PubMed

Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase.

Scherpenzeel MV, van den Berg RJ, Donker-Koopman WE, Liskamp RM, Aerts JM, Overkleeft HS, Pieters RJ.

Bioorg Med Chem. 2009 Oct 31. [Epub ahead of print]PMID: 19931460 [PubMed - as supplied by publisher]

Xenotransplantation in immunodeficient mice to study ovarian follicular development in domestic animals.

Bols PE, Aerts JM, Langbeen A, Goovaerts IG, Leroy JL.

Theriogenology. 2009 Nov 11. [Epub ahead of print]PMID: 19913288 [PubMed - as supplied by publisher]Related articles

Vasculopathy in patients with Fabry disease: Current controversies and research directions.

Rombach SM, Twickler TB, Aerts JM, Linthorst GE, Wijburg FA, Hollak CE.

Mol Genet Metab. 2009 Oct 13. [Epub ahead of print]PMID: 19900828 [PubMed - as supplied by publisher]Related articles

Glycosphingolipids--nature, function, and pharmacological modulation.

Wennekes T, van den Berg RJ, Boot RG, van der Marel GA, Overkleeft HS, Aerts JM.

Angew Chem Int Ed Engl. 2009;48(47):8848-69.PMID: 19862781 [PubMed - in process]Related articles

Synthesis and evaluation of d-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.

Risseeuw MD, van den Berg RJ, Donker-Koopman WE, van der Marel GA, Aerts JM, Overhand M, Overkleeft HS.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6600-3. Epub 2009 Oct 8.PMID: 19853441 [PubMed - in process]Related articles

Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis.

Boot RG, Hollak CE, Verhoek M, Alberts C, Jonkers RE, Aerts JM.

Clin Chim Acta. 2010 Jan;411(1-2):31-6. Epub 2009 Oct 4.PMID: 19808030 [PubMed - in process]Related articles

Force Majeure: Therapeutic measures in response to restricted supply of imiglucerase (Cerezyme) for patients with Gaucher disease.

Hollak CE, Vom Dahl S, Aerts JM, Belmatoug N, Bembi B, Cohen Y, Collin-Histed T, Deegan P, van Dussen L, Giraldo P, Mengel E, Michelakakis H, Manuel J, Hrebicek M, Parini R, Reinke J, di Rocco M, Pocovi M, Sa Miranda MC, Tylki-Szymanska A, Zimran A, Cox TM.

Blood Cells Mol Dis. 2009 Oct 3. [Epub ahead of print]PMID: 19804996 [PubMed - as supplied by publisher]Related articles

Screening for Fabry disease in high risk populations: a systematic review.

Linthorst GE, Bouwman MG, Wijburg FA, Aerts JM, Poorthuis BJ, Hollak CE.

J Med Genet. 2009 Sep 24. [Epub ahead of print]PMID: 19797197 [PubMed - as supplied by publisher]Related articles

Proteomic profiling of plasma and serum in elderly patients with delirium.

van Munster BC, van Breemen MJ, Moerland PD, Speijer D, De Rooij SE, Pfrommer CJ, Levi M, Hollmann MW, Aerts JM, Zwinderman AH, Korevaar JC.

J Neuropsychiatry Clin Neurosci. 2009 Summer;21(3):284-91.PMID: 19776308 [PubMed - in process]Related articles

Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism.

Soeters MR, Lammers NM, Dubbelhuis PF, Ackermans M, Jonkers-Schuitema CF, Fliers E, Sauerwein HP, Aerts JM, Serlie MJ.

Am J Clin Nutr. 2009 Nov;90(5):1244-51. Epub 2009 Sep 23.PMID: 19776143 [PubMed - in process]Related articles

Dynamic data analysis and data mining for prediction of clinical stability.

Van Loon K, Guiza F, Meyfroidt G, Aerts JM, Ramon J, Blockeel H, Bruynooghe M, Van Den Berghe G, Berckmans D.

Stud Health Technol Inform. 2009;150:590-4.PMID: 19745380 [PubMed - in process]Related articles

Enzyme therapy for the treatment of type 1 Gaucher disease: clinical outcomes and dose - response relationships.

Hollak CE, de Fost M, van Dussen L, Vom Dahl S, Aerts JM.

Expert Opin Pharmacother. 2009 Nov;10(16):2641-52.PMID: 19743939 [PubMed - in process]Related articles

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.

Bijl N, Sokolović M, Vrins C, Langeveld M, Moerland PD, Ottenhoff R, van Roomen CP, Claessen N, Boot RG, Aten J, Groen AK, Aerts JM, van Eijk M.

Hepatology. 2009 Nov;50(5):1431-41.PMID: 19731235 [PubMed - in process]Related articles

Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates.

