PubMed

Screening for iron overload: Lessons from the HEmochromatosis and IRon Overload Screening (HEIRS) Study.

Adams P, Barton JC, McLaren GD, Acton RT, Speechley M, McLaren CE, Reboussin DM, Leiendecker-Foster C, Harris EL, Snively BM, Vogt T, Sholinsky P, Thomson E, Dawkins FW, Gordeuk VR, Eckfeldt JH.

Can J Gastroenterol. 2009 Nov;23(11):769-72.PMID: 19893773 [PubMed - in process]Related articlesFree article

HAMP promoter mutation nc.-153C>T in 785 HEIRS Study participants.

Barton JC, Leiendecker-Foster C, Li H, DelRio-LaFreniere S, Acton RT, Eckfeldt JH; HEIRS Study.

Haematologica. 2009 Oct;94(10):1465; author reply 1465-6. No abstract available. PMID: 19794094 [PubMed - in process]Related articlesFree article

HFE, SLC40A1, HAMP, HJV, TFR2, and FTL mutations detected by denaturing high-performance liquid chromatography after iron phenotyping and HFE C282Y and H63D genotyping in 785 HEIRS Study participants.

Barton JC, Lafreniere SA, Leiendecker-Foster C, Li H, Acton RT, Press RD, Eckfeldt JH.

Am J Hematol. 2009 Nov;84(11):710-4.PMID: 19787796 [PubMed - in process]Related articles

Relationships of serum free thyroxine and erythrocyte measures in euthyroid HFE C282Y homozygotes and control subjects: the HEIRS Study.

Barton JC, Leiendecker-Foster C, Reboussin DM, Adams PC, Acton RT, Eckfeldt JH; FOR THE HEMOCHROMATOSIS AND IRON OVERLOAD SCREENING STUDY RESEARCH INVESTIGATORS.

Int J Lab Hematol. 2009 Aug 25. [Epub ahead of print]PMID: 19706067 [PubMed - as supplied by publisher]Related articles

HFE hemochromatosis and hepatic sarcoid.

Barton JC, McGuire BM, Acton RT.

Am J Med Sci. 2009 May;337(5):386-90.PMID: 19440063 [PubMed - indexed for MEDLINE]Related articles

Hemochromatosis and Vibrio vulnificus Wound Infections.

Barton JC, Acton RT.

J Clin Gastroenterol. 2009 Apr 3. [Epub ahead of print]PMID: 19349902 [PubMed - as supplied by publisher]Related articles

A comparison between whites and blacks with severe multi-organ iron overload identified in 16,152 autopsies.

Barton JC, Acton RT, Anderson LE, Alexander CB.

Clin Gastroenterol Hepatol. 2009 Jul;7(7):781-785.e2. Epub 2009 Mar 21.PMID: 19306945 [PubMed - indexed for MEDLINE]Related articles

Influence of CYP2C9 and VKORC1 on warfarin response during initiation of therapy.

Limdi NA, Wiener H, Goldstein JA, Acton RT, Beasley TM.

Blood Cells Mol Dis. 2009 Jul-Aug;43(1):119-28. Epub 2009 Mar 17.PMID: 19297219 [PubMed - indexed for MEDLINE]Related articles

Kidney function influences warfarin responsiveness and hemorrhagic complications.

Limdi NA, Beasley TM, Baird MF, Goldstein JA, McGwin G, Arnett DK, Acton RT, Allon M.

J Am Soc Nephrol. 2009 Apr;20(4):912-21. Epub 2009 Feb 18.PMID: 19225037 [PubMed - indexed for MEDLINE]Related articles

Heme carrier protein 1 (HCP1) genetic variants in the Hemochromatosis and Iron Overload Screening (HEIRS) Study participants.

Wang X, Leiendecker-Foster C, Acton RT, Barton JC, McLaren CE, McLaren GD, Gordeuk VR, Eckfeldt JH.

Blood Cells Mol Dis. 2009 Mar-Apr;42(2):150-4. Epub 2009 Jan 26.PMID: 19176287 [PubMed - indexed for MEDLINE]Related articles

Clinical manifestations of hemochromatosis in HFE C282Y homozygotes identified by screening.

