PubMed

Polycystins play a key role in the modulation of cholangiocyte proliferation.

Torrice A, Cardinale V, Gatto M, Semeraro R, Napoli C, Onori P, Alpini G, Gaudio E, Alvaro D.

Dig Liver Dis. 2009 Nov 6. [Epub ahead of print]PMID: 19897428 [PubMed - as supplied by publisher]Related articles

Increased local dopamine secretion has growth promoting effects in cholangiocarcinoma.

Coufal M, Invernizzi P, Gaudio E, Bernuzzi F, Frampton GA, Onori P, Franchitto A, Carpino G, Ramirez JC, Alvaro D, Marzioni M, Battisti G, Benedetti A, Demorrow S.

Int J Cancer. 2009 Sep 30. [Epub ahead of print]PMID: 19795457 [PubMed - as supplied by publisher]Related articles

New insights into liver stem cells.

Gaudio E, Carpino G, Cardinale V, Franchitto A, Onori P, Alvaro D.

Dig Liver Dis. 2009 Jul;41(7):455-62. Epub 2009 Apr 28. Review.PMID: 19403350 [PubMed - indexed for MEDLINE]Related articles

Serum and bile biomarkers for cholangiocarcinoma.

Alvaro D.

Curr Opin Gastroenterol. 2009 May;25(3):279-84. Review.PMID: 19396965 [PubMed - indexed for MEDLINE]Related articles

Follicle-stimulating hormone increases cholangiocyte proliferation by an autocrine mechanism via cAMP-dependent phosphorylation of ERK1/2 and Elk-1.

Mancinelli R, Onori P, Gaudio E, DeMorrow S, Franchitto A, Francis H, Glaser S, Carpino G, Venter J, Alvaro D, Kopriva S, White M, Kossie A, Savage J, Alpini G.

Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G11-26. Epub 2009 Apr 23.PMID: 19389804 [PubMed - indexed for MEDLINE]Related articles

Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-kappaB and induction of apoptosis.

Onori P, DeMorrow S, Gaudio E, Franchitto A, Mancinelli R, Venter J, Kopriva S, Ueno Y, Alvaro D, Savage J, Alpini G, Francis H.

Int J Cancer. 2009 Aug 1;125(3):565-76.PMID: 19358267 [PubMed - indexed for MEDLINE]Related articles

Endothelin inhibits cholangiocarcinoma growth by a decrease in the vascular endothelial growth factor expression.

Fava G, Demorrow S, Gaudio E, Franchitto A, Onori P, Carpino G, Glaser S, Francis H, Coufal M, Marucci L, Alvaro D, Marzioni M, Horst T, Mancinelli R, Benedetti A, Alpini G.

Liver Int. 2009 Aug;29(7):1031-42. Epub 2009 Mar 9.PMID: 19291182 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholangiocyte proliferation and liver fibrosis.

Glaser SS, Gaudio E, Miller T, Alvaro D, Alpini G.

Expert Rev Mol Med. 2009 Feb 25;11:e7. Review.PMID: 19239726 [PubMed - indexed for MEDLINE]Related articlesFree article

Taurocholate feeding to bile duct ligated rats prevents caffeic acid-induced bile duct damage by changes in cholangiocyte VEGF expression.

Mancinelli R, Onori P, Gaudio E, Franchitto A, Carpino G, Ueno Y, Alvaro D, Annarale LP, Demorrow S, Francis H.

Exp Biol Med (Maywood). 2009 Apr;234(4):462-74. Epub 2009 Feb 20.PMID: 19234059 [PubMed - indexed for MEDLINE]Related articles

Morphological and functional heterogeneity of the mouse intrahepatic biliary epithelium.

Glaser SS, Gaudio E, Rao A, Pierce LM, Onori P, Franchitto A, Francis HL, Dostal DE, Venter JK, DeMorrow S, Mancinelli R, Carpino G, Alvaro D, Kopriva SE, Savage JM, Alpini GD.

Lab Invest. 2009 Apr;89(4):456-69. Epub 2009 Feb 9.PMID: 19204666 [PubMed - indexed for MEDLINE]Related articlesFree article

Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth.

Alpini G, Invernizzi P, Gaudio E, Venter J, Kopriva S, Bernuzzi F, Onori P, Franchitto A, Coufal M, Frampton G, Alvaro D, Lee SP, Marzioni M, Benedetti A, DeMorrow S.

Cancer Res. 2008 Nov 15;68(22):9184-93.PMID: 19010890 [PubMed - indexed for MEDLINE]Related articlesFree article

Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls.

Invernizzi P, Selmi C, Poli F, Frison S, Floreani A, Alvaro D, Almasio P, Rosina F, Marzioni M, Fabris L, Muratori L, Qi L, Seldin MF, Gershwin ME, Podda M; Italian PBC Genetic Study Group.

