PubMed

CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis and microtubular transport: relevance to pathophysiology of Dent's disease.

Reed AA, Loh NY, Terryn S, Lippiat JD, Partridge CJ, Galvanovskis J, Williams SE, Jouret F, Wu FT, Courtoy PJ, Nesbit MA, Rorsman P, Devuyst O, Ashcroft FM, Thakker RV.

Am J Physiol Renal Physiol. 2009 Nov 25. [Epub ahead of print]PMID: 19940036 [PubMed - as supplied by publisher]

PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations.

Stansfeld PJ, Hopkinson R, Ashcroft FM, Sansom MS.

Biochemistry. 2009 Nov 24;48(46):10926-33.PMID: 19839652 [PubMed - in process]Related articles

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.

Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, Gerken T, Lee A, Moir L, Mecinović J, Quwailid MM, Schofield CJ, Ashcroft FM, Cox RD.

PLoS Genet. 2009 Aug;5(8):e1000599. Epub 2009 Aug 14.PMID: 19680540 [PubMed - indexed for MEDLINE]Related articlesFree article

Retraction for Ma et al. "Glucose regulates the effects of leptin on hypothalamic POMC neurons".

Ashcroft FM, Zubcevic L.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7263. Epub 2009 Apr 20. No abstract available. PMID: 19380749 [PubMed - indexed for MEDLINE]Related articlesFree article

An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1.

Craig TJ, Shimomura K, Holl RW, Flanagan SE, Ellard S, Ashcroft FM.

J Clin Endocrinol Metab. 2009 Jul;94(7):2551-7. Epub 2009 Apr 7.PMID: 19351728 [PubMed - indexed for MEDLINE]Related articles

A cytosolic factor that inhibits KATP channels expressed in Xenopus oocytes by impairing Mg-nucleotide activation by SUR1.

Tammaro P, Ashcroft FM.

J Physiol. 2009 Apr 15;587(Pt 8):1649-56. Epub 2009 Feb 23.PMID: 19237428 [PubMed - indexed for MEDLINE]Related articles

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.

Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, Cox R, Rorsman P, Brüning JC, Ashcroft FM.

J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8.PMID: 19065048 [PubMed - indexed for MEDLINE]Related articlesFree article

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.

Zehetner J, Danzer C, Collins S, Eckhardt K, Gerber PA, Ballschmieter P, Galvanovskis J, Shimomura K, Ashcroft FM, Thorens B, Rorsman P, Krek W.

Genes Dev. 2008 Nov 15;22(22):3135-46.PMID: 19056893 [PubMed - indexed for MEDLINE]Related articlesFree article

Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.

Aittoniemi J, Fotinou C, Craig TJ, de Wet H, Proks P, Ashcroft FM.

Philos Trans R Soc Lond B Biol Sci. 2009 Jan 27;364(1514):257-67. Review.PMID: 18990670 [PubMed - indexed for MEDLINE]Related articles

Modeling K(ATP) channel gating and its regulation.

Proks P, Ashcroft FM.

Prog Biophys Mol Biol. 2009 Jan;99(1):7-19. Epub 2008 Oct 17. Review.PMID: 18983870 [PubMed - indexed for MEDLINE]Related articles

Glucose regulates the effects of leptin on hypothalamic POMC neurons.

Ma X, Zubcevic L, Ashcroft FM.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9811-6. Epub 2008 Jul 3. Retraction in: Ashcroft FM, Zubcevic L. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7263. PMID: 18599453 [PubMed - indexed for MEDLINE]Related articlesFree article

How ATP inhibits the open K(ATP) channel.

Craig TJ, Ashcroft FM, Proks P.

J Gen Physiol. 2008 Jul;132(1):131-44.PMID: 18591420 [PubMed - indexed for MEDLINE]Related articlesFree article

Coincidence of a novel KCNJ11 missense variant R365H with a paternally inherited 6q24 duplication in a patient with transient neonatal diabetes.

Staník J, Lethby M, Flanagan SE, Gasperíková D, Milosovicová B, Lever M, Bullman H, Zubcevic L, Hattersley AT, Ellard S, Ashcroft FM, Klimes I.

Diabetes Care. 2008 Sep;31(9):1736-7. Epub 2008 Jun 12.PMID: 18556340 [PubMed - indexed for MEDLINE]Related articlesFree article

Variable phenotypic spectrum of diabetes mellitus in a family carrying a novel KCNJ11 gene mutation.

D'Amato E, Tammaro P, Craig TJ, Tosi A, Giorgetti R, Lorini R, Ashcroft FM.

Diabet Med. 2008 Jun;25(6):651-6.PMID: 18544102 [PubMed - indexed for MEDLINE]Related articles

A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes.

de Wet H, Proks P, Lafond M, Aittoniemi J, Sansom MS, Flanagan SE, Pearson ER, Hattersley AT, Ashcroft FM.

EMBO Rep. 2008 Jul;9(7):648-54. Epub 2008 May 23.PMID: 18497752 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance.

