PubMed

Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.

Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, Aiello LP, Kern TS, King GL.

Nat Med. 2009 Nov;15(11):1298-306. Epub 2009 Nov 1.PMID: 19881493 [PubMed - in process]Related articles

Diabetes complications and the renin-angiotensin system.

Perkins BA, Aiello LP, Krolewski AS.

N Engl J Med. 2009 Jul 2;361(1):83-5. No abstract available. PMID: 19571288 [PubMed - indexed for MEDLINE]Related articles

Ruboxistaurin mesilate hydrate for diabetic retinopathy.

Schwartz SG, Flynn HW Jr, Aiello LP.

Drugs Today (Barc). 2009 Apr;45(4):269-74. Review.PMID: 19499092 [PubMed - indexed for MEDLINE]Related articles

Possible contribution of hyalocytes to idiopathic epiretinal membrane formation and its contraction.

Kohno RI, Hata Y, Kawahara S, Kita T, Arita R, Mochizuki Y, Aiello LP, Ishibashi T.

Br J Ophthalmol. 2009 Aug;93(8):1020-6. Epub 2009 May 7.PMID: 19429593 [PubMed - indexed for MEDLINE]Related articles

Role of steroids in the management of diabetic macular edema and proliferative diabetic retinopathy.

Silva PS, Sun JK, Aiello LP.

Semin Ophthalmol. 2009 Mar-Apr;24(2):93-9. Review.PMID: 19373693 [PubMed - indexed for MEDLINE]Related articles

Three-year follow-up of a randomized trial comparing focal/grid photocoagulation and intravitreal triamcinolone for diabetic macular edema.

Diabetic Retinopathy Clinical Research Network (DRCR.net), Beck RW, Edwards AR, Aiello LP, Bressler NM, Ferris F, Glassman AR, Hartnett E, Ip MS, Kim JE, Kollman C.

Arch Ophthalmol. 2009 Mar;127(3):245-51.PMID: 19273785 [PubMed - indexed for MEDLINE]Related articles

Sustained moderate visual loss as a predictive end point for visual loss in non-proliferative diabetic retinopathy.

Girach A, Aiello LP, Milton RC, Davis MD, Danis RP, Zhi X, Sheetz MJ, Vignati L; PKC-DRS2 Study Group.

Eye (Lond). 2009 Jan;23(1):209-14. Epub 2008 Nov 7.PMID: 18989348 [PubMed - indexed for MEDLINE]Related articles

Effects of dilation on electronic-ETDRS visual acuity in diabetic patients.

Sun JK, Aiello LP, Stockman M, Cavallerano JD, Kopple A, Eagan S, Qin H, Kollman C, Beck RW, Glassman AR; Diabetic Retinopathy Clinical Research Network.

Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1580-4. Epub 2008 Oct 20.PMID: 18936147 [PubMed - indexed for MEDLINE]Related articles

Targeting intraocular neovascularization and edema--one drop at a time.

Aiello LP.

N Engl J Med. 2008 Aug 28;359(9):967-9. No abstract available. PMID: 18753655 [PubMed - indexed for MEDLINE]Related articles

Effect of ruboxistaurin on the visual acuity decline associated with long-standing diabetic macular edema.

Davis MD, Sheetz MJ, Aiello LP, Milton RC, Danis RP, Zhi X, Girach A, Jimenez MC, Vignati L; PKC-DRS2 Study Group.

Invest Ophthalmol Vis Sci. 2009 Jan;50(1):1-4. Epub 2008 Aug 15.PMID: 18708615 [PubMed - indexed for MEDLINE]Related articles

Optical coherence tomography measurements and analysis methods in optical coherence tomography studies of diabetic macular edema.

Browning DJ, Glassman AR, Aiello LP, Bressler NM, Bressler SB, Danis RP, Davis MD, Ferris FL, Huang SS, Kaiser PK, Kollman C, Sadda S, Scott IU, Qin H; Diabetic Retinopathy Clinical Research Network.