Hepatology. 2008 Dec;48(6):1906-12.PMID: 19003916 [PubMed - indexed for MEDLINE]Related articles

Leptin enhances cholangiocarcinoma cell growth.

Fava G, Alpini G, Rychlicki C, Saccomanno S, DeMorrow S, Trozzi L, Candelaresi C, Venter J, Di Sario A, Marzioni M, Bearzi I, Glaser S, Alvaro D, Marucci L, Francis H, Svegliati-Baroni G, Benedetti A.

Cancer Res. 2008 Aug 15;68(16):6752-61.PMID: 18701500 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury.

Gatto M, Drudi-Metalli V, Torrice A, Alpini G, Cantafora A, Blotta I, Alvaro D.

Lab Invest. 2008 Sep;88(9):986-94. Epub 2008 Jul 7.PMID: 18607346 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of cholangiocyte adaptive responses by visceral hormones and neuropeptides.

Marzioni M, Fava G, Alvaro D, Alpini G, Benedetti A.

Clin Rev Allergy Immunol. 2009 Feb;36(1):13-22. Review.PMID: 18548352 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor.

Mancino A, Mancino MG, Glaser SS, Alpini G, Bolognese A, Izzo L, Francis H, Onori P, Franchitto A, Ginanni-Corradini S, Gaudio E, Alvaro D.

Dig Liver Dis. 2009 Feb;41(2):156-63. Epub 2008 Apr 18.PMID: 18395502 [PubMed - indexed for MEDLINE]Related articlesFree article

New insights on the molecular and cell biology of human cholangiopathies.

Alvaro D, Mancino MG.

Mol Aspects Med. 2008 Feb-Apr;29(1-2):50-7. Epub 2007 Oct 24. Review.PMID: 18230407 [PubMed - indexed for MEDLINE]Related articles

Morphological and functional features of hepatic cyst epithelium in autosomal dominant polycystic kidney disease.

Alvaro D, Onori P, Alpini G, Franchitto A, Jefferson DM, Torrice A, Cardinale V, Stefanelli F, Mancino MG, Strazzabosco M, Angelico M, Attili A, Gaudio E.

Am J Pathol. 2008 Feb;172(2):321-32. Epub 2008 Jan 17.PMID: 18202196 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination.

Alvaro D, Lisby M, Rothstein R.

PLoS Genet. 2007 Dec;3(12):e228.PMID: 18085829 [PubMed - indexed for MEDLINE]Related articlesFree article

[Pathophysiology of cholangiocytes: recent advances]

Mancino MG, Alvaro D.

Recenti Prog Med. 2007 Nov;98(11):583-8. Review. Italian. PMID: 18044410 [PubMed - indexed for MEDLINE]Related articles

Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis.

Alvaro D, Macarri G, Mancino MG, Marzioni M, Bragazzi M, Onori P, Corradini SG, Invernizzi P, Franchitto A, Attili AF, Gaudio E, Benedetti A.

Ann Intern Med. 2007 Oct 2;147(7):451-9. Erratum in: Ann Intern Med. 2007 Nov 6;147(9):676. PMID: 17909206 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic "stem" cells: state of the art.

Mancino MG, Carpino G, Onori P, Franchitto A, Alvaro D, Gaudio E.

Ital J Anat Embryol. 2007 Apr-Jun;112(2):93-109. Review.PMID: 17687874 [PubMed - indexed for MEDLINE]Related articles

Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms.

Taffetani S, Glaser S, Francis H, DeMorrow S, Ueno Y, Alvaro D, Marucci L, Marzioni M, Fava G, Venter J, Vaculin S, Vaculin B, Lam IP, Lee VH, Gaudio E, Carpino G, Benedetti A, Alpini G.

BMC Physiol. 2007 Jul 19;7:6.PMID: 17640386 [PubMed - indexed for MEDLINE]Related articlesFree article

The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats.

Francis H, LeSage G, DeMorrow S, Alvaro D, Ueno Y, Venter J, Glaser S, Mancino MG, Marucci L, Benedetti A, Alpini G.

Am J Physiol Cell Physiol. 2007 Oct;293(4):C1252-62. Epub 2007 Jul 18.PMID: 17634418 [PubMed - indexed for MEDLINE]Related articlesFree article

Bile salts regulate proliferation and apoptosis of liver cells by modulating the IGF1 system.

Drudi Metalli V, Mancino MG, Mancino A, Torrice A, Gatto M, Attili AF, Alpini G, Alvaro D.

Dig Liver Dis. 2007 Jul;39(7):654-62. Epub 2007 May 24.PMID: 17531559 [PubMed - indexed for MEDLINE]Related articles

Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver.

