PubMed

Mouse Models of Diabetic Nephropathy.

Brosius FC 3rd, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T; for the Animal Models of Diabetic Complications Consortium.

J Am Soc Nephrol. 2009 Sep 3. [Epub ahead of print]PMID: 19729434 [PubMed - as supplied by publisher]Related articles

TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes.

Xavier S, Niranjan T, Krick S, Zhang T, Ju W, Shaw AS, Schiffer M, Böttinger EP.

J Am Soc Nephrol. 2009 Oct;20(10):2127-37. Epub 2009 Aug 13.PMID: 19679673 [PubMed - indexed for MEDLINE]Related articles

Renal gene and protein expression signatures for prediction of kidney disease progression.

Ju W, Eichinger F, Bitzer M, Oh J, McWeeney S, Berthier CC, Shedden K, Cohen CD, Henger A, Krick S, Kopp JB, Stoeckert CJ Jr, Dikman S, Schröppel B, Thomas DB, Schlondorff D, Kretzler M, Böttinger EP.

Am J Pathol. 2009 Jun;174(6):2073-85.PMID: 19465643 [PubMed - indexed for MEDLINE]Related articles

Laser capture microdissection of kidney tissue.

Woroniecki RP, Bottinger EP.

Methods Mol Biol. 2009;466:73-82.PMID: 19148600 [PubMed - indexed for MEDLINE]Related articles

Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.

Lal G, Zhang N, van der Touw W, Ding Y, Ju W, Bottinger EP, Reid SP, Levy DE, Bromberg JS.

J Immunol. 2009 Jan 1;182(1):259-73.PMID: 19109157 [PubMed - indexed for MEDLINE]Related articles

Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis.

Shi S, Yu L, Chiu C, Sun Y, Chen J, Khitrov G, Merkenschlager M, Holzman LB, Zhang W, Mundel P, Bottinger EP.

J Am Soc Nephrol. 2008 Nov;19(11):2159-69. Epub 2008 Sep 5.PMID: 18776119 [PubMed - indexed for MEDLINE]Related articlesFree article

Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease.

Krick S, Shi S, Ju W, Faul C, Tsai SY, Mundel P, Böttinger EP.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14106-11. Epub 2008 Sep 4.PMID: 18772386 [PubMed - indexed for MEDLINE]Related articlesFree article

The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells.

Saleem MA, Zavadil J, Bailly M, McGee K, Witherden IR, Pavenstadt H, Hsu H, Sanday J, Satchell SC, Lennon R, Ni L, Bottinger EP, Mundel P, Mathieson PW.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F959-70. Epub 2008 Aug 6.PMID: 18684887 [PubMed - indexed for MEDLINE]Related articlesFree article

Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival.

Rajagopal R, Dattilo LK, Kaartinen V, Deng CX, Umans L, Zwijsen A, Roberts AB, Bottinger EP, Beebe DC.

Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4953-60. Epub 2008 Jun 19.PMID: 18566469 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated renal macrophages are markers of disease onset and disease remission in lupus nephritis.

Schiffer L, Bethunaickan R, Ramanujam M, Huang W, Schiffer M, Tao H, Madaio MP, Bottinger EP, Davidson A.

J Immunol. 2008 Feb 1;180(3):1938-47. Erratum in: J Immunol. 2008 Mar 1;180(5):3613. Madaio, Michael M [corrected to Madaio, Michael P]. PMID: 18209092 [PubMed - indexed for MEDLINE]Related articlesFree article

Chromatin structure regulation in transforming growth factor-beta-directed epithelial-mesenchymal transition.

Blumenberg M, Gao S, Dickman K, Grollman AP, Bottinger EP, Zavadil J.

Cells Tissues Organs. 2007;185(1-3):162-74. Review.PMID: 17587822 [PubMed - indexed for MEDLINE]Related articles

TGF-beta in renal injury and disease.

Böttinger EP.

