PubMed

Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers.

Altavilla D, Bitto A, Polito F, Marini H, Minutoli L, Di Stefano V, Irrera N, Cattarini G, Squadrito F.

Cardiovasc Hematol Agents Med Chem. 2009 Oct;7(4):313-21.PMID: 19860658 [PubMed - in process]Related articles

Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice: a comparison study with methylprednisolone.

Messina S, Bitto A, Aguennouz M, Mazzeo A, Migliorato A, Polito F, Irrera N, Altavilla D, Vita GL, Russo M, Naro A, De Pasquale MG, Rizzuto E, Musarò A, Squadrito F, Vita G.

Exp Neurol. 2009 Dec;220(2):349-58. Epub 2009 Sep 25.PMID: 19786019 [PubMed - in process]Related articles

Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages.

Altavilla D, Squadrito F, Bitto A, Polito F, Burnett BP, Di Stefano V, Minutoli L.

Br J Pharmacol. 2009 Aug;157(8):1410-8.PMID: 19681869 [PubMed - in process]Related articles

High mobility group box-1 expression correlates with poor outcome in lung injury patients.

Bitto A, Barone M, David A, Polito F, Familiari D, Monaco F, Giardina M, David T, Messina R, Noto A, Di Stefano V, Altavilla D, Bonaiuto A, Minutoli L, Guarini S, Ottani A, Squadrito F, Venuti FS.

Pharmacol Res. 2009 Aug 8. [Epub ahead of print]PMID: 19666121 [PubMed - as supplied by publisher]Related articles

Efficacy of genistein aglycone on some cardiovascular risk factors and homocysteine levels: A follow-up study.

Marini H, Bitto A, Altavilla D, Burnett BP, Polito F, Di Stefano V, Minutoli L, Atteritano M, Levy RM, Frisina N, Mazzaferro S, Frisina A, D'Anna R, Cancellieri F, Cannata ML, Corrado F, Lubrano C, Marini R, Adamo EB, Squadrito F.

Nutr Metab Cardiovasc Dis. 2009 Jul 22. [Epub ahead of print]PMID: 19631515 [PubMed - as supplied by publisher]Related articles

Cytochrome P450 (CYP1A) induction in sea bream (Sparus Aurata) gills and liver following exposure to polychlorobiphenyls (PCBs).

Calò M, Bitto A, Lo Cascio P, Polito F, Lauriano ER, Minutoli L, Altavilla D, Squadrito F.

Vet Res Commun. 2009 Sep;33 Suppl 1:181-4. No abstract available. PMID: 19588260 [PubMed - in process]Related articles

Functional recovery after delayed treatment of ischemic stroke with melanocortins is associated with overexpression of the activity-dependent gene Zif268.

Giuliani D, Ottani A, Minutoli L, Stefano VD, Galantucci M, Bitto A, Zaffe D, Altavilla D, Botticelli AR, Squadrito F, Guarini S.

Brain Behav Immun. 2009 Aug;23(6):844-50. Epub 2009 Apr 5.PMID: 19345727 [PubMed - indexed for MEDLINE]Related articles

Protective effect of genistein aglycone on the development of osteonecrosis of the femoral head and secondary osteoporosis induced by methylprednisolone in rats.

Bitto A, Polito F, Burnett B, Levy R, Di Stefano V, Armbruster MA, Marini H, Minutoli L, Altavilla D, Squadrito F.

J Endocrinol. 2009 Jun;201(3):321-8. Epub 2009 Mar 30.PMID: 19332450 [PubMed - indexed for MEDLINE]Related articles

Genistein aglycone reverses glucocorticoid-induced osteoporosis and increases bone breaking strength in rats: a comparative study with alendronate.

Bitto A, Burnett BP, Polito F, Levy RM, Marini H, Di Stefano V, Irrera N, Armbruster MA, Minutoli L, Altavilla D, Squadrito F.

Br J Pharmacol. 2009 Apr;156(8):1287-95. Epub 2009 Mar 19.PMID: 19302595 [PubMed - in process]Related articles

Peroxisome proliferator activated receptor beta/delta activation prevents extracellular regulated kinase 1/2 phosphorylation and protects the testis from ischemia and reperfusion injury.

Minutoli L, Antonuccio P, Polito F, Bitto A, Squadrito F, Irrera N, Nicotina PA, Fazzari C, Montalto AS, Di Stefano V, Romeo C, Altavilla D.