Ophthalmology. 2008 Aug;115(8):1366-71, 1371.e1.PMID: 18675696 [PubMed - indexed for MEDLINE]Related articlesFree article

Can OCT serve as a surrogate for visual acuity in eyes with DME?

Sun JK, Aiello LP.

Curr Diab Rep. 2008 Aug;8(4):255-6. No abstract available. PMID: 18631435 [PubMed]Related articles

Rosiglitazone and delayed onset of proliferative diabetic retinopathy.

Shen LQ, Child A, Weber GM, Folkman J, Aiello LP.

Arch Ophthalmol. 2008 Jun;126(6):793-9.PMID: 18541841 [PubMed - indexed for MEDLINE]Related articlesFree article

Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.

Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, Hau VS, Kaminoh Y, Harmon J, Pearson E, Buehler J, Chen Y, Yu B, Tinkham NH, Zabriskie NA, Zeng J, Luo L, Sun JK, Prakash M, Hamam RN, Tonna S, Constantine R, Ronquillo CC, Sadda S, Avery RL, Brand JM, London N, Anduze AL, King GL, Bernstein PS, Watkins S; Genetics of Diabetes and Diabetic Complication Study Group, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):6998-7003. Epub 2008 May 5.PMID: 18458324 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy.

Gao BB, Chen X, Timothy N, Aiello LP, Feener EP.

J Proteome Res. 2008 Jun;7(6):2516-25. Epub 2008 Apr 24.PMID: 18433156 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of time-domain OCT and fundus photographic assessments of retinal thickening in eyes with diabetic macular edema.

Davis MD, Bressler SB, Aiello LP, Bressler NM, Browning DJ, Flaxel CJ, Fong DS, Foster WJ, Glassman AR, Hartnett ME, Kollman C, Li HK, Qin H, Scott IU; Diabetic Retinopathy Clinical Research Network Study Group.

Invest Ophthalmol Vis Sci. 2008 May;49(5):1745-52. Epub 2008 Mar 3.PMID: 18316700 [PubMed - indexed for MEDLINE]Related articlesFree article

Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells.

Geraldes P, Yamagata M, Rook SL, Sassa Y, Ma RC, Clermont A, Gao B, Aiello LP, Feener EP, King GL.

Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5750-5.PMID: 18055828 [PubMed - indexed for MEDLINE]Related articlesFree article

Short-term effects of intravitreal bevacizumab for subfoveal choroidal neovascularization in pathologic myopia.

Hernández-Rojas ML, Quiroz-Mercado H, Dalma-Weiszhausz J, Fromow-Guerra J, Amaya-Espinosa A, Solís-Vivanco A, Reyna-Castelán E, Abraham-Marín M, Martínez-Castellanos MA, Aiello LP.

Retina. 2007 Jul-Aug;27(6):707-12.PMID: 17621179 [PubMed - indexed for MEDLINE]Related articles

Randomized trial of peribulbar triamcinolone acetonide with and without focal photocoagulation for mild diabetic macular edema: a pilot study.

Diabetic Retinopathy Clinical Research Network, Chew E, Strauber S, Beck R, Aiello LP, Antoszyk A, Bressler N, Browning D, Danis R, Fan J, Flaxel C, Friedman S, Glassman A, Kollman C, Lazarus H.

Ophthalmology. 2007 Jun;114(6):1190-6.PMID: 17544778 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study.

Keenan HA, Costacou T, Sun JK, Doria A, Cavellerano J, Coney J, Orchard TJ, Aiello LP, King GL.

Diabetes Care. 2007 Aug;30(8):1995-7. Epub 2007 May 16. No abstract available. PMID: 17507696 [PubMed - indexed for MEDLINE]Related articlesFree article

Relation of optical coherence tomography and unusual angiographic leakage patterns in central serous chorioretinopathy.

