PubMed

Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability.

Murakami T, Felinski EA, Antonetti DA.

J Biol Chem. 2009 Jul 31;284(31):21036-46. Epub 2009 May 28.PMID: 19478092 [PubMed - indexed for MEDLINE]Related articles

Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the intracranial brain tumor model.

Madhankumar AB, Slagle-Webb B, Wang X, Yang QX, Antonetti DA, Miller PA, Sheehan JM, Connor JR.

Mol Cancer Ther. 2009 Mar;8(3):648-54. Epub 2009 Mar 10.PMID: 19276162 [PubMed - indexed for MEDLINE]Related articles

Identification and analysis of occludin phosphosites: a combined mass spectrometry and bioinformatics approach.

Sundstrom JM, Tash BR, Murakami T, Flanagan JM, Bewley MC, Stanley BA, Gonsar KB, Antonetti DA.

J Proteome Res. 2009 Feb;8(2):808-17.PMID: 19125584 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation site mapping of endogenous proteins: a combined MS and bioinformatics approach.

Sundstrom JM, Sundstrom CJ, Sundstrom SA, Fort PE, Rauscher RL, Gardner TW, Antonetti DA.

J Proteome Res. 2009 Feb;8(2):798-807.PMID: 19125583 [PubMed - indexed for MEDLINE]Related articles

Novel potential mechanisms for diabetic macular edema: leveraging new investigational approaches.

Gardner TW, Antonetti DA.

Curr Diab Rep. 2008 Aug;8(4):263-9. Review.PMID: 18631437 [PubMed - indexed for MEDLINE]Related articles

Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response.

Brucklacher RM, Patel KM, VanGuilder HD, Bixler GV, Barber AJ, Antonetti DA, Lin CM, LaNoue KF, Gardner TW, Bronson SK, Freeman WM.

BMC Med Genomics. 2008 Jun 13;1:26.PMID: 18554398 [PubMed]Related articlesFree article

Glucocorticoids induce transactivation of tight junction genes occludin and claudin-5 in retinal endothelial cells via a novel cis-element.

Felinski EA, Cox AE, Phillips BE, Antonetti DA.

Exp Eye Res. 2008 Jun;86(6):867-78. Epub 2008 Jan 12.PMID: 18501346 [PubMed - indexed for MEDLINE]Related articlesFree article

Occludin independently regulates permeability under hydrostatic pressure and cell division in retinal pigment epithelial cells.

Phillips BE, Cancel L, Tarbell JM, Antonetti DA.

Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2568-76. Epub 2008 Feb 8.PMID: 18263810 [PubMed - indexed for MEDLINE]Related articlesFree article

Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response.

Brucklacher RM, Patel KM, VanGuilder HD, Bixler GV, Barber AJ, Antonetti DA, Lin CM, LaNoue KF, Gardner TW, Bronson SK, Freeman WM.

BMC Med Genomics. 2008;1:26.PMID: 19623761 [PubMed]Related articlesFree article

Vascular permeability in ocular disease and the role of tight junctions.

Erickson KK, Sundstrom JM, Antonetti DA.

Angiogenesis. 2007;10(2):103-17. Epub 2007 Mar 6. Review.PMID: 17340211 [PubMed - indexed for MEDLINE]Related articles

A prize catch for diabetic retinopathy.

Gardner TW, Antonetti DA.

Nat Med. 2007 Feb;13(2):131-2. No abstract available. PMID: 17290269 [PubMed - indexed for MEDLINE]Related articles

Ruboxistaurin for diabetic retinopathy.

Gardner TW, Antonetti DA.

Ophthalmology. 2006 Dec;113(12):2135-6. No abstract available. PMID: 17157131 [PubMed - indexed for MEDLINE]Related articles

VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability.

Harhaj NS, Felinski EA, Wolpert EB, Sundstrom JM, Gardner TW, Antonetti DA.

Invest Ophthalmol Vis Sci. 2006 Nov;47(11):5106-15.PMID: 17065532 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases.

Maines LW, French KJ, Wolpert EB, Antonetti DA, Smith CD.

Invest Ophthalmol Vis Sci. 2006 Nov;47(11):5022-31.PMID: 17065523 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.

Antonetti DA, Barber AJ, Bronson SK, Freeman WM, Gardner TW, Jefferson LS, Kester M, Kimball SR, Krady JK, LaNoue KF, Norbury CC, Quinn PG, Sandirasegarane L, Simpson IA; JDRF Diabetic Retinopathy Center Group.

Diabetes. 2006 Sep;55(9):2401-11.PMID: 16936187 [PubMed - indexed for MEDLINE]Related articlesFree article

New insights for glutaric aciduria type I.