J Urol. 2009 Apr;181(4):1913-21. Epub 2009 Feb 23.PMID: 19237170 [PubMed - indexed for MEDLINE]Related articles

Mitogen-activated protein kinase 3/mitogen-activated protein kinase 1 activates apoptosis during testicular ischemia-reperfusion injury in a nuclear factor-kappaB-independent manner.

Minutoli L, Antonuccio P, Polito F, Bitto A, Squadrito F, Di Stefano V, Nicotina PA, Fazzari C, Maisano D, Romeo C, Altavilla D.

Eur J Pharmacol. 2009 Feb 14;604(1-3):27-35. Epub 2008 Dec 24.PMID: 19135439 [PubMed - indexed for MEDLINE]Related articles

Effects of aglycone genistein in a rat experimental model of postmenopausal metabolic syndrome.

Bitto A, Altavilla D, Bonaiuto A, Polito F, Minutoli L, Di Stefano V, Giuliani D, Guarini S, Arcoraci V, Squadrito F.

J Endocrinol. 2009 Mar;200(3):367-76. Epub 2008 Dec 9.PMID: 19066292 [PubMed - indexed for MEDLINE]Related articles

Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 2-year randomized, double-blind, placebo-controlled study.

D'Anna R, Cannata ML, Marini H, Atteritano M, Cancellieri F, Corrado F, Triolo O, Rizzo P, Russo S, Gaudio A, Frisina N, Bitto A, Polito F, Minutoli L, Altavilla D, Adamo EB, Squadrito F.

Menopause. 2009 Mar-Apr;16(2):301-6.PMID: 19034051 [PubMed - indexed for MEDLINE]Related articles

Vagus nerve mediates the protective effects of melanocortins against cerebral and systemic damage after ischemic stroke.

Ottani A, Giuliani D, Mioni C, Galantucci M, Minutoli L, Bitto A, Altavilla D, Zaffe D, Botticelli AR, Squadrito F, Guarini S.

J Cereb Blood Flow Metab. 2009 Mar;29(3):512-23. Epub 2008 Nov 19.PMID: 19018269 [PubMed - indexed for MEDLINE]Related articles

Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease.

Bitto A, Polito F, Altavilla D, Minutoli L, Migliorato A, Squadrito F.

J Vasc Surg. 2008 Nov;48(5):1292-300.PMID: 18971038 [PubMed - indexed for MEDLINE]Related articles

Protective effects of IRFI-042 in monensin induced neurotoxicity in chicks.

Calò M, Marini H, Bitto A, Altavilla D, Polito F, Minutoli L, Lo Cascio P, Antoci S, Squadrito F.

Food Chem Toxicol. 2008 Nov;46(11):3528-33. Epub 2008 Sep 13.PMID: 18834916 [PubMed - indexed for MEDLINE]Related articles

Anti-inflammatory effects of the methanol extract of Sedum telephium ssp. maximum in lipopolysaccharide- stimulated rat peritoneal macrophages.

Altavilla D, Polito F, Bitto A, Minutoli L, Miraldi E, Fiumara T, Biagi M, Marini H, Giachetti D, Vaccaro M, Squadrito F.

Pharmacology. 2008;82(4):250-6. Epub 2008 Sep 26.PMID: 18818510 [PubMed - indexed for MEDLINE]Related articles

Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study.

Marini H, Bitto A, Altavilla D, Burnett BP, Polito F, Di Stefano V, Minutoli L, Atteritano M, Levy RM, D'Anna R, Frisina N, Mazzaferro S, Cancellieri F, Cannata ML, Corrado F, Frisina A, Adamo V, Lubrano C, Sansotta C, Marini R, Adamo EB, Squadrito F.

J Clin Endocrinol Metab. 2008 Dec;93(12):4787-96. Epub 2008 Sep 16.PMID: 18796517 [PubMed - indexed for MEDLINE]Related articles

Effects of genistein aglycone in osteoporotic, ovariectomized rats: a comparison with alendronate, raloxifene and oestradiol.

Bitto A, Burnett BP, Polito F, Marini H, Levy RM, Armbruster MA, Minutoli L, Di Stefano V, Irrera N, Antoci S, Granese R, Squadrito F, Altavilla D.

Br J Pharmacol. 2008 Nov;155(6):896-905. Epub 2008 Aug 11.PMID: 18695641 [PubMed - indexed for MEDLINE]Related articlesFree article

Trehalose: a biophysics approach to modulate the inflammatory response during endotoxic shock.