McLaren GD, McLaren CE, Adams PC, Barton JC, Reboussin DM, Gordeuk VR, Acton RT, Harris EL, Speechley MR, Sholinsky P, Dawkins FW, Snively BM, Vogt TM, Eckfeldt JH; Hemochromatosis and Iron Overload Screen (HEIRS) Study Research Investigators.

Can J Gastroenterol. 2008 Nov;22(11):923-30.PMID: 19018338 [PubMed - indexed for MEDLINE]Related articlesFree article

Screening for hemochromatosis and iron overload: satisfaction with results notification and understanding of mailed results in unaffected participants of the HEIRS study.

Harrison HF, Harrison BW, Walker AP, Lohman K, Ellis SD, Hall MA, Reiss J, Adams PC, Holup J, Acton RT, Bent T, Rivers C, Fadojutimi-Akinsiku M.

Genet Test. 2008 Dec;12(4):491-500.PMID: 18939938 [PubMed - indexed for MEDLINE]Related articles

VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans.

Limdi NA, Beasley TM, Crowley MR, Goldstein JA, Rieder MJ, Flockhart DA, Arnett DK, Acton RT, Liu N.

Pharmacogenomics. 2008 Oct;9(10):1445-58.PMID: 18855533 [PubMed - indexed for MEDLINE]Related articlesFree article

Serial serum ferritin measurements in untreated HFE C282Y homozygotes in the Hemochromatosis and Iron Overload Screening Study.

Adams PC, Reboussin DM, Barton JC, Acton RT, Speechley M, Leiendecker-Foster C, Meenan R, Passmore L, McLaren CE, McLaren GD, Gordeuk V, Dawkins F, Eckfeldt JH.

Int J Lab Hematol. 2008 Aug;30(4):300-5.PMID: 18665827 [PubMed - indexed for MEDLINE]Related articles

Thyroid-stimulating hormone and free thyroxine levels in persons with HFE C282Y homozygosity, a common hemochromatosis genotype: the HEIRS study.

Barton JC, Leiendecker-Foster C, Reboussin DM, Adams PC, Acton RT, Eckfeldt JH; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Thyroid. 2008 Aug;18(8):831-8.PMID: 18651828 [PubMed - indexed for MEDLINE]Related articles

Accuracy of family history of hemochromatosis or iron overload: the hemochromatosis and iron overload screening study.

Acton RT, Barton JC, Passmore LV, Adams PC, McLaren GD, Leiendecker-Foster C, Speechley MR, Harris EL, Castro O, Reiss JA, Snively BM, Harrison BW, McLaren CE.

Clin Gastroenterol Hepatol. 2008 Aug;6(8):934-8. Epub 2008 Jun 27.PMID: 18585964 [PubMed - indexed for MEDLINE]Related articles

Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans.

Limdi NA, Arnett DK, Goldstein JA, Beasley TM, McGwin G, Adler BK, Acton RT.

Pharmacogenomics. 2008 May;9(5):511-26.PMID: 18466099 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.

Gordeuk VR, Reboussin DM, McLaren CE, Barton JC, Acton RT, McLaren GD, Harris EL, Reiss JA, Adams PC, Speechley M, Phatak PD, Sholinsky P, Eckfeldt JH, Chen WP, Passmore L, Dawkins FW.

Am J Hematol. 2008 Aug;83(8):618-26.PMID: 18429050 [PubMed - indexed for MEDLINE]Related articles

Bivariate mixture modeling of transferrin saturation and serum ferritin concentration in Asians, African Americans, Hispanics, and whites in the Hemochromatosis and Iron Overload Screening (HEIRS) Study.

McLaren CE, Gordeuk VR, Chen WP, Barton JC, Acton RT, Speechley M, Castro O, Adams PC, Snively BM, Harris EL, Reboussin DM, McLachlan GJ, Bean R; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Transl Res. 2008 Feb;151(2):97-109. Epub 2007 Nov 9.PMID: 18201677 [PubMed - indexed for MEDLINE]Related articles

Results communication and patient education after screening for possible hemochromatosis and iron overload: experience from the HEIRS Study of a large ethnically and linguistically diverse group.

Walker AP, Tucker DC, Hall MA, Lohman K, Harrison H, Harrison BW, Reiss J, Acton RT, Adams PC, Diaz S, Holup J, Thomson E, Ellis SD, McLaren CE; Hemochromatosis and Iron Overload Study Research Investigators.

