PubMed

Hypoxia inducible factor 1 alpha (HIF-1{alpha}) induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 (HDAC2) transcription.

Charron CE, Chou PC, Coutts DJ, Kumar V, To M, Akashi K, Pinhu L, Griffiths M, Adcock IM, Barnes PJ, Ito K.

J Biol Chem. 2009 Oct 30. [Epub ahead of print]PMID: 19880520 [PubMed - as supplied by publisher]Related articlesFree article

Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor.

Mortaz E, Adcock IM, Ito K, Kraneveld AD, Nijkamp FP, Folkerts G.

Eur Respir J. 2009 Oct 19. [Epub ahead of print]PMID: 19840968 [PubMed - as supplied by publisher]Related articles

The developmental origins of asthma: does epigenetics hold the key?

Shaheen SO, Adcock IM.

Am J Respir Crit Care Med. 2009 Oct 15;180(8):690-1. No abstract available. PMID: 19824169 [PubMed - indexed for MEDLINE]Related articles

PHF11 and DPP10: A Tale of Two Genes in Asthma.

Adcock IM, Kirkham PA.

Respiration. 2010;79(1):14-16. Epub 2009 Aug 29. No abstract available. PMID: 19729874 [PubMed - as supplied by publisher]Related articles

MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients.

Caramori G, Casolari P, Di Gregorio C, Saetta M, Baraldo S, Boschetto P, Ito K, Fabbri LM, Barnes PJ, Adcock IM, Cavallesco G, Chung KF, Papi A.

Histopathology. 2009 Sep;55(3):321-31.PMID: 19723147 [PubMed - indexed for MEDLINE]Related articles

Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD.

Di Stefano A, Caramori G, Gnemmi I, Contoli M, Bristot L, Capelli A, Ricciardolo FL, Magno F, D'Anna SE, Zanini A, Carbone M, Sabatini F, Usai C, Brun P, Chung KF, Barnes PJ, Papi A, Adcock IM, Balbi B.

Thorax. 2009 Nov;64(11):968-75. Epub 2009 Aug 23.PMID: 19703829 [PubMed - in process]Related articles

Overcoming steroid unresponsiveness in airways disease.

Adcock IM, Chou PC, Durham A, Ford P.

Biochem Soc Trans. 2009 Aug;37(Pt 4):824-9. Review.PMID: 19614602 [PubMed - indexed for MEDLINE]Related articles

Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites.

Wort SJ, Ito M, Chou PC, Mc Master SK, Badiger R, Jazrawi E, de Souza P, Evans TW, Mitchell JA, Pinhu L, Ito K, Adcock IM.

J Biol Chem. 2009 Sep 4;284(36):24297-305. Epub 2009 Jul 10.PMID: 19592490 [PubMed - indexed for MEDLINE]Related articles

Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future.

Chung KF, Caramori G, Adcock IM.

Eur J Clin Pharmacol. 2009 Sep;65(9):853-71. Epub 2009 Jun 26. Review.PMID: 19557399 [PubMed - indexed for MEDLINE]Related articles

Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor.

Ho SC, Lee KY, Chan YF, Kuo LW, Ito K, Adcock IM, Chen BC, Sheu JR, Lin CH, Kuo HP.

J Immunol. 2009 Jul 1;183(1):411-20.PMID: 19542452 [PubMed - indexed for MEDLINE]Related articles

MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy.

Williams AE, Larner-Svensson H, Perry MM, Campbell GA, Herrick SE, Adcock IM, Erjefalt JS, Chung KF, Lindsay MA.

PLoS One. 2009 Jun 12;4(6):e5889.PMID: 19521514 [PubMed - indexed for MEDLINE]Related articlesFree article

Rescue treatment in asthma. More than as-needed bronchodilation.

Papi A, Caramori G, Adcock IM, Barnes PJ.