Bussink AP, Verhoek M, Vreede J, Ghauharali-van der Vlugt K, Donker-Koopman WE, Sprenger RR, Hollak CE, Aerts JM, Boot RG.

FEBS J. 2009 Oct;276(19):5678-88. Epub 2009 Sep 2.PMID: 19725875 [PubMed - indexed for MEDLINE]Related articles

Gaucher disease: a model disorder for biomarker discovery.

Boot RG, van Breemen MJ, Wegdam W, Sprenger RR, de Jong S, Speijer D, Hollak CE, van Dussen L, Hoefsloot HC, Smilde AK, de Koster CG, Vissers JP, Aerts JM.

Expert Rev Proteomics. 2009 Aug;6(4):411-9. Review.PMID: 19681676 [PubMed - indexed for MEDLINE]Related articles

Automatic analysis of altered gait in arylsulphatase A-deficient mice in the open field.

Leroy T, Stroobants S, Aerts JM, D'Hooge R, Berckmans D.

Behav Res Methods. 2009 Aug;41(3):787-94.PMID: 19587193 [PubMed - indexed for MEDLINE]Related articles

Plasma markers of coagulation and endothelial activation in Fabry disease: impact of renal impairment.

Vedder AC, Biró E, Aerts JM, Nieuwland R, Sturk G, Hollak CE.

Nephrol Dial Transplant. 2009 Oct;24(10):3074-81. Epub 2009 Jun 10.PMID: 19515805 [PubMed - in process]Related articles

Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice.

Zhao H, Przybylska M, Wu IH, Zhang J, Maniatis P, Pacheco J, Piepenhagen P, Copeland D, Arbeeny C, Shayman JA, Aerts JM, Jiang C, Cheng SH, Yew NS.

Hepatology. 2009 Jul;50(1):85-93.PMID: 19444873 [PubMed - indexed for MEDLINE]Related articles

Classification-based comparison of pre-processing methods for interpretation of mass spectrometry generated clinical datasets.

Wegdam W, Moerland PD, Buist MR, Ver Loren van Themaat E, Bleijlevens B, Hoefsloot HC, de Koster CG, Aerts JM.

Proteome Sci. 2009 May 14;7:19.PMID: 19442271 [PubMed - in process]Related articlesFree article

Xenotransplantation by injection of a suspension of isolated preantral ovarian follicles and stroma cells under the kidney capsule of nude mice.

Aerts JM, Martinez-Madrid B, Leroy JL, Van Aelst S, Bols PE.

Fertil Steril. 2009 May 5. [Epub ahead of print]PMID: 19423102 [PubMed - as supplied by publisher]Related articles

Increased chitotriosidase activity in serum of leprosy patients: association with bacillary leprosy.

Iyer A, van Eijk M, Silva E, Hatta M, Faber W, Aerts JM, Das PK.

Clin Immunol. 2009 Jun;131(3):501-9.PMID: 19307157 [PubMed - indexed for MEDLINE]Related articles

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.

van Eijk M, Aten J, Bijl N, Ottenhoff R, van Roomen CP, Dubbelhuis PF, Seeman I, Ghauharali-van der Vlugt K, Overkleeft HS, Arbeeny C, Groen AK, Aerts JM.

PLoS One. 2009;4(3):e4723. Epub 2009 Mar 23.PMID: 19305508 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycosphingolipids and insulin resistance.

Langeveld M, Aerts JM.

Prog Lipid Res. 2009 May-Jul;48(3-4):196-205. Epub 2009 Mar 20.PMID: 19303901 [PubMed - in process]Related articles

Different dose-dependent correction of MIP-1beta and chitotriosidase during initial enzyme replacement therapy.

van Breemen MJ, de Fost M, Maas M, Wiersma MG, Hollak CE, Poll LW, Vom Dahl S, Boot RG, Aerts JM.

J Inherit Metab Dis. 2009 Apr;32(2):274-9. Epub 2009 Mar 4.PMID: 19255873 [PubMed - indexed for MEDLINE]Related articles

Ovarian Follicular Dynamics: A Review with Emphasis on the Bovine Species. Part I: Folliculogenesis and Pre-antral Follicle Development.

Aerts JM, Bols PE.

Reprod Domest Anim. 2008 Dec 6. [Epub ahead of print]PMID: 19210660 [PubMed - as supplied by publisher]Related articles

Time-series analysis for online recognition and localization of sick pig (Sus scrofa) cough sounds.

Exadaktylos V, Silva M, Ferrari S, Guarino M, Taylor CJ, Aerts JM, Berckmans D.

J Acoust Soc Am. 2008 Dec;124(6):3803-9.PMID: 19206806 [PubMed - indexed for MEDLINE]Related articles

Automated gait analysis in the open-field test for laboratory mice.

