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Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset.

Kawabata Y, Ikegami H, Awata T, Imagawa A, Maruyama T, Kawasaki E, Tanaka S, Shimada A, Osawa H, Kobayashi T, Hanafusa T, Tokunaga K, Makino H; on behalf of the Committee on Type 1 Diabetes, Japan Diabetes Society.

Diabetologia. 2009 Oct 8. [Epub ahead of print]PMID: 19812988 [PubMed - as supplied by publisher]Related articles

Sequence polymorphisms in porcine homologs of murine coat colour-related genes.

Okumura N, Hayashi T, Uenishi H, Fukudome N, Komatsuda A, Suzuki A, Shibata M, Nii M, Yamaguchi T, Kojima-Shibata C, Hamasima N, Awata T.

Anim Genet. 2009 Sep 26. [Epub ahead of print]PMID: 19793267 [PubMed - as supplied by publisher]Related articles

Fine mapping of quantitative trait loci for meat color on SSC6: analysis of the swine NUDT7 gene.

Taniguchi M, Hayashi T, Nii M, Yamaguchi T, Fujishima-Kanaya N, Awata T, Mikawa S.

J Anim Sci. 2009 Sep 11. [Epub ahead of print]PMID: 19749013 [PubMed - as supplied by publisher]Related articles

The Fibronectin RGD Motif Is Required for Multiple Angiogenic Events During Early Embryonic Development.

Takahashi S, Moser M, Montanez E, Nakano T, Seo M, Backert S, Inoue I, Awata T, Katayama S, Komoda T, Fässler R.

Arterioscler Thromb Vasc Biol. 2009 Sep 15. [Epub ahead of print]PMID: 19713531 [PubMed - as supplied by publisher]Related articles

Dopamine D1-like receptor antagonist, SCH23390, exhibits a preventive effect on diabetes mellitus that occurs naturally in NOD mice.

Hashimoto K, Inoue T, Higashi T, Takei S, Awata T, Katayama S, Takagi R, Okada H, Matsushita S.

Biochem Biophys Res Commun. 2009 Jun 12;383(4):460-3. Epub 2009 Apr 14.PMID: 19371725 [PubMed - indexed for MEDLINE]Related articles

Treatment with glimepiride, but not mitiglinide and short-acting insulin, resists body weight and abdominal fat reduction under dietary energy restriction.

Nakano T, Inoue I, Satoh K, Yamazaki M, Awata T, Kurihara S, Goto S, Shinoda Y, Komoda T, Katayama S.

J Atheroscler Thromb. 2009 Mar;16(1):63-6. Epub 2009 Mar 5. No abstract available. PMID: 19261996 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid and simple profiling of lipoproteins by polyacrylamide-gel disc electrophoresis to determine the heterogeneity of low-density lipoproteins (LDLs) including small, dense LDL.

Nakano T, Inoue I, Seo M, Takahashi S, Awata T, Komoda T, Katayama S.

Recent Pat Cardiovasc Drug Discov. 2009 Jan;4(1):31-6.PMID: 19149704 [PubMed - indexed for MEDLINE]Related articles

Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population.

Kawasaki E, Awata T, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Uga M, Kurihara S, Kawabata Y, Tanaka S, Kanazawa Y, Eguchi K; Japanese Study Group on Type 1 Diabetes Genetics.

J Clin Endocrinol Metab. 2009 Mar;94(3):947-52. Epub 2008 Dec 23.PMID: 19106270 [PubMed - indexed for MEDLINE]Related articles

Molecular cloning and characterization of porcine Mx2 gene.

Morozumi T, Naito T, Lan PD, Nakajima E, Mitsuhashi T, Mikawa S, Hayashi T, Awata T, Uenishi H, Nagata K, Watanabe T, Hamasima N.

Mol Immunol. 2009 Feb;46(5):858-65. Epub 2008 Nov 1.PMID: 18977535 [PubMed - indexed for MEDLINE]Related articles

Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese.

