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment.

Ishii-Morita H, Agbaria R, Mullen CA, Hirano H, Koeplin DA, Ram Z, Oldfield EH, Johns DG, Blaese RM.

Gene Ther. 1997 Mar;4(3):244-51.PMID: 9135738 [PubMed - indexed for MEDLINE]Related articlesFree article

Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.

Oakes SA, Candotti F, Johnston JA, Chen YQ, Ryan JJ, Taylor N, Liu X, Hennighausen L, Notarangelo LD, Paul WE, Blaese RM, O'Shea JJ.

Immunity. 1996 Dec;5(6):605-15.PMID: 8986719 [PubMed - indexed for MEDLINE]Related articles

Human gene marker/therapy clinical protocols.

Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley FD, Lotze MT, Wilson JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell SR, Oldfield E, Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA, Crystal RG, Welsh MJ, Culver K, Heslop HE, Simons J, Wilmott RW, Tiberghien P, et al.

Hum Gene Ther. 1996 Dec 1;7(18):2287-313. No abstract available. PMID: 8953320 [PubMed - indexed for MEDLINE]Related articles