PubMed

Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting.

Sangar MC, Anandatheerthavarada HK, Martin MV, Guengerich FP, Avadhani NG.

Mol Genet Metab. 2009 Sep 3. [Epub ahead of print]PMID: 19781968 [PubMed - as supplied by publisher]Related articles

Heterogeneous nuclear ribonucleoprotein A2 is a common transcriptional coactivator in the nuclear transcription response to mitochondrial respiratory stress.

Guha M, Pan H, Fang JK, Avadhani NG.

Mol Biol Cell. 2009 Sep;20(18):4107-19. Epub 2009 Jul 29.PMID: 19641020 [PubMed - in process]Related articlesFree article

Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism.

Sangar MC, Anandatheerthavarada HK, Tang W, Prabu SK, Martin MV, Dostalek M, Guengerich FP, Avadhani NG.

FEBS J. 2009 Jul;276(13):3440-53. Epub 2009 May 11.PMID: 19438707 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.

Anandatheerthavarada HK, Sepuri NB, Avadhani NG.

J Biol Chem. 2009 Jun 19;284(25):17352-63. Epub 2009 Apr 28.PMID: 19401463 [PubMed - indexed for MEDLINE]Related articles

Role of nuclear-encoded subunit Vb in the assembly and stability of cytochrome c oxidase complex: implications in mitochondrial dysfunction and ROS production.

Galati D, Srinivasan S, Raza H, Prabu SK, Hardy M, Chandran K, Lopez M, Kalyanaraman B, Avadhani NG.

Biochem J. 2009 May 27;420(3):439-49.PMID: 19338496 [PubMed - indexed for MEDLINE]Related articlesFree article

Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q.

Chandran K, Aggarwal D, Migrino RQ, Joseph J, McAllister D, Konorev EA, Antholine WE, Zielonka J, Srinivasan S, Avadhani NG, Kalyanaraman B.

Biophys J. 2009 Feb 18;96(4):1388-98.PMID: 19217856 [PubMed - indexed for MEDLINE]Related articles

An unusual TOM20/TOM22 bypass mechanism for the mitochondrial targeting of cytochrome P450 proteins containing N-terminal chimeric signals.

Anandatheerthavarada HK, Sepuri NB, Biswas G, Avadhani NG.

J Biol Chem. 2008 Dec 19;283(51):36060. No abstract available. PMID: 19160472 [PubMed - indexed for MEDLINE]Related articles

Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle.

Dong H, Dalton TP, Miller ML, Chen Y, Uno S, Shi Z, Shertzer HG, Bansal S, Avadhani NG, Nebert DW.

Mol Pharmacol. 2009 Mar;75(3):555-67. Epub 2008 Dec 1. Erratum in: Mol Pharmacol. 2009 Aug;76(2):452. PMID: 19047483 [PubMed - indexed for MEDLINE]Related articles

Bimodal protein targeting through activation of cryptic mitochondrial targeting signals by an inducible cytosolic endoprotease.

Boopathi E, Srinivasan S, Fang JK, Avadhani NG.

Mol Cell. 2008 Oct 10;32(1):32-42.PMID: 18851831 [PubMed - indexed for MEDLINE]Related articlesFree article

An unusual TOM20/TOM22 bypass mechanism for the mitochondrial targeting of cytochrome P450 proteins containing N-terminal chimeric signals.

Anandatheerthavarada HK, Sepuri NB, Biswas G, Avadhani NG.

J Biol Chem. 2008 Jul 11;283(28):19769-80. Epub 2008 May 14. Retraction in: Anandatheerthavarada HK, Sepuri NB, Biswas G, Avadhani NG. J Biol Chem. 2008 Dec 19;283(51):36060. PMID: 18480056 [PubMed - indexed for MEDLINE]Related articlesFree article

A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling.

Biswas G, Tang W, Sondheimer N, Guha M, Bansal S, Avadhani NG.

J Biol Chem. 2008 May 2;283(18):12586-94. Epub 2008 Feb 13.PMID: 18272519 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain.

Devi L, Raghavendran V, Prabhu BM, Avadhani NG, Anandatheerthavarada HK.