Marzioni M, Ueno Y, Glaser S, Francis H, Benedetti A, Alvaro D, Venter J, Fava G, Alpini G.

Liver Int. 2007 May;27(4):558-68.PMID: 17403196 [PubMed - indexed for MEDLINE]Related articles

H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway.

Francis H, Franchitto A, Ueno Y, Glaser S, DeMorrow S, Venter J, Gaudio E, Alvaro D, Fava G, Marzioni M, Vaculin B, Alpini G.

Lab Invest. 2007 May;87(5):473-87. Epub 2007 Mar 5.PMID: 17334413 [PubMed - indexed for MEDLINE]Related articlesFree article

Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver.

Alvaro D, Mancino MG, Glaser S, Gaudio E, Marzioni M, Francis H, Alpini G.

Gastroenterology. 2007 Jan;132(1):415-31. Epub 2006 Jul 24. Review.PMID: 17241889 [PubMed - indexed for MEDLINE]Related articles

Activation of the IGF1 system characterizes cholangiocyte survival during progression of primary biliary cirrhosis.

Onori P, Alvaro D, Floreani AR, Mancino MG, Franchitto A, Guido M, Carpino G, De Santis A, Angelico M, Attili AF, Gaudio E.

J Histochem Cytochem. 2007 Apr;55(4):327-34. Epub 2006 Dec 12.PMID: 17164408 [PubMed - indexed for MEDLINE]Related articlesFree article

Systematic hybrid LOH: a new method to reduce false positives and negatives during screening of yeast gene deletion libraries.

Alvaro D, Sunjevaric I, Reid RJ, Lisby M, Stillman DJ, Rothstein R.

Yeast. 2006 Oct-Nov;23(14-15):1097-106.PMID: 17083134 [PubMed - indexed for MEDLINE]Related articles

Functional genomics of the yeast DNA-damage response.

Cagney G, Alvaro D, Reid RJ, Thorpe PH, Rothstein R, Krogan NJ.

Genome Biol. 2006;7(9):233.PMID: 16959047 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma.

Alvaro D, Barbaro B, Franchitto A, Onori P, Glaser SS, Alpini G, Francis H, Marucci L, Sterpetti P, Ginanni-Corradini S, Onetti Muda A, Dostal DE, De Santis A, Attili AF, Benedetti A, Gaudio E.

Am J Pathol. 2006 Sep;169(3):877-88.PMID: 16936263 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholangiocytes and blood supply.

Gaudio E, Franchitto A, Pannarale L, Carpino G, Alpini G, Francis H, Glaser S, Alvaro D, Onori P.

World J Gastroenterol. 2006 Jun 14;12(22):3546-52. Review.PMID: 16773711 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogens and the pathophysiology of the biliary tree.

Alvaro D, Mancino MG, Onori P, Franchitto A, Alpini G, Francis H, Glaser S, Gaudio E.

World J Gastroenterol. 2006 Jun 14;12(22):3537-45. Review.PMID: 16773710 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism.

Gaudio E, Barbaro B, Alvaro D, Glaser S, Francis H, Ueno Y, Meininger CJ, Franchitto A, Onori P, Marzioni M, Taffetani S, Fava G, Stoica G, Venter J, Reichenbach R, De Morrow S, Summers R, Alpini G.

Gastroenterology. 2006 Apr;130(4):1270-82.PMID: 16618418 [PubMed - indexed for MEDLINE]Related articles

Administration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated rats.

Gaudio E, Barbaro B, Alvaro D, Glaser S, Francis H, Franchitto A, Onori P, Ueno Y, Marzioni M, Fava G, Venter J, Reichenbach R, Summers R, Alpini G.

Am J Physiol Gastrointest Liver Physiol. 2006 Aug;291(2):G307-17. Epub 2006 Mar 30.PMID: 16574985 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogens maintain bile duct mass and reduce apoptosis after biliodigestive anastomosis in bile duct ligated rats.

Svegliati-Baroni G, Ghiselli R, Marzioni M, Alvaro D, Mocchegiani F, Saccomanno S, Sisti V, Ugili L, Orlando F, Alpini G, Saba V, Benedetti A.

J Hepatol. 2006 Jun;44(6):1158-66. Epub 2005 Dec 28.PMID: 16481066 [PubMed - indexed for MEDLINE]Related articles

gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway.

Fava G, Marucci L, Glaser S, Francis H, De Morrow S, Benedetti A, Alvaro D, Venter J, Meininger C, Patel T, Taffetani S, Marzioni M, Summers R, Reichenbach R, Alpini G.

