PubMed

Targeting hepatic glucokinase in type 2 diabetes: weighing the benefits and risks.

Agius L.

Diabetes. 2009 Jan;58(1):18-20. No abstract available. PMID: 19114725 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase and molecular aspects of liver glycogen metabolism.

Agius L.

Biochem J. 2008 Aug 15;414(1):1-18. Review.PMID: 18651836 [PubMed - indexed for MEDLINE]Related articles

Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

Mukhtar MH, Payne VA, Arden C, Harbottle A, Khan S, Lange AJ, Agius L.

Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R766-74. Epub 2008 Jan 16.PMID: 18199594 [PubMed - indexed for MEDLINE]Related articles

New hepatic targets for glycaemic control in diabetes.

Agius L.

Best Pract Res Clin Endocrinol Metab. 2007 Dec;21(4):587-605. Review.PMID: 18054737 [PubMed - indexed for MEDLINE]Related articles

A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.

Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L.

Biochem J. 2008 Apr 1;411(1):41-51.PMID: 18039179 [PubMed - indexed for MEDLINE]Related articlesFree article

Acetylcholine exerts additive and permissive but not synergistic effects with insulin on glycogen synthesis in hepatocytes.

Hampson LJ, Agius L.

FEBS Lett. 2007 Aug 21;581(21):3955-60. Epub 2007 Jul 23.PMID: 17662981 [PubMed - indexed for MEDLINE]Related articles

Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.

Hampson LJ, Mackin P, Agius L.

Diabetologia. 2007 Aug;50(8):1743-51. Epub 2007 Jun 20.PMID: 17579833 [PubMed - indexed for MEDLINE]Related articles

Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats.

Payne VA, Arden C, Lange AJ, Agius L.

Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R618-25. Epub 2007 Jun 6.PMID: 17553851 [PubMed - indexed for MEDLINE]Related articles

Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity.

Arden C, Trainer A, de la Iglesia N, Scougall KT, Gloyn AL, Lange AJ, Shaw JA, Matschinsky FM, Agius L.

Diabetes. 2007 Jul;56(7):1773-82. Epub 2007 Mar 27.PMID: 17389332 [PubMed - indexed for MEDLINE]Related articlesFree article

Complicated atheromatous plaque as integral atherogenesis.

Agius LM.

J Clin Pathol. 2007 Jun;60(6):589-92. Epub 2006 Nov 1. Review. No abstract available. PMID: 17079352 [PubMed - indexed for MEDLINE]Related articles

Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.

Oikonomakos NG, Tiraidis C, Leonidas DD, Zographos SE, Kristiansen M, Jessen CU, Nørskov-Lauritsen L, Agius L.

J Med Chem. 2006 Sep 21;49(19):5687-701.PMID: 16970395 [PubMed - indexed for MEDLINE]Related articles

Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site.

Hampson LJ, Arden C, Agius L, Ganotidis M, Kosmopoulou MN, Tiraidis C, Elemes Y, Sakarellos C, Leonidas DD, Oikonomakos NG.

Bioorg Med Chem. 2006 Dec 1;14(23):7835-45.PMID: 16908161 [PubMed - indexed for MEDLINE]Related articles

Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats.

Arden C, Green AR, Hampson LJ, Aiston S, Härndahl L, Greenberg CC, Brady MJ, Freeman S, Poucher SM, Agius L.

FEBS J. 2006 May;273(9):1989-99.PMID: 16640562 [PubMed - indexed for MEDLINE]Related articles

Glucokinase regulatory protein is associated with mitochondria in hepatocytes.

Arden C, Baltrusch S, Agius L.

FEBS Lett. 2006 Apr 3;580(8):2065-70. Epub 2006 Mar 10.PMID: 16542652 [PubMed - indexed for MEDLINE]Related articles

The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism.

Härndahl L, Schmoll D, Herling AW, Agius L.

FEBS J. 2006 Jan;273(2):336-46.PMID: 16403021 [PubMed - indexed for MEDLINE]Related articles

The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes.

Aiston S, Hampson LJ, Arden C, Iynedjian PB, Agius L.

Diabetologia. 2006 Jan;49(1):174-82. Epub 2005 Dec 10.PMID: 16341839 [PubMed - indexed for MEDLINE]Related articles

Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes.

Payne VA, Arden C, Wu C, Lange AJ, Agius L.