Awata T, Kawasaki E, Tanaka S, Ikegami H, Maruyama T, Shimada A, Nakanishi K, Kobayashi T, Iizuka H, Uga M, Kawabata Y, Kanazawa Y, Kurihara S, Osaki M, Katayama S; Japanese Study Group on Type 1 Diabetes Genetics.

J Clin Endocrinol Metab. 2009 Jan;94(1):231-5. Epub 2008 Oct 21.PMID: 18940880 [PubMed - indexed for MEDLINE]Related articles

Adiponectin upregulates ferritin heavy chain in skeletal muscle cells.

Ikegami Y, Inukai K, Imai K, Sakamoto Y, Katagiri H, Kurihara S, Awata T, Katayama S.

Diabetes. 2009 Jan;58(1):61-70. Epub 2008 Oct 17.PMID: 18931039 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of low adiponectin levels in impaired glucose tolerance.

Nakashima Y, Inukai K, Imai K, Ikegami Y, Awata T, Katayama S.

Metabolism. 2008 Oct;57(10):1350-4.PMID: 18803937 [PubMed - indexed for MEDLINE]Related articles

A Bayesian method for simultaneously detecting Mendelian and imprinted quantitative trait loci in experimental crosses of outbred species.

Hayashi T, Awata T.

Genetics. 2008 Jan;178(1):527-38.PMID: 18202392 [PubMed - indexed for MEDLINE]Related articlesFree article

A new 4016-marker radiation hybrid map for porcine-human genome analysis.

Hamasima N, Mikawa A, Suzuki H, Suzuki K, Uenishi H, Awata T.

Mamm Genome. 2008 Jan;19(1):51-60. Epub 2008 Jan 11.PMID: 18188646 [PubMed - indexed for MEDLINE]Related articles

[Adiponectin receptor regulation in diabetic states]

Inukai K, Awata T, Katayama S.

Nippon Rinsho. 2007 Nov;65(11):2125-30. Review. Japanese. PMID: 18018580 [PubMed - indexed for MEDLINE]Related articles

SH3 domain of the phosphatidylinositol 3-kinase regulatory subunit is responsible for the formation of a sequestration complex with insulin receptor substrate-1.

Ikegami Y, Inukai K, Awata T, Asano T, Katayama S.

Biochem Biophys Res Commun. 2008 Jan 18;365(3):433-8. Epub 2007 Nov 6.PMID: 17991427 [PubMed - indexed for MEDLINE]Related articles

Coding and noncoding variants in the CFH gene and cigarette smoking influence the risk of age-related macular degeneration in a Japanese population.

Mori K, Gehlbach PL, Kabasawa S, Kawasaki I, Oosaki M, Iizuka H, Katayama S, Awata T, Yoneya S.

Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5315-9.PMID: 17962488 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in Japanese.

Shimada A, Kanazawa Y, Motohashi Y, Yamada S, Maruyama T, Ikegami H, Awata T, Kawasaki E, Kobayashi T, Nakanishi K, Kawabata Y, Kurihara S, Uga M, Tanaka S; Japanese Study Group on Type 1 Diabetes Genetics.

J Autoimmun. 2008 Jun;30(4):207-11. Epub 2007 Oct 23.PMID: 17959356 [PubMed - indexed for MEDLINE]Related articles

Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy.

Iizuka H, Awata T, Osaki M, Neda T, Kurihara S, Inoue K, Inukai K, Kabasawa S, Mori K, Yoneya S, Katayama S.

Biochem Biophys Res Commun. 2007 Sep 21;361(2):421-6. Epub 2007 Jul 16.PMID: 17658465 [PubMed - indexed for MEDLINE]Related articles

Association of the HTRA1 gene variant with age-related macular degeneration in the Japanese population.

Mori K, Horie-Inoue K, Kohda M, Kawasaki I, Gehlbach PL, Awata T, Yoneya S, Okazaki Y, Inoue S.

J Hum Genet. 2007;52(7):636-41. Epub 2007 Jun 14.PMID: 17568988 [PubMed - indexed for MEDLINE]Related articles

Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis.