Semin Nephrol. 2007 May;27(3):309-20. Review.PMID: 17533008 [PubMed - indexed for MEDLINE]Related articles

Foundations, promises and uncertainties of personalized medicine.

Bottinger EP.

Mt Sinai J Med. 2007 Apr;74(1):15-21. Review.PMID: 17516562 [PubMed - indexed for MEDLINE]Related articles

Suppression of transforming growth factor beta signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations.

Wildi S, Kleeff J, Mayerle J, Zimmermann A, Böttinger EP, Wakefield L, Büchler MW, Friess H, Korc M.

Gut. 2007 May;56(5):685-92. Epub 2006 Nov 29.PMID: 17135311 [PubMed - indexed for MEDLINE]Related articles

Nephritogenic anti-DNA antibodies regulate gene expression in MRL/lpr mouse glomerular mesangial cells.

Qing X, Zavadil J, Crosby MB, Hogarth MP, Hahn BH, Mohan C, Gilkeson GS, Bottinger EP, Putterman C.

Arthritis Rheum. 2006 Jul;54(7):2198-210.PMID: 16804897 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role of Smad3 in angiotensin II-induced vascular fibrosis.

Wang W, Huang XR, Canlas E, Oka K, Truong LD, Deng C, Bhowmick NA, Ju W, Bottinger EP, Lan HY.

Circ Res. 2006 Apr 28;98(8):1032-9. Epub 2006 Mar 23.PMID: 16556868 [PubMed - indexed for MEDLINE]Related articlesFree article

B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-beta-directed IgA switching and changes in B cell fate.

Klein J, Ju W, Heyer J, Wittek B, Haneke T, Knaus P, Kucherlapati R, Böttinger EP, Nitschke L, Kneitz B.

J Immunol. 2006 Feb 15;176(4):2389-96.PMID: 16455997 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic nephropathy: a frontier for personalized medicine.

Susztak K, Böttinger EP.

J Am Soc Nephrol. 2006 Feb;17(2):361-7. Epub 2006 Jan 11. Review.PMID: 16407421 [PubMed - indexed for MEDLINE]Related articlesFree article

Glomerular expression of transforming growth factor-beta (TGF-beta) isoforms in mice lacking CD2-associated protein.

Woroniecki RP, Schiffer M, Shaw AS, Kaskel FJ, Bottinger EP.

Pediatr Nephrol. 2006 Mar;21(3):333-8. Epub 2005 Dec 31.PMID: 16388393 [PubMed - indexed for MEDLINE]Related articles

Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation.

Ju W, Ogawa A, Heyer J, Nierhof D, Yu L, Kucherlapati R, Shafritz DA, Böttinger EP.

Mol Cell Biol. 2006 Jan;26(2):654-67.PMID: 16382155 [PubMed - indexed for MEDLINE]Related articlesFree article

QTL MatchMaker: a multi-species quantitative trait loci (QTL) database and query system for annotation of genes and QTL.

Star KV, Song Q, Zhu A, Böttinger EP.

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D586-9.PMID: 16381937 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy.

Susztak K, Raff AC, Schiffer M, Böttinger EP.

Diabetes. 2006 Jan;55(1):225-33.PMID: 16380497 [PubMed - indexed for MEDLINE]Related articlesFree article

TGF-beta concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes.

Wu DT, Bitzer M, Ju W, Mundel P, Böttinger EP.

J Am Soc Nephrol. 2005 Nov;16(11):3211-21. Epub 2005 Oct 5.PMID: 16207831 [PubMed - indexed for MEDLINE]Related articlesFree article

TGF-beta and epithelial-to-mesenchymal transitions.

Zavadil J, Böttinger EP.

Oncogene. 2005 Aug 29;24(37):5764-74. Review.PMID: 16123809 [PubMed - indexed for MEDLINE]Related articles

Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions.

Schiffer M, Susztak K, Ranalletta M, Raff AC, Böttinger EP, Charron MJ.