Shukla D, Aiello LP, Kolluru C, Baddela S, Jager RD, Kim R.

Eye (Lond). 2008 Apr;22(4):592-6. Epub 2007 Apr 20.PMID: 17464304 [PubMed - indexed for MEDLINE]Related articles

Comparison of the modified Early Treatment Diabetic Retinopathy Study and mild macular grid laser photocoagulation strategies for diabetic macular edema.

Writing Committee for the Diabetic Retinopathy Clinical Research Network, Fong DS, Strauber SF, Aiello LP, Beck RW, Callanan DG, Danis RP, Davis MD, Feman SS, Ferris F, Friedman SM, Garcia CA, Glassman AR, Han DP, Le D, Kollman C, Lauer AK, Recchia FM, Solomon SD.

Arch Ophthalmol. 2007 Apr;125(4):469-80.PMID: 17420366 [PubMed - indexed for MEDLINE]Related articlesFree article

Reproducibility of macular thickness and volume using Zeiss optical coherence tomography in patients with diabetic macular edema.

Diabetic Retinopathy Clinical Research Network, Krzystolik MG, Strauber SF, Aiello LP, Beck RW, Berger BB, Bressler NM, Browning DJ, Chambers RB, Danis RP, Davis MD, Glassman AR, Gonzalez VH, Greenberg PB, Gross JG, Kim JE, Kollman C.

Ophthalmology. 2007 Aug;114(8):1520-5. Epub 2007 Mar 13.PMID: 17353052 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation.

Gao BB, Clermont A, Rook S, Fonda SJ, Srinivasan VJ, Wojtkowski M, Fujimoto JG, Avery RL, Arrigg PG, Bursell SE, Aiello LP, Feener EP.

Nat Med. 2007 Feb;13(2):181-8. Epub 2007 Jan 28.PMID: 17259996 [PubMed - indexed for MEDLINE]Related articles

Diurnal variation in retinal thickening measurement by optical coherence tomography in center-involved diabetic macular edema.

Diabetic Retinopathy Clinical Research Network, Danis RP, Glassman AR, Aiello LP, Antoszyk AN, Beck RW, Browning DJ, Ciardella AP, Kinyoun JL, Murtha TJ, Topping TM, Shami M, Sharuk GS, Wells JA 3rd.

Arch Ophthalmol. 2006 Dec;124(12):1701-7.PMID: 17159029 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship between optical coherence tomography-measured central retinal thickness and visual acuity in diabetic macular edema.

Diabetic Retinopathy Clinical Research Network, Browning DJ, Glassman AR, Aiello LP, Beck RW, Brown DM, Fong DS, Bressler NM, Danis RP, Kinyoun JL, Nguyen QD, Bhavsar AR, Gottlieb J, Pieramici DJ, Rauser ME, Apte RS, Lim JI, Miskala PH.

Ophthalmology. 2007 Mar;114(3):525-36. Epub 2006 Nov 21.PMID: 17123615 [PubMed - indexed for MEDLINE]Related articlesFree article

Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.

Yamagata M, Rook SL, Sassa Y, Ma RC, Geraldes P, Goddard L, Clermont A, Gao B, Salti H, Gundel R, White M, Feener EP, Aiello LP, King GL.

FASEB J. 2006 Oct;20(12):2058-67.PMID: 17012258 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy.

PKC-DRS2 Group, Aiello LP, Davis MD, Girach A, Kles KA, Milton RC, Sheetz MJ, Vignati L, Zhi XE.

Ophthalmology. 2006 Dec;113(12):2221-30. Epub 2006 Sep 20.PMID: 16989901 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte growth factor induces retinal vascular permeability via MAP-kinase and PI-3 kinase without altering retinal hemodynamics.

Clermont AC, Cahill M, Salti H, Rook SL, Rask-Madsen C, Goddard L, Wong JS, Bursell D, Bursell SE, Aiello LP.

Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2701-8.PMID: 16723489 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain.

