PubMed

Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?

Brandys MK, van Elburg AA, Loos RJ, Bauer F, Hendriks J, van der Schouw YT, Adan RA.

Am J Med Genet B Neuropsychiatr Genet. 2009 Sep 10. [Epub ahead of print]PMID: 19746409 [PubMed - as supplied by publisher]Related articles

Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference.

Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, Grobbee DE, van Vliet-Ostaptchouk JV, Wijmenga C, van der Schouw YT.

Am J Clin Nutr. 2009 Oct;90(4):951-9. Epub 2009 Aug 19.PMID: 19692490 [PubMed - indexed for MEDLINE]Related articles

Sustained NPY overexpression in the PVN results in obesity via temporarily increasing food intake.

Tiesjema B, la Fleur SE, Luijendijk MC, Adan RA.

Obesity (Silver Spring). 2009 Jul;17(7):1448-50. Epub 2009 Feb 19.PMID: 19553928 [PubMed - indexed for MEDLINE]Related articles

Genetic variation and effects on human eating behavior.

de Krom M, Bauer F, Collier D, Adan RA, la Fleur SE.

Annu Rev Nutr. 2009;29:283-304. Review.PMID: 19400703 [PubMed - indexed for MEDLINE]Related articles

Dopamine and serotonin release in the nucleus accumbens during starvation-induced hyperactivity.

Verhagen LA, Luijendijk MC, Korte-Bouws GA, Korte SM, Adan RA.

Eur Neuropsychopharmacol. 2009 May;19(5):309-16. Epub 2009 Jan 31.PMID: 19181487 [PubMed - indexed for MEDLINE]Related articles

Improved identification of endogenous peptides from murine nervous tissue by multiplexed peptide extraction methods and multiplexed mass spectrometric analysis.

Altelaar AF, Mohammed S, Brans MA, Adan RA, Heck AJ.

J Proteome Res. 2009 Feb;8(2):870-6.PMID: 19152261 [PubMed - indexed for MEDLINE]Related articles

Lentivirus-mediated transgene delivery to the hippocampus reveals sub-field specific differences in expression.

van Hooijdonk LW, Ichwan M, Dijkmans TF, Schouten TG, de Backer MW, Adan RA, Verbeek FJ, Vreugdenhil E, Fitzsimons CP.

BMC Neurosci. 2009 Jan 13;10:2.PMID: 19144149 [PubMed - indexed for MEDLINE]Related articlesFree article

Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa.

Verhagen LA, Luijendijk MC, Hillebrand JJ, Adan RA.

Eur Neuropsychopharmacol. 2009 Mar;19(3):153-60. Epub 2008 Nov 1.PMID: 18977121 [PubMed - indexed for MEDLINE]Related articles

Leptin's effect on hyperactivity: potential downstream effector mechanisms.

Hillebrand JJ, Kas MJ, van Elburg AA, Hoek HW, Adan RA.

Physiol Behav. 2008 Aug 6;94(5):689-95. Epub 2008 Apr 13. Review.PMID: 18495181 [PubMed - indexed for MEDLINE]Related articles

Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes.

van Abeelen AF, de Krom M, Hendriks J, Grobbee DE, Adan RA, van der Schouw YT.

Eur J Endocrinol. 2008 May;158(5):669-76. Erratum in: Eur J Endocrinol. 2008 Jul;159(1):159. PMID: 18426825 [PubMed - indexed for MEDLINE]Related articlesFree article

Olanzapine-induced weight gain: chronic infusion using osmotic minipumps does not result in stable plasma levels due to degradation of olanzapine in solution.

van der Zwaal EM, Luijendijk MC, Adan RA, la Fleur SE.

Eur J Pharmacol. 2008 May 6;585(1):130-6. Epub 2008 Mar 4. Review.PMID: 18378227 [PubMed - indexed for MEDLINE]Related articles

Multimeric alpha-MSH has increased efficacy to activate the melanocortin MC4 receptor.

Tiesjema B, Merkestein M, Garner KM, de Krom M, Adan RA.

