PubMed

Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

Mukhtar MH, Payne VA, Arden C, Harbottle A, Khan S, Lange AJ, Agius L.

Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R766-74. Epub 2008 Jan 16.PMID: 18199594 [PubMed - indexed for MEDLINE]Related articles

A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.

Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L.

Biochem J. 2008 Apr 1;411(1):41-51.PMID: 18039179 [PubMed - indexed for MEDLINE]Related articlesFree article

Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats.

Payne VA, Arden C, Lange AJ, Agius L.

Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R618-25. Epub 2007 Jun 6.PMID: 17553851 [PubMed - indexed for MEDLINE]Related articles

Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity.

Arden C, Trainer A, de la Iglesia N, Scougall KT, Gloyn AL, Lange AJ, Shaw JA, Matschinsky FM, Agius L.

Diabetes. 2007 Jul;56(7):1773-82. Epub 2007 Mar 27.PMID: 17389332 [PubMed - indexed for MEDLINE]Related articlesFree article

Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site.

Hampson LJ, Arden C, Agius L, Ganotidis M, Kosmopoulou MN, Tiraidis C, Elemes Y, Sakarellos C, Leonidas DD, Oikonomakos NG.

Bioorg Med Chem. 2006 Dec 1;14(23):7835-45.PMID: 16908161 [PubMed - indexed for MEDLINE]Related articles

Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats.

Arden C, Green AR, Hampson LJ, Aiston S, Härndahl L, Greenberg CC, Brady MJ, Freeman S, Poucher SM, Agius L.

FEBS J. 2006 May;273(9):1989-99.PMID: 16640562 [PubMed - indexed for MEDLINE]Related articles

Glucokinase regulatory protein is associated with mitochondria in hepatocytes.

Arden C, Baltrusch S, Agius L.

FEBS Lett. 2006 Apr 3;580(8):2065-70. Epub 2006 Mar 10.PMID: 16542652 [PubMed - indexed for MEDLINE]Related articles

The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes.

Aiston S, Hampson LJ, Arden C, Iynedjian PB, Agius L.

Diabetologia. 2006 Jan;49(1):174-82. Epub 2005 Dec 10.PMID: 16341839 [PubMed - indexed for MEDLINE]Related articles

Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes.

Payne VA, Arden C, Wu C, Lange AJ, Agius L.

Diabetes. 2005 Jul;54(7):1949-57.PMID: 15983194 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation.

Arden C, Harbottle A, Baltrusch S, Tiedge M, Agius L.

Diabetes. 2004 Sep;53(9):2346-52.PMID: 15331544 [PubMed - indexed for MEDLINE]Related articlesFree article