Sotiropoulos KB, Clermont A, Yasuda Y, Rask-Madsen C, Mastumoto M, Takahashi J, Della Vecchia K, Kondo T, Aiello LP, King GL.

FASEB J. 2006 Jun;20(8):1203-5. Epub 2006 May 3.PMID: 16672634 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of nonmydriatic digital retinal imaging versus dilated ophthalmic examination for nondiabetic eye disease in persons with diabetes.

Chow SP, Aiello LM, Cavallerano JD, Katalinic P, Hock K, Tolson A, Kirby R, Bursell SE, Aiello LP.

Ophthalmology. 2006 May;113(5):833-40.PMID: 16650680 [PubMed - indexed for MEDLINE]Related articles

A modeled economic analysis of a digital tele-ophthalmology system as used by three federal health care agencies for detecting proliferative diabetic retinopathy.

Whited JD, Datta SK, Aiello LM, Aiello LP, Cavallerano JD, Conlin PR, Horton MB, Vigersky RA, Poropatich RK, Challa P, Darkins AW, Bursell SE.

Telemed J E Health. 2005 Dec;11(6):641-51.PMID: 16430383 [PubMed - indexed for MEDLINE]Related articles

Closure of macular hole following vitrectomy for diabetic tractional macular detachment.

Shukla D, Dhoble P, Jager RD, Aiello LP, Ramasamy K.

Eye (Lond). 2006 Dec;20(12):1386-8. Epub 2006 Jan 13. Review. No abstract available. PMID: 16410807 [PubMed - indexed for MEDLINE]Related articles

Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients.

Aiello LP, Clermont A, Arora V, Davis MD, Sheetz MJ, Bursell SE.

Invest Ophthalmol Vis Sci. 2006 Jan;47(1):86-92.PMID: 16384948 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema.

Strøm C, Sander B, Klemp K, Aiello LP, Lund-Andersen H, Larsen M.

Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3855-8.PMID: 16186374 [PubMed - indexed for MEDLINE]Related articlesFree article

A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema.

Cunningham ET Jr, Adamis AP, Altaweel M, Aiello LP, Bressler NM, D'Amico DJ, Goldbaum M, Guyer DR, Katz B, Patel M, Schwartz SD; Macugen Diabetic Retinopathy Study Group.

Ophthalmology. 2005 Oct;112(10):1747-57.PMID: 16154196 [PubMed - indexed for MEDLINE]Related articles

Angiogenic pathways in diabetic retinopathy.

Aiello LP.

N Engl J Med. 2005 Aug 25;353(8):839-41. No abstract available. PMID: 16120866 [PubMed - indexed for MEDLINE]Related articles

Nonmydriatic digital imaging alternative for annual retinal examination in persons with previously documented no or mild diabetic retinopathy.

Cavallerano JD, Aiello LP, Cavallerano AA, Katalinic P, Hock K, Kirby R, Aiello LM; Joslin Vision Network Clinical Team.

Am J Ophthalmol. 2005 Oct;140(4):667-73. Epub 2005 Aug 3.PMID: 16083842 [PubMed - indexed for MEDLINE]Related articles

Congenital retinal macrovessel.

Jager RD, Timothy NH, Coney JM, Katalinic P, Cavicchi RW, Strong J, Cavallerano JD, Aiello LP.

Retina. 2005 Jun;25(4):538-40. No abstract available. PMID: 15933610 [PubMed - indexed for MEDLINE]Related articles

A telemedicine program for diabetic retinopathy in a Veterans Affairs Medical Center--the Joslin Vision Network Eye Health Care Model.

Cavallerano AA, Cavallerano JD, Katalinic P, Blake B, Rynne M, Conlin PR, Hock K, Tolson AM, Aiello LP, Aiello LM; Joslin Vision Network Research Team.

