PubMed

The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria.

Wang XX, Jiang T, Shen Y, Adorini L, Pruzanski M, Gonzalez FJ, Scherzer P, Lewis L, Miyazaki-Anzai S, Levi M.

Am J Physiol Renal Physiol. 2009 Dec;297(6):F1587-96. Epub 2009 Sep 23.PMID: 19776172 [PubMed - in process]Related articles

Chronic inflammation in the pathogenesis of benign prostatic hyperplasia.

Fibbi B, Penna G, Morelli A, Adorini L, Maggi M.

Int J Androl. 2009 Jun 8. [Epub ahead of print]PMID: 19508330 [PubMed - as supplied by publisher]Related articles

Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists.

Adorini L, Penna G.

Hum Immunol. 2009 May;70(5):345-52.PMID: 19405173 [PubMed - indexed for MEDLINE]Related articles

Vitamin D receptor polymorphisms in primary biliary cirrhosis: a functional connection?

Adorini L.

J Hepatol. 2009 Jun;50(6):1071-3. Epub 2009 Mar 27. Review. No abstract available. PMID: 19398232 [PubMed - indexed for MEDLINE]Related articles

Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response.

Tang J, Zhou R, Luger D, Zhu W, Silver PB, Grajewski RS, Su SB, Chan CC, Adorini L, Caspi RR.

J Immunol. 2009 Apr 15;182(8):4624-32.PMID: 19342637 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.

Laverny G, Penna G, Uskokovic M, Marczak S, Maehr H, Jankowski P, Ceailles C, Vouros P, Smith B, Robinson M, Reddy GS, Adorini L.

J Med Chem. 2009 Apr 23;52(8):2204-13.PMID: 19309155 [PubMed - indexed for MEDLINE]Related articles

Human benign prostatic hyperplasia stromal cells as inducers and targets of chronic immuno-mediated inflammation.

Penna G, Fibbi B, Amuchastegui S, Cossetti C, Aquilano F, Laverny G, Gacci M, Crescioli C, Maggi M, Adorini L.

J Immunol. 2009 Apr 1;182(7):4056-64.PMID: 19299703 [PubMed - indexed for MEDLINE]Related articles

Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity.

Lee HJ, Paul S, Atalla N, Thomas PE, Lin X, Yang I, Buckley B, Lu G, Zheng X, Lou YR, Conney AH, Maehr H, Adorini L, Uskokovic M, Suh N.

Cancer Prev Res (Phila Pa). 2008 Nov;1(6):476-84.PMID: 19138995 [PubMed - indexed for MEDLINE]Related articlesFree article

The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways.

Penna G, Fibbi B, Amuchastegui S, Corsiero E, Laverny G, Silvestrini E, Chavalmane A, Morelli A, Sarchielli E, Vannelli GB, Gacci M, Colli E, Maggi M, Adorini L.

Prostate. 2009 Apr 1;69(5):480-93.PMID: 19107880 [PubMed - indexed for MEDLINE]Related articles

Induction of tolerogenic dendritic cells by vitamin D receptor agonists.

Adorini L, Penna G.

Handb Exp Pharmacol. 2009;(188):251-73. Review.PMID: 19031030 [PubMed - indexed for MEDLINE]Related articles

Immunomodulatory effects of BXL-01-0029, a less hypercalcemic vitamin D analogue, in human cardiomyocytes and T cells.

Sottili M, Cosmi L, Borgogni E, Sarchielli E, Maggi L, Francalanci M, Vannelli GB, Ronconi E, Adorini L, Annunziato F, Romagnani P, Serio M, Crescioli C.

Exp Cell Res. 2009 Jan 15;315(2):264-73. Epub 2008 Nov 5.PMID: 19014933 [PubMed - indexed for MEDLINE]Related articles

Control of autoimmune diseases by the vitamin D endocrine system.

Adorini L, Penna G.

Nat Clin Pract Rheumatol. 2008 Aug;4(8):404-12. Epub 2008 Jul 1. Review.PMID: 18594491 [PubMed - indexed for MEDLINE]Related articles

Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells.

Borgogni E, Sarchielli E, Sottili M, Santarlasci V, Cosmi L, Gelmini S, Lombardi A, Cantini G, Perigli G, Luconi M, Vannelli GB, Annunziato F, Adorini L, Serio M, Crescioli C.

