PubMed

Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.

Gier B, Krippeit-Drews P, Sheiko T, Aguilar-Bryan L, Bryan J, Düfer M, Drews G.

J Clin Invest. 2009 Nov;119(11):3246-56. doi: 10.1172/JCI38817. Epub 2009 Oct 1.PMID: 19805912 [PubMed - indexed for MEDLINE]Related articlesFree article

Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion.

Ernst SJ, Aguilar-Bryan L, Noebels JL.

Endocrinology. 2009 Mar;150(3):1132-9. Epub 2008 Nov 6.PMID: 18988673 [PubMed - indexed for MEDLINE]Related articles

Channel regulation of glucose sensing in the pancreatic beta-cell.

Hiriart M, Aguilar-Bryan L.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1298-306. Epub 2008 Oct 21. Review.PMID: 18940941 [PubMed - indexed for MEDLINE]Related articles

Activation of the Na+/K+-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells.

Düfer M, Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G.

Pflugers Arch. 2009 Apr;457(6):1351-60. Epub 2008 Oct 3.PMID: 18836740 [PubMed - indexed for MEDLINE]Related articles

Novel Nonimmunological Forms of {beta}-Cell Dysfunction: Diabetic Syndromes and Pathogenic Mechanisms.

Robertson RP, Aguilar-Bryan L.

Endocr Rev. 2008 May;29(3):253. No abstract available. PMID: 18480303 [PubMed - indexed for MEDLINE]Related articlesFree article

Neonatal diabetes mellitus.

Aguilar-Bryan L, Bryan J.

Endocr Rev. 2008 May;29(3):265-91. Epub 2008 Apr 24. Review.PMID: 18436707 [PubMed - indexed for MEDLINE]Related articlesFree article

The KATP channel is critical for calcium sequestration into non-ER compartments in mouse pancreatic beta cells.

Dufer M, Haspel D, Krippeit-Drews P, Kelm M, Ranta F, Nitschke R, Ullrich S, Aguilar-Bryan L, Bryan J, Drews G.

Cell Physiol Biochem. 2007;20(1-4):65-74.PMID: 17595516 [PubMed - indexed for MEDLINE]Related articles

Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels.

Szollosi A, Nenquin M, Aguilar-Bryan L, Bryan J, Henquin JC.

J Biol Chem. 2007 Jan 19;282(3):1747-56. Epub 2006 Nov 30.PMID: 17138557 [PubMed - indexed for MEDLINE]Related articlesFree article

ABCC8 and ABCC9: ABC transporters that regulate K+ channels.

Bryan J, Muñoz A, Zhang X, Düfer M, Drews G, Krippeit-Drews P, Aguilar-Bryan L.

Pflugers Arch. 2007 Feb;453(5):703-18. Epub 2006 Aug 8. Review.PMID: 16897043 [PubMed - indexed for MEDLINE]Related articles

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus.

Babenko AP, Polak M, Cavé H, Busiah K, Czernichow P, Scharfmann R, Bryan J, Aguilar-Bryan L, Vaxillaire M, Froguel P.

N Engl J Med. 2006 Aug 3;355(5):456-66.PMID: 16885549 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinism.

Hussain K, Bryan J, Christesen HT, Brusgaard K, Aguilar-Bryan L.

Diabetes. 2005 Oct;54(10):2946-51.PMID: 16186397 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement.

Muñoz A, Hu M, Hussain K, Bryan J, Aguilar-Bryan L, Rajan AS.

Endocrinology. 2005 Dec;146(12):5514-21. Epub 2005 Aug 25.PMID: 16123162 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretagogues, sulfonylurea receptors and K(ATP) channels.

Bryan J, Crane A, Vila-Carriles WH, Babenko AP, Aguilar-Bryan L.

Curr Pharm Des. 2005;11(21):2699-716. Review.PMID: 16101450 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic K(ATP) channels control hepatic glucose production.

Pocai A, Lam TK, Gutierrez-Juarez R, Obici S, Schwartz GJ, Bryan J, Aguilar-Bryan L, Rossetti L.

