PubMed

A new generation of stable, non-antibiotic, low copy number plasmids improve immune responses to foreign antigens in Salmonella enterica serovar Typhi live vectors.

Galen JE, Wang JY, Chinchilla M, Vindurampulle C, Vogel JE, Levy H, Blackwelder WC, Pasetti MF, Levine MM.

Infect Immun. 2009 Nov 2. [Epub ahead of print]PMID: 19884333 [PubMed - as supplied by publisher]Related articles

Advanced Phase I/II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Gemcitabine-resistant Metastatic Pancreatic Cancer.

Chawla SP, Chua VS, Fernandez L, Quon D, Blackwelder WC, Gordon EM, Hall FL.

Mol Ther. 2009 Oct 13. [Epub ahead of print]PMID: 19826403 [PubMed - as supplied by publisher]Related articles

Phase I/II and phase II studies of targeted gene delivery in vivo: intravenous Rexin-G for chemotherapy-resistant sarcoma and osteosarcoma.

Chawla SP, Chua VS, Fernandez L, Quon D, Saralou A, Blackwelder WC, Hall FL, Gordon EM.

Mol Ther. 2009 Sep;17(9):1651-7. Epub 2009 Jun 16.PMID: 19532136 [PubMed - indexed for MEDLINE]Related articles

Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.

Kato GJ, Wang Z, Machado RF, Blackwelder WC, Taylor JG 6th, Hazen SL.

Br J Haematol. 2009 May;145(4):506-13. Epub 2008 Mar 17.PMID: 19344390 [PubMed - indexed for MEDLINE]Related articles

Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption: a randomized controlled trial.

Porter BO, Anthony KB, Shen J, Hahn B, Keh CE, Maldarelli F, Blackwelder WC, Lane HC, Kovacs JA, Davey RT, Sereti I.

AIDS. 2009 Jan 14;23(2):203-12.PMID: 19098490 [PubMed - indexed for MEDLINE]Related articles

Age- and serotype-specific pediatric invasive pneumococcal disease: insights from systematic surveillance in Santiago, Chile, 1994--2007.

Lagos R, Muñoz A, San Martin O, Maldonado A, Hormazabal JC, Blackwelder WC, Levine MM.

J Infect Dis. 2008 Dec 15;198(12):1809-17.PMID: 18959497 [PubMed - indexed for MEDLINE]Related articles

Use of mchI encoding immunity to the antimicrobial peptide microcin H47 as a plasmid selection marker in attenuated bacterial live vectors.

Fang CM, Wang JY, Chinchilla M, Levine MM, Blackwelder WC, Galen JE.

Infect Immun. 2008 Oct;76(10):4422-30. Epub 2008 Jul 28.PMID: 18663003 [PubMed - indexed for MEDLINE]Related articlesFree article

Preventing contamination between injections with multiple-use nozzle needle-free injectors: a safety trial.

Kelly K, Loskutov A, Zehrung D, Puaa K, LaBarre P, Muller N, Guiqiang W, Ding HG, Hu D, Blackwelder WC.

Vaccine. 2008 Mar 4;26(10):1344-52. Epub 2008 Jan 18.PMID: 18272265 [PubMed - indexed for MEDLINE]Related articles

Safety and immunogenicity of CVD 1208S, a live, oral DeltaguaBA Deltasen Deltaset Shigella flexneri 2a vaccine grown on animal-free media.

Kotloff KL, Simon JK, Pasetti MF, Sztein MB, Wooden SL, Livio S, Nataro JP, Blackwelder WC, Barry EM, Picking W, Levine MM.

Hum Vaccin. 2007 Nov-Dec;3(6):268-75. Epub 2007 Jul 15.PMID: 17938573 [PubMed - indexed for MEDLINE]Related articles

Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica Serovar Paratyphi B.

Levine MM, Ferreccio C, Black RE, Lagos R, San Martin O, Blackwelder WC.

Clin Infect Dis. 2007 Jul 15;45 Suppl 1:S24-8.PMID: 17582564 [PubMed - indexed for MEDLINE]Related articles

Interaction of nicotinic and histamine H(3) systems in the radial-arm maze repeated acquisition task.

Kholdebarin E, Caldwell DP, Blackwelder WP, Kao M, Christopher NC, Levin ED.

Eur J Pharmacol. 2007 Aug 13;569(1-2):64-9. Epub 2007 May 22.PMID: 17544392 [PubMed - indexed for MEDLINE]Related articlesFree article

Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease.

Sachdev V, Machado RF, Shizukuda Y, Rao YN, Sidenko S, Ernst I, St Peter M, Coles WA, Rosing DR, Blackwelder WC, Castro O, Kato GJ, Gladwin MT.