Cancer Res. 2005 Dec 15;65(24):11437-46.PMID: 16357152 [PubMed - indexed for MEDLINE]Related articlesFree article

Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of Akt.

Glaser S, Alvaro D, Francis H, Ueno Y, Marucci L, Benedetti A, De Morrow S, Marzioni M, Mancino MG, Phinizy JL, Reichenbach R, Fava G, Summers R, Venter J, Alpini G.

Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G813-26. Epub 2005 Dec 8.PMID: 16339297 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic microcirculation and cholangiocyte physiopathology.

Gaudio E, Onori P, Franchitto A, Pannarale L, Alpini G, Alvaro D.

Ital J Anat Embryol. 2005;110(2 Suppl 1):71-5.PMID: 16101023 [PubMed - indexed for MEDLINE]Related articles

The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis.

Alvaro D, Metalli VD, Alpini G, Onori P, Franchitto A, Barbaro B, Glaser SS, Francis H, Cantafora A, Blotta I, Attili AF, Gaudio E.

J Hepatol. 2005 Nov;43(5):875-83. Epub 2005 May 31.PMID: 16083987 [PubMed - indexed for MEDLINE]Related articles

Estrogen receptors in cholangiocytes and the progression of primary biliary cirrhosis.

Alvaro D, Invernizzi P, Onori P, Franchitto A, De Santis A, Crosignani A, Sferra R, Ginanni-Corradini S, Mancino MG, Maggioni M, Attili AF, Podda M, Gaudio E.

J Hepatol. 2004 Dec;41(6):905-12.PMID: 15645536 [PubMed - indexed for MEDLINE]Related articles

Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin.

Marzioni M, Glaser S, Francis H, Marucci L, Benedetti A, Alvaro D, Taffetani S, Ueno Y, Roskams T, Phinizy JL, Venter J, Fava G, Lesage GD, Alpini G.

Gastroenterology. 2005 Jan;128(1):121-37.PMID: 15633129 [PubMed - indexed for MEDLINE]Related articles

Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP.

LeSage GD, Alvaro D, Glaser S, Francis H, Marucci L, Roskams T, Phinizy JL, Marzioni M, Benedetti A, Taffetani S, Barbaro B, Fava G, Ueno Y, Alpini G.

Hepatology. 2004 Nov;40(5):1116-27.PMID: 15486932 [PubMed - indexed for MEDLINE]Related articles

Nerve growth factor modulates the proliferative capacity of the intrahepatic biliary epithelium in experimental cholestasis.

Gigliozzi A, Alpini G, Baroni GS, Marucci L, Metalli VD, Glaser SS, Francis H, Mancino MG, Ueno Y, Barbaro B, Benedetti A, Attili AF, Alvaro D.

Gastroenterology. 2004 Oct;127(4):1198-209.PMID: 15480997 [PubMed - indexed for MEDLINE]Related articles

cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway.

Francis H, Glaser S, Ueno Y, Lesage G, Marucci L, Benedetti A, Taffetani S, Marzioni M, Alvaro D, Venter J, Reichenbach R, Fava G, Phinizy JL, Alpini G.

J Hepatol. 2004 Oct;41(4):528-37.PMID: 15464232 [PubMed - indexed for MEDLINE]Related articles

Tamoxifen in treatment of primary biliary cirrhosis.

Invernizzi P, Alvaro D, Crosignani A, Gaudio E, Podda M.

Hepatology. 2004 Apr;39(4):1175-6. No abstract available. PMID: 15057925 [PubMed - indexed for MEDLINE]Related articles

White coat hypertension in patients with obstructive sleep apnea-hypopnea syndrome.

García-Río F, Pino JM, Alonso A, Arias MA, Martínez I, Alvaro D, Villamor J.

Chest. 2004 Mar;125(3):817-22.PMID: 15006937 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of ERK/JNK/p70S6K in two rat models of liver injury and fibrosis.

Svegliati-Baroni G, Ridolfi F, Caradonna Z, Alvaro D, Marzioni M, Saccomanno S, Candelaresi C, Trozzi L, Macarri G, Benedetti A, Folli F.

J Hepatol. 2003 Oct;39(4):528-37.PMID: 12971962 [PubMed - indexed for MEDLINE]Related articles

Gastrin reverses established cholangiocyte proliferation and enhanced secretin-stimulated ductal secretion of BDL rats by activation of apoptosis through increased expression of Ca2+- dependent PKC isoforms.

Glaser S, Alvaro D, Ueno Y, Francis H, Marzioni M, Phinizy JL, Baumann B, Mancino MG, Venter J, LeSage G, Alpini G.

Liver Int. 2003 Apr;23(2):78-88.PMID: 12698962 [PubMed - indexed for MEDLINE]Related articles