Kavvoura FK, Akamizu T, Awata T, Ban Y, Chistiakov DA, Frydecka I, Ghaderi A, Gough SC, Hiromatsu Y, Ploski R, Wang PW, Ban Y, Bednarczuk T, Chistiakova EI, Chojm M, Heward JM, Hiratani H, Juo SH, Karabon L, Katayama S, Kurihara S, Liu RT, Miyake I, Omrani GH, Pawlak E, Taniyama M, Tozaki T, Ioannidis JP.

J Clin Endocrinol Metab. 2007 Aug;92(8):3162-70. Epub 2007 May 15. Review.PMID: 17504905 [PubMed - indexed for MEDLINE]Related articlesFree article

Homozygosity haplotype allows a genomewide search for the autosomal segments shared among patients.

Miyazawa H, Kato M, Awata T, Kohda M, Iwasa H, Koyama N, Tanaka T, Huqun, Kyo S, Okazaki Y, Hagiwara K.

Am J Hum Genet. 2007 Jun;80(6):1090-102. Epub 2007 May 2.PMID: 17503327 [PubMed - indexed for MEDLINE]Related articlesFree article

Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan nuclear receptor, germ cell nuclear factor (NR6A1).

Mikawa S, Morozumi T, Shimanuki S, Hayashi T, Uenishi H, Domukai M, Okumura N, Awata T.

Genome Res. 2007 May;17(5):586-93. Epub 2007 Apr 6.PMID: 17416745 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes.

Awata T, Kawasaki E, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Iizuka H, Kurihara S, Osaki M, Uga M, Kawabata Y, Tanaka S, Kanazawa Y, Katayama S.

J Clin Endocrinol Metab. 2007 May;92(5):1791-5. Epub 2007 Mar 6.PMID: 17341563 [PubMed - indexed for MEDLINE]Related articlesFree article

PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences.

Uenishi H, Eguchi-Ogawa T, Shinkai H, Okumura N, Suzuki K, Toki D, Hamasima N, Awata T.

Nucleic Acids Res. 2007 Jan;35(Database issue):D650-3. Epub 2006 Dec 1.PMID: 17145712 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations.

Noso S, Ikegami H, Fujisawa T, Kawabata Y, Asano K, Hiromine Y, Sugihara S, Lee I, Kawasaki E, Awata T, Ogihara T.

Ann N Y Acad Sci. 2006 Oct;1079:41-6. Review.PMID: 17130530 [PubMed - indexed for MEDLINE]Related articles

Analysis of the genomic structure of the porcine CD1 gene cluster.

Eguchi-Ogawa T, Morozumi T, Tanaka M, Shinkai H, Okumura N, Suzuki K, Awata T, Uenishi H.

Genomics. 2007 Feb;89(2):248-61. Epub 2006 Nov 16.PMID: 17112699 [PubMed - indexed for MEDLINE]Related articles

LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells.

Imai K, Inukai K, Ikegami Y, Awata T, Katayama S.

Biochem Biophys Res Commun. 2006 Dec 22;351(3):595-601. Epub 2006 Oct 18.PMID: 17083919 [PubMed - indexed for MEDLINE]Related articles

Quantitative trait loci mapping for fatty acid composition traits in perirenal and back fat using a Japanese wild boar x Large White intercross.

Nii M, Hayashi T, Tani F, Niki A, Mori N, Fujishima-Kanaya N, Komatsu M, Aikawa K, Awata T, Mikawa S.

Anim Genet. 2006 Aug;37(4):342-7.PMID: 16879343 [PubMed - indexed for MEDLINE]Related articles

Acarbose ameliorates atherogenecity of low-density lipoprotein in patients with impaired glucose tolerance.

Inoue I, Shinoda Y, Nakano T, Sassa M, Goto S, Awata T, Komoda T, Katayama S.

Metabolism. 2006 Jul;55(7):946-52.PMID: 16784969 [PubMed - indexed for MEDLINE]Related articles

Acarbose improves fibrinolytic activity in patients with impaired glucose tolerance.