Genet Med. 2007 Nov;9(11):778-91.PMID: 18007147 [PubMed - indexed for MEDLINE]Related articles

Biological variability of transferrin saturation and unsaturated iron-binding capacity.

Adams PC, Reboussin DM, Press RD, Barton JC, Acton RT, Moses GC, Leiendecker-Foster C, McLaren GD, Dawkins FW, Gordeuk VR, Lovato L, Eckfeldt JH.

Am J Med. 2007 Nov;120(11):999.e1-7.PMID: 17976429 [PubMed - indexed for MEDLINE]Related articlesFree article

HFE C282Y homozygotes aged 25-29 years at HEIRS Study initial screening.

Barton JC, Acton RT, Leiendecker-Foster C, Lovato L, Adams PC, McLaren GD, Eckfeldt JH, McLaren CE, Reboussin DM, Gordeuk VR, Speechley MR, Reiss JA, Press RD, Dawkins FW; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators.

Genet Test. 2007 Fall;11(3):269-75.PMID: 17949288 [PubMed - indexed for MEDLINE]Related articles

Genetic screening for iron overload: No evidence of discrimination at 1 year.

Hall MA, Barton JC, Adams PC, McLaren CE, Reiss JA, Castro O, Ruggiero A, Acton RT, Power TE, Bent TC.

J Fam Pract. 2007 Oct;56(10):829-34.PMID: 17908514 [PubMed - indexed for MEDLINE]Related articles

DMPK-associated myotonic dystrophy and CTG repeats in Alabama African Americans.

Acton RT, Rivers CA, Watson B, Oh SJ.

Clin Genet. 2007 Nov;72(5):448-53. Epub 2007 Sep 17.PMID: 17877752 [PubMed - indexed for MEDLINE]Related articles

Characteristics of participants with self-reported hemochromatosis or iron overload at HEIRS study initial screening.

Barton JC, Acton RT, Leiendecker-Foster C, Lovato L, Adams PC, Eckfeldt JH, McLaren CE, Reiss JA, McLaren GD, Reboussin DM, Gordeuk VR, Speechley MR, Press RD, Dawkins FW; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators.

Am J Hematol. 2008 Feb;83(2):126-32.PMID: 17726683 [PubMed - indexed for MEDLINE]Related articles

African Americans at risk for increased iron stores or liver disease.

Dawkins FW, Gordeuk VR, Snively BM, Lovato L, Barton JC, Acton RT, McLaren GD, Leiendecker-Foster C, McLaren CE, Adams PC, Speechley M, Harris EL, Jackson S, Thomson EJ.

Am J Med. 2007 Aug;120(8):734.e1-9. Epub 2007 Mar 21.PMID: 17679134 [PubMed - indexed for MEDLINE]Related articles

Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin.

Limdi NA, McGwin G, Goldstein JA, Beasley TM, Arnett DK, Adler BK, Baird MF, Acton RT.

Clin Pharmacol Ther. 2008 Feb;83(2):312-21. Epub 2007 Jul 25.PMID: 17653141 [PubMed - indexed for MEDLINE]Related articlesFree article

Determinants and characteristics of mean corpuscular volume and hemoglobin concentration in white HFE C282Y homozygotes in the hemochromatosis and iron overload screening study.

McLaren CE, Barton JC, Gordeuk VR, Wu L, Adams PC, Reboussin DM, Speechley M, Chang H, Acton RT, Harris EL, Ruggiero AM, Castro O; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Am J Hematol. 2007 Oct;82(10):898-905.PMID: 17597476 [PubMed - indexed for MEDLINE]Related articles

A genome-wide linkage scan for iron phenotype quantitative trait loci: the HEIRS Family Study.

Acton RT, Snively BM, Barton JC, McLaren CE, Adams PC, Rich SS, Eckfeldt JH, Press RD, Sholinsky P, Leiendecker-Foster C, McLaren GD, Speechley MR, Harris EL, Dawkins FW, Gordeuk VR; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Clin Genet. 2007 Jun;71(6):518-29.PMID: 17539901 [PubMed - indexed for MEDLINE]Related articles

SLC40A1 Q248H allele frequencies and Q248H-associated risk of non-HFE iron overload in persons of sub-Saharan African descent.

Barton JC, Acton RT, Lee PL, West C.