J Am Coll Cardiol. 2007 Jan 30;49(4):472-9. Epub 2007 Jan 16.PMID: 17258093 [PubMed - indexed for MEDLINE]Related articlesFree article

N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease.

Machado RF, Anthi A, Steinberg MH, Bonds D, Sachdev V, Kato GJ, Taveira-DaSilva AM, Ballas SK, Blackwelder W, Xu X, Hunter L, Barton B, Waclawiw M, Castro O, Gladwin MT; MSH Investigators.

JAMA. 2006 Jul 19;296(3):310-8.PMID: 16849664 [PubMed - indexed for MEDLINE]Related articlesFree article

Diarrheagenic Escherichia coli infection in Baltimore, Maryland, and New Haven, Connecticut.

Nataro JP, Mai V, Johnson J, Blackwelder WC, Heimer R, Tirrell S, Edberg SC, Braden CR, Glenn Morris J Jr, Hirshon JM.

Clin Infect Dis. 2006 Aug 15;43(4):402-7. Epub 2006 Jul 11.PMID: 16838226 [PubMed - indexed for MEDLINE]Related articles

Lopinavir-ritonavir: effects on endothelial cell function in healthy subjects.

Grubb JR, Dejam A, Voell J, Blackwelder WC, Sklar PA, Kovacs JA, Cannon RO, Masur H, Gladwin MT.

J Infect Dis. 2006 Jun 1;193(11):1516-9. Epub 2006 Apr 27.PMID: 16652279 [PubMed - indexed for MEDLINE]Related articles

Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer.

Rapoport AP, Stadtmauer EA, Aqui N, Badros A, Cotte J, Chrisley L, Veloso E, Zheng Z, Westphal S, Mair R, Chi N, Ratterree B, Pochran MF, Natt S, Hinkle J, Sickles C, Sohal A, Ruehle K, Lynch C, Zhang L, Porter DL, Luger S, Guo C, Fang HB, Blackwelder W, Hankey K, Mann D, Edelman R, Frasch C, Levine BL, Cross A, June CH.

Nat Med. 2005 Nov;11(11):1230-7. Epub 2005 Oct 16.PMID: 16227990 [PubMed - indexed for MEDLINE]Related articles

Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality.

Kato GJ, Martyr S, Blackwelder WC, Nichols JS, Coles WA, Hunter LA, Brennan ML, Hazen SL, Gladwin MT.

Br J Haematol. 2005 Sep;130(6):943-53.PMID: 16156864 [PubMed - indexed for MEDLINE]Related articlesFree article

Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.

Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, Hazen SL, Vichinsky EP, Morris SM Jr, Gladwin MT.

JAMA. 2005 Jul 6;294(1):81-90.PMID: 15998894 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of influenza vaccination on seasonal mortality in the US elderly population.

Simonsen L, Reichert TA, Viboud C, Blackwelder WC, Taylor RJ, Miller MA.

Arch Intern Med. 2005 Feb 14;165(3):265-72.PMID: 15710788 [PubMed - indexed for MEDLINE]Related articlesFree article

Safety and immunogenicity of new cell-cultured smallpox vaccine compared with calf-lymph derived vaccine: a blind, single-centre, randomised controlled trial.

Greenberg RN, Kennedy JS, Clanton DJ, Plummer EA, Hague L, Cruz J, Ennis FA, Blackwelder WC, Hopkins RJ.

Lancet. 2005 Jan 29-Feb 4;365(9457):398-409.PMID: 15680454 [PubMed - indexed for MEDLINE]Related articles

Safety and pharmacokinetic evaluation of intravenous vaccinia immune globulin in healthy volunteers.

Hopkins RJ, Kramer WG, Blackwelder WC, Ashtekar M, Hague L, Winker-La Roche SD, Berezuk G, Smith D, Leese PT.

Clin Infect Dis. 2004 Sep 15;39(6):759-66. Epub 2004 Aug 23.PMID: 15472804 [PubMed - indexed for MEDLINE]Related articles

Current issues in clinical equivalence trials.

Blackwelder WC.

J Dent Res. 2004;83 Spec No C:C113-5.PMID: 15286135 [PubMed - indexed for MEDLINE]Related articles

Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation.

Icenogle LM, Christopher NC, Blackwelder WP, Caldwell DP, Qiao D, Seidler FJ, Slotkin TA, Levin ED.

Neurotoxicol Teratol. 2004 Jan-Feb;26(1):95-101.PMID: 15001218 [PubMed - indexed for MEDLINE]Related articles

Pulmonary hypertension as a risk factor for death in patients with sickle cell disease.