Am J Physiol Renal Physiol. 2005 Jul;289(1):F186-93. Epub 2005 Mar 1.PMID: 15741607 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy.

Susztak K, Ciccone E, McCue P, Sharma K, Böttinger EP.

PLoS Med. 2005 Feb;2(2):e45. Epub 2005 Feb 22.PMID: 15737001 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts.

Nakagawa T, Lan HY, Glushakova O, Zhu HJ, Kang DH, Schreiner GF, Böttinger EP, Johnson RJ, Sautin YY.

J Am Soc Nephrol. 2005 Apr;16(4):899-904. Epub 2005 Feb 16.PMID: 15716330 [PubMed - indexed for MEDLINE]Related articlesFree article

TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways.

Nakagawa T, Li JH, Garcia G, Mu W, Piek E, Böttinger EP, Chen Y, Zhu HJ, Kang DH, Schreiner GF, Lan HY, Johnson RJ.

Kidney Int. 2004 Aug;66(2):605-13.PMID: 15253713 [PubMed - indexed for MEDLINE]Related articles

RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta.

Piek E, Van Dinther M, Parks WT, Sallee JM, Böttinger EP, Roberts AB, Ten Dijke P.

Biochem J. 2004 Oct 1;383(Pt 1):187-99.PMID: 15239668 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis.

Schiffer M, Mundel P, Shaw AS, Böttinger EP.

J Biol Chem. 2004 Aug 27;279(35):37004-12. Epub 2004 Jun 22.PMID: 15213232 [PubMed - indexed for MEDLINE]Related articlesFree article

Utility of endogenous creatinine clearance as a measure of renal function in mice.

Dunn SR, Qi Z, Bottinger EP, Breyer MD, Sharma K.

Kidney Int. 2004 May;65(5):1959-67.PMID: 15086941 [PubMed - indexed for MEDLINE]Related articles

Gene expression pattern in hepatic stem/progenitor cells during rat fetal development using complementary DNA microarrays.

Petkov PM, Zavadil J, Goetz D, Chu T, Carver R, Rogler CE, Bottinger EP, Shafritz DA, Dabeva MD.

Hepatology. 2004 Mar;39(3):617-27.PMID: 14999680 [PubMed - indexed for MEDLINE]Related articles

Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition.

Zavadil J, Cermak L, Soto-Nieves N, Böttinger EP.

EMBO J. 2004 Mar 10;23(5):1155-65. Epub 2004 Feb 19.PMID: 14976548 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation.

Yoo J, Ghiassi M, Jirmanova L, Balliet AG, Hoffman B, Fornace AJ Jr, Liebermann DA, Bottinger EP, Roberts AB.

J Biol Chem. 2003 Oct 31;278(44):43001-7. Epub 2003 Aug 21.PMID: 12933797 [PubMed - indexed for MEDLINE]Related articlesFree article

Hierarchical model of gene regulation by transforming growth factor beta.

Yang YC, Piek E, Zavadil J, Liang D, Xie D, Heyer J, Pavlidis P, Kucherlapati R, Roberts AB, Böttinger EP.

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10269-74. Epub 2003 Aug 20.PMID: 12930890 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse.

Wang W, Wyckoff JB, Wang Y, Bottinger EP, Segall JE, Condeelis JS.

BMC Biotechnol. 2003 Aug 12;3:13. Epub 2003 Aug 12.PMID: 12914671 [PubMed - indexed for MEDLINE]Related articlesFree article

RNA labeling and hybridization of DNA microarrays.

Böttinger EP, Novetsky A, Zavadil J.

Methods Mol Med. 2003;86:275-84. No abstract available. PMID: 12886775 [PubMed - indexed for MEDLINE]Related articles

Genomic strategies for diabetic nephropathy.

Susztak K, Sharma K, Schiffer M, McCue P, Ciccone E, Böttinger EP.