Nature. 2005 Apr 21;434(7036):1026-31.PMID: 15846348 [PubMed - indexed for MEDLINE]Related articles

Crosstalk between membrane potential and cytosolic Ca2+ concentration in beta cells from Sur1-/- mice.

Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G, Düfer M.

Diabetologia. 2005 May;48(5):913-21. Epub 2005 Apr 14.PMID: 15830184 [PubMed - indexed for MEDLINE]Related articles

Docking and fusion of insulin secretory granules in SUR1 knock out mouse beta-cells observed by total internal reflection fluorescence microscopy.

Kikuta T, Ohara-Imaizumi M, Nakazaki M, Nishiwaki C, Nakamichi Y, Tei C, Aguilar-Bryan L, Bryan J, Nagamatsu S.

FEBS Lett. 2005 Mar 14;579(7):1602-6.PMID: 15757648 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis.

Lam TK, Pocai A, Gutierrez-Juarez R, Obici S, Bryan J, Aguilar-Bryan L, Schwartz GJ, Rossetti L.

Nat Med. 2005 Mar;11(3):320-7. Epub 2005 Feb 27.PMID: 15735652 [PubMed - indexed for MEDLINE]Related articles

Hyperinsulinism of infancy: novel ABCC8 and KCNJ11 mutations and evidence for additional locus heterogeneity.

Tornovsky S, Crane A, Cosgrove KE, Hussain K, Lavie J, Heyman M, Nesher Y, Kuchinski N, Ben-Shushan E, Shatz O, Nahari E, Potikha T, Zangen D, Tenenbaum-Rakover Y, de Vries L, Argente J, Gracia R, Landau H, Eliakim A, Lindley K, Dunne MJ, Aguilar-Bryan L, Glaser B.

J Clin Endocrinol Metab. 2004 Dec;89(12):6224-34.PMID: 15579781 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward linking structure with function in ATP-sensitive K+ channels.

Bryan J, Vila-Carriles WH, Zhao G, Babenko AP, Aguilar-Bryan L.

Diabetes. 2004 Dec;53 Suppl 3:S104-12. Review.PMID: 15561897 [PubMed - indexed for MEDLINE]Related articlesFree article

Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells.

Nenquin M, Szollosi A, Aguilar-Bryan L, Bryan J, Henquin JC.

J Biol Chem. 2004 Jul 30;279(31):32316-24. Epub 2004 Jun 1.PMID: 15175349 [PubMed - indexed for MEDLINE]Related articlesFree article

Oscillations of membrane potential and cytosolic Ca(2+) concentration in SUR1(-/-) beta cells.

Düfer M, Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G.

Diabetologia. 2004 Mar;47(3):488-98. Epub 2004 Feb 11.PMID: 14872319 [PubMed - indexed for MEDLINE]Related articles

Assembly, maturation, and turnover of K(ATP) channel subunits.

Crane A, Aguilar-Bryan L.

J Biol Chem. 2004 Mar 5;279(10):9080-90. Epub 2003 Dec 29.PMID: 14699091 [PubMed - indexed for MEDLINE]Related articlesFree article

Epinephrine-induced hyperpolarization of islet cells without KATP channels.

Sieg A, Su J, Muñoz A, Buchenau M, Nakazaki M, Aguilar-Bryan L, Bryan J, Ullrich S.

Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E463-71. Epub 2003 Nov 12.PMID: 14613926 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical and molecular characterization of a dominant form of congenital hyperinsulinism caused by a mutation in the high-affinity sulfonylurea receptor.

Thornton PS, MacMullen C, Ganguly A, Ruchelli E, Steinkrauss L, Crane A, Aguilar-Bryan L, Stanley CA.

Diabetes. 2003 Sep;52(9):2403-10.PMID: 12941782 [PubMed - indexed for MEDLINE]Related articlesFree article

Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels.

Muñoz A, Nakazaki M, Goodman JC, Barrios R, Onetti CG, Bryan J, Aguilar-Bryan L.

Stroke. 2003 Jan;34(1):164-70.PMID: 12511769 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets.