Blood Cells Mol Dis. 2007 Sep-Oct;39(2):206-11. Epub 2007 May 9.PMID: 17490902 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of CYP2C9 Genotype on warfarin dose among African American and European Americans.

Limdi N, Goldstein J, Blaisdell J, Beasley T, Rivers C, Acton R.

Per Med. 2007 May 1;4(2):157-169.PMID: 19802360 [PubMed]Free article

Serum ferritin and transferrin saturation in Asians and Pacific Islanders.

Harris EL, McLaren CE, Reboussin DM, Gordeuk VR, Barton JC, Acton RT, McLaren GD, Vogt TM, Snively BM, Leiendecker-Foster C, Holup JL, Passmore LV, Eckfeldt JH, Lin E, Adams PC.

Arch Intern Med. 2007 Apr 9;167(7):722-6.PMID: 17420432 [PubMed - indexed for MEDLINE]Related articlesFree article

Psychosocial impact of genetic testing for hemochromatosis in the HEIRS Study: a comparison of participants recruited in Canada and in the United States.

Power TE, Adams PC, Barton JC, Acton RT, Howe E, Palla S, Walker AP, Anderson R, Harrison B.

Genet Test. 2007 Spring;11(1):55-64.PMID: 17394393 [PubMed - indexed for MEDLINE]Related articles

Association of ferroportin Q248H polymorphism with elevated levels of serum ferritin in African Americans in the Hemochromatosis and Iron Overload Screening (HEIRS) Study.

Rivers CA, Barton JC, Gordeuk VR, Acton RT, Speechley MR, Snively BM, Leiendecker-Foster C, Press RD, Adams PC, McLaren GD, Dawkins FW, McLaren CE, Reboussin DM.

Blood Cells Mol Dis. 2007 May-Jun;38(3):247-52. Epub 2007 Feb 5.PMID: 17276706 [PubMed - indexed for MEDLINE]Related articles

Impact of hemochromatosis screening in patients with indeterminate results: the hemochromatosis and iron overload screening study.

Anderson RT, Wenzel L, Walker AP, Ruggiero A, Acton RT, Hall MA, Tucker DC, Thomson E, Harrison B, Howe E 3rd, Holup J, Leiendecker-Foster C, Power T, Adams P.

Genet Med. 2006 Nov;8(11):681-7.PMID: 17108759 [PubMed - indexed for MEDLINE]Related articles

Geographic and racial/ethnic differences in HFE mutation frequencies in the Hemochromatosis and Iron Overload Screening (HEIRS) Study.

Acton RT, Barton JC, Snively BM, McLaren CE, Adams PC, Harris EL, Speechley MR, McLaren GD, Dawkins FW, Leiendecker-Foster C, Holup JL, Balasubramanyam A; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Ethn Dis. 2006 Autumn;16(4):815-21.PMID: 17061732 [PubMed - indexed for MEDLINE]Related articles

Mixture models of serum iron measures in population screening for hemochromatosis and iron overload.

McLaren CE, Li KT, McLaren GD, Gordeuk VR, Snively BM, Reboussin DM, Barton JC, Acton RT, Dawkins FW, Harris EL, Eckfeldt JH, Moses GC, Adams PC.

Transl Res. 2006 Oct;148(4):196-206.PMID: 17002922 [PubMed - indexed for MEDLINE]Related articles

Relationships of serum ferritin, transferrin saturation, and HFE mutations and self-reported diabetes in the Hemochromatosis and Iron Overload Screening (HEIRS) study.

Acton RT, Barton JC, Passmore LV, Adams PC, Speechley MR, Dawkins FW, Sholinsky P, Reboussin DM, McLaren GD, Harris EL, Bent TC, Vogt TM, Castro O.

Diabetes Care. 2006 Sep;29(9):2084-9.PMID: 16936157 [PubMed - indexed for MEDLINE]Related articlesFree article

Racial differences in the prevalence of Factor V Leiden mutation among patients on chronic warfarin therapy.

Limdi NA, Beasley TM, Allison DB, Rivers CA, Acton RT.

Blood Cells Mol Dis. 2006 Sep-Oct;37(2):100-6. Epub 2006 Aug 2.PMID: 16889993 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver diseases in the hemochromatosis and iron overload screening study.