Diabetes. 2005 Jul;54(7):1949-57.PMID: 15983194 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased potency and efficacy of combined phosphorylase inactivation and glucokinase activation in control of hepatocyte glycogen metabolism.

Hampson LJ, Agius L.

Diabetes. 2005 Mar;54(3):617-23.PMID: 15734835 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation.

Arden C, Harbottle A, Baltrusch S, Tiedge M, Agius L.

Diabetes. 2004 Sep;53(9):2346-52.PMID: 15331544 [PubMed - indexed for MEDLINE]Related articlesFree article

The glycogenic action of protein targeting to glycogen in hepatocytes involves multiple mechanisms including phosphorylase inactivation and glycogen synthase translocation.

Green AR, Aiston S, Greenberg CC, Freeman S, Poucher SM, Brady MJ, Agius L.

J Biol Chem. 2004 Nov 5;279(45):46474-82. Epub 2004 Aug 18.PMID: 15322104 [PubMed - indexed for MEDLINE]Related articlesFree article

The malignant transformation event as a clonal transformation of apoptosis to anti-apoptosis pathways and of cell cycle dynamics.

Agius LM.

Med Hypotheses. 2004;62(6):914-8.PMID: 15142647 [PubMed - indexed for MEDLINE]Related articles

The focality of the global Alzheimer brain process: is the selective vulnerability of neurons a specific phenomenon of primary neuronal pathobiology?

Agius LM.

Med Hypotheses. 2004;62(5):783-7.PMID: 15082107 [PubMed - indexed for MEDLINE]Related articles

Viral participation in cellular and microenvironmental transformation and amplification towards malignancy in AIDS patients.

Agius LM.

Med Hypotheses. 2004;62(4):593-9.PMID: 15050113 [PubMed - indexed for MEDLINE]Related articles

Is repetitive opportunistic infection in AIDS patients the effective mechanism for neurodegeneration in terms of endlessly amplifying cytokine/chemokine effect?

Agius LM.

Med Hypotheses. 2004;62(4):587-92.PMID: 15050112 [PubMed - indexed for MEDLINE]Related articles

A primary dysregulation in the immunoregulatory role of the intestinal mucosal epithelial cell in inflammatory bowel disease pathogenesis? Biology of inflammatory response as tissue pattern entities in Crohn's versus ulcerative colitis.

Agius LM.

J Theor Biol. 2004 Mar 21;227(2):219-28.PMID: 14990386 [PubMed - indexed for MEDLINE]Related articles

Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators.

Brocklehurst KJ, Payne VA, Davies RA, Carroll D, Vertigan HL, Wightman HJ, Aiston S, Waddell ID, Leighton B, Coghlan MP, Agius L.

Diabetes. 2004 Mar;53(3):535-41.PMID: 14988235 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences in regulatory properties between human and rat glucokinase regulatory protein.

Brocklehurst KJ, Davies RA, Agius L.

Biochem J. 2004 Mar 1;378(Pt 2):693-7.PMID: 14627435 [PubMed - indexed for MEDLINE]Related articlesFree article

Justification of glioma biology beyond a cellular basis of interpretation.

Agius LM.

Med Hypotheses. 2003 Oct;61(4):486-94.PMID: 13679018 [PubMed - indexed for MEDLINE]Related articles

Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose.

Aiston S, Green A, Mukhtar M, Agius L.

Biochem J. 2004 Jan 1;377(Pt 1):195-204.PMID: 13678417 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylase regulates the association of glycogen synthase with a proteoglycogen substrate in hepatocytes.

Tavridou A, Agius L.

FEBS Lett. 2003 Sep 11;551(1-3):87-91.PMID: 12965209 [PubMed - indexed for MEDLINE]Related articles

A concept of essentially secondary factors central to definitive subtype characterization of Hodgkin's disease.

Agius LM.

Med Hypotheses. 2003 Aug;61(2):297-302.PMID: 12888322 [PubMed - indexed for MEDLINE]Related articles

Is beta-amyloid fibrillogenesis a strict process of deposition inherently interactive in molecular terms?

Agius LM.

Med Hypotheses. 2003 Aug;61(2):292-6.PMID: 12888321 [PubMed - indexed for MEDLINE]Related articles

Towards a pathogenetic definition of multiple sclerosis in terms of integrative transformation of generic pathologic processes.

Agius LM.