Nakazaki M, Crane A, Hu M, Seghers V, Ullrich S, Aguilar-Bryan L, Bryan J.

Diabetes. 2002 Dec;51(12):3440-9.PMID: 12453898 [PubMed - indexed for MEDLINE]Related articlesFree article

Transactivation of the mouse sulfonylurea receptor I gene by BETA2/NeuroD.

Kim JW, Seghers V, Cho JH, Kang Y, Kim S, Ryu Y, Baek K, Aguilar-Bryan L, Lee YD, Bryan J, Suh-Kim H.

Mol Endocrinol. 2002 May;16(5):1097-107.PMID: 11981044 [PubMed - indexed for MEDLINE]Related articlesFree article

Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations.

Grimberg A, Ferry RJ Jr, Kelly A, Koo-McCoy S, Polonsky K, Glaser B, Permutt MA, Aguilar-Bryan L, Stafford D, Thornton PS, Baker L, Stanley CA.

Diabetes. 2001 Feb;50(2):322-8.PMID: 11272143 [PubMed - indexed for MEDLINE]Related articlesFree article

Of mice and men: K(ATP) channels and insulin secretion.

Aguilar-Bryan L, Bryan J, Nakazaki M.

Recent Prog Horm Res. 2001;56:47-68. Review.PMID: 11237225 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcium-stimulated insulin secretion in diffuse and focal forms of congenital hyperinsulinism.

Ferry RJ Jr, Kelly A, Grimberg A, Koo-McCoy S, Shapiro MJ, Fellows KE, Glaser B, Aguilar-Bryan L, Stafford DE, Stanley CA.

J Pediatr. 2000 Aug;137(2):239-46.PMID: 10931418 [PubMed - indexed for MEDLINE]Related articles

Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion.

Seghers V, Nakazaki M, DeMayo F, Aguilar-Bryan L, Bryan J.

J Biol Chem. 2000 Mar 31;275(13):9270-7.PMID: 10734066 [PubMed - indexed for MEDLINE]Related articlesFree article

Familial hyperinsulinism and pancreatic beta-cell ATP-sensitive potassium channels.

Sharma N, Crane A, Gonzalez G, Bryan J, Aguilar-Bryan L.

Kidney Int. 2000 Mar;57(3):803-8. Review.PMID: 10720932 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfonylurea receptors: ABC transporters that regulate ATP-sensitive K(+) channels.

Bryan J, Aguilar-Bryan L.

Biochim Biophys Acta. 1999 Dec 6;1461(2):285-303. Review.PMID: 10581362 [PubMed - indexed for MEDLINE]Related articles

The C terminus of SUR1 is required for trafficking of KATP channels.

Sharma N, Crane A, Clement JP 4th, Gonzalez G, Babenko AP, Bryan J, Aguilar-Bryan L.

J Biol Chem. 1999 Jul 16;274(29):20628-32.PMID: 10400694 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular biology of adenosine triphosphate-sensitive potassium channels.

Aguilar-Bryan L, Bryan J.

Endocr Rev. 1999 Apr;20(2):101-35. Review.PMID: 10204114 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfonylurea receptors set the maximal open probability, ATP sensitivity and plasma membrane density of KATP channels.

Babenko AP, Gonzalez G, Aguilar-Bryan L, Bryan J.

FEBS Lett. 1999 Feb 19;445(1):131-6.PMID: 10069387 [PubMed - indexed for MEDLINE]Related articles

ATP-sensitive potassium channels.

Schwanstecher M, Schwanstecher C, Chudziak F, Panten U, Clement JP 4th, Gonzalez G, Aguilar-Bryan L, Bryan J.

Methods Enzymol. 1999;294:445-58. No abstract available. PMID: 9916242 [PubMed - indexed for MEDLINE]Related articles

Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells.

Babenko AP, Gonzalez G, Aguilar-Bryan L, Bryan J.

Circ Res. 1998 Nov 30;83(11):1132-43.PMID: 9831708 [PubMed - indexed for MEDLINE]Related articlesFree article

Variant in sulfonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-1 gene variant and hyperinsulinemia.

