PubMed

Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood.

Luopajärvi K, Savilahti E, Virtanen SM, Ilonen J, Knip M, Akerblom HK, Vaarala O.

Pediatr Diabetes. 2008 Oct;9(5):434-41. Epub 2008 May 21.PMID: 18503496 [PubMed - indexed for MEDLINE]Related articles

Cohort profile: the cardiovascular risk in Young Finns Study.

Raitakari OT, Juonala M, Rönnemaa T, Keltikangas-Järvinen L, Räsänen L, Pietikäinen M, Hutri-Kähönen N, Taittonen L, Jokinen E, Marniemi J, Jula A, Telama R, Kähönen M, Lehtimäki T, Akerblom HK, Viikari JS.

Int J Epidemiol. 2008 Dec;37(6):1220-6. Epub 2008 Feb 8. No abstract available. PMID: 18263651 [PubMed - indexed for MEDLINE]Related articles

Does the secular increase in body mass in children contribute to the increasing incidence of type 1 diabetes?

Knip M, Reunanen A, Virtanen SM, Nuutinen M, Viikari J, Akerblom HK.

Pediatr Diabetes. 2008 Jun;9(3 Pt 2):46-9. Epub 2008 Jan 21.PMID: 18221438 [PubMed - indexed for MEDLINE]Related articles

Prediction of type 1 diabetes among siblings of affected children and in the general population.

Siljander HT, Veijola R, Reunanen A, Virtanen SM, Akerblom HK, Knip M.

Diabetologia. 2007 Nov;50(11):2272-5. Epub 2007 Sep 4.PMID: 17768605 [PubMed - indexed for MEDLINE]Related articles

Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations.

Laine AP, Holmberg H, Nilsson A, Ortqvist E, Kiviniemi M, Vaarala O, Akerblom HK, Simell O, Knip M, Ludvigsson J, Ivarsson SA, Larsson K, Lernmark A, Ilonen J; Finnish Paediatric Diabetes Registry.

Dis Markers. 2007;23(3):139-45.PMID: 17473382 [PubMed - indexed for MEDLINE]Related articlesFree article

Maternal antibodies in breast milk protect the child from enterovirus infections.

Sadeharju K, Knip M, Virtanen SM, Savilahti E, Tauriainen S, Koskela P, Akerblom HK, Hyöty H; Finnish TRIGR Study Group.

Pediatrics. 2007 May;119(5):941-6.PMID: 17473095 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced CCR4, interleukin-13 and GATA-3 up-regulation in response to type 2 cytokines of cord blood T lymphocytes in infants at genetic risk of type 1 diabetes.

Luopajärvi K, Skarsvik S, Ilonen J, Akerblom HK, Vaarala O.

Immunology. 2007 Jun;121(2):189-96. Epub 2007 Jan 18.PMID: 17244154 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary insulin as an immunogen and tolerogen.

Tiittanen M, Paronen J, Savilahti E, Virtanen SM, Ilonen J, Knip M, Akerblom HK, Vaarala O; Finnish TRIGR Study Group.

Pediatr Allergy Immunol. 2006 Nov;17(7):538-43.PMID: 17014631 [PubMed - indexed for MEDLINE]Related articles

Human leukocyte antigen non-class II determinants for type 1 diabetes in the Finnish population.

Gombos Z, Wachowicz J, Veijola R, Akerblom HK, Simell O, Knip M, Ilonen J, Hermann R.

Hum Immunol. 2006 Sep;67(9):714-21. Epub 2006 Jun 22.PMID: 17002902 [PubMed - indexed for MEDLINE]Related articles

Relative validity of a dietary interview for assessing infant diet and compliance in a dietary intervention trial.

Vähätalo L, Bärlund S, Hannila ML, Uusitalo U, Pigg HM, Salonen M, Nucci A, Krischer JP, Knip M, Akerblom HK, Virtanen SM.

Matern Child Nutr. 2006 Jul;2(3):181-7.PMID: 16881930 [PubMed - indexed for MEDLINE]Related articles

Models for predicting type 1 diabetes in siblings of affected children.

Mrena S, Virtanen SM, Laippala P, Kulmala P, Hannila ML, Akerblom HK, Knip M.

Diabetes Care. 2006 Mar;29(3):662-7.PMID: 16505523 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum alpha-tocopherol concentrations and risk of type 1 diabetes mellitus: a cohort study in siblings of affected children.

Uusitalo L, Knip M, Kenward MG, Alfthan G, Sundvall J, Aro A, Reunanen A, Akerblom HK, Virtanen SM; Childhood Diabetes in Finland Study Group.

J Pediatr Endocrinol Metab. 2005 Dec;18(12):1409-16.PMID: 16459467 [PubMed - indexed for MEDLINE]Related articles

Environmental triggers and determinants of type 1 diabetes.

