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ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.
Shu Q, Lennemann NJ, Sarkar SN, Sadovsky Y, Coyne CB. Shu Q, et al. PLoS Pathog. 2015 Sep 15;11(9):e1005150. doi: 10.1371/journal.ppat.1005150. eCollection 2015 Sep. PLoS Pathog. 2015. PMID: 26372645 Free PMC article.
ADAP2 functions as a GTPase-activating protein (GAP) for Arf6 and binds to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) and PI(3,4)P2. ...We further show that ADAP2 expression induces macropinocytosis and that ADAP2 strongly associates with actin-en …
ADAP2 functions as a GTPase-activating protein (GAP) for Arf6 and binds to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) and …
Elevated Expression of ADAP2 is Associated With Aggressive Behavior of Human Clear-Cell Renal Cell Carcinoma and Poor Patient Survival.
Qiang Y, Wang X, Ding J, Wang Z, Li B, Ji H, Zhang X, Yang Y, Liu K, Zhang L, Ma S, Zhao D, Lu G. Qiang Y, et al. Clin Genitourin Cancer. 2023 Apr;21(2):e78-e91. doi: 10.1016/j.clgc.2022.08.003. Epub 2022 Aug 6. Clin Genitourin Cancer. 2023. PMID: 36127253
The role of ADAP2 in ccRCC progression is unknown. METHODS: ADAP2 expression in ccRCC cell lines and tissues was examined via real-time PCR, Western blot and IHC. ...The prognostic role of ADAP2 was evaluated by survival analysis. RESULTS: ADAP2 mRNA w …
The role of ADAP2 in ccRCC progression is unknown. METHODS: ADAP2 expression in ccRCC cell lines and tissues was examined via …
ADAP2 in heart development: a candidate gene for the occurrence of cardiovascular malformations in NF1 microdeletion syndrome.
Venturin M, Carra S, Gaudenzi G, Brunelli S, Gallo GR, Moncini S, Cotelli F, Riva P. Venturin M, et al. J Med Genet. 2014 Jul;51(7):436-43. doi: 10.1136/jmedgenet-2013-102240. Epub 2014 Apr 7. J Med Genet. 2014. PMID: 24711647 Free article.
In order to investigate the role of ADAP2 in cardiac development, we performed loss-of-function experiments of zebrafish ADAP2 ortholog, adap2, by injecting two different morpholino oligos (adap2-MO and UTR-adap2-MO). adap2-MOs-injected e …
In order to investigate the role of ADAP2 in cardiac development, we performed loss-of-function experiments of zebrafish ADAP2 …
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
Majdoul S, Compton AA. Majdoul S, et al. Nat Rev Immunol. 2022 Jun;22(6):339-352. doi: 10.1038/s41577-021-00626-8. Epub 2021 Oct 13. Nat Rev Immunol. 2022. PMID: 34646033 Free PMC article. Review.
Several host factors with antiviral potential are now implicated in the regulation of virus entry, including cholesterol 25-hydroxylase (CH25H), lymphocyte antigen 6E (LY6E), nuclear receptor co-activator protein 7 (NCOA7), interferon-gamma-inducible lysosomal thiol reductase (GI …
Several host factors with antiviral potential are now implicated in the regulation of virus entry, including cholesterol 25-hydroxylase (CH2 …
ArfGAP Domain-Containing Protein 2 (ADAP2) Integrates Upstream and Downstream Modules of RIG-I Signaling and Facilitates Type I Interferon Production.
Bist P, Kim SS, Pulloor NK, McCaffrey K, Nair SK, Liu Y, Lin R, Krishnan MN. Bist P, et al. Mol Cell Biol. 2017 Mar 1;37(6):e00537-16. doi: 10.1128/MCB.00537-16. Print 2017 Mar 15. Mol Cell Biol. 2017. PMID: 27956705 Free PMC article.
Furthermore, independently, ADAP2 also functioned as a major orchestrator of the interaction of TBK1 with NEMO and IRF3. Mutational and in vitro cell-free reconstituted RIG-I signaling assay-based analyses identified that the ArfGAP domain of ADAP2 mediates the inte …
Furthermore, independently, ADAP2 also functioned as a major orchestrator of the interaction of TBK1 with NEMO and IRF3. Mutational a …
Down regulation of Cathepsin W is associated with poor prognosis in pancreatic cancer.