Eur J Pharmacol. 2008 May 6;585(1):24-30. Epub 2008 Feb 26.PMID: 18378226 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic neuropeptide expression of juvenile and middle-aged rats after early postnatal food restriction.

Remmers F, Verhagen LA, Adan RA, Delemarre-van de Waal HA.

Endocrinology. 2008 Jul;149(7):3617-25. Epub 2008 Mar 27.PMID: 18372335 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-obesity drugs and neural circuits of feeding.

Adan RA, Vanderschuren LJ, la Fleur SE.

Trends Pharmacol Sci. 2008 Apr;29(4):208-17. Epub 2008 Mar 18. Review.PMID: 18353447 [PubMed - indexed for MEDLINE]Related articles

Differential effects of recombinant adeno-associated virus-mediated neuropeptide Y overexpression in the hypothalamic paraventricular nucleus and lateral hypothalamus on feeding behavior.

Tiesjema B, Adan RA, Luijendijk MC, Kalsbeek A, la Fleur SE.

J Neurosci. 2007 Dec 19;27(51):14139-46.PMID: 18094253 [PubMed - indexed for MEDLINE]Related articlesFree article

Viral mediated neuropeptide Y expression in the rat paraventricular nucleus results in obesity.

Tiesjema B, la Fleur SE, Luijendijk MC, Brans MA, Lin EJ, During MJ, Adan RA.

Obesity (Silver Spring). 2007 Oct;15(10):2424-35.PMID: 17925468 [PubMed - indexed for MEDLINE]Related articles

A reciprocal interaction between food-motivated behavior and diet-induced obesity.

la Fleur SE, Vanderschuren LJ, Luijendijk MC, Kloeze BM, Tiesjema B, Adan RA.

Int J Obes (Lond). 2007 Aug;31(8):1286-94. Epub 2007 Feb 27.PMID: 17325683 [PubMed - indexed for MEDLINE]Related articles

Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns.

de Krom M, van der Schouw YT, Hendriks J, Ophoff RA, van Gils CH, Stolk RP, Grobbee DE, Adan R.

Diabetes. 2007 Jan;56(1):276-80.PMID: 17192493 [PubMed - indexed for MEDLINE]Related articlesFree article

A polymorphism in the 3' untranslated region of the CCK gene is associated with anorexia nervosa in Dutch patients.

de Krom M, Hendriks J, Hillebrand J, van Elburg A, Adan R.

Psychiatr Genet. 2006 Dec;16(6):239. No abstract available. PMID: 17106425 [PubMed - indexed for MEDLINE]Related articles

The MC4 receptor and control of appetite.

Adan RA, Tiesjema B, Hillebrand JJ, la Fleur SE, Kas MJ, de Krom M.

Br J Pharmacol. 2006 Dec;149(7):815-27. Epub 2006 Oct 16. Review.PMID: 17043670 [PubMed - indexed for MEDLINE]Related articlesFree article

Melanocortin receptors as drug targets for disorders of energy balance.

Adan RA, van Dijk G.

CNS Neurol Disord Drug Targets. 2006 Jun;5(3):251-61. Review.PMID: 16787227 [PubMed - indexed for MEDLINE]Related articles

Difference in susceptibility to activity-based anorexia in two inbred strains of mice.

Gelegen C, Collier DA, Campbell IC, Oppelaar H, van den Heuvel J, Adan RA, Kas MJ.

Eur Neuropsychopharmacol. 2007 Feb;17(3):199-205. Epub 2006 Jun 2.PMID: 16735105 [PubMed - indexed for MEDLINE]Related articles

To eat or not to eat; regulation by the melanocortin system.

Hillebrand JJ, Kas MJ, Adan RA.

Physiol Behav. 2006 Aug 30;89(1):97-102. Epub 2006 Mar 6. Review.PMID: 16574172 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults.

van Rossum CT, Pijl H, Adan RA, Hoebee B, Seidell JC.