Knip M, Veijola R, Virtanen SM, Hyöty H, Vaarala O, Akerblom HK.

Diabetes. 2005 Dec;54 Suppl 2:S125-36. Review.PMID: 16306330 [PubMed - indexed for MEDLINE]Related articlesFree article

Maternal consumption of dairy products during pregnancy and lactation, and the development of cow's milk antibodies in the offspring.

Erkkola M, Kronberg-Kippilä C, Savilahti E, Kenward MG, Salonen M, Ilonen J, Knip M, Akerblom HK, Virtanen SM.

Acta Paediatr. 2005 Jun;94(6):696-704.PMID: 16188771 [PubMed - indexed for MEDLINE]Related articles

Early nutrition and later diabetes risk.

Knip M, Akerblom HK.

Adv Exp Med Biol. 2005;569:142-50. Review.PMID: 16137119 [PubMed - indexed for MEDLINE]Related articles

Early programming of diabetes risk--an introduction.

Akerblom HK.

Adv Exp Med Biol. 2005;569:139-41. Review. No abstract available. PMID: 16137118 [PubMed - indexed for MEDLINE]Related articles

Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study.

Akerblom HK, Virtanen SM, Ilonen J, Savilahti E, Vaarala O, Reunanen A, Teramo K, Hämäläinen AM, Paronen J, Riikjärv MA, Ormisson A, Ludvigsson J, Dosch HM, Hakulinen T, Knip M; National TRIGR Study Groups.

Diabetologia. 2005 May;48(5):829-37. Epub 2005 Apr 19. Erratum in: Diabetologia. 2005 Aug;48(8):1676. Riikjärv, MA [added]; Ormisson, A [added]; Ludvigsson, J [added]; Dosch, HM [added]; Hakulinen, T [added]; Knip, M [added]. PMID: 15838685 [PubMed - indexed for MEDLINE]Related articles

IA-2 antibody epitopes and isotypes during the prediabetic process in siblings of children with type 1 diabetes.

Hoppu S, Härkönen T, Ronkainen MS, Akerblom HK, Knip M; Childhood Diabetes in Finland Study Group.

J Autoimmun. 2004 Dec;23(4):361-70.PMID: 15571930 [PubMed - indexed for MEDLINE]Related articles

Geographic origin as a determinant of carotid artery intima-media thickness and brachial artery flow-mediated dilation: the Cardiovascular Risk in Young Finns study.

Juonala M, Viikari JS, Kähönen M, Taittonen L, Rönnemaa T, Laitinen T, Mäki-Torkko N, Mikkilä V, Räsänen L, Akerblom HK, Pesonen E, Raitakari OT.

Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):392-8. Epub 2004 Nov 11.PMID: 15539623 [PubMed - indexed for MEDLINE]Related articlesFree article

A linkage study of 12 IDDM susceptibility loci in the Finnish population.

Laine AP, Nejentsev S, Veijola R, Korpinen E, Sjöroos M, Simell O, Knip M, Akerblom HK, Ilonen J.

Diabetes Metab Res Rev. 2004 Mar-Apr;20(2):144-9.PMID: 15037990 [PubMed - indexed for MEDLINE]Related articles

GAD65 antibody isotypes and epitope recognition during the prediabetic process in siblings of children with type I diabetes.

Hoppu S, Ronkainen MS, Kulmala P, Akerblom HK, Knip M; Childhood Diabetes in Finland Study Group.

Clin Exp Immunol. 2004 Apr;136(1):120-8.PMID: 15030523 [PubMed - indexed for MEDLINE]Related articlesFree article

Natural course of preclinical type 1 diabetes in siblings of affected children.

Mrena S, Savola K, Kulmala P, Akerblom HK, Knip M; Childhood Diabetes in Finland Study Group.

Acta Paediatr. 2003 Dec;92(12):1403-10.PMID: 14971790 [PubMed - indexed for MEDLINE]Related articles

The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population.

Laine AP, Hermann R, Knip M, Simell O, Akerblom HK, Ilonen J.

Tissue Antigens. 2004 Jan;63(1):72-4.PMID: 14651526 [PubMed - indexed for MEDLINE]Related articles

Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study.

Raitakari OT, Juonala M, Kähönen M, Taittonen L, Laitinen T, Mäki-Torkko N, Järvisalo MJ, Uhari M, Jokinen E, Rönnemaa T, Akerblom HK, Viikari JS.

JAMA. 2003 Nov 5;290(17):2277-83.PMID: 14600186 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: an analysis of 622 nuclear families.

Hermann R, Turpeinen H, Laine AP, Veijola R, Knip M, Simell O, Sipilä I, Akerblom HK, Ilonen J.