Shinoda Y, Inoue I, Nakano T, Seo M, Sassa M, Goto S, Awata T, Komoda T, Katayama S.

Metabolism. 2006 Jul;55(7):935-9.PMID: 16784967 [PubMed - indexed for MEDLINE]Related articles

Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population.

Tsurumaru M, Kawasaki E, Ida H, Migita K, Moriuchi A, Fukushima K, Fukushima T, Abiru N, Yamasaki H, Noso S, Ikegami H, Awata T, Sasaki H, Eguchi K.

J Clin Endocrinol Metab. 2006 Aug;91(8):3138-43. Epub 2006 May 30.PMID: 16735488 [PubMed - indexed for MEDLINE]Related articlesFree article

Biased distribution of single nucleotide polymorphisms (SNPs) in porcine Toll-like receptor 1 (TLR1), TLR2, TLR4, TLR5, and TLR6 genes.

Shinkai H, Tanaka M, Morozumi T, Eguchi-Ogawa T, Okumura N, Muneta Y, Awata T, Uenishi H.

Immunogenetics. 2006 May;58(4):324-30. Epub 2006 Apr 5.PMID: 16604477 [PubMed - indexed for MEDLINE]Related articles

Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations.

Kawasaki E, Awata T, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Uga M, Kurihara S, Kawabata Y, Tanaka S, Kanazawa Y, Lee I, Eguchi K.

Am J Med Genet A. 2006 Mar 15;140(6):586-93. Erratum in: Am J Med Genet A. 2007 Aug 1;143(15):18212-3. Uga, Mho [corrected to Uga, Miho]. PMID: 16470599 [PubMed - indexed for MEDLINE]Related articles

Sequencing, mapping and nucleotide variation of porcine coat colour genes EDNRB, MYO5A, KITLG, SLC45A2, RAB27A, SILV and MITF.

Okumura N, Hayashi T, Sekikawa H, Matsumoto T, Mikawa A, Hamasima N, Awata T.

Anim Genet. 2006 Feb;37(1):80-2. No abstract available. PMID: 16441305 [PubMed - indexed for MEDLINE]Related articles

Genomic structure and gene order of swine chromosome 7q1.1-->q1.2.

Tanaka M, Suzuki K, Morozumi T, Kobayashi E, Matsumoto T, Domukai M, Eguchi-Ogawa T, Shinkai H, Awata T, Uenishi H.

Anim Genet. 2006 Feb;37(1):10-6.PMID: 16441290 [PubMed - indexed for MEDLINE]Related articles

Interval mapping for loci affecting unordered categorical traits.

Hayashi T, Awata T.

Heredity. 2006 Feb;96(2):185-94.PMID: 16391550 [PubMed - indexed for MEDLINE]Related articlesFree article

The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan.

Ikegami H, Awata T, Kawasaki E, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Amemiya S, Kawabata Y, Kurihara S, Tanaka S, Kanazawa Y, Mochizuki M, Ogihara T.

J Clin Endocrinol Metab. 2006 Mar;91(3):1087-92. Epub 2005 Dec 13.PMID: 16352685 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure and polymorphism analysis of transforming growth factor beta receptor 1 (TGFBR1) in pigs.

Shimanuki S, Mikawa A, Miyake Y, Hamasima N, Mikawa S, Awata T.

Biochem Genet. 2005 Oct;43(9-10):491-500.PMID: 16341765 [PubMed - indexed for MEDLINE]Related articles

Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes.

Noso S, Ikegami H, Fujisawa T, Kawabata Y, Asano K, Hiromine Y, Tsurumaru M, Sugihara S, Lee I, Kawasaki E, Awata T, Ogihara T.

Diabetes. 2005 Dec;54(12):3582-6.PMID: 16306380 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequences and mapping of genes encoding porcine tyrosinase (TYR) and tyrosinase-related proteins (TYRP1 and TYRP2).