Gladwin MT, Sachdev V, Jison ML, Shizukuda Y, Plehn JF, Minter K, Brown B, Coles WA, Nichols JS, Ernst I, Hunter LA, Blackwelder WC, Schechter AN, Rodgers GP, Castro O, Ognibene FP.

N Engl J Med. 2004 Feb 26;350(9):886-95.PMID: 14985486 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro assay for neutralizing antibody to hepatitis C virus: evidence for broadly conserved neutralization epitopes.

Bartosch B, Bukh J, Meunier JC, Granier C, Engle RE, Blackwelder WC, Emerson SU, Cosset FL, Purcell RH.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14199-204. Epub 2003 Nov 14.PMID: 14617769 [PubMed - indexed for MEDLINE]Related articlesFree article

Learning impairment caused by a toxin produced by Pfiesteria piscicida infused into the hippocampus of rats.

Levin ED, Blackwelder WP, Glasgow HB Jr, Burkholder JM, Moeller PD, Ramsdell JS.

Neurotoxicol Teratol. 2003 Jul-Aug;25(4):419-26.PMID: 12798959 [PubMed - indexed for MEDLINE]Related articles

Estimating deaths due to influenza and respiratory syncytial virus.

Simonsen L, Blackwelder WC, Reichert TA, Miller MA.

JAMA. 2003 May 21;289(19):2499-500; author reply 2500-2. No abstract available. PMID: 12759317 [PubMed - indexed for MEDLINE]Related articles

Pre-clinical immunogenicity and efficacy trial of a recombinant hepatitis E vaccine.

Purcell RH, Nguyen H, Shapiro M, Engle RE, Govindarajan S, Blackwelder WC, Wong DC, Prieels JP, Emerson SU.

Vaccine. 2003 Jun 2;21(19-20):2607-15.PMID: 12744897 [PubMed - indexed for MEDLINE]Related articles

Virus-inhibiting surgical glove to reduce the risk of infection by enveloped viruses.

Bricout F, Moraillon A, Sonntag P, Hoerner P, Blackwelder W, Plotkin S.

J Med Virol. 2003 Apr;69(4):538-45.PMID: 12601762 [PubMed - indexed for MEDLINE]Related articles

Sample size determination for phase II studies of new vaccines.

Rao MR, Blackwelder WC, Troendle JF, Naficy AB, Clemens JD.

Vaccine. 2002 Sep 10;20(27-28):3364-9.PMID: 12213406 [PubMed - indexed for MEDLINE]Related articles

Recombinant vaccine against hepatitis E: duration of protective immunity in rhesus macaques.

Zhang M, Emerson SU, Nguyen H, Engle R, Govindarajan S, Blackwelder WC, Gerin J, Purcell RH.

Vaccine. 2002 Sep 10;20(27-28):3285-91.PMID: 12213398 [PubMed - indexed for MEDLINE]Related articles

High prevalence of osteonecrosis of the femoral head in HIV-infected adults.

Miller KD, Masur H, Jones EC, Joe GO, Rick ME, Kelly GG, Mican JM, Liu S, Gerber LH, Blackwelder WC, Falloon J, Davey RT, Polis MA, Walker RE, Lane HC, Kovacs JA.

Ann Intern Med. 2002 Jul 2;137(1):17-25.PMID: 12093241 [PubMed - indexed for MEDLINE]Related articlesFree article

Ecological studies, rotavirus vaccination, and intussusception.

Simonsen L, Morens DM, Blackwelder WC.

Lancet. 2002 Mar 23;359(9311):1066-7; author reply 1066. No abstract available. PMID: 11937210 [PubMed - indexed for MEDLINE]Related articles

Analysis of the ratio of marginal probabilities in a matched-pair setting.

Nam JM, Blackwelder WC.

Stat Med. 2002 Mar 15;21(5):689-99. Erratum in: Stat Med. 2003 Jul 15;22(13):2235. PMID: 11870810 [PubMed - indexed for MEDLINE]Related articles

Showing a treatment is good because it is not bad: when does "noninferiority" imply effectiveness?

Blackwelder WC.

Control Clin Trials. 2002 Feb;23(1):52-4. No abstract available. PMID: 11852164 [PubMed - indexed for MEDLINE]Related articles

Effect of rotavirus vaccination programme on trends in admission of infants to hospital for intussusception.

Simonsen L, Morens D, Elixhauser A, Gerber M, Van Raden M, Blackwelder W.

Lancet. 2001 Oct 13;358(9289):1224-9.PMID: 11675060 [PubMed - indexed for MEDLINE]Related articles

Allocation of subjects to test null relative risks smaller than one.

Hoover DR, Blackwelder WC.

