PubMed

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110{gamma}

Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, Schaefer M, Gohla A, Harteneck C, Wymann MP, Jeanclos E, Nürnberg B.

Proc Natl Acad Sci U S A. 2009 Nov 11. [Epub ahead of print]PMID: 19906996 [PubMed - as supplied by publisher]Related articles

The skinny on fat: lipolysis and fatty acid utilization in adipocytes.

Ahmadian M, Duncan RE, Sul HS.

Trends Endocrinol Metab. 2009 Nov;20(9):424-8. Epub 2009 Sep 30.PMID: 19796963 [PubMed - in process]Related articles

Characterization of desnutrin functional domains:Critical residues for triacylglycerol hydrolysis in cultured cells.

Duncan RE, Wang Y, Ahmadian M, Lu J, Sarkadi-Nagy E, Sul HS.

J Lipid Res. 2009 Aug 19. [Epub ahead of print]PMID: 19692632 [PubMed - as supplied by publisher]Related articlesFree article

Gbetagamma-copurified lipid kinase impurity from Sf9 cells.

Shymanets A, Ahmadian MR, Nürnberg B.

Protein Pept Lett. 2009;16(9):1053-6. Epub 2009 Sep 1.PMID: 19508220 [PubMed - in process]Related articles

In vitro GEF and GAP assays.

Eberth A, Ahmadian MR.

Curr Protoc Cell Biol. 2009 Jun;Chapter 14:Unit 14.9.PMID: 19499504 [PubMed - indexed for MEDLINE]Related articles

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.

Jaworski K, Ahmadian M, Duncan RE, Sarkadi-Nagy E, Varady KA, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Kim KH, de Val S, Kang C, Sul HS.

Nat Med. 2009 Feb;15(2):159-68. Epub 2009 Jan 11.PMID: 19136964 [PubMed - indexed for MEDLINE]Related articles

Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity.

Ahmadian M, Duncan RE, Varady KA, Frasson D, Hellerstein MK, Birkenfeld AL, Samuel VT, Shulman GI, Wang Y, Kang C, Sul HS.

Diabetes. 2009 Apr;58(4):855-66. Epub 2009 Jan 9.PMID: 19136649 [PubMed - indexed for MEDLINE]Related articlesFree article

A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family.

Eberth A, Lundmark R, Gremer L, Dvorsky R, Koessmeier KT, McMahon HT, Ahmadian MR.

Biochem J. 2009 Jan 1;417(1):371-7.PMID: 18954304 [PubMed - indexed for MEDLINE]Related articles

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction.

Gremer L, Gilsbach B, Ahmadian MR, Wittinghofer A.

Biol Chem. 2008 Sep;389(9):1163-71.PMID: 18713003 [PubMed - indexed for MEDLINE]Related articles

Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA).

Duncan RE, Sarkadi-Nagy E, Jaworski K, Ahmadian M, Sul HS.

J Biol Chem. 2008 Sep 12;283(37):25428-36. Epub 2008 Jul 9.PMID: 18614531 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins.

Gasper R, Thomas C, Ahmadian MR, Wittinghofer A.

J Mol Biol. 2008 May 23;379(1):51-63. Epub 2008 Mar 14.PMID: 18440551 [PubMed - indexed for MEDLINE]Related articles

Palladium-mediated C5 substitution of pyrimidine nucleosides.

Ahmadian M, Klewer DA, Bergstrom DE.

Curr Protoc Nucleic Acid Chem. 2001 May;Chapter 1:Unit 1.1.PMID: 18428816 [PubMed - indexed for MEDLINE]Related articles

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction.

Pena V, Hothorn M, Eberth A, Kaschau N, Parret A, Gremer L, Bonneau F, Ahmadian MR, Scheffzek K.

EMBO Rep. 2008 Apr;9(4):350-5. Epub 2008 Mar 7.PMID: 18323856 [PubMed - indexed for MEDLINE]Related articlesFree article

Multicystic dysplastic kidney in association with congenital ichthyosiform erythroderma.