Endocrinology. 2008 Jul;149(7):3626-34. Epub 2008 Mar 27.PMID: 18372324 [PubMed - indexed for MEDLINE]Related articlesFree article

The vitamin D receptor agonist elocalcitol upregulates L-type calcium channel activity in human and rat bladder.

Morelli A, Squecco R, Failli P, Filippi S, Vignozzi L, Chavalmane AK, Fibbi B, Mancina R, Luciani G, Gacci M, Colli E, Francini F, Adorini L, Maggi M.

Am J Physiol Cell Physiol. 2008 May;294(5):C1206-14. Epub 2008 Mar 19.PMID: 18353900 [PubMed - indexed for MEDLINE]Related articlesFree article

Vitamin D receptor agonists in the treatment of autoimmune diseases: selective targeting of myeloid but not plasmacytoid dendritic cells.

Penna G, Amuchastegui S, Laverny G, Adorini L.

J Bone Miner Res. 2007 Dec;22 Suppl 2:V69-73. Review.PMID: 18290726 [PubMed - indexed for MEDLINE]Related articles

Animal models of spontaneous autoimmune disease: type 1 diabetes in the nonobese diabetic mouse.

Giarratana N, Penna G, Adorini L.

Methods Mol Biol. 2007;380:285-311. Review.PMID: 17876100 [PubMed - indexed for MEDLINE]Related articles

Atorvastatin but not elocalcitol increases sildenafil responsiveness in spontaneously hypertensive rats by regulating the RhoA/ROCK pathway.

Fibbi B, Morelli A, Marini M, Zhang XH, Mancina R, Vignozzi L, Filippi S, Chavalmane A, Silvestrini E, Colli E, Adorini L, Vannelli GB, Maggi M.

J Androl. 2008 Jan-Feb;29(1):70-84. Epub 2007 Aug 15.PMID: 17699803 [PubMed - indexed for MEDLINE]Related articlesFree article

Spontaneous and prostatic steroid binding protein peptide-induced autoimmune prostatitis in the nonobese diabetic mouse.

Penna G, Amuchastegui S, Cossetti C, Aquilano F, Mariani R, Giarratana N, De Carli E, Fibbi B, Adorini L.

J Immunol. 2007 Aug 1;179(3):1559-67.PMID: 17641022 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcitriol derivatives with two different side-chains at C-20. Part 4: further chain modifications that alter VDR-dependent monocytic differentiation potency in human leukemia cells.

Garay E, Jankowski P, Lizano P, Marczak S, Maehr H, Adorini L, Uskokovic MR, Studzinski GP.

Bioorg Med Chem. 2007 Jul 1;15(13):4444-55. Epub 2007 Apr 25.PMID: 17485214 [PubMed - indexed for MEDLINE]Related articles

Selective vitamin D receptor modulators and their effects on colorectal tumor growth.

Spina CS, Ton L, Yao M, Maehr H, Wolfe MM, Uskokovic M, Adorini L, Holick MF.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):757-62.PMID: 17368190 [PubMed - indexed for MEDLINE]Related articles

Calcitriol derivatives with two different side chains at C-20 III. An epimeric pair of the gemini family with unprecedented antiproliferative effects on tumor cells and renin mRNA expression inhibition.

Maehr H, Uskokovic M, Adorini L, Penna G, Mariani R, Panina P, Passini N, Bono E, Perego S, Biffi M, Holick M, Spina C, Suh N.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):277-81. Epub 2007 Jan 24.PMID: 17254779 [PubMed - indexed for MEDLINE]Related articles

Inhibition of prostate growth and inflammation by the vitamin D receptor agonist BXL-628 (elocalcitol).

Adorini L, Penna G, Amuchastegui S, Cossetti C, Aquilano F, Mariani R, Fibbi B, Morelli A, Uskokovic M, Colli E, Maggi M.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):689-93. Epub 2007 Jan 22.PMID: 17241782 [PubMed - indexed for MEDLINE]Related articles

1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells.

Penna G, Amuchastegui S, Giarratana N, Daniel KC, Vulcano M, Sozzani S, Adorini L.

J Immunol. 2007 Jan 1;178(1):145-53.PMID: 17182549 [PubMed - indexed for MEDLINE]Related articlesFree article

BXL-628, a vitamin D receptor agonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder.