J Biol Chem. 2008 Apr 4;283(14):9089-100. Epub 2008 Feb 1.PMID: 18245082 [PubMed - indexed for MEDLINE]Related articlesFree article

Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling.

Biswas G, Srinivasan S, Anandatheerthavarada HK, Avadhani NG.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):186-91. Epub 2008 Jan 2.PMID: 18172213 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers.

Zielonka J, Srinivasan S, Hardy M, Ouari O, Lopez M, Vasquez-Vivar J, Avadhani NG, Kalyanaraman B.

Free Radic Biol Med. 2008 Mar 1;44(5):835-46. Epub 2007 Dec 4.PMID: 18155177 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia-mediated mitochondrial stress in RAW264.7 cells induces osteoclast-like TRAP-positive cells.

Srinivasan S, Avadhani NG.

Ann N Y Acad Sci. 2007 Nov;1117:51-61.PMID: 18056037 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae--role of protein kinase A in the mitochondrial targeting of CYP2E1.

Sepuri NB, Yadav S, Anandatheerthavarada HK, Avadhani NG.

FEBS J. 2007 Sep;274(17):4615-30. Epub 2007 Aug 14.PMID: 17697118 [PubMed - indexed for MEDLINE]Related articles

Activation of a novel calcineurin-mediated insulin-like growth factor-1 receptor pathway, altered metabolism, and tumor cell invasion in cells subjected to mitochondrial respiratory stress.

Guha M, Srinivasan S, Biswas G, Avadhani NG.

J Biol Chem. 2007 May 11;282(19):14536-46. Epub 2007 Mar 13.PMID: 17355970 [PubMed - indexed for MEDLINE]Related articlesFree article

Site specific phosphorylation of cytochrome c oxidase subunits I, IVi1 and Vb in rabbit hearts subjected to ischemia/reperfusion.

Fang JK, Prabu SK, Sepuri NB, Raza H, Anandatheerthavarada HK, Galati D, Spear J, Avadhani NG.

FEBS Lett. 2007 Apr 3;581(7):1302-10. Epub 2007 Feb 28.PMID: 17349628 [PubMed - indexed for MEDLINE]Related articlesFree article

beta1-Adrenoreceptor activation contributes to ischemia-reperfusion damage as well as playing a role in ischemic preconditioning.

Spear JF, Prabu SK, Galati D, Raza H, Anandatheerthavarada HK, Avadhani NG.

Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2459-66. Epub 2007 Jan 19.PMID: 17237252 [PubMed - indexed for MEDLINE]Related articlesFree article

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

Devi L, Prabhu BM, Galati DF, Avadhani NG, Anandatheerthavarada HK.

J Neurosci. 2006 Aug 30;26(35):9057-68.PMID: 16943564 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of protein kinase C-mediated protein phosphorylation in mitochondrial translocation of mouse CYP1A1, which contains a non-canonical targeting signal.

Dasari VR, Anandatheerthavarada HK, Robin MA, Boopathi E, Biswas G, Fang JK, Nebert DW, Avadhani NG.

J Biol Chem. 2006 Oct 13;281(41):30834-47. Epub 2006 Aug 9.PMID: 16899466 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of mitochondrial metabolic function by phorbol 12-myristate 13-acetate through increased mitochondrial translocation of protein kinase Calpha in C2C12 myocytes.

Wang Y, Biswas G, Prabu SK, Avadhani NG.

Biochem Pharmacol. 2006 Sep 28;72(7):881-92. Epub 2006 Aug 8.PMID: 16899228 [PubMed - indexed for MEDLINE]Related articles

Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury.

Prabu SK, Anandatheerthavarada HK, Raza H, Srinivasan S, Spear JF, Avadhani NG.

J Biol Chem. 2006 Jan 27;281(4):2061-70. Epub 2005 Nov 22.PMID: 16303765 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis.

Biswas G, Guha M, Avadhani NG.

Gene. 2005 Jul 18;354:132-9.PMID: 15978749 [PubMed - indexed for MEDLINE]Related articles

Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness.