Int J Obes (Lond). 2006 Oct;30(10):1522-8. Epub 2006 Mar 28.PMID: 16568137 [PubMed - indexed for MEDLINE]Related articles

Constitutive receptor activity series: endogenous inverse agonists and constitutive receptor activity in the melanocortin system.

Adan RA.

Trends Pharmacol Sci. 2006 Apr;27(4):183-6. Epub 2006 Feb 28.PMID: 16500715 [PubMed - indexed for MEDLINE]Related articles

The appetite suppressant d-fenfluramine reduces water intake, but not food intake, in activity-based anorexia.

Hillebrand JJ, Heinsbroek AC, Kas MJ, Adan RA.

J Mol Endocrinol. 2006 Feb;36(1):153-62.PMID: 16461935 [PubMed - indexed for MEDLINE]Related articlesFree article

Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry.

Altelaar AF, Klinkert I, Jalink K, de Lange RP, Adan RA, Heeren RM, Piersma SR.

Anal Chem. 2006 Feb 1;78(3):734-42.PMID: 16448046 [PubMed - indexed for MEDLINE]Related articles

AgRP(83-132) and SHU9119 differently affect activity-based anorexia.

Hillebrand JJ, Kas MJ, Scheurink AJ, van Dijk G, Adan RA.

Eur Neuropsychopharmacol. 2006 Aug;16(6):403-12. Epub 2005 Dec 15.PMID: 16360312 [PubMed - indexed for MEDLINE]Related articles

Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients.

de Krom M, de Rijke CE, Hendriks J, van Engeland H, van Elburg AA, Adan RA.

Psychiatr Genet. 2005 Dec;15(4):237. No abstract available. PMID: 16314751 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic neuropeptide expression following chronic food restriction in sedentary and wheel-running rats.

de Rijke CE, Hillebrand JJ, Verhagen LA, Roeling TA, Adan RA.

J Mol Endocrinol. 2005 Oct;35(2):381-90.PMID: 16216917 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats.

van Dijk G, de Vries K, Nyakas C, Buwalda B, Adage T, Kuipers F, Kas MJ, Adan RA, Wilkinson CW, Thiele TE, Scheurink AJ.

Endocrinology. 2005 Dec;146(12):5247-56. Epub 2005 Sep 15.PMID: 16166222 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event.

Kas MJ, Bruijnzeel AW, Haanstra JR, Wiegant VM, Adan RA.

J Mol Endocrinol. 2005 Aug;35(1):159-64.PMID: 16087729 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin treatment in activity-based anorexia.

Hillebrand JJ, Koeners MP, de Rijke CE, Kas MJ, Adan RA.

Biol Psychiatry. 2005 Jul 15;58(2):165-71.PMID: 16038687 [PubMed - indexed for MEDLINE]Related articles

Olanzapine reduces physical activity in rats exposed to activity-based anorexia: possible implications for treatment of anorexia nervosa?

Hillebrand JJ, van Elburg AA, Kas MJ, van Engeland H, Adan RA.

Biol Psychiatry. 2005 Oct 15;58(8):651-7. Epub 2005 Jul 14.PMID: 16018979 [PubMed - indexed for MEDLINE]Related articles

Peptoid-peptide hybrids as potent novel melanocortin receptor ligands.

Kruijtzer JA, Nijenhuis WA, Wanders N, Gispen WH, Liskamp RM, Adan RA.

J Med Chem. 2005 Jun 30;48(13):4224-30.PMID: 15974575 [PubMed - indexed for MEDLINE]Related articles

alpha-MSH enhances activity-based anorexia.

Hillebrand JJ, Kas MJ, Adan RA.

Peptides. 2005 Oct;26(10):1690-6.PMID: 15964664 [PubMed - indexed for MEDLINE]Related articles

Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness.

de Rijke CE, Jackson PJ, Garner KM, van Rozen RJ, Douglas NR, Kas MJ, Millhauser GL, Adan RA.

Biochem Pharmacol. 2005 Jul 15;70(2):308-16.PMID: 15927146 [PubMed - indexed for MEDLINE]Related articles

Voluntary access to a warm plate reduces hyperactivity in activity-based anorexia.