Tissue Antigens. 2003 Aug;62(2):162-9.PMID: 12889996 [PubMed - indexed for MEDLINE]Related articles

The HLA-DR phenotype modulates the humoral immune response to enterovirus antigens.

Sadeharju K, Knip M, Hiltunen M, Akerblom HK, Hyöty H.

Diabetologia. 2003 Aug;46(8):1100-5. Epub 2003 Jul 5.PMID: 12845430 [PubMed - indexed for MEDLINE]Related articles

Genetic modification of risk assessment based on staging of preclinical type 1 diabetes in siblings of affected children.

Mrena S, Savola K, Kulmala P, Reijonen H, Ilonen J, Akerblom HK, Knip M; Childhood Diabetes in Finland Study Group.

J Clin Endocrinol Metab. 2003 Jun;88(6):2682-9.PMID: 12788873 [PubMed - indexed for MEDLINE]Related articlesFree article

Enterovirus infections as a risk factor for type I diabetes: virus analyses in a dietary intervention trial.

Sadeharju K, Hämäläinen AM, Knip M, Lönnrot M, Koskela P, Virtanen SM, Ilonen J, Akerblom HK, Hyöty H; Finnish TRIGR Study Group.

Clin Exp Immunol. 2003 May;132(2):271-7.PMID: 12699416 [PubMed - indexed for MEDLINE]Related articlesFree article

Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes--indication of an increased environmental pressure?

Hermann R, Knip M, Veijola R, Simell O, Laine AP, Akerblom HK, Groop PH, Forsblom C, Pettersson-Fernholm K, Ilonen J; FinnDiane Study Group.

Diabetologia. 2003 Mar;46(3):420-5. Epub 2003 Mar 18.PMID: 12687342 [PubMed - indexed for MEDLINE]Related articles

-to: Pani MA, Van Autreve J, Van Der Auwera BJ, Gorus FK, Badenhoop K (2002) Non-transmitted maternal HLA DQ2 or DQ8 alleles and risk of Type I diabetes in offspring: the importance of foetal or post partum exposure to diabetogenic molecules. Diabetologia 45:1340-1343.

Hermann R, Veijola R, Sipilä I, Knip M, Akerblom HK, Simell O, Ilonen J.

Diabetologia. 2003 Apr;46(4):588-9; author reply 591-2. Epub 2003 Apr 9. No abstract available. PMID: 12684751 [PubMed - indexed for MEDLINE]Related articles

Soluble adhesion molecules in pre-clinical Type 1 diabetes: a prospective study.

Toivonen AM, Kulmala P, Savola K, Akerblom HK, Knip M.

Diabetologia. 2003 Apr;46(4):492-5. Epub 2003 Apr 9. Erratum in: Diabetologia. 2004 Jan;47(1):154. PMID: 12684750 [PubMed - indexed for MEDLINE]Related articles

Increased frequency of islet cell antibodies in unaffected brothers of children with type 1 diabetes.

Eskola V, Vähäsalo P, Akerblom HK, Knip M; Finnish ENDIT Study Group.

Horm Res. 2003;59(4):195-200.PMID: 12649574 [PubMed - indexed for MEDLINE]Related articles

Intestinal permeability to mannitol and lactulose in children with type 1 diabetes with the HLA-DQB1*02 allele.

Kuitunen M, Saukkonen T, Ilonen J, Akerblom HK, Savilahti E.

Autoimmunity. 2002 Aug;35(5):365-8.PMID: 12515291 [PubMed - indexed for MEDLINE]Related articles

CD86 gene polymorphisms: no association with Type I diabetes among Finnish subjects.

Turpeinen H, Laine AP, Nejentsev S, Sjöroos M, Ilonen J, Simell O, Veijola R, Knip M, Akerblom HK, Knip M.

Diabetologia. 2002 Jul;45(7):1041-2. No abstract available. PMID: 12187923 [PubMed - indexed for MEDLINE]Related articles

Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes.

Knip M, Kukko M, Kulmala P, Veijola R, Simell O, Akerblom HK, Ilonen J.

Am J Med Genet. 2002 May 30;115(1):48-54. Review.PMID: 12116176 [PubMed - indexed for MEDLINE]Related articles

Estimation of genetic risk for type 1 diabetes.

Ilonen J, Sjöroos M, Knip M, Veijola R, Simell O, Akerblom HK, Paschou P, Bozas E, Havarani B, Malamitsi-Puchner A, Thymelli J, Vazeou A, Bartsocas CS.

Am J Med Genet. 2002 May 30;115(1):30-6. Review.PMID: 12116174 [PubMed - indexed for MEDLINE]Related articles

Environmental factors in the etiology of type 1 diabetes.