Chest. 2009 Jun;135(6):1628-33. Review.PMID: 19497897 [PubMed - indexed for MEDLINE]Related articles

Glucocorticoid resistance in inflammatory diseases.

Barnes PJ, Adcock IM.

Lancet. 2009 May 30;373(9678):1905-17. Review.PMID: 19482216 [PubMed - indexed for MEDLINE]Related articles

Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease.

Maneechotesuwan K, Yao X, Ito K, Jazrawi E, Usmani OS, Adcock IM, Barnes PJ.

PLoS Med. 2009 May 12;6(5):e1000076. Epub 2009 May 19.PMID: 19436703 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2.

Osoata GO, Yamamura S, Ito M, Vuppusetty C, Adcock IM, Barnes PJ, Ito K.

Biochem Biophys Res Commun. 2009 Jul 3;384(3):366-71. Epub 2009 May 3.PMID: 19410558 [PubMed - indexed for MEDLINE]Related articles

Bronchodilatory effect of the PPAR-gamma agonist rosiglitazone in smokers with asthma.

Spears M, Donnelly I, Jolly L, Brannigan M, Ito K, McSharry C, Lafferty J, Chaudhuri R, Braganza G, Bareille P, Sweeney L, Adcock IM, Barnes PJ, Wood S, Thomson NC.

Clin Pharmacol Ther. 2009 Jul;86(1):49-53. Epub 2009 Apr 8.PMID: 19357642 [PubMed - indexed for MEDLINE]Related articles

Activation of NF-kappaB transcription factor in asthma death.

Caramori G, Oates T, Nicholson AG, Casolari P, Ito K, Barnes PJ, Papi A, Adcock IM, Chung KF.

Histopathology. 2009 Mar;54(4):507-9. No abstract available. PMID: 19309411 [PubMed - indexed for MEDLINE]Related articles

Clinical definition of COPD exacerbations and classification of their severity.

Caramori G, Adcock IM, Papi A.

South Med J. 2009 Mar;102(3):277-82.PMID: 19204646 [PubMed - indexed for MEDLINE]Related articles

Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study.

Spears M, Donnelly I, Jolly L, Brannigan M, Ito K, McSharry C, Lafferty J, Chaudhuri R, Braganza G, Adcock IM, Barnes PJ, Wood S, Thomson NC.

Eur Respir J. 2009 May;33(5):1010-7. Epub 2009 Feb 5.PMID: 19196814 [PubMed - indexed for MEDLINE]Related articles

Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice.

Marwick JA, Caramori G, Stevenson CS, Casolari P, Jazrawi E, Barnes PJ, Ito K, Adcock IM, Kirkham PA, Papi A.

Am J Respir Crit Care Med. 2009 Apr 1;179(7):542-8. Epub 2009 Jan 22.PMID: 19164702 [PubMed - indexed for MEDLINE]Related articles

Role of cathepsin S in ozone-induced airway hyperresponsiveness and inflammation.

Williams AS, Eynott PR, Leung SY, Nath P, Jupp R, De Sanctis GT, Resnick R, Adcock IM, Chung KF.

Pulm Pharmacol Ther. 2009 Feb;22(1):27-32. Epub 2008 Nov 14.PMID: 19041950 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress modulates theophylline effects on steroid responsiveness.

Marwick JA, Wallis G, Meja K, Kuster B, Bouwmeester T, Chakravarty P, Fletcher D, Whittaker PA, Barnes PJ, Ito K, Adcock IM, Kirkham PA.

Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802. Epub 2008 Oct 23.PMID: 18951874 [PubMed - indexed for MEDLINE]Related articles

Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation.

Williams AS, Issa R, Durham A, Leung SY, Kapoun A, Medicherla S, Higgins LS, Adcock IM, Chung KF.

Eur J Pharmacol. 2008 Dec 14;600(1-3):117-22. Epub 2008 Sep 30. Erratum in: Eur J Pharmacol. 2009 May 1;609(1-3):155-6. PMID: 18926814 [PubMed - indexed for MEDLINE]Related articles

New targets for drug development in asthma.