Nikonova EV, Vijayasarathy C, Zhang L, Cater JR, Galante RJ, Ward SE, Avadhani NG, Pack AI.

Sleep. 2005 Jan 1;28(1):21-7.PMID: 15700717 [PubMed - indexed for MEDLINE]Related articles

Mechanism of mitochondrial stress-induced resistance to apoptosis in mitochondrial DNA-depleted C2C12 myocytes.

Biswas G, Anandatheerthavarada HK, Avadhani NG.

Cell Death Differ. 2005 Mar;12(3):266-78.PMID: 15650755 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and heterogeneous nuclear ribonucleoprotein D-like protein (JKTBP1) reciprocally regulate transcription activity by physical interaction with the BERF-1/ZBP-89 factor.

Boopathi E, Lenka N, Prabu SK, Fang JK, Wilkinson F, Atchison M, Giallongo A, Avadhani NG.

J Biol Chem. 2004 Aug 20;279(34):35242-54. Epub 2004 Jun 9.PMID: 15190078 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial signaling: the retrograde response.

Butow RA, Avadhani NG.

Mol Cell. 2004 Apr 9;14(1):1-15. Review.PMID: 15068799 [PubMed - indexed for MEDLINE]Related articles

Competitive and noncompetitive inhibition of myocardial cytochrome C oxidase in sepsis.

Levy RJ, Vijayasarathy C, Raj NR, Avadhani NG, Deutschman CS.

Shock. 2004 Feb;21(2):110-4.PMID: 14752282 [PubMed - indexed for MEDLINE]Related articles

Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress.

Raza H, Prabu SK, Robin MA, Avadhani NG.

Diabetes. 2004 Jan;53(1):185-94.PMID: 14693714 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta.

Biswas G, Anandatheerthavarada HK, Zaidi M, Avadhani NG.

J Cell Biol. 2003 May 12;161(3):507-19. Epub 2003 May 5.PMID: 12732617 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells.

Anandatheerthavarada HK, Biswas G, Robin MA, Avadhani NG.

J Cell Biol. 2003 Apr 14;161(1):41-54.PMID: 12695498 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70.

Robin MA, Prabu SK, Raza H, Anandatheerthavarada HK, Avadhani NG.

J Biol Chem. 2003 May 23;278(21):18960-70. Epub 2003 Mar 19.PMID: 12646569 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription termination at the mouse mitochondrial H-strand promoter distal site requires an A/T rich sequence motif and sequence specific DNA binding proteins.

Camasamudram V, Fang JK, Avadhani NG.

Eur J Biochem. 2003 Mar;270(6):1128-40.PMID: 12631272 [PubMed - indexed for MEDLINE]Related articlesFree article

Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia.

Vijayasarathy C, Damle S, Prabu SK, Otto CM, Avadhani NG.

Eur J Biochem. 2003 Mar;270(5):871-9.PMID: 12603320 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells.

Amuthan G, Biswas G, Ananadatheerthavarada HK, Vijayasarathy C, Shephard HM, Avadhani NG.

Oncogene. 2002 Nov 7;21(51):7839-49.PMID: 12420221 [PubMed - indexed for MEDLINE]Related articlesFree article

Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation.

Robin MA, Anandatheerthavarada HK, Biswas G, Sepuri NB, Gordon DM, Pain D, Avadhani NG.

J Biol Chem. 2002 Oct 25;277(43):40583-93. Epub 2002 Aug 20.PMID: 12191992 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress.

Raza H, Robin MA, Fang JK, Avadhani NG.

Biochem J. 2002 Aug 15;366(Pt 1):45-55.PMID: 12020353 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel mechanism for coupling cellular intermediary metabolism to cytosolic Ca2+ signaling via CD38/ADP-ribosyl cyclase, a putative intracellular NAD+ sensor.

Sun L, Adebanjo OA, Koval A, Anandatheerthavarada HK, Iqbal J, Wu XY, Moonga BS, Wu XB, Biswas G, Bevis PJ, Kumegawa M, Epstein S, Huang CL, Avadhani NG, Abe E, Zaidi M.