Am J Ophthalmol. 2005 Apr;139(4):597-604.PMID: 15808153 [PubMed - indexed for MEDLINE]Related articles

Telehealth practice recommendations for diabetic retinopathy.

Cavallerano J, Lawrence MG, Zimmer-Galler I, Bauman W, Bursell S, Gardner WK, Horton M, Hildebrand L, Federman J, Carnahan L, Kuzmak P, Peters JM, Darkins A, Ahmed J, Aiello LM, Aiello LP, Buck G, Cheng YL, Cunningham D, Goodall E, Hope N, Huang E, Hubbard L, Janczewski M, Lewis JW, Matsuzaki H, McVeigh FL, Motzno J, Parker-Taillon D, Read R, Soliz P, Szirth B, Vigersky RA, Ward T; American Telemedicine Association, Ocular Telehealth Special Interest Group; National Institute of Standards and Technology Working Group.

Telemed J E Health. 2004 Winter;10(4):469-82. Review.PMID: 15689653 [PubMed - indexed for MEDLINE]Related articles

Risks of intravitreous injection: a comprehensive review.

Jager RD, Aiello LP, Patel SC, Cunningham ET Jr.

Retina. 2004 Oct;24(5):676-98. Review.PMID: 15492621 [PubMed - indexed for MEDLINE]Related articles

Evolving guidelines for intravitreous injections.

Aiello LP, Brucker AJ, Chang S, Cunningham ET Jr, D'Amico DJ, Flynn HW Jr, Grillone LR, Hutcherson S, Liebmann JM, O'Brien TP, Scott IU, Spaide RF, Ta C, Trese MT.

Retina. 2004 Oct;24(5 Suppl):S3-19. Review.PMID: 15483476 [PubMed - indexed for MEDLINE]Related articles

Diabetic retinopathy.

Fong DS, Aiello LP, Ferris FL 3rd, Klein R.

Diabetes Care. 2004 Oct;27(10):2540-53. Review. No abstract available. PMID: 15451934 [PubMed - indexed for MEDLINE]Related articlesFree article

Bifunctional properties of peroxisome proliferator-activated receptor gamma1 in KDR gene regulation mediated via interaction with both Sp1 and Sp3.

Sassa Y, Hata Y, Aiello LP, Taniguchi Y, Kohno K, Ishibashi T.

Diabetes. 2004 May;53(5):1222-9.PMID: 15111490 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth factors and protein kinase C inhibitors as novel therapies for the medical management diabetic retinopathy.

Aiello LP, Cahill MT, Cavallerano JD.

Eye (Lond). 2004 Feb;18(2):117-25. Review.PMID: 14762400 [PubMed - indexed for MEDLINE]Related articles

Angiogenesis and ophthalmic disease.

Adamis AP, Aiello LP, D'Amato RA.

Angiogenesis. 1999;3(1):9-14.PMID: 14517440 [PubMed]Related articles

Use of Joslin Vision Network digital-video nonmydriatic retinal imaging to assess diabetic retinopathy in a clinical program.

Cavallerano AA, Cavallerano JD, Katalinic P, Tolson AM, Aiello LP, Aiello LM; Joslin Vision Network Clinical Team.

Retina. 2003 Apr;23(2):215-23.PMID: 12707602 [PubMed - indexed for MEDLINE]Related articles

The potential role of PKC beta in diabetic retinopathy and macular edema.

Aiello LP.

Surv Ophthalmol. 2002 Dec;47 Suppl 2:S263-9. Review.PMID: 12507628 [PubMed - indexed for MEDLINE]Related articles

Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes.

Joussen AM, Poulaki V, Mitsiades N, Cai WY, Suzuma I, Pak J, Ju ST, Rook SL, Esser P, Mitsiades CS, Kirchhof B, Adamis AP, Aiello LP.

FASEB J. 2003 Jan;17(1):76-8. Epub 2002 Nov 15.PMID: 12475915 [PubMed - indexed for MEDLINE]Related articlesFree article