Akerblom HK, Vaarala O, Hyöty H, Ilonen J, Knip M.

Am J Med Genet. 2002 May 30;115(1):18-29. Review.PMID: 12116173 [PubMed - indexed for MEDLINE]Related articles

Coeliac disease in children and adolescents with type 1 diabetes: a study of growth, glycaemic control, and experiences of families.

Saukkonen T, Väisänen S, Akerblom HK, Savilahti E; Childhood Diabetes in Finland Study Group.

Acta Paediatr. 2002;91(3):297-302.PMID: 12022302 [PubMed - indexed for MEDLINE]Related articles

Autoantibodies to GAD, IA-2 and insulin in ICA-positive first-degree relatives of children with type 1 diabetes: a comparison between parents and siblings.

Korhonen S, Knip MM, Kulmala P, Savola K, Akerblom HK, Knip M; Finnish Study Group for ICA Screening.

Diabetes Metab Res Rev. 2002 Jan-Feb;18(1):43-8.PMID: 11921417 [PubMed - indexed for MEDLINE]Related articles

Disease-associated autoantibodies during pregnancy and at birth in families affected by type 1 diabetes.

Hämäläinen AM, Savola K, Kulmala PK, Koskela P, Akerblom HK, Knip M; Finnish TRIGR Study Group.

Clin Exp Immunol. 2001 Nov;126(2):230-5.PMID: 11703365 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamic pattern of disease-associated autoantibodies in siblings of children with type 1 diabetes: a population-based study.

Savola K, Läärä E, Vähäsalo P, Kulmala P, Akerblom HK, Knip M; Childhood Diabetes in Finland Study Group.

Diabetes. 2001 Nov;50(11):2625-32.PMID: 11679444 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalence of coeliac disease in siblings of patients with Type I diabetes is related to the prevalence of DQB1*02 allele.

Saukkonen T, Ilonen J, Akerblom HK, Savilahti E.

Diabetologia. 2001 Aug;44(8):1051-3.PMID: 11484084 [PubMed - indexed for MEDLINE]Related articles

New technologies and genetics of type 1 diabetes.

Ilonen J, Akerblom HK.

Diabetes Technol Ther. 1999 Summer;1(2):205-7. No abstract available. PMID: 11475295 [PubMed - indexed for MEDLINE]Related articles

Pregnancy induces nonimmunoglobulin insulin-binding activity in both maternal and cord blood serum.

Ronkainen MS, Hämäläinen AM, Koskela P, Akerblom HK, Knip M; Finnish Trigr Study Group.

Clin Exp Immunol. 2001 May;124(2):190-6.PMID: 11422194 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in food habits in families with a newly diagnosed child with type 1 diabetes mellitus.

Virtanen SM, Virta-Autio P, Räsänen L, Akerblom HK.

J Pediatr Endocrinol Metab. 2001;14 Suppl 1:627-36. Review.PMID: 11393555 [PubMed - indexed for MEDLINE]Related articles

Increased secretion of TGF-beta1 by peripheral blood mononuclear cells from patients with Type 1 diabetes mellitus with diabetic nephropathy.

Korpinen E, Groop PH, Fagerudd JA, Teppo AM, Akerblom HK, Vaarala O.

Diabet Med. 2001 Feb;18(2):121-5.PMID: 11251675 [PubMed - indexed for MEDLINE]Related articles

Epitope spreading and a varying but not disease-specific GAD65 antibody response in Type I diabetes. The Childhood Diabetes in Finland Study Group.

Söhnlein P, Müller M, Syren K, Hartmann U, Böhm BO, Meinck HM, Knip M, Akerblom HK, Richter W.

Diabetologia. 2000 Feb;43(2):210-7.PMID: 10753043 [PubMed - indexed for MEDLINE]Related articles

Soluble adhesion molecules in preclinical type 1 diabetes. The Childhood Diabetes in Finland Study Group.

Toivonen A, Kulmala P, Savola K, Akerblom HK, Knip M, The Childhood Diabetes In Finl.

Pediatr Res. 2001 Jan;49(1):24-9.PMID: 11134487 [PubMed - indexed for MEDLINE]Related articles

Obesity, increased linear growth, and risk of type 1 diabetes in children.

Hyppönen E, Virtanen SM, Kenward MG, Knip M, Akerblom HK; Childhood Diabetes in Finland Study Group.

Diabetes Care. 2000 Dec;23(12):1755-60.PMID: 11128347 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B.

Nejentsev S, Gombos Z, Laine AP, Veijola R, Knip M, Simell O, Vaarala O, Akerblom HK, Ilonen J.

Diabetes. 2000 Dec;49(12):2217-21.PMID: 11118029 [PubMed - indexed for MEDLINE]Related articlesFree article