Okumura N, Hayashi T, Sekikawa H, Matsumoto T, Mikawa A, Hamasima N, Awata T.

Anim Genet. 2005 Dec;36(6):513-6. No abstract available. PMID: 16293128 [PubMed - indexed for MEDLINE]Related articles

Porcine Toll-like receptor 1, 6, and 10 genes: complete sequencing of genomic region and expression analysis.

Shinkai H, Muneta Y, Suzuki K, Eguchi-Ogawa T, Awata T, Uenishi H.

Mol Immunol. 2006 Mar;43(9):1474-80. Epub 2005 Nov 2.PMID: 16263171 [PubMed - indexed for MEDLINE]Related articles

Development of dense microsatellite markers in the entire SLA region and evaluation of their polymorphisms in porcine breeds.

Tanaka M, Ando A, Renard C, Chardon P, Domukai M, Okumura N, Awata T, Uenishi H.

Immunogenetics. 2005 Oct;57(9):690-6. Epub 2005 Oct 18.PMID: 16189668 [PubMed - indexed for MEDLINE]Related articles

Two quantitative trait loci on Sus scrofa chromosomes 1 and 7 affecting the number of vertebrae.

Mikawa S, Hayashi T, Nii M, Shimanuki S, Morozumi T, Awata T.

J Anim Sci. 2005 Oct;83(10):2247-54.PMID: 16160033 [PubMed - indexed for MEDLINE]Related articlesFree article

CLOCK/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element.

Inoue I, Shinoda Y, Ikeda M, Hayashi K, Kanazawa K, Nomura M, Matsunaga T, Xu H, Kawai S, Awata T, Komoda T, Katayama S.

J Atheroscler Thromb. 2005;12(3):169-74.PMID: 16020918 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a novel WFS1 mutation (AFF344-345ins) in Japanese patients with Wolfram syndrome.

Inukai K, Awata T, Inoue K, Kurihara S, Nakashima Y, Watanabe M, Sawa T, Takata N, Katayama S.

Diabetes Res Clin Pract. 2005 Aug;69(2):136-41. Epub 2005 Feb 24.PMID: 16005363 [PubMed - indexed for MEDLINE]Related articles

Functional VEGF C-634G polymorphism is associated with development of diabetic macular edema and correlated with macular retinal thickness in type 2 diabetes.

Awata T, Kurihara S, Takata N, Neda T, Iizuka H, Ohkubo T, Osaki M, Watanabe M, Nakashima Y, Inukai K, Inoue I, Kawasaki I, Mori K, Yoneya S, Katayama S.

Biochem Biophys Res Commun. 2005 Aug 5;333(3):679-85.PMID: 15963467 [PubMed - indexed for MEDLINE]Related articles

Jalpha-gene segment usage and the CDR3 diversity of porcine TCRalpha-chain cDNA clones from the PBL of a five-month-old pig and the thymus of a one-month-old pig.

Yamamoto R, Uenishi H, Hatsuse H, Sato E, Awata T, Yasue H, Takagaki Y.

Mol Immunol. 2005 Jul;42(11):1375-83. Epub 2005 Feb 19.PMID: 15950733 [PubMed - indexed for MEDLINE]Related articles

Efficacy of glimepiride in Japanese type 2 diabetic subjects.

Inukai K, Watanabe M, Nakashima Y, Sawa T, Takata N, Tanaka M, Kashiwabara H, Yokota K, Suzuki M, Kurihara S, Awata T, Katayama S.

Diabetes Res Clin Pract. 2005 Jun;68(3):250-7. Epub 2004 Nov 19.PMID: 15936468 [PubMed - indexed for MEDLINE]Related articles

TRAV gene usage in pig T-cell receptor alpha cDNA.

Yamamoto R, Uenishi H, Hatsuse H, Sato E, Awata T, Yasue H, Takagaki Y.

Immunogenetics. 2005 May;57(3-4):219-25. Epub 2005 Apr 5.PMID: 15900493 [PubMed - indexed for MEDLINE]Related articles