Minutoli L, Altavilla D, Bitto A, Polito F, Bellocco E, Laganà G, Fiumara T, Magazù S, Migliardo F, Venuti FS, Squadrito F.

Eur J Pharmacol. 2008 Jul 28;589(1-3):272-80. Epub 2008 Apr 12.PMID: 18555988 [PubMed - indexed for MEDLINE]Related articles

Polydeoxyribonucleotide improves angiogenesis and wound healing in experimental thermal injury.

Bitto A, Galeano M, Squadrito F, Minutoli L, Polito F, Dye JF, Clayton EA, Calò M, Venuti FS, Vaccaro M, Altavilla D.

Crit Care Med. 2008 May;36(5):1594-602.PMID: 18434887 [PubMed - indexed for MEDLINE]Related articles

OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration.

Marini H, Minutoli L, Polito F, Bitto A, Altavilla D, Atteritano M, Gaudio A, Mazzaferro S, Frisina A, Frisina N, Lubrano C, Bonaiuto M, D'Anna R, Cannata ML, Corrado F, Cancellieri F, Faraci M, Marini R, Adamo EB, Wilson S, Squadrito F.

J Bone Miner Res. 2008 May;23(5):715-20.PMID: 18433304 [PubMed - indexed for MEDLINE]Related articles

Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse.

Galeano M, Bitto A, Altavilla D, Minutoli L, Polito F, Calò M, Lo Cascio P, Stagno d'Alcontres F, Squadrito F.

Wound Repair Regen. 2008 Mar-Apr;16(2):208-17.PMID: 18318806 [PubMed - indexed for MEDLINE]Related articles

Simvastatin enhances VEGF production and ameliorates impaired wound healing in experimental diabetes.

Bitto A, Minutoli L, Altavilla D, Polito F, Fiumara T, Marini H, Galeano M, Calò M, Lo Cascio P, Bonaiuto M, Migliorato A, Caputi AP, Squadrito F.

Pharmacol Res. 2008 Feb;57(2):159-69. Epub 2008 Feb 2.PMID: 18316203 [PubMed - indexed for MEDLINE]Related articles

Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression.

Bitto A, Minutoli L, Galeano MR, Altavilla D, Polito F, Fiumara T, Calò M, Lo Cascio P, Zentilin L, Giacca M, Squadrito F.

Clin Sci (Lond). 2008 Jun;114(12):707-18.PMID: 18078386 [PubMed - indexed for MEDLINE]Related articles

Microsurgical arterovenous loops and biological templates: a novel in vivo chamber for tissue engineering.

Manasseri B, Cuccia G, Moimas S, D'Alcontres FS, Polito F, Bitto A, Altavilla D, Squadrito F, Geuna S, Pattarini L, Zentilin L, Collesi C, Puligadda U, Giacca M, Colonna MR.

Microsurgery. 2007;27(7):623-9.PMID: 17868145 [PubMed - indexed for MEDLINE]Related articles

Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study.

Atteritano M, Marini H, Minutoli L, Polito F, Bitto A, Altavilla D, Mazzaferro S, D'Anna R, Cannata ML, Gaudio A, Frisina A, Frisina N, Corrado F, Cancellieri F, Lubrano C, Bonaiuto M, Adamo EB, Squadrito F.

J Clin Endocrinol Metab. 2007 Aug;92(8):3068-75. Epub 2007 May 22.PMID: 17682090 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of mitogen-activated protein kinases (MAPKs) during testicular ischemia-reperfusion injury in nuclear factor-kappaB knock-out mice.

Minutoli L, Antonuccio P, Polito F, Bitto A, Fiumara T, Squadrito F, Nicotina PA, Arena S, Marini H, Romeo C, Altavilla D.

Life Sci. 2007 Jul 12;81(5):413-22. Epub 2007 Jun 30.PMID: 17631357 [PubMed - indexed for MEDLINE]Related articles

Genistein administration & climacteric symptoms: from plasma levels to biological activity.

Bitto A, Minutoli L, Squadrito F, D'Anna R, Polito F, Altavilla D.

Indian J Med Res. 2007 Apr;125(4):508-9. No abstract available. PMID: 17598936 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial.

Marini H, Minutoli L, Polito F, Bitto A, Altavilla D, Atteritano M, Gaudio A, Mazzaferro S, Frisina A, Frisina N, Lubrano C, Bonaiuto M, D'Anna R, Cannata ML, Corrado F, Adamo EB, Wilson S, Squadrito F.