Stat Med. 2001 Oct 30;20(20):3071-82.PMID: 11590633 [PubMed - indexed for MEDLINE]Related articles

Importance of complement source in measuring meningococcal bactericidal titers.

Santos GF, Deck RR, Donnelly J, Blackwelder W, Granoff DM.

Clin Diagn Lab Immunol. 2001 May;8(3):616-23.PMID: 11329468 [PubMed - indexed for MEDLINE]Related articlesFree article

Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humans.

Treanor JJ, Wilkinson BE, Masseoud F, Hu-Primmer J, Battaglia R, O'Brien D, Wolff M, Rabinovich G, Blackwelder W, Katz JM.

Vaccine. 2001 Feb 8;19(13-14):1732-7.PMID: 11166898 [PubMed - indexed for MEDLINE]Related articles

Decreased bone mineral density during low dose glucocorticoid administration in a randomized, placebo controlled trial.

McKenzie R, Reynolds JC, O'Fallon A, Dale J, Deloria M, Blackwelder W, Straus SE.

J Rheumatol. 2000 Sep;27(9):2222-6.PMID: 10990237 [PubMed - indexed for MEDLINE]Related articles

Safety and immunogenicity of six acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fifth dose in four- to six-year-old children.

Pichichero ME, Edwards KM, Anderson EL, Rennels MB, Englund JA, Yerg DE, Blackwelder WC, Jansen DL, Meade BD.

Pediatrics. 2000 Jan;105(1):e11.PMID: 10617748 [PubMed - indexed for MEDLINE]Related articles

Low-dose hydrocortisone for treatment of chronic fatigue syndrome: a randomized controlled trial.

McKenzie R, O'Fallon A, Dale J, Demitrack M, Sharma G, Deloria M, Garcia-Borreguero D, Blackwelder W, Straus SE.

JAMA. 1998 Sep 23-30;280(12):1061-6.PMID: 9757853 [PubMed - indexed for MEDLINE]Related articlesFree article

Human papillomavirus, anal squamous intraepithelial lesions, and human immunodeficiency virus in a cohort of gay men.

Friedman HB, Saah AJ, Sherman ME, Busseniers AE, Blackwelder WC, Kaslow RA, Ghaffari AM, Daniel RW, Shah KV.

J Infect Dis. 1998 Jul;178(1):45-52.PMID: 9652422 [PubMed - indexed for MEDLINE]Related articles

Estimation of pertussis vaccine efficacy in the presence of covariates in three randomized trials.

Blackwelder WC, VanRaden MJ, Deloria MA.

Dev Biol Stand. 1997;89:161-6.PMID: 9272346 [PubMed - indexed for MEDLINE]Related articles

Colonization with group B streptococci in pregnancy and adverse outcome. VIP Study Group.

Regan JA, Klebanoff MA, Nugent RP, Eschenbach DA, Blackwelder WC, Lou Y, Gibbs RS, Rettig PJ, Martin DH, Edelman R.

Am J Obstet Gynecol. 1996 Apr;174(4):1354-60.PMID: 8623869 [PubMed - indexed for MEDLINE]Related articles

A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group.

Greco D, Salmaso S, Mastrantonio P, Giuliano M, Tozzi AE, Anemona A, Ciofi degli Atti ML, Giammanco A, Panei P, Blackwelder WC, Klein DL, Wassilak SG.

N Engl J Med. 1996 Feb 8;334(6):341-8.PMID: 8538704 [PubMed - indexed for MEDLINE]Related articlesFree article

A placebo-controlled trial of a pertussis-toxoid vaccine.

Trollfors B, Taranger J, Lagergård T, Lind L, Sundh V, Zackrisson G, Lowe CU, Blackwelder W, Robbins JB.

N Engl J Med. 1995 Oct 19;333(16):1045-50.PMID: 7675047 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of reactions after consecutive acellular or whole-cell pertussis vaccine immunizations.

Deloria MA, Blackwelder WC, Decker MD, Englund JA, Steinhoff MC, Pichichero ME, Rennels MB, Anderson EL, Edwards KM.

Pediatrics. 1995 Sep;96(3 Pt 2):592-4.PMID: 7659483 [PubMed - indexed for MEDLINE]Related articles

Comparison of five calculation modes for antibody ELISA procedures using pertussis serology as a model.

Reizenstein E, Hallander HO, Blackwelder WC, Kühn I, Ljungman M, Möllby R.

J Immunol Methods. 1995 Jun 28;183(2):279-90.PMID: 7602150 [PubMed - indexed for MEDLINE]Related articles

Similarity/equivalence trials for combination vaccines.

Blackwelder WC.

Ann N Y Acad Sci. 1995 May 31;754:321-8.PMID: 7625668 [PubMed - indexed for MEDLINE]Related articles