Zinnanti WJ, Lazovic J, Wolpert EB, Antonetti DA, Smith MB, Connor JR, Woontner M, Goodman SI, Cheng KC.

Brain. 2006 Aug;129(Pt 8):e55. No abstract available. PMID: 16870880 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin.

Reiter CE, Wu X, Sandirasegarane L, Nakamura M, Gilbert KA, Singh RS, Fort PE, Antonetti DA, Gardner TW.

Diabetes. 2006 Apr;55(4):1148-56.PMID: 16567541 [PubMed - indexed for MEDLINE]Related articlesFree article

A diet-induced mouse model for glutaric aciduria type I.

Zinnanti WJ, Lazovic J, Wolpert EB, Antonetti DA, Smith MB, Connor JR, Woontner M, Goodman SI, Cheng KC.

Brain. 2006 Apr;129(Pt 4):899-910. Epub 2006 Jan 30.PMID: 16446282 [PubMed - indexed for MEDLINE]Related articlesFree article

Shear stress regulates HUVEC hydraulic conductivity by occludin phosphorylation.

Pang Z, Antonetti DA, Tarbell JM.

Ann Biomed Eng. 2005 Nov;33(11):1536-45.PMID: 16341921 [PubMed - indexed for MEDLINE]Related articles

Glucocorticoid regulation of endothelial cell tight junction gene expression: novel treatments for diabetic retinopathy.

Felinski EA, Antonetti DA.

Curr Eye Res. 2005 Nov;30(11):949-57. Review.PMID: 16282129 [PubMed - indexed for MEDLINE]Related articles

Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells.

Maines LW, Antonetti DA, Wolpert EB, Smith CD.

Neuropharmacology. 2005 Oct;49(5):610-7.PMID: 15961125 [PubMed - indexed for MEDLINE]Related articles

The Ins2Akita mouse as a model of early retinal complications in diabetes.

Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK.

Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2210-8.PMID: 15914643 [PubMed - indexed for MEDLINE]Related articlesFree article

VEGF increases paracellular transport without altering the solvent-drag reflection coefficient.

DeMaio L, Antonetti DA, Scaduto RC Jr, Gardner TW, Tarbell JM.

Microvasc Res. 2004 Nov;68(3):295-302.PMID: 15501249 [PubMed - indexed for MEDLINE]Related articles

Alterations in expression of angiopoietins and the Tie-2 receptor in the retina of streptozotocin induced diabetic rats.

Ohashi H, Takagi H, Koyama S, Oh H, Watanabe D, Antonetti DA, Matsubara T, Nagai K, Arai H, Kita T, Honda Y.

Mol Vis. 2004 Aug 26;10:608-17.PMID: 15354084 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of tight junctions and loss of barrier function in pathophysiology.

Harhaj NS, Antonetti DA.

Int J Biochem Cell Biol. 2004 Jul;36(7):1206-37. Review.PMID: 15109567 [PubMed - indexed for MEDLINE]Related articles

Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner.

Wu X, Reiter CE, Antonetti DA, Kimball SR, Jefferson LS, Gardner TW.

J Biol Chem. 2004 Mar 5;279(10):9167-75. Epub 2003 Dec 5.PMID: 14660591 [PubMed - indexed for MEDLINE]Related articlesFree article

Mapping the blood vessels with paracellular permeability in the retinas of diabetic rats.

Barber AJ, Antonetti DA.

Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5410-6.PMID: 14638745 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system.

Burdo JR, Antonetti DA, Wolpert EB, Connor JR.

Neuroscience. 2003;121(4):883-90.PMID: 14580938 [PubMed - indexed for MEDLINE]Related articles

A transmural pressure gradient induces mechanical and biological adaptive responses in endothelial cells.

DeMaio L, Tarbell JM, Scaduto RC Jr, Gardner TW, Antonetti DA.

Am J Physiol Heart Circ Physiol. 2004 Feb;286(2):H731-41. Epub 2003 Oct 2.PMID: 14527936 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolation and characterization of retinal endothelial cells.

Antonetti DA, Wolpert EB.

Methods Mol Med. 2003;89:365-74. No abstract available. PMID: 12958433 [PubMed - indexed for MEDLINE]Related articles

Characterization of insulin signaling in rat retina in vivo and ex vivo.

Reiter CE, Sandirasegarane L, Wolpert EB, Klinger M, Simpson IA, Barber AJ, Antonetti DA, Kester M, Gardner TW.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E763-74. Epub 2003 Jun 10.PMID: 12799319 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic retinopathy: more than meets the eye.

Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Levison SW.

Surv Ophthalmol. 2002 Dec;47 Suppl 2:S253-62. Review.PMID: 12507627 [PubMed - indexed for MEDLINE]Related articles

Platelet-derived growth factor mediates tight junction redistribution and increases permeability in MDCK cells.