Ann Intern Med. 2007 Jun 19;146(12):839-47.PMID: 17577003 [PubMed - indexed for MEDLINE]Related articlesFree article

VEGF overexpression via adeno-associated virus gene transfer promotes skeletal muscle regeneration and enhances muscle function in mdx mice.

Messina S, Mazzeo A, Bitto A, Aguennouz M, Migliorato A, De Pasquale MG, Minutoli L, Altavilla D, Zentilin L, Giacca M, Squadrito F, Vita G.

FASEB J. 2007 Nov;21(13):3737-46. Epub 2007 Jun 15.PMID: 17575261 [PubMed - indexed for MEDLINE]Related articlesFree article

Raxofelast, (+/-)5-(acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic acid: a new antioxidant to modulate the inflammatory response during ischemia-reperfusion injury and impaired wound healing.

Bitto A, Minutoli L, Squadrito F, Polito F, Altavilla D.

Mini Rev Med Chem. 2007 Mar;7(3):339-43. Review.PMID: 17346222 [PubMed - indexed for MEDLINE]Related articles

Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 1-year randomized, double-blind, placebo-controlled study.

D'Anna R, Cannata ML, Atteritano M, Cancellieri F, Corrado F, Baviera G, Triolo O, Antico F, Gaudio A, Frisina N, Bitto A, Polito F, Minutoli L, Altavilla D, Marini H, Squadrito F.

Menopause. 2007 Jul-Aug;14(4):648-55.PMID: 17251874 [PubMed - indexed for MEDLINE]Related articles

The disaccharide trehalose inhibits proinflammatory phenotype activation in macrophages and prevents mortality in experimental septic shock.

Minutoli L, Altavilla D, Bitto A, Polito F, Bellocco E, Laganà G, Giuliani D, Fiumara T, Magazù S, Ruggeri P, Guarini S, Squadrito F.

Shock. 2007 Jan;27(1):91-6.PMID: 17172986 [PubMed - indexed for MEDLINE]Related articles

Lipid peroxidation activates mitogen-activated protein kinases in testicular ischemia-reperfusion injury.

Antonuccio P, Minutoli L, Romeo C, Nicòtina PA, Bitto A, Arena S, Altavilla D, Zuccarello B, Polito F, Squadrito F.

J Urol. 2006 Oct;176(4 Pt 1):1666-72.PMID: 16952711 [PubMed - indexed for MEDLINE]Related articles

Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects againts splanchic artery occlusion shock.

Altavilla D, Guarini S, Bitto A, Mioni C, Giuliani D, Bigiani A, Squadrito G, Minutoli L, Venuti FS, Messineo F, De Meo V, Bazzani C, Squadrito F.

Shock. 2006 May;25(5):500-6.PMID: 16680015 [PubMed - indexed for MEDLINE]Related articles

Broad therapeutic treatment window of [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils.

Giuliani D, Leone S, Mioni C, Bazzani C, Zaffe D, Botticelli AR, Altavilla D, Galantucci M, Minutoli L, Bitto A, Squadrito F, Guarini S.

Eur J Pharmacol. 2006 May 24;538(1-3):48-56. Epub 2006 Mar 24.PMID: 16647700 [PubMed - indexed for MEDLINE]Related articles

Lipid peroxidation inhibition blunts nuclear factor-kappaB activation, reduces skeletal muscle degeneration, and enhances muscle function in mdx mice.

Messina S, Altavilla D, Aguennouz M, Seminara P, Minutoli L, Monici MC, Bitto A, Mazzeo A, Marini H, Squadrito F, Vita G.

Am J Pathol. 2006 Mar;168(3):918-26.PMID: 16507907 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds.

Galeano M, Altavilla D, Bitto A, Minutoli L, Calò M, Lo Cascio P, Polito F, Giugliano G, Squadrito G, Mioni C, Giuliani D, Venuti FS, Squadrito F.

Crit Care Med. 2006 Apr;34(4):1139-46.PMID: 16484928 [PubMed - indexed for MEDLINE]Related articles

Nuclear factor kappa-B blockade reduces skeletal muscle degeneration and enhances muscle function in Mdx mice.

Messina S, Bitto A, Aguennouz M, Minutoli L, Monici MC, Altavilla D, Squadrito F, Vita G.