Morelli A, Vignozzi L, Filippi S, Vannelli GB, Ambrosini S, Mancina R, Crescioli C, Donati S, Fibbi B, Colli E, Adorini L, Maggi M.

Prostate. 2007 Feb 15;67(3):234-47.PMID: 17163492 [PubMed - indexed for MEDLINE]Related articles

Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol.

Penna G, Amuchastegui S, Cossetti C, Aquilano F, Mariani R, Sanvito F, Doglioni C, Adorini L.

J Immunol. 2006 Dec 15;177(12):8504-11.PMID: 17142748 [PubMed - indexed for MEDLINE]Related articlesFree article

The vitamin D receptor as a therapeutic target.

Campbell MJ, Adorini L.

Expert Opin Ther Targets. 2006 Oct;10(5):735-48. Review.PMID: 16981830 [PubMed - indexed for MEDLINE]Related articles

Pre-clinical evidence and clinical translation of benign prostatic hyperplasia treatment by the vitamin D receptor agonist BXL-628 (Elocalcitol).

Maggi M, Crescioli C, Morelli A, Colli E, Adorini L.

J Endocrinol Invest. 2006 Jul-Aug;29(7):665-74. Review.PMID: 16957418 [PubMed - indexed for MEDLINE]Related articles

Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia.

Penna G, Mondaini N, Amuchastegui S, Degli Innocenti S, Carini M, Giubilei G, Fibbi B, Colli E, Maggi M, Adorini L.

Eur Urol. 2007 Feb;51(2):524-33; discussion 533. Epub 2006 Jul 28.PMID: 16905241 [PubMed - indexed for MEDLINE]Related articles

Vitamin D receptor agonists, cancer and the immune system: an intricate relationship.

Adorini L, Daniel KC, Penna G.

Curr Top Med Chem. 2006;6(12):1297-301.PMID: 16848743 [PubMed - indexed for MEDLINE]Related articles

C-20 cyclopropyl vitamin D3 analogs.

Uskokovic MR, Manchand P, Marczak S, Maehr H, Jankowski P, Adorini L, Reddy GS.

Curr Top Med Chem. 2006;6(12):1289-96.PMID: 16848742 [PubMed - indexed for MEDLINE]Related articles

The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells.

Marchiani S, Bonaccorsi L, Ferruzzi P, Crescioli C, Muratori M, Adorini L, Forti G, Maggi M, Baldi E.

J Cancer Res Clin Oncol. 2006 Jun;132(6):408-16. Epub 2006 Feb 17.PMID: 16485114 [PubMed - indexed for MEDLINE]Related articles

Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells.

Del Cornò M, Gauzzi MC, Penna G, Belardelli F, Adorini L, Gessani S.

J Virol. 2005 Oct;79(19):12597-601.PMID: 16160188 [PubMed - indexed for MEDLINE]Related articlesFree article

Colon cancer and solar ultraviolet B radiation and prevention and treatment of colon cancer in mice with vitamin D and its Gemini analogs.

Spina C, Tangpricha V, Yao M, Zhou W, Wolfe MM, Maehr H, Uskokovic M, Adorini L, Holick MF.

J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):111-20. Epub 2005 Sep 8.PMID: 16154354 [PubMed - indexed for MEDLINE]Related articles

Cutting edge: proangiogenic properties of alternatively activated dendritic cells.

Riboldi E, Musso T, Moroni E, Urbinati C, Bernasconi S, Rusnati M, Adorini L, Presta M, Sozzani S.

J Immunol. 2005 Sep 1;175(5):2788-92.PMID: 16116163 [PubMed - indexed for MEDLINE]Related articlesFree article

New trends in clinical and experimental immunosuppression--fourth international conference. 17-20 February 2000, Geneva, Switzerland.

Adorini L.

IDrugs. 2000 May;3(5):496-8.PMID: 16100680 [PubMed]Related articles

Prevention of chronic allograft rejection by Vitamin D receptor agonists.

Adorini L, Amuchastegui S, Daniel KC.

Immunol Lett. 2005 Aug 15;100(1):34-41. Review.PMID: 16054704 [PubMed - indexed for MEDLINE]Related articles

Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice.

Olcott AP, Tian J, Walker V, Dang H, Middleton B, Adorini L, Washburn L, Kaufman DL.