FASEB J. 2002 Mar;16(3):302-14.PMID: 11874980 [PubMed - indexed for MEDLINE]Related articlesFree article

Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points.

Anandatheerthavarada HK, Amuthan G, Biswas G, Robin MA, Murali R, Waterman MR, Avadhani NG.

EMBO J. 2001 May 15;20(10):2394-403.PMID: 11350928 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity.

Robin MA, Anandatheerthavarada HK, Fang JK, Cudic M, Otvos L, Avadhani NG.

J Biol Chem. 2001 Jul 6;276(27):24680-9. Epub 2001 Apr 26.PMID: 11325963 [PubMed - indexed for MEDLINE]Related articles

Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion.

Amuthan G, Biswas G, Zhang SY, Klein-Szanto A, Vijayasarathy C, Avadhani NG.

EMBO J. 2001 Apr 17;20(8):1910-20.PMID: 11296224 [PubMed - indexed for MEDLINE]Related articlesFree article

Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter.

Mullick J, Anandatheerthavarada HK, Amuthan G, Bhagwat SV, Biswas G, Camasamudram V, Bhat NK, Reddy SE, Rao V, Avadhani NG.

J Biol Chem. 2001 May 25;276(21):18007-17. Epub 2001 Feb 21.PMID: 11279115 [PubMed - indexed for MEDLINE]Related articlesFree article

Accumulation of mitochondrial P450MT2, NH(2)-terminal truncated cytochrome P4501A1 in rat brain during chronic treatment with beta-naphthoflavone. A role in the metabolism of neuroactive drugs.

Boopathi E, Anandatheerthavarada HK, Bhagwat SV, Biswas G, Fang JK, Avadhani NG.

J Biol Chem. 2000 Nov 3;275(44):34415-23.PMID: 10915793 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel biochemical and functional insights into nuclear Ca(2+) transport through IP(3)Rs and RyRs in osteoblasts.

Adebanjo OA, Biswas G, Moonga BS, Anandatheerthavarada HK, Sun L, Bevis PJ, Sodam BR, Lai FA, Avadhani NG, Zaidi M.

Am J Physiol Renal Physiol. 2000 May;278(5):F784-91.PMID: 10807590 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning, characterisation and bacterial expression of full length cDNA for the mouse liver microsomal glutathione S-transferase.

Raza H, Mullick J, John A, Bhagwat SV, Avadhani NG.

Oncol Rep. 2000 May-Jun;7(3):645-9.PMID: 10767383 [PubMed - indexed for MEDLINE]Related articles

A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis.

Adebanjo OA, Anandatheerthavarada HK, Koval AP, Moonga BS, Biswas G, Sun L, Sodam BR, Bevis PJ, Huang CL, Epstein S, Lai FA, Avadhani NG, Zaidi M.

Nat Cell Biol. 1999 Nov;1(7):409-14.PMID: 10559984 [PubMed - indexed for MEDLINE]Related articles

Tissue variant effects of heme inhibitors on the mouse cytochrome c oxidase gene expression and catalytic activity of the enzyme complex.

Vijayasarathy C, Damle S, Lenka N, Avadhani NG.

Eur J Biochem. 1999 Nov;266(1):191-200.PMID: 10542064 [PubMed - indexed for MEDLINE]Related articlesFree article

Down-regulation of the rat hepatic sterol 27-hydroxylase gene by bile acids in transfected primary hepatocytes: possible role of hepatic nuclear factor 1alpha.

Rao YP, Vlahcevic ZR, Stravitz RT, Mallonee DH, Mullick J, Avadhani NG, Hylemon PB.

J Steroid Biochem Mol Biol. 1999 Jul-Aug;70(1-3):1-14.PMID: 10528998 [PubMed - indexed for MEDLINE]Related articles

Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at ser128.

Anandatheerthavarada HK, Biswas G, Mullick J, Sepuri NB, Otvos L, Pain D, Avadhani NG.

EMBO J. 1999 Oct 15;18(20):5494-504.PMID: 10523294 [PubMed - indexed for MEDLINE]Related articlesFree article