Khojasteh-Leylakoohi F, Mohit R, Khalili-Tanha N, Asadnia A, Naderi H, Pourali G, Yousefli Z, Khalili-Tanha G, Khazaei M, Maftooh M, Nassiri M, Hassanian SM, Ghayour-Mobarhan M, Ferns GA, Shahidsales S, Lam AK, Giovannetti E, Nazari E, Batra J, Avan A. Khojasteh-Leylakoohi F, et al. Sci Rep. 2023 Oct 4;13(1):16678. doi: 10.1038/s41598-023-42928-y. Sci Rep. 2023. PMID: 37794108 Free PMC article.
The results of Machine learning identified 23 genes with negative regulation, five genes with positive regulation, seven microRNAs with negative regulation, and 20 microRNAs with positive regulation in PDAC. Key genes BMF, FRMD4A, ADAP2, PPP1R17, and CACNG3 had the highest …
The results of Machine learning identified 23 genes with negative regulation, five genes with positive regulation, seven microRNAs with nega …
LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2.
Zhao X, Zheng S, Chen D, Zheng M, Li X, Li G, Lin H, Chang J, Zeng H, Guo JT. Zhao X, et al. J Virol. 2020 Aug 31;94(18):e00562-20. doi: 10.1128/JVI.00562-20. Print 2020 Aug 31. J Virol. 2020. PMID: 32641482 Free PMC article.
Functional analyses revealed that ectopic expression of LY6E, but not GILT or ADAP2, in HEK 293 cells inhibited the entry of HCoV-O43. While overexpression of LY6E in C3A and A549 cells efficiently inhibited the infection of HCoV-OC43, knockdown of LY6E expression in HepG2 …
Functional analyses revealed that ectopic expression of LY6E, but not GILT or ADAP2, in HEK 293 cells inhibited the entry of HCoV-O43 …
Multisite learning of high-dimensional heterogeneous data with applications to opioid use disorder study of 15,000 patients across 5 clinical sites.
Liu X, Duan R, Luo C, Ogdie A, Moore JH, Kranzler HR, Bian J, Chen Y. Liu X, et al. Sci Rep. 2022 Jun 30;12(1):11073. doi: 10.1038/s41598-022-14029-9. Sci Rep. 2022. PMID: 35773438 Free PMC article.
ADAP utilizes patient-level data from a lead site and incorporates the first-order (ADAP1) and second-order gradients (ADAP2) of the objective function from collaborating sites to construct a surrogate objective function at the lead site, where model fitting is then comple …
ADAP utilizes patient-level data from a lead site and incorporates the first-order (ADAP1) and second-order gradients (ADAP2) of the …
Identification of key genes as predictive biomarkers for osteosarcoma metastasis using translational bioinformatics.
Ding FP, Tian JY, Wu J, Han DF, Zhao D. Ding FP, et al. Cancer Cell Int. 2021 Dec 2;21(1):640. doi: 10.1186/s12935-021-02308-w. Cancer Cell Int. 2021. PMID: 34856991 Free PMC article.
Of the 45 genes, 17 were found to be significantly correlated with survival time. Finally, 5/17 genes, including ADAP2 (P = 0.0094), LCP2 (P = 0.013), ARHGAP25 (P = 0.0049), CD53 (P = 0.016), and TLR7 (P = 0.04) were significantly correlated with the metastatic phenotype. …
Of the 45 genes, 17 were found to be significantly correlated with survival time. Finally, 5/17 genes, including ADAP2 (P = 0.0094), …
Functions of the neuron-specific protein ADAP1 (centaurin-α1) in neuronal differentiation and neurodegenerative diseases, with an overview of structural and biochemical properties of ADAP1.
Stricker R, Reiser G. Stricker R, et al. Biol Chem. 2014 Nov 1;395(11):1321-40. doi: 10.1515/hsz-2014-0107. Biol Chem. 2014. PMID: 24854535 Review.
The mammalian ADAP subfamily consists of two identified isoforms, ADAP1 and ADAP2 (centaurin-alpha1 and -alpha2). ADAP1 is highly expressed in neurons. ...
The mammalian ADAP subfamily consists of two identified isoforms, ADAP1 and ADAP2 (centaurin-alpha1 and -alpha2). ADAP1 is highly exp …
25 results