Med Hypotheses. 2003 Aug;61(2):177-81.PMID: 12888299 [PubMed - indexed for MEDLINE]Related articles

Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis.

Aiston S, Coghlan MP, Agius L.

Eur J Biochem. 2003 Jul;270(13):2773-81.PMID: 12823547 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase.

Aiston S, Andersen B, Agius L.

Diabetes. 2003 Jun;52(6):1333-9.PMID: 12765941 [PubMed - indexed for MEDLINE]Related articlesFree article

Does transmissibility necessarily imply infectivity in spongiform encephalopathy?

Agius LM.

Med Hypotheses. 2003 Jun;60(6):886-92.PMID: 12699719 [PubMed - indexed for MEDLINE]Related articles

Beta-amyloidosis as an index of activity of the Alzheimer process rather than as a primary mechanism of neuronal injury in organic dementia.

Agius LM.

Med Hypotheses. 2003 Jun;60(6):880-5.PMID: 12699718 [PubMed - indexed for MEDLINE]Related articles

Possible close analogy between HIV and EBV infection and, respectively, induced lymphomas.

Agius LM.

Med Hypotheses. 2003 Jun;60(6):874-9.PMID: 12699717 [PubMed - indexed for MEDLINE]Related articles

Dysregulatory dysequilibrium of gene transcription and of nuclear transport in polyglutamine neuro-degeneration.

Agius LM.

Med Hypotheses. 2003 Jun;60(6):869-73.PMID: 12699716 [PubMed - indexed for MEDLINE]Related articles

Are tau and alpha synuclein filamentous inclusions in neurons and glia analogous to accumulation of myosin/actin filaments in myofiber hypertrophy?

Agius LM.

Med Hypotheses. 2003 Mar;60(3):413-7.PMID: 12581622 [PubMed - indexed for MEDLINE]Related articles

Neuro-endocrine neoplasms as a result of gene desuppression rather than of a specific cell type of origin.

Agius LM.

Med Hypotheses. 2003 Mar;60(3):408-12.PMID: 12581621 [PubMed - indexed for MEDLINE]Related articles

Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes.

Latsis T, Andersen B, Agius L.

Biochem J. 2002 Nov 15;368(Pt 1):309-16.PMID: 12186629 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple glucose 6-phosphate pools or channelling of flux in diverse pathways?

Agius L, Centelles J, Cascante M.

Biochem Soc Trans. 2002 Apr;30(2):38-43. Review.PMID: 12023820 [PubMed - indexed for MEDLINE]Related articles

Occurrence of paradoxical or sustained control by an enzyme when overexpressed: necessary conditions and experimental evidence with regard to hepatic glucokinase.

De Atauri P, Acerenza L, Kholodenko BN, De La Iglesia N, Guinovart JJ, Agius L, Cascante M.

Biochem J. 2001 May 1;355(Pt 3):787-93.PMID: 11311143 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis.

Aiston S, Hampson L, Gómez-Foix AM, Guinovart JJ, Agius L.

J Biol Chem. 2001 Jun 29;276(26):23858-66. Epub 2001 Apr 17.PMID: 11309391 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells.

Stubbs M, Aiston S, Agius L.

Diabetes. 2000 Dec;49(12):2048-55.PMID: 11118006 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of alpha-toxin from Staphylococcus aureus to test for channelling of intermediates of glycolysis between glucokinase and aldolase in hepatocytes.

Cascante M, Centelles JJ, Agius L.

Biochem J. 2000 Dec 15;352 Pt 3:899-905.PMID: 11104701 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired glycogen synthesis in hepatocytes from Zucker fatty fa/fa rats: the role of increased phosphorylase activity.

Aiston S, Peak M, Agius L.

Diabetologia. 2000 May;43(5):589-97.PMID: 10855534 [PubMed - indexed for MEDLINE]Related articles

The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte.

de la Iglesia N, Mukhtar M, Seoane J, Guinovart JJ, Agius L.

J Biol Chem. 2000 Apr 7;275(14):10597-603.PMID: 10744755 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigation of the mechanism by which glucose analogues cause translocation of glucokinase in hepatocytes: evidence for two glucose binding sites.

Agius L, Stubbs M.

Biochem J. 2000 Mar 1;346 Pt 2:413-21.PMID: 10677361 [PubMed - indexed for MEDLINE]Related articlesFree article