Exp Neurol. 2006 Mar;198(1):234-41. Epub 2006 Jan 10.PMID: 16410003 [PubMed - indexed for MEDLINE]Related articles

Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats.

Mioni C, Bazzani C, Giuliani D, Altavilla D, Leone S, Ferrari A, Minutoli L, Bitto A, Marini H, Zaffe D, Botticelli AR, Iannone A, Tomasi A, Bigiani A, Bertolini A, Squadrito F, Guarini S.

Crit Care Med. 2005 Nov;33(11):2621-8.PMID: 16276189 [PubMed - indexed for MEDLINE]Related articles

Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia.

Giuliani D, Mioni C, Altavilla D, Leone S, Bazzani C, Minutoli L, Bitto A, Cainazzo MM, Marini H, Zaffe D, Botticelli AR, Pizzala R, Savio M, Necchi D, Schiöth HB, Bertolini A, Squadrito F, Guarini S.

Endocrinology. 2006 Mar;147(3):1126-35. Epub 2005 Oct 27.PMID: 16254026 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of lipid peroxidation by IRFI 042, a vitamin E analogue, decreases monensin cardiotoxicity in chicks.

Calò M, Altavilla D, Seminara P, Marini H, Minutoli L, Bitto A, Naccari F, Squadrito F.

Toxicol Appl Pharmacol. 2005 Oct 15;208(2):137-44.PMID: 16183387 [PubMed - indexed for MEDLINE]Related articles

Lipid peroxidation inhibition by raxofelast improves angiogenesis and wound healing in experimental burn wounds.

Altavilla D, Galeano M, Bitto A, Minutoli L, Squadrito G, Seminara P, Venuti FS, Torre V, Calò M, Colonna M, Lo Cascio P, Giugliano G, Scuderi N, Mioni C, Leone S, Squadrito F.

Shock. 2005 Jul;24(1):85-91.PMID: 15988325 [PubMed - indexed for MEDLINE]Related articles

Evidence for a role of mitogen-activated protein kinase 3/mitogen-activated protein kinase in the development of testicular ischemia-reperfusion injury.

Minutoli L, Antonuccio P, Romeo C, Nicòtina PA, Bitto A, Arena S, Polito F, Altavilla D, Turiaco N, Cutrupi A, Zuccarello B, Squadrito F.

Biol Reprod. 2005 Oct;73(4):730-6. Epub 2005 Jun 8.PMID: 15944243 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum levels of osteoprotegerin and RANKL in patients with ST elevation acute myocardial infarction.

Crisafulli A, Micari A, Altavilla D, Saporito F, Sardella A, Passaniti M, Raffa S, D'anneo G, Lucà F, Mioni C, Arrigo F, Squadrito F.

Clin Sci (Lond). 2005 Oct;109(4):389-95.PMID: 15926884 [PubMed - indexed for MEDLINE]Related articles

Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women.

Crisafulli A, Altavilla D, Marini H, Bitto A, Cucinotta D, Frisina N, Corrado F, D'Anna R, Squadrito G, Adamo EB, Marini R, Romeo A, Cancellieri F, Buemi M, Squadrito F.

Menopause. 2005 Mar;12(2):186-92.PMID: 15772566 [PubMed - indexed for MEDLINE]Related articles

Lipid peroxidation triggers both c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK) activation and neointimal hyperplasia induced by cessation of blood flow in the mouse carotid artery.

Squadrito F, Minutoli L, Esposito M, Bitto A, Marini H, Seminara P, Crisafulli A, Passaniti M, Adamo EB, Marini R, Guarini S, Altavilla D.

Atherosclerosis. 2005 Feb;178(2):295-302.PMID: 15694937 [PubMed - indexed for MEDLINE]Related articles

Protective effects of antioxidant raxofelast in alcohol-induced liver disease in mice.

Altavilla D, Marini H, Seminara P, Squadrito G, Minutoli L, Passaniti M, Bitto A, Calapai G, Calò M, Caputi AP, Squadrito F.

Pharmacology. 2005 Apr;74(1):6-14. Epub 2004 Dec 27.PMID: 15627848 [PubMed - indexed for MEDLINE]Related articles

Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis.

Minutoli L, Altavilla D, Marini H, Passaniti M, Bitto A, Seminara P, Venuti FS, Famulari C, Macrì A, Versaci A, Squadrito F.

Life Sci. 2004 Oct 29;75(24):2853-66.PMID: 15454338 [PubMed - indexed for MEDLINE]Related articles