Goldsworthy M, Hugill A, Freeman H, Horner E, Shimomura K, Bogani D, Pieles G, Mijat V, Arkell R, Bhattacharya S, Ashcroft FM, Cox RD.

Diabetes. 2008 Aug;57(8):2234-44. Epub 2008 May 13.PMID: 18477811 [PubMed - indexed for MEDLINE]Related articlesFree article

A Kir6.2 mutation causing severe functional effects in vitro produces neonatal diabetes without the expected neurological complications.

Tammaro P, Flanagan SE, Zadek B, Srinivasan S, Woodhead H, Hameed S, Klimes I, Hattersley AT, Ellard S, Ashcroft FM.

Diabetologia. 2008 May;51(5):802-10. Epub 2008 Mar 12.PMID: 18335204 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes.

de Wet H, Rees MG, Shimomura K, Aittoniemi J, Patch AM, Flanagan SE, Ellard S, Hattersley AT, Sansom MS, Ashcroft FM.

Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18988-92. Epub 2007 Nov 19.PMID: 18025464 [PubMed - indexed for MEDLINE]Related articlesFree article

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ.

Science. 2007 Nov 30;318(5855):1469-72. Epub 2007 Nov 8.PMID: 17991826 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11.

Mlynarski W, Tarasov AI, Gach A, Girard CA, Pietrzak I, Zubcevic L, Kusmierek J, Klupa T, Malecki MT, Ashcroft FM.

Nat Clin Pract Neurol. 2007 Nov;3(11):640-5.PMID: 17982434 [PubMed - indexed for MEDLINE]Related articles

Mosaic paternal uniparental isodisomy and an ABCC8 gene mutation in a patient with permanent neonatal diabetes and hemihypertrophy.

Shield JP, Flanagan SE, Mackay DJ, Harries LW, Proks P, Girard C, Ashcroft FM, Temple IK, Ellard S.

Diabetes. 2008 Jan;57(1):255-8. Epub 2007 Oct 17.PMID: 17942821 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional analysis of two Kir6.2 (KCNJ11) mutations, K170T and E322K, causing neonatal diabetes.

Tarasov AI, Girard CA, Larkin B, Tammaro P, Flanagan SE, Ellard S, Ashcroft FM.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:46-55.PMID: 17919178 [PubMed - indexed for MEDLINE]Related articles

A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.

Tammaro P, Ashcroft FM.

J Physiol. 2007 Nov 1;584(Pt 3):743-53. Epub 2007 Sep 13.PMID: 17855752 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.

Tricarico D, Mele A, Liss B, Ashcroft FM, Lundquist AL, Desai RR, George AL Jr, Conte Camerino D.

Neuromuscul Disord. 2008 Jan;18(1):74-80. Epub 2007 Sep 6.PMID: 17825556 [PubMed - indexed for MEDLINE]Related articles

Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.

Haider S, Tarasov AI, Craig TJ, Sansom MS, Ashcroft FM.

EMBO J. 2007 Aug 22;26(16):3749-59. Epub 2007 Aug 2.PMID: 17673911 [PubMed - indexed for MEDLINE]Related articlesFree article

Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects.

Ellard S, Flanagan SE, Girard CA, Patch AM, Harries LW, Parrish A, Edghill EL, Mackay DJ, Proks P, Shimomura K, Haberland H, Carson DJ, Shield JP, Hattersley AT, Ashcroft FM.

Am J Hum Genet. 2007 Aug;81(2):375-82. Epub 2007 Jun 29.PMID: 17668386 [PubMed - indexed for MEDLINE]Related articlesFree article

The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady.

Ashcroft FM.

Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E880-9. Epub 2007 Jul 24.PMID: 17652156 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons.

Ma X, Bruning J, Ashcroft FM.

J Neurosci. 2007 Jul 4;27(27):7125-9.PMID: 17611265 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome.

Proks P, Shimomura K, Craig TJ, Girard CA, Ashcroft FM.

Hum Mol Genet. 2007 Aug 15;16(16):2011-9. Epub 2007 Jun 21.PMID: 17584766 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies of the ATPase activity of the ABC protein SUR1.

de Wet H, Mikhailov MV, Fotinou C, Dreger M, Craig TJ, Vénien-Bryan C, Ashcroft FM.

FEBS J. 2007 Jul;274(14):3532-44. Epub 2007 Jun 11.PMID: 17561960 [PubMed - indexed for MEDLINE]Related articles

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

Könner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Brüning JC.

Cell Metab. 2007 Jun;5(6):438-49.PMID: 17550779 [PubMed - indexed for MEDLINE]Related articles

PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.

Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A.

PLoS Genet. 2007 Apr 27;3(4):e64.PMID: 17465682 [PubMed - indexed for MEDLINE]Related articlesFree article

R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.