Badeli HR, Sajedi SA, Tangestaninejad A, Ahmadian MR, Alipour Kanafi K.

Iran J Kidney Dis. 2007 Oct;1(2):102-4.PMID: 19363284 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of cell volume and shape in confluent rat hepatocytes under hypertonic stress.

Olsen H, ter Veld F, Herbrand U, Ahmadian MR, Kinne RK, Wehner F.

Cell Physiol Biochem. 2007;19(5-6):259-68.PMID: 17495466 [PubMed - indexed for MEDLINE]Related articles

Myopathy caused by HRAS germline mutations: implications for disturbed myogenic differentiation in the presence of constitutive HRas activation.

van der Burgt I, Kupsky W, Stassou S, Nadroo A, Barroso C, Diem A, Kratz CP, Dvorsky R, Ahmadian MR, Zenker M.

J Med Genet. 2007 Jul;44(7):459-62. Epub 2007 Apr 5.PMID: 17412879 [PubMed - indexed for MEDLINE]Related articles

Triacylglycerol metabolism in adipose tissue.

Ahmadian M, Duncan RE, Jaworski K, Sarkadi-Nagy E, Sul HS.

Future Lipidol. 2007 Apr;2(2):229-237.PMID: 19194515 [PubMed]Related articlesFree article

DNA-controlled reversible switching of peptide conformation and bioactivity.

Röglin L, Ahmadian MR, Seitz O.

Angew Chem Int Ed Engl. 2007;46(15):2704-7. No abstract available. PMID: 17330908 [PubMed - indexed for MEDLINE]Related articles

Regulation of lipolysis in adipocytes.

Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS.

Annu Rev Nutr. 2007;27:79-101. Review.PMID: 17313320 [PubMed - indexed for MEDLINE]Related articles

Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.

Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M, Sul HS.

Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G1-4. Epub 2007 Jan 11. Review.PMID: 17218471 [PubMed - indexed for MEDLINE]Related articlesFree article

Asef is a Cdc42-specific guanine nucleotide exchange factor.

Gotthardt K, Ahmadian MR.

Biol Chem. 2007 Jan;388(1):67-71.PMID: 17214551 [PubMed - indexed for MEDLINE]Related articles

Synthesis and evaluation of antitumor activity of novel N-acyllavendamycin analogues and quinoline-5,8-diones.

Behforouz M, Cai W, Mohammadi F, Stocksdale MG, Gu Z, Ahmadian M, Baty DE, Etling MR, Al-Anzi CH, Swiftney TM, Tanzer LR, Merriman RL, Behforouz NC.

Bioorg Med Chem. 2007 Jan 1;15(1):495-510. Epub 2006 Oct 10.PMID: 17035024 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin glulisine: viewpoints.

Dailey G, Ahmadian M, Duckworth WC, Eckel J.

Drugs. 2006;66(6):870-2. No abstract available. PMID: 16706559 [PubMed - indexed for MEDLINE]Related articles

p190-RhoGAP as an integral component of the Tiam1/Rac1-induced downregulation of Rho.

Herbrand U, Ahmadian MR.

Biol Chem. 2006 Mar;387(3):311-7.PMID: 16542153 [PubMed - indexed for MEDLINE]Related articles

Purification and biochemical properties of Rac1, 2, 3 and the splice variant Rac1b.

Haeusler LC, Hemsath L, Fiegen D, Blumenstein L, Herbrand U, Stege P, Dvorsky R, Ahmadian MR.

Methods Enzymol. 2006;406:1-11.PMID: 16472645 [PubMed - indexed for MEDLINE]Related articles

GTPase activating proteins: structural and functional insights 18 years after discovery.

Scheffzek K, Ahmadian MR.

Cell Mol Life Sci. 2005 Dec;62(24):3014-38. Review.PMID: 16314935 [PubMed - indexed for MEDLINE]Related articles

Monitoring the real-time kinetics of the hydrolysis reaction of guanine nucleotide-binding proteins.