Goksel DL, Fischbach K, Duggirala R, Mitchell BD, Aguilar-Bryan L, Blangero J, Stern MP, O'Connell P.

Hum Genet. 1998 Sep;103(3):280-5.PMID: 9799081 [PubMed - indexed for MEDLINE]Related articles

Potassium channel openers require ATP to bind to and act through sulfonylurea receptors.

Schwanstecher M, Sieverding C, Dörschner H, Gross I, Aguilar-Bryan L, Schwanstecher C, Bryan J.

EMBO J. 1998 Oct 1;17(19):5529-35.PMID: 9755153 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfonylurea receptors and ATP-sensitive potassium ion channels.

Aguilar-Bryan L, Clement JP 4th, Nelson DA.

Methods Enzymol. 1998;292:732-44. No abstract available. PMID: 9711595 [PubMed - indexed for MEDLINE]Related articles

Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.

Hansen T, Echwald SM, Hansen L, Møller AM, Almind K, Clausen JO, Urhammer SA, Inoue H, Ferrer J, Bryan J, Aguilar-Bryan L, Permutt MA, Pedersen O.

Diabetes. 1998 Apr;47(4):598-605.PMID: 9568693 [PubMed - indexed for MEDLINE]Related articlesFree article

A view of sur/KIR6.X, KATP channels.

Babenko AP, Aguilar-Bryan L, Bryan J.

Annu Rev Physiol. 1998;60:667-87. Review.PMID: 9558481 [PubMed - indexed for MEDLINE]Related articles

Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.

Ohta Y, Tanizawa Y, Inoue H, Hosaka T, Ueda K, Matsutani A, Repunte VP, Yamada M, Kurachi Y, Bryan J, Aguilar-Bryan L, Permutt MA, Oka Y.

Diabetes. 1998 Mar;47(3):476-81.PMID: 9519757 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward understanding the assembly and structure of KATP channels.

Aguilar-Bryan L, Clement JP 4th, Gonzalez G, Kunjilwar K, Babenko A, Bryan J.

Physiol Rev. 1998 Jan;78(1):227-45. Review.PMID: 9457174 [PubMed - indexed for MEDLINE]Related articlesFree article

The ABCs of ATP-sensitive potassium channels: more pieces of the puzzle.

Bryan J, Aguilar-Bryan L.

Curr Opin Cell Biol. 1997 Aug;9(4):553-9. Review.PMID: 9261054 [PubMed - indexed for MEDLINE]Related articles

Association and stoichiometry of K(ATP) channel subunits.

Clement JP 4th, Kunjilwar K, Gonzalez G, Schwanstecher M, Panten U, Aguilar-Bryan L, Bryan J.

Neuron. 1997 May;18(5):827-38.PMID: 9182806 [PubMed - indexed for MEDLINE]Related articles

Familial persistent hyperinsulinemic hypoglycemia of infancy and mutations in the sulfonylurea receptor.

Dunne MJ, Kane C, Shepherd RM, Sanchez JA, James RF, Johnson PR, Aynsley-Green A, Lu S, Clement JP 4th, Lindley KJ, Seino S, Aguilar-Bryan L.

N Engl J Med. 1997 Mar 6;336(10):703-6. No abstract available. PMID: 9041101 [PubMed - indexed for MEDLINE]Related articles

Molecular basis of functional diversity of ATP-sensitive K+ channels.

Seino S, Inagaki N, Namba N, Wang CH, Kotake K, Nagashima K, Miki T, Aguilar-Bryan L, Bryan J, Gonoi T.

Jpn J Physiol. 1997;47 Suppl 1:S3-4. Review. No abstract available. PMID: 9266305 [PubMed - indexed for MEDLINE]Related articles

The high-affinity sulfonylurea receptor: distribution, glycosylation, purification, and immunoprecipitation of two forms from endocrine and neuroendocrine cell lines.

Nelson DA, Bryan J, Wechsler S, Clement JP 4th, Aguilar-Bryan L.

Biochemistry. 1996 Nov 26;35(47):14793-9.PMID: 8942641 [PubMed - indexed for MEDLINE]Related articles