Leroy T, Silva M, D'Hooge R, Aerts JM, Berckmans D.

Behav Res Methods. 2009 Feb;41(1):148-53.PMID: 19182134 [PubMed - indexed for MEDLINE]Related articles

Morphological, physiological and behavioural evaluation of a 'Mice in Space' housing system.

Blottner D, Serradj N, Salanova M, Touma C, Palme R, Silva M, Aerts JM, Berckmans D, Vico L, Liu Y, Giuliani A, Rustichelli F, Cancedda R, Jamon M.

J Comp Physiol B. 2009 May;179(4):519-33. Epub 2009 Jan 8.PMID: 19130060 [PubMed - indexed for MEDLINE]Related articlesFree article

Ovarian Follicular Dynamics. A review with Emphasis on the Bovine Species. Part II: Antral Development, Exogenous Influence and Future Prospects.

Aerts JM, Bols PE.

Reprod Domest Anim. 2008 Dec 15. [Epub ahead of print]PMID: 19090819 [PubMed - as supplied by publisher]Related articles

Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice.

Bijl N, van Roomen CP, Triantis V, Sokolovic M, Ottenhoff R, Scheij S, van Eijk M, Boot RG, Aerts JM, Groen AK.

Hepatology. 2009 Feb;49(2):637-45.PMID: 19072830 [PubMed - indexed for MEDLINE]Related articles

Quantification of the spatial distribution of surface temperatures of broilers.

Cangar O, Aerts JM, Buyse J, Berckmans D.

Poult Sci. 2008 Dec;87(12):2493-9.PMID: 19038804 [PubMed - indexed for MEDLINE]Related articles

Effects of different target trajectories on the broiler performance in growth control.

Cangar O, Aerts JM, Vranken E, Berckmans D.

Poult Sci. 2008 Nov;87(11):2196-207.PMID: 18931168 [PubMed - indexed for MEDLINE]Related articlesFree article

Detection of chitinase activity by 2-aminobenzoic acid labeling of chito-oligosaccharides.

Ghauharali-van der Vlugt K, Bussink AP, Groener JE, Boot RG, Aerts JM.

Anal Biochem. 2009 Jan 1;384(1):191-3. Epub 2008 Sep 23.PMID: 18926793 [PubMed - indexed for MEDLINE]Related articles

Potential efficacy of enzyme replacement and substrate reduction therapy in three siblings with Gaucher disease type III.

Cox-Brinkman J, van Breemen MJ, van Maldegem BT, Bour L, Donker WE, Hollak CE, Wijburg FA, Aerts JM.

J Inherit Metab Dis. 2008 Dec;31(6):745-52. Epub 2008 Oct 15.PMID: 18850301 [PubMed - indexed for MEDLINE]Related articles

Enzyme replacement therapy in Fabry disease: towards a better understanding of the implications of antibody formation and dose.

Hollak CE, Vedder AC, Winchester B, Aerts JM, Breunig F.

Mol Genet Metab. 2008 Dec;95(4):239-40. Epub 2008 Oct 7. No abstract available. PMID: 18842432 [PubMed - indexed for MEDLINE]Related articles

Low HDL cholesterol levels in type I Gaucher disease do not lead to an increased risk of cardiovascular disease.

de Fost M, Langeveld M, Franssen R, Hutten BA, Groener JE, de Groot E, Mannens MM, Bikker H, Aerts JM, Kastelein JJ, Hollak CE.

Atherosclerosis. 2009 May;204(1):267-72. Epub 2008 Sep 2.PMID: 18842264 [PubMed - indexed for MEDLINE]Related articles

Follicle survival and growth to antral stages in short-term murine ovarian cortical transplants after Cryologic solid surface vitrification or slow-rate freezing.

Aerts JM, De Clercq JB, Andries S, Leroy JL, Van Aelst S, Bols PE.

Cryobiology. 2008 Oct;57(2):163-9. Epub 2008 Aug 7.PMID: 18725217 [PubMed - indexed for MEDLINE]Related articles

Spatial differences in sensible and latent heat losses under a bicycle helmet.

De Bruyne G, Aerts JM, Van der Perre G, Goffin J, Verpoest I, Berckmans D.

Eur J Appl Physiol. 2008 Nov;104(4):719-26. Epub 2008 Jul 23.PMID: 18649086 [PubMed - indexed for MEDLINE]Related articles

Potential artefacts in proteome analysis of plasma of Gaucher patients due to protease abnormalities.

van Breemen MJ, Aerts JM, Sprenger RR, Speijer D.

Clin Chim Acta. 2008 Oct;396(1-2):26-32. Epub 2008 Jun 25.PMID: 18640107 [PubMed - indexed for MEDLINE]Related articles

The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells.