Adams PC, Passmore L, Chakrabarti S, Reboussin DM, Acton RT, Barton JC, McLaren GD, Eckfeldt JH, Dawkins FW, Gordeuk VR, Harris EL, Leiendecker-Foster C, Gossman E, Sholinsky P; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Clin Gastroenterol Hepatol. 2006 Jul;4(7):918-23; quiz 807.PMID: 16797244 [PubMed - indexed for MEDLINE]Related articles

Predictors of belief that genetic test information about hemochromatosis should be shared with family members.

Tucker DC, Acton RT, Press N, Ruggiero A, Reiss JA, Walker AP, Wenzel L, Harrison B, Fadojutimi-Akinsiku M, Harrison H, Adams P, Crabb JA, Anderson R, Thomson E.

Genet Test. 2006 Spring;10(1):50-9.PMID: 16545004 [PubMed - indexed for MEDLINE]Related articles

Effect of Native American ancestry on iron-related phenotypes of Alabama hemochromatosis probands with HFE C282Y homozygosity.

Barton JC, Barton EH, Acton RT.

BMC Med Genet. 2006 Mar 13;7:22.PMID: 16533407 [PubMed - indexed for MEDLINE]Related articlesFree article

Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in Native Americans and whites in the Hemochromatosis and Iron Overload Screening Study.

Barton JC, Acton RT, Lovato L, Speechley MR, McLaren CE, Harris EL, Reboussin DM, Adams PC, Dawkins FW, Gordeuk VR, Walker AP; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Clin Genet. 2006 Jan;69(1):48-57.PMID: 16451136 [PubMed - indexed for MEDLINE]Related articles

Three kinships with ALAS2 P520L (c. 1559 C --> T) mutation, two in association with severe iron overload, and one with sideroblastic anemia and severe iron overload.

Lee PL, Barton JC, Rao SV, Acton RT, Adler BK, Beutler E.

Blood Cells Mol Dis. 2006 Mar-Apr;36(2):292-7. Epub 2006 Jan 30.PMID: 16446107 [PubMed - indexed for MEDLINE]Related articles

Patient acceptability of genotypic testing for hemochromatosis in primary care.

Anderson RT, Press N, Tucker DC, Snively BM, Wenzel L, Ellis SD, Hall MA, Walker AP, Thomson EJ, Lewis-Jack O, Acton RT.

Genet Med. 2005 Oct;7(8):557-63.PMID: 16247294 [PubMed - indexed for MEDLINE]Related articles

Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in whites and blacks in the Hemochromatosis and Iron Overload Screening Study.

Barton JC, Acton RT, Dawkins FW, Adams PC, Lovato L, Leiendecker-Foster C, McLaren CE, Reboussin DM, Speechley MR, Gordeuk VR, McLaren GD, Sholinsky P, Harris EL.

Genet Test. 2005 Fall;9(3):231-41.PMID: 16225403 [PubMed - indexed for MEDLINE]Related articles

Total blood lymphocyte counts in hemochromatosis probands with HFE C282Y homozygosity: relationship to severity of iron overload and HLA-A and -B alleles and haplotypes.

Barton JC, Wiener HW, Acton RT, Go RC.

BMC Blood Disord. 2005 Jul 25;5:5.PMID: 16042809 [PubMed]Related articlesFree article

Hemochromatosis and iron-overload screening in a racially diverse population.

Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Sholinsky P; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators.

N Engl J Med. 2005 Apr 28;352(17):1769-78.PMID: 15858186 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of the unsaturated iron-binding capacity with transferrin saturation as a screening test to detect C282Y homozygotes for hemochromatosis in 101,168 participants in the hemochromatosis and iron overload screening (HEIRS) study.

Adams PC, Reboussin DM, Leiendecker-Foster C, Moses GC, McLaren GD, McLaren CE, Dawkins FW, Kasvosve I, Acton RT, Barton JC, Zaccaro D, Harris EL, Press R, Chang H, Eckfeldt JH.

Clin Chem. 2005 Jun;51(6):1048-52. Epub 2005 Apr 15. No abstract available. PMID: 15833784 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic predictors of coronary heart disease risk factors in premenopausal African-American women.

Giger JN, Strickland OL, Weaver M, Taylor H, Acton RT.

Ethn Dis. 2005 Spring;15(2):221-32.PMID: 15825968 [PubMed - indexed for MEDLINE]Related articles