Zhang Q, Bengtsson M, Partridge C, Salehi A, Braun M, Cox R, Eliasson L, Johnson PR, Renström E, Schneider T, Berggren PO, Göpel S, Ashcroft FM, Rorsman P.

Nat Cell Biol. 2007 Apr;9(4):453-60. Epub 2007 Mar 18.PMID: 17369816 [PubMed - indexed for MEDLINE]Related articles

Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study.

Haider S, Khalid S, Tucker SJ, Ashcroft FM, Sansom MS.

Biochemistry. 2007 Mar 27;46(12):3643-52. Epub 2007 Feb 28.PMID: 17326663 [PubMed - indexed for MEDLINE]Related articles

Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin.

Ma X, Zubcevic L, Brüning JC, Ashcroft FM, Burdakov D.

J Neurosci. 2007 Feb 14;27(7):1529-33.PMID: 17301161 [PubMed - indexed for MEDLINE]Related articlesFree article

Keeping the heart going: a new role for KATP channels.

Tammaro P, Ashcroft FM.

J Physiol. 2006 Dec 15;577(Pt 3):767. Epub 2006 Oct 26. No abstract available. PMID: 17068097 [PubMed - indexed for MEDLINE]Related articlesFree article

A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells.

Tarasov AI, Welters HJ, Senkel S, Ryffel GU, Hattersley AT, Morgan NG, Ashcroft FM.

Diabetes. 2006 Nov;55(11):3075-82.PMID: 17065345 [PubMed - indexed for MEDLINE]Related articlesFree article

Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress.

Freeman H, Shimomura K, Cox RD, Ashcroft FM.

Biochem Soc Trans. 2006 Nov;34(Pt 5):806-10.PMID: 17052203 [PubMed - indexed for MEDLINE]Related articles

Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface transport of ATP-sensitive K+ channels.

Heusser K, Yuan H, Neagoe I, Tarasov AI, Ashcroft FM, Schwappach B.

J Cell Sci. 2006 Oct 15;119(Pt 20):4353-63.PMID: 17038548 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.

Girard CA, Shimomura K, Proks P, Absalom N, Castano L, Perez de Nanclares G, Ashcroft FM.

Pflugers Arch. 2006 Dec;453(3):323-32. Epub 2006 Sep 22.PMID: 17021801 [PubMed - indexed for MEDLINE]Related articles

ATP sensitivity of the ATP-sensitive K+ channel in intact and permeabilized pancreatic beta-cells.

Tarasov AI, Girard CA, Ashcroft FM.

Diabetes. 2006 Sep;55(9):2446-54.PMID: 16936192 [PubMed - indexed for MEDLINE]Related articlesFree article

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

Pearson ER, Flechtner I, Njølstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, Ellard S, Søvik O, Polak M, Hattersley AT; Neonatal Diabetes International Collaborative Group.

N Engl J Med. 2006 Aug 3;355(5):467-77.PMID: 16885550 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice.

Freeman HC, Hugill A, Dear NT, Ashcroft FM, Cox RD.

Diabetes. 2006 Jul;55(7):2153-6.PMID: 16804088 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC.

J Clin Invest. 2006 Jul;116(7):1886-901. Epub 2006 Jun 22.PMID: 16794735 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy.

Proks P, Girard C, Baevre H, Njølstad PR, Ashcroft FM.

Diabetes. 2006 Jun;55(6):1731-7.PMID: 16731836 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.

Shimomura K, Girard CA, Proks P, Nazim J, Lippiat JD, Cerutti F, Lorini R, Ellard S, Hattersley AT, Barbetti F, Ashcroft FM.

Diabetes. 2006 Jun;55(6):1705-12. Erratum in: Diabetes. 2007 Mar;56(3):897. Hattersely, Andrew T [corrected to Hattersley, Andrew T]. PMID: 16731833 [PubMed - indexed for MEDLINE]Related articlesFree article

A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes.

Proks P, Arnold AL, Bruining J, Girard C, Flanagan SE, Larkin B, Colclough K, Hattersley AT, Ashcroft FM, Ellard S.

Hum Mol Genet. 2006 Jun 1;15(11):1793-800. Epub 2006 Apr 13.PMID: 16613899 [PubMed - indexed for MEDLINE]Related articlesFree article

From molecule to malady.

Ashcroft FM.

Nature. 2006 Mar 23;440(7083):440-7. Review.PMID: 16554803 [PubMed - indexed for MEDLINE]Related articles

K(ATP) channels and insulin secretion: a key role in health and disease.

Ashcroft FM.

Biochem Soc Trans. 2006 Apr;34(Pt 2):243-6. Review.PMID: 16545085 [PubMed - indexed for MEDLINE]Related articles

Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.

Deacon RM, Brook RC, Meyer D, Haeckel O, Ashcroft FM, Miki T, Seino S, Liss B.

Physiol Behav. 2006 Apr 15;87(4):723-33. Epub 2006 Mar 10.PMID: 16530794 [PubMed - indexed for MEDLINE]Related articles