Eberth A, Dvorsky R, Becker CF, Beste A, Goody RS, Ahmadian MR.

Biol Chem. 2005 Nov;386(11):1105-14.PMID: 16307476 [PubMed - indexed for MEDLINE]Related articles

Guanine nucleotide exchange factors operate by a simple allosteric competitive mechanism.

Guo Z, Ahmadian MR, Goody RS.

Biochemistry. 2005 Nov 29;44(47):15423-9.PMID: 16300389 [PubMed - indexed for MEDLINE]Related articles

Fluorescence approaches for monitoring interactions of Rho GTPases with nucleotides, regulators, and effectors.

Hemsath L, Ahmadian MR.

Methods. 2005 Oct;37(2):173-82.PMID: 16289968 [PubMed - indexed for MEDLINE]Related articles

An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins.

Hemsath L, Dvorsky R, Fiegen D, Carlier MF, Ahmadian MR.

Mol Cell. 2005 Oct 28;20(2):313-24.PMID: 16246732 [PubMed - indexed for MEDLINE]Related articles

Time-dependent analysis of leaflets in mechanical aortic bileaflet heart valves in closing phase using the finite strip method.

Mohammadi H, Ahmadian MT, Wan WK.

Med Eng Phys. 2006 Mar;28(2):122-33. Epub 2005 Jun 8.PMID: 15946890 [PubMed - indexed for MEDLINE]Related articles

Structural and mechanistic insights into the interaction between Rho and mammalian Dia.

Rose R, Weyand M, Lammers M, Ishizaki T, Ahmadian MR, Wittinghofer A.

Nature. 2005 May 26;435(7041):513-8. Epub 2005 May 1.PMID: 15864301 [PubMed - indexed for MEDLINE]Related articles

Always look on the bright site of Rho: structural implications for a conserved intermolecular interface.

Dvorsky R, Ahmadian MR.

EMBO Rep. 2004 Dec;5(12):1130-6. Review.PMID: 15577926 [PubMed - indexed for MEDLINE]Related articlesFree article

Inactivation and activation of Ras by the neurotrophin receptor p75.

Blöchl A, Blumenstein L, Ahmadian MR.

Eur J Neurosci. 2004 Nov;20(9):2321-35.PMID: 15525274 [PubMed - indexed for MEDLINE]Related articles

Models of the cooperative mechanism for Rho effector recognition: implications for RhoA-mediated effector activation.

Blumenstein L, Ahmadian MR.

J Biol Chem. 2004 Dec 17;279(51):53419-26. Epub 2004 Oct 8.PMID: 15475352 [PubMed - indexed for MEDLINE]Related articlesFree article

The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism.

Uhlenbrock K, Eberth A, Herbrand U, Daryab N, Stege P, Meier F, Friedl P, Collard JG, Ahmadian MR.

J Cell Sci. 2004 Sep 15;117(Pt 20):4863-71. Epub 2004 Aug 31.PMID: 15340013 [PubMed - indexed for MEDLINE]Related articlesFree article

The molecular structure of tetra-tert-butyldiphosphine: an extremely distorted, sterically crowded molecule.

Hinchley SL, Robertson HE, Borisenko KB, Turner AR, Johnston BF, Rankin DW, Ahmadian M, Jones JN, Cowley AH.

Dalton Trans. 2004 Aug 21;(16):2469-76. Epub 2004 Jul 6.PMID: 15303161 [PubMed]Related articlesFree article

Implementation of multichannel sensors for remote biomedical measurements in a microsystems format.

Johannessen EA, Wang L, Cui L, Tang TB, Ahmadian M, Astaras A, Reid SW, Yam PS, Murray AF, Flynn BW, Beaumont SP, Cumming DR, Cooper JM.

IEEE Trans Biomed Eng. 2004 Mar;51(3):525-35.PMID: 15000383 [PubMed - indexed for MEDLINE]Related articles

Comparative functional analysis of the Rac GTPases.

Haeusler LC, Blumenstein L, Stege P, Dvorsky R, Ahmadian MR.

