PubMed

Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats.

Arden C, Green AR, Hampson LJ, Aiston S, Härndahl L, Greenberg CC, Brady MJ, Freeman S, Poucher SM, Agius L.

FEBS J. 2006 May;273(9):1989-99.PMID: 16640562 [PubMed - indexed for MEDLINE]Related articles

The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes.

Aiston S, Hampson LJ, Arden C, Iynedjian PB, Agius L.

Diabetologia. 2006 Jan;49(1):174-82. Epub 2005 Dec 10.PMID: 16341839 [PubMed - indexed for MEDLINE]Related articles

The glycogenic action of protein targeting to glycogen in hepatocytes involves multiple mechanisms including phosphorylase inactivation and glycogen synthase translocation.

Green AR, Aiston S, Greenberg CC, Freeman S, Poucher SM, Brady MJ, Agius L.

J Biol Chem. 2004 Nov 5;279(45):46474-82. Epub 2004 Aug 18.PMID: 15322104 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators.

Brocklehurst KJ, Payne VA, Davies RA, Carroll D, Vertigan HL, Wightman HJ, Aiston S, Waddell ID, Leighton B, Coghlan MP, Agius L.

Diabetes. 2004 Mar;53(3):535-41.PMID: 14988235 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose.

Aiston S, Green A, Mukhtar M, Agius L.

Biochem J. 2004 Jan 1;377(Pt 1):195-204.PMID: 13678417 [PubMed - indexed for MEDLINE]Related articlesFree article

Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis.

Aiston S, Coghlan MP, Agius L.

Eur J Biochem. 2003 Jul;270(13):2773-81.PMID: 12823547 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase.

Aiston S, Andersen B, Agius L.

Diabetes. 2003 Jun;52(6):1333-9.PMID: 12765941 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis.

Aiston S, Hampson L, Gómez-Foix AM, Guinovart JJ, Agius L.

J Biol Chem. 2001 Jun 29;276(26):23858-66. Epub 2001 Apr 17.PMID: 11309391 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells.

Stubbs M, Aiston S, Agius L.

Diabetes. 2000 Dec;49(12):2048-55.PMID: 11118006 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired glycogen synthesis in hepatocytes from Zucker fatty fa/fa rats: the role of increased phosphorylase activity.

Aiston S, Peak M, Agius L.

Diabetologia. 2000 May;43(5):589-97.PMID: 10855534 [PubMed - indexed for MEDLINE]Related articles

Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase.

Aiston S, Trinh KY, Lange AJ, Newgard CB, Agius L.

J Biol Chem. 1999 Aug 27;274(35):24559-66.PMID: 10455119 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin enhances glycogen storage in hepatocytes by inhibition of phosphorylase and exerts an additive effect with insulin.

Aiston S, Agius L.

Diabetes. 1999 Jan;48(1):15-20.PMID: 9892217 [PubMed - indexed for MEDLINE]Related articlesFree article