Hillebrand JJ, de Rijke CE, Brakkee JH, Kas MJ, Adan RA.

Physiol Behav. 2005 Jun 2;85(2):151-7.PMID: 15924912 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms in the brain-derived neurotrophic factor gene are not associated with either anorexia nervosa or schizophrenia in Dutch patients.

de Krom M, Bakker SC, Hendriks J, van Elburg A, Hoogendoorn M, Verduijn W, Sinke R, Kahn R, Adan RA.

Psychiatr Genet. 2005 Jun;15(2):81. No abstract available. PMID: 15900221 [PubMed - indexed for MEDLINE]Related articles

Synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis.

Wels B, Kruijtzer JA, Garner K, Nijenhuis WA, Gispen WH, Adan RA, Liskamp RM.

Bioorg Med Chem. 2005 Jul 1;13(13):4221-7.PMID: 15876540 [PubMed - indexed for MEDLINE]Related articles

Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups.

Wels B, Kruijtzer JA, Garner KM, Adan RA, Liskamp RM.

Bioorg Med Chem Lett. 2005 Jan 17;15(2):287-90.PMID: 15603941 [PubMed - indexed for MEDLINE]Related articles

Induction of brain-region-specific forms of obesity by agouti.

Kas MJ, Tiesjema B, van Dijk G, Garner KM, Barsh GS, ter Brake O, Verhaagen J, Adan RA.

J Neurosci. 2004 Nov 10;24(45):10176-81.PMID: 15537888 [PubMed - indexed for MEDLINE]Related articlesFree article

Accelerating sensory recovery after sciatic nerve crush: non-selective versus melanocortin MC4 receptor-selective peptides.

Nijenhuis WA, Wanders N, Kruijtzer JA, Liskamp RM, Gispen WH, Adan RA.

Eur J Pharmacol. 2004 Jul 14;495(2-3):145-52.PMID: 15249163 [PubMed - indexed for MEDLINE]Related articles

Refinement of behavioural traits in animals for the genetic dissection of eating disorders.

Kas MJ, Van Elburg AA, Van Engeland H, Adan RA.

Eur J Pharmacol. 2003 Nov 7;480(1-3):13-20. Review.PMID: 14623346 [PubMed - indexed for MEDLINE]Related articles

Interaction between the spinal melanocortin and opioid systems in a rat model of neuropathic pain.

Vrinten DH, Gispen WH, Kalkman CJ, Adan RA.

Anesthesiology. 2003 Aug;99(2):449-54.PMID: 12883419 [PubMed - indexed for MEDLINE]Related articlesFree article

Melanocortin system and eating disorders.

Adan RA, Hillebrand JJ, De Rijke C, Nijenhuis W, Vink T, Garner KM, Kas MJ.

Ann N Y Acad Sci. 2003 Jun;994:267-74.PMID: 12851325 [PubMed - indexed for MEDLINE]Related articles

Inverse agonism gains weight.

Adan RA, Kas MJ.

Trends Pharmacol Sci. 2003 Jun;24(6):315-21. Review.PMID: 12823958 [PubMed - indexed for MEDLINE]Related articles

Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity.

Nijenhuis WA, Garner KM, van Rozen RJ, Adan RA.

J Biol Chem. 2003 Jun 20;278(25):22939-45. Epub 2003 Apr 9.PMID: 12690102 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides.

Nijenhuis WA, Kruijtzer JA, Wanders N, Vrinten DH, Garner KM, Schaaper WM, Meloen RH, Gispen WH, Liskamp RM, Adan RA.

Peptides. 2003 Feb;24(2):271-80.PMID: 12668212 [PubMed - indexed for MEDLINE]Related articles

Agouti-related protein prevents self-starvation.

Kas MJ, van Dijk G, Scheurink AJ, Adan RA.

Mol Psychiatry. 2003 Feb;8(2):235-40.PMID: 12610657 [PubMed - indexed for MEDLINE]Related articles