FEBS Lett. 2003 Dec 18;555(3):556-60.PMID: 14675773 [PubMed - indexed for MEDLINE]Related articles

Structural insights into the interaction of ROCKI with the switch regions of RhoA.

Dvorsky R, Blumenstein L, Vetter IR, Ahmadian MR.

J Biol Chem. 2004 Feb 20;279(8):7098-104. Epub 2003 Dec 2.PMID: 14660612 [PubMed - indexed for MEDLINE]Related articlesFree article

Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase.

Fiegen D, Haeusler LC, Blumenstein L, Herbrand U, Dvorsky R, Vetter IR, Ahmadian MR.

J Biol Chem. 2004 Feb 6;279(6):4743-9. Epub 2003 Nov 18.PMID: 14625275 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-casein-derived peptides, produced by bacteria, stimulate cancer cell invasion and motility.

Oliveira MJ, Van Damme J, Lauwaet T, De Corte V, De Bruyne G, Verschraegen G, Vaneechoutte M, Goethals M, Ahmadian MR, Müller O, Vandekerckhove J, Mareel M, Leroy A.

EMBO J. 2003 Nov 17;22(22):6161-73.PMID: 14609961 [PubMed - indexed for MEDLINE]Related articlesFree article

The RhoGAP activity of OPHN1, a new F-actin-binding protein, is negatively controlled by its amino-terminal domain.

Fauchereau F, Herbrand U, Chafey P, Eberth A, Koulakoff A, Vinet MC, Ahmadian MR, Chelly J, Billuart P.

Mol Cell Neurosci. 2003 Aug;23(4):574-86.PMID: 12932438 [PubMed - indexed for MEDLINE]Related articles

Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP.

Ahmadian MR, Kiel C, Stege P, Scheffzek K.

J Mol Biol. 2003 Jun 13;329(4):699-710.PMID: 12787671 [PubMed - indexed for MEDLINE]Related articles

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes.

Tiede I, Fritz G, Strand S, Poppe D, Dvorsky R, Strand D, Lehr HA, Wirtz S, Becker C, Atreya R, Mudter J, Hildner K, Bartsch B, Holtmann M, Blumberg R, Walczak H, Iven H, Galle PR, Ahmadian MR, Neurath MF.

J Clin Invest. 2003 Apr;111(8):1133-45.PMID: 12697733 [PubMed - indexed for MEDLINE]Related articlesFree article

Crystal structure of Rnd3/RhoE: functional implications.

Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR.

FEBS Lett. 2002 Aug 14;525(1-3):100-4.PMID: 12163169 [PubMed - indexed for MEDLINE]Related articles

Fluorescence methods in the study of small GTP-binding proteins.

Ahmadian MR, Wittinghofer A, Herrmann C.

Methods Mol Biol. 2002;189:45-63. No abstract available. PMID: 12094594 [PubMed - indexed for MEDLINE]Related articles

The new sulindac derivative IND 12 reverses Ras-induced cell transformation.

Karaguni IM, Herter P, Debruyne P, Chtarbova S, Kasprzynski A, Herbrand U, Ahmadian MR, Glüsenkamp KH, Winde G, Mareel M, Möröy T, Müller O.

Cancer Res. 2002 Mar 15;62(6):1718-23.PMID: 11912145 [PubMed - indexed for MEDLINE]Related articlesFree article

The actin filament architecture: tightly regulated by the cells, manipulated by pathogens. International Titisee Conference on the actin cytoskeleton: from signalling to bacterial pathogenesis.

Ahmadian MR, Wittinghofer A, Schmidt G.

EMBO Rep. 2002 Mar;3(3):214-8. No abstract available. PMID: 11882539 [PubMed - indexed for MEDLINE]Related articlesFree article

Prospects for anti-ras drugs.

Ahmadian MR.

Br J Haematol. 2002 Mar;116(3):511-8. Review. No abstract available. PMID: 11849206 [PubMed - indexed for MEDLINE]Related articles