Bijl N, Scheij S, Houten S, Boot RG, Groen AK, Aerts JM.

J Pharmacol Exp Ther. 2008 Sep;326(3):849-55. Epub 2008 Jun 12.PMID: 18550691 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistent bone disease in adult type 1 Gaucher disease despite increasing doses of enzyme replacement therapy.

de Fost M, van Noesel CJ, Aerts JM, Maas M, Pöll RG, Hollak CE.

Haematologica. 2008 Jul;93(7):1119-20. Epub 2008 Jun 2. No abstract available. PMID: 18519519 [PubMed - indexed for MEDLINE]Related articlesFree article

Management of non-neuronopathic Gaucher disease with special reference to pregnancy, splenectomy, bisphosphonate therapy, use of biomarkers and bone disease monitoring.

Cox TM, Aerts JM, Belmatoug N, Cappellini MD, vom Dahl S, Goldblatt J, Grabowski GA, Hollak CE, Hwu P, Maas M, Martins AM, Mistry PK, Pastores GM, Tylki-Szymanska A, Yee J, Weinreb N.

J Inherit Metab Dis. 2008 Jun;31(3):319-36. Epub 2008 May 23. Review.PMID: 18509745 [PubMed - indexed for MEDLINE]Related articles

Biomarkers for lysosomal storage disorders: identification and application as exemplified by chitotriosidase in Gaucher disease.

Aerts JM, van Breemen MJ, Bussink AP, Ghauharali K, Sprenger R, Boot RG, Groener JE, Hollak CE, Maas M, Smit S, Hoefsloot HC, Smilde AK, Vissers JP, de Jong S, Speijer D, de Koster CG.

Acta Paediatr Suppl. 2008 Apr;97(457):7-14. Review.PMID: 18339181 [PubMed - indexed for MEDLINE]Related articles

Treatment of Fabry disease with different dosing regimens of agalsidase: effects on antibody formation and GL-3.

Vedder AC, Breunig F, Donker-Koopman WE, Mills K, Young E, Winchester B, Ten Berge IJ, Groener JE, Aerts JM, Wanner C, Hollak CE.

Mol Genet Metab. 2008 Jul;94(3):319-25. Epub 2008 Apr 18.PMID: 18424138 [PubMed - indexed for MEDLINE]Related articles

'Non-neuronopathic' Gaucher disease reconsidered. Prevalence of neurological manifestations in a Dutch cohort of type I Gaucher disease patients and a systematic review of the literature.

Biegstraaten M, van Schaik IN, Aerts JM, Hollak CE.

J Inherit Metab Dis. 2008 Jun;31(3):337-49. Epub 2008 Apr 4. Review.PMID: 18404411 [PubMed - indexed for MEDLINE]Related articles

Muscle adaptation to short-term fasting in healthy lean humans.

Soeters MR, Sauerwein HP, Dubbelhuis PF, Groener JE, Ackermans MT, Fliers E, Aerts JM, Serlie MJ.

J Clin Endocrinol Metab. 2008 Jul;93(7):2900-3. Epub 2008 Apr 8.PMID: 18397976 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of a dynamic model to predict PM10 emissions from swine houses.

Haeussermann A, Costa A, Aerts JM, Hartung E, Jungbluth T, Guarino M, Berckmans D.

J Environ Qual. 2008 Mar-Apr;37(2):557-64.PMID: 18396541 [PubMed - indexed for MEDLINE]Related articlesFree article

Early signs of neurolipidosis-related behavioural alterations in a murine model of metachromatic leukodystrophy.

Stroobants S, Leroy T, Eckhardt M, Aerts JM, Berckmans D, D'Hooge R.

Behav Brain Res. 2008 Jun 3;189(2):306-16. Epub 2008 Jan 31.PMID: 18336930 [PubMed - indexed for MEDLINE]Related articles

A single histidine residue modulates enzymatic activity in acidic mammalian chitinase.

Bussink AP, Vreede J, Aerts JM, Boot RG.

FEBS Lett. 2008 Mar 19;582(6):931-5. Epub 2008 Feb 21.PMID: 18294964 [PubMed - indexed for MEDLINE]Related articles

Elevated globotriaosylsphingosine is a hallmark of Fabry disease.

Aerts JM, Groener JE, Kuiper S, Donker-Koopman WE, Strijland A, Ottenhoff R, van Roomen C, Mirzaian M, Wijburg FA, Linthorst GE, Vedder AC, Rombach SM, Cox-Brinkman J, Somerharju P, Boot RG, Hollak CE, Brady RO, Poorthuis BJ.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2812-7. Epub 2008 Feb 19.PMID: 18287059 [PubMed - indexed for MEDLINE]Related articlesFree article