PubMed

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in AgRP and POMC Neurons.

Lin HV, Plum L, Ono H, Gutiérrez-Juárez R, Shanabrough M, Borok E, Horvath TL, Rossetti L, Accili D.

Diabetes. 2009 Nov 23. [Epub ahead of print]PMID: 19933998 [PubMed - as supplied by publisher]

Genetic and biochemical pathways of beta-cell failure in type 2 diabetes.

Talchai C, Lin HV, Kitamura T, Accili D.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:38-45.PMID: 19817787 [PubMed - in process]Related articles

beta-Cell research - A decade of rapid growth.

Ahrén B, Accili D, Boitard C, Efendic S, Henquin JC, Seino S, Steiner DF, Cerasi E.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:iv-ix. No abstract available. PMID: 19817782 [PubMed - in process]Related articles

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.

Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP, DePinho RA, Wardlaw SL, Accili D.

Nat Med. 2009 Oct;15(10):1195-201. Epub 2009 Sep 20.PMID: 19767734 [PubMed - indexed for MEDLINE]Related articles

Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells.

Tanaka J, Qiang L, Banks AS, Welch CL, Matsumoto M, Kitamura T, Ido-Kitamura Y, DePinho RA, Accili D.

Diabetes. 2009 Oct;58(10):2344-54. Epub 2009 Jul 7.PMID: 19584310 [PubMed - indexed for MEDLINE]Related articles

Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1.

Kitamura T, Kitamura YI, Kobayashi M, Kikuchi O, Sasaki T, Depinho RA