Harhaj NS, Barber AJ, Antonetti DA.

J Cell Physiol. 2002 Dec;193(3):349-64.PMID: 12384987 [PubMed - indexed for MEDLINE]Related articles

Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin.

Antonetti DA, Wolpert EB, DeMaio L, Harhaj NS, Scaduto RC Jr.

J Neurochem. 2002 Feb;80(4):667-77.PMID: 11841574 [PubMed - indexed for MEDLINE]Related articles

Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons.

Nakamura M, Barber AJ, Antonetti DA, LaNoue KF, Robinson KA, Buse MG, Gardner TW.

J Biol Chem. 2001 Nov 23;276(47):43748-55. Epub 2001 Sep 17.PMID: 11560942 [PubMed - indexed for MEDLINE]Related articlesFree article

New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets.

Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Nakamura M.

Diabetes Technol Ther. 2000 Winter;2(4):601-8. Review.PMID: 11469624 [PubMed - indexed for MEDLINE]Related articles

Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.

Barber AJ, Nakamura M, Wolpert EB, Reiter CE, Seigel GM, Antonetti DA, Gardner TW.

J Biol Chem. 2001 Aug 31;276(35):32814-21. Epub 2001 Jul 6.PMID: 11443130 [PubMed - indexed for MEDLINE]Related articlesFree article

Shear stress regulates occludin content and phosphorylation.

DeMaio L, Chang YS, Gardner TW, Tarbell JM, Antonetti DA.

Am J Physiol Heart Circ Physiol. 2001 Jul;281(1):H105-13.PMID: 11406474 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinal neurodegeneration: early pathology in diabetes.

Lieth E, Gardner TW, Barber AJ, Antonetti DA; Penn State Retina Research Group.

Clin Experiment Ophthalmol. 2000 Feb;28(1):3-8. Review.PMID: 11345341 [PubMed - indexed for MEDLINE]Related articles

Effect of VEGF on retinal microvascular endothelial hydraulic conductivity: the role of NO.

Lakshminarayanan S, Antonetti DA, Gardner TW, Tarbell JM.

Invest Ophthalmol Vis Sci. 2000 Dec;41(13):4256-61.PMID: 11095623 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group.

Barber AJ, Antonetti DA, Gardner TW.

Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3561-8.PMID: 11006253 [PubMed - indexed for MEDLINE]Related articlesFree article

The molecular structure and function of the inner blood-retinal barrier. Penn State Retina Research Group.

Gardner TW, Antonetti DA, Barber AJ, Lieth E, Tarbell JA.

Doc Ophthalmol. 1999;97(3-4):229-37. Review. No abstract available. PMID: 10896336 [PubMed - indexed for MEDLINE]Related articles

Diabetes reduces glutamate oxidation and glutamine synthesis in the retina. The Penn State Retina Research Group.

Lieth E, LaNoue KF, Antonetti DA, Ratz M.

Exp Eye Res. 2000 Jun;70(6):723-30.PMID: 10843776 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms of vascular permeability in diabetic retinopathy.

Antonetti DA, Lieth E, Barber AJ, Gardner TW.

Semin Ophthalmol. 1999 Dec;14(4):240-8. Review.PMID: 10758225 [PubMed - indexed for MEDLINE]Related articles

Leucine, glutamine, and tyrosine reciprocally modulate the translation initiation factors eIF4F and eIF2B in perfused rat liver.

Shah OJ, Antonetti DA, Kimball SR, Jefferson LS.

J Biol Chem. 1999 Dec 17;274(51):36168-75.PMID: 10593901 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors.

Antonetti DA, Barber AJ, Hollinger LA, Wolpert EB, Gardner TW.

J Biol Chem. 1999 Aug 13;274(33):23463-7.PMID: 10438525 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group.

Antonetti DA, Barber AJ, Khin S, Lieth E, Tarbell JM, Gardner TW.

Diabetes. 1998 Dec;47(12):1953-9.PMID: 9836530 [PubMed - indexed for MEDLINE]Related articlesFree article

Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin.

Barber AJ, Lieth E, Khin SA, Antonetti DA, Buchanan AG, Gardner TW.

J Clin Invest. 1998 Aug 15;102(4):783-91.PMID: 9710447 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart.

Algenstaedt P, Antonetti DA, Yaffe MB, Kahn CR.

J Biol Chem. 1997 Sep 19;272(38):23696-702.PMID: 9295312 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.

Antonetti DA, Algenstaedt P, Kahn CR.

Mol Cell Biol. 1996 May;16(5):2195-203.PMID: 8628286 [PubMed - indexed for MEDLINE]Related articlesFree article