J Immunol. 2005 Aug 1;175(3):1991-9.PMID: 16034144 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3.

Penna G, Roncari A, Amuchastegui S, Daniel KC, Berti E, Colonna M, Adorini L.

Blood. 2005 Nov 15;106(10):3490-7. Epub 2005 Jul 19.PMID: 16030186 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of acute and chronic allograft rejection in mouse models by BXL-628, a nonhypercalcemic vitamin D receptor agonist.

Amuchastegui S, Daniel KC, Adorini L.

Transplantation. 2005 Jul 15;80(1):81-7.PMID: 16003237 [PubMed - indexed for MEDLINE]Related articles

Intervention in autoimmunity: the potential of vitamin D receptor agonists.

Adorini L.

Cell Immunol. 2005 Feb;233(2):115-24. Review.PMID: 15936743 [PubMed - indexed for MEDLINE]Related articles

Manipulating dendritic cells to induce regulatory T cells.

Penna G, Giarratana N, Amuchastegui S, Mariani R, Daniel KC, Adorini L.

Microbes Infect. 2005 Jun;7(7-8):1033-9. Epub 2005 Apr 26. Review.PMID: 15919222 [PubMed - indexed for MEDLINE]Related articles

IRF-4 expression in the human myeloid lineage: up-regulation during dendritic cell differentiation and inhibition by 1alpha,25-dihydroxyvitamin D3.

Gauzzi MC, Purificato C, Conti L, Adorini L, Belardelli F, Gessani S.

J Leukoc Biol. 2005 Jun;77(6):944-7. Epub 2005 Apr 13.PMID: 15829558 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressive effect of 1alpha,25-dihydroxyvitamin D3 on type I IFN-mediated monocyte differentiation into dendritic cells: impairment of functional activities and chemotaxis.

Gauzzi MC, Purificato C, Donato K, Jin Y, Wang L, Daniel KC, Maghazachi AA, Belardelli F, Adorini L, Gessani S.

J Immunol. 2005 Jan 1;174(1):270-6.PMID: 15611249 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcitriol derivatives with two different side chains at C-20. II. Diastereoselective syntheses of the metabolically produced 24(R)-hydroxygemini.

Maehr H, Uskokovic MR, Adorini L, Reddy GS.

J Med Chem. 2004 Dec 16;47(26):6476-84.PMID: 15588082 [PubMed - indexed for MEDLINE]Related articles

Human bladder as a novel target for vitamin D receptor ligands.

Crescioli C, Morelli A, Adorini L, Ferruzzi P, Luconi M, Vannelli GB, Marini M, Gelmini S, Fibbi B, Donati S, Villari D, Forti G, Colli E, Andersson KE, Maggi M.

J Clin Endocrinol Metab. 2005 Feb;90(2):962-72. Epub 2004 Nov 30.PMID: 15572423 [PubMed - indexed for MEDLINE]Related articlesFree article

Antigen-based immunointervention in human autoimmune diseases.

Adorini L.

Trends Biotechnol. 2004 Nov;22(11):547-9.PMID: 15491794 [PubMed - indexed for MEDLINE]Related articles

A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes development.

Giarratana N, Penna G, Amuchastegui S, Mariani R, Daniel KC, Adorini L.

J Immunol. 2004 Aug 15;173(4):2280-7.PMID: 15294940 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunotherapeutic approaches in multiple sclerosis.

Adorini L.

J Neurol Sci. 2004 Aug 15;223(1):13-24. Review.PMID: 15261555 [PubMed - indexed for MEDLINE]Related articles

Dendritic cells as key targets for immunomodulation by Vitamin D receptor ligands.

Adorini L, Penna G, Giarratana N, Roncari A, Amuchastegui S, Daniel KC, Uskokovic M.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):437-41. Review.PMID: 15225816 [PubMed - indexed for MEDLINE]Related articles

Characterization of five 19-nor-analogs of 1alpha,25(OH)2-Vitamin D3 with 20-cyclopropyl-modified side-chains: implications for ligand binding and calcemic properties.

Olivera CJ, Bula CM, Bishop JE, Adorini L, Manchand P, Uskokovic MR, Norman AW.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):99-106.PMID: 15225754 [PubMed - indexed for MEDLINE]Related articles