J Am Soc Nephrol. 2003 Aug;14(8 Suppl 3):S271-8. Review.PMID: 12874445 [PubMed - indexed for MEDLINE]Related articlesFree article

Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insult.

Goswami S, Sheets NL, Zavadil J, Chauhan BK, Bottinger EP, Reddy VN, Kantorow M, Cvekl A.

Invest Ophthalmol Vis Sci. 2003 May;44(5):2084-93.PMID: 12714647 [PubMed - indexed for MEDLINE]Related articlesFree article

Smad3 mediates the TGF-beta-induced contraction of type I collagen gels by mouse embryo fibroblasts.

Liu X, Wen FQ, Kobayashi T, Abe S, Fang Q, Piek E, Bottinger EP, Roberts AB, Rennard SI.

Cell Motil Cytoskeleton. 2003 Mar;54(3):248-53.PMID: 12589683 [PubMed - indexed for MEDLINE]Related articles

CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD.

Nicolaou F, Teodoridis JM, Park H, Georgakis A, Farokhzad OC, Böttinger EP, Da Silva N, Rousselot P, Chomienne C, Ferenczi K, Arnaout MA, Shelley CS.

Blood. 2003 May 15;101(10):4033-41. Epub 2003 Feb 6.PMID: 12576324 [PubMed - indexed for MEDLINE]Related articlesFree article

Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling.

Wang W, Wyckoff JB, Frohlich VC, Oleynikov Y, Hüttelmaier S, Zavadil J, Cermak L, Bottinger EP, Singer RH, White JG, Segall JE, Condeelis JS.

Cancer Res. 2002 Nov 1;62(21):6278-88. Erratum in: Cancer Res 2002 Dec 1;62(23):7132. PMID: 12414658 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitory smads and tgf-Beta signaling in glomerular cells.

Schiffer M, Schiffer LE, Gupta A, Shaw AS, Roberts IS, Mundel P, Böttinger EP.

J Am Soc Nephrol. 2002 Nov;13(11):2657-66.PMID: 12397035 [PubMed - indexed for MEDLINE]Related articlesFree article

TGF-beta signaling in renal disease.

Böttinger EP, Bitzer M.

J Am Soc Nephrol. 2002 Oct;13(10):2600-10. Review.PMID: 12239251 [PubMed - indexed for MEDLINE]Related articlesFree article

Applications for microarrays in renal biology and medicine.

Böttinger EP, Ju W, Zavadil J.

Exp Nephrol. 2002;10(2):93-101. Review.PMID: 11937756 [PubMed - indexed for MEDLINE]Related articles

During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter.

Shelley CS, Teodoridis JM, Park H, Farokhzad OC, Böttinger EP, Arnaout MA.

J Immunol. 2002 Apr 15;168(8):3887-93.PMID: 11937543 [PubMed - indexed for MEDLINE]Related articlesFree article

Apoptosis in podocytes induced by TGF-beta and Smad7.

Schiffer M, Bitzer M, Roberts IS, Kopp JB, ten Dijke P, Mundel P, Böttinger EP.

J Clin Invest. 2001 Sep;108(6):807-16.PMID: 11560950 [PubMed - indexed for MEDLINE]Related articlesFree article

TGF-beta signaling in mammary gland development and tumorigenesis.

Wakefield LM, Piek E, Böttinger EP.

J Mammary Gland Biol Neoplasia. 2001 Jan;6(1):67-82. Review.PMID: 11467453 [PubMed - indexed for MEDLINE]Related articles

Is Smad3 a major player in signal transduction pathways leading to fibrogenesis?

Roberts AB, Piek E, Böttinger EP, Ashcroft G, Mitchell JB, Flanders KC.

Chest. 2001 Jul;120(1 Suppl):43S-47S.PMID: 11451911 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta.

Zavadil J, Bitzer M, Liang D, Yang YC, Massimi A, Kneitz S, Piek E, Bottinger EP.

Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6686-91.PMID: 11390996 [PubMed - indexed for MEDLINE]Related articlesFree article