Adcock IM, Caramori G, Chung KF.

Lancet. 2008 Sep 20;372(9643):1073-87. Review.PMID: 18805336 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms of corticosteroid resistance.

Adcock IM, Barnes PJ.

Chest. 2008 Aug;134(2):394-401. Review.PMID: 18682458 [PubMed - indexed for MEDLINE]Related articlesFree article

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction.

Chung KF, Adcock IM.

Eur Respir J. 2008 Jun;31(6):1334-56. Review.PMID: 18515558 [PubMed - indexed for MEDLINE]Related articles

Overcoming steroid insensitivity in smoking asthmatics.

Ahmad T, Barnes PJ, Adcock IM.

Curr Opin Investig Drugs. 2008 May;9(5):470-7. Review.PMID: 18465656 [PubMed - indexed for MEDLINE]Related articles

Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13.

Williams AS, Nath P, Leung SY, Khorasani N, McKenzie AN, Adcock IM, Chung KF.

Eur Respir J. 2008 Sep;32(3):571-8. Epub 2008 Apr 16.PMID: 18417511 [PubMed - indexed for MEDLINE]Related articles

Steroid resistance in asthma: mechanisms and treatment options.

Adcock IM, Ford PA, Bhavsar P, Ahmad T, Chung KF.

Curr Allergy Asthma Rep. 2008 Apr;8(2):171-8. Review.PMID: 18417060 [PubMed - indexed for MEDLINE]Related articles

Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity.

Tahan F, Jazrawi E, Moodley T, Rovati GE, Adcock IM.

Clin Exp Allergy. 2008 May;38(5):805-11. Epub 2008 Mar 5.PMID: 18325031 [PubMed - indexed for MEDLINE]Related articles

New drugs targeting Th2 lymphocytes in asthma.

Caramori G, Groneberg D, Ito K, Casolari P, Adcock IM, Papi A.

J Occup Med Toxicol. 2008 Feb 27;3 Suppl 1:S6.PMID: 18315837 [PubMed - in process]Related articlesFree article

The role of histone deacetylases in asthma and allergic diseases.

Bhavsar P, Ahmad T, Adcock IM.

J Allergy Clin Immunol. 2008 Mar;121(3):580-4. Epub 2008 Jan 30. Review.PMID: 18234319 [PubMed - indexed for MEDLINE]Related articles

Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCepsilon and JAK2 in RAW macrophages.

Jones E, Adcock IM, Ahmed BY, Punchard NA.

J Inflamm (Lond). 2007 Nov 24;4:23.PMID: 18036230 [PubMed - in process]Related articlesFree article

Epigenetic regulation of airway inflammation.

Adcock IM, Tsaprouni L, Bhavsar P, Ito K.

Curr Opin Immunol. 2007 Dec;19(6):694-700. Epub 2007 Aug 27. Review.PMID: 17720468 [PubMed - indexed for MEDLINE]Related articles

Impact of protein acetylation in inflammatory lung diseases.

Ito K, Charron CE, Adcock IM.

Pharmacol Ther. 2007 Nov;116(2):249-65. Epub 2007 Jul 24. Review.PMID: 17720252 [PubMed - indexed for MEDLINE]Related articles

Suppression of lipopolysaccharide- and tumour necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation.

Tsaprouni LG, Ito K, Adcock IM, Punchard N.

Clin Exp Immunol. 2007 Oct;150(1):151-7. Epub 2007 Aug 17.PMID: 17711487 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia.

Williams AS, Leung SY, Nath P, Khorasani NM, Bhavsar P, Issa R, Mitchell JA, Adcock IM, Chung KF.

J Appl Physiol. 2007 Oct;103(4):1189-95. Epub 2007 Jul 12.PMID: 17626835 [PubMed - indexed for MEDLINE]Related articlesFree article

Degree of control of physician-diagnosed asthma and COPD in Italy.

Caramori G, Bettoncelli G, Carone M, Tosatto R, Di Blasi P, Pieretto A, Invernizzi G, Novelletto BF, Ciaccia A, Adcock IM, Papi A.

Monaldi Arch Chest Dis. 2007 Mar;67(1):15-22.PMID: 17564280 [PubMed - indexed for MEDLINE]Related articles

Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils.

Maneechotesuwan K, Essilfie-Quaye S, Kharitonov SA, Adcock IM, Barnes PJ.

Chest. 2007 Jul;132(1):98-105. Epub 2007 Jun 5.PMID: 17550933 [PubMed - indexed for MEDLINE]Related articlesFree article

Corticosteroid inhibition of growth-related oncogene protein-alpha via mitogen-activated kinase phosphatase-1 in airway smooth muscle cells.

Issa R, Xie S, Khorasani N, Sukkar M, Adcock IM, Lee KY, Chung KF.

J Immunol. 2007 Jun 1;178(11):7366-75.PMID: 17513787 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy.

Marwick JA, Ito K, Adcock IM, Kirkham PA.

Expert Opin Ther Targets. 2007 Jun;11(6):745-55. Review.PMID: 17504013 [PubMed - indexed for MEDLINE]Related articles

Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125.

Williams AS, Issa R, Leung SY, Nath P, Ferguson GD, Bennett BL, Adcock IM, Chung KF.

J Pharmacol Exp Ther. 2007 Jul;322(1):351-9. Epub 2007 Apr 25.PMID: 17460151 [PubMed - indexed for MEDLINE]Related articlesFree article

HDAC inhibitors as anti-inflammatory agents.

Adcock IM.

Br J Pharmacol. 2007 Apr;150(7):829-31. Epub 2007 Feb 26.PMID: 17325655 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3.

Maneechotesuwan K, Xin Y, Ito K, Jazrawi E, Lee KY, Usmani OS, Barnes PJ, Adcock IM.

J Immunol. 2007 Feb 15;178(4):2491-8.PMID: 17277157 [PubMed - indexed for MEDLINE]Related articlesFree article

Histone deacetylation: an important mechanism in inflammatory lung diseases.

Adcock IM, Ito K, Barnes PJ.

COPD. 2005 Dec;2(4):445-55. Review.PMID: 17147010 [PubMed - indexed for MEDLINE]Related articles

Histone deacetylase inhibitors as novel anti-inflammatory agents.

Adcock IM.

Curr Opin Investig Drugs. 2006 Nov;7(11):966-73. Review.PMID: 17117583 [PubMed - indexed for MEDLINE]Related articles

Expression of nonmuscle cofilin-1 and steroid responsiveness in severe asthma.

Vasavda N, Eichholtz T, Takahashi A, Affleck K, Matthews JG, Barnes PJ, Adcock IM.

J Allergy Clin Immunol. 2006 Nov;118(5):1090-6. Epub 2006 Sep 25.PMID: 17088134 [PubMed - indexed for MEDLINE]Related articles

IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter.

Morello S, Ito K, Yamamura S, Lee KY, Jazrawi E, Desouza P, Barnes P, Cicala C, Adcock IM.

J Immunol. 2006 Nov 15;177(10):7173-83.PMID: 17082635 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease.

Ito K, Caramori G, Adcock IM.

J Pharmacol Exp Ther. 2007 Apr;321(1):1-8. Epub 2006 Oct 4. Review.PMID: 17021257 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal histone acetylase and deacetylase expression and function in lung inflammation.

Adcock IM, Lee KY.

Inflamm Res. 2006 Aug;55(8):311-21. Review. Erratum in: Inflamm Res. 2006 Dec;55(12):572. PMID: 16977378 [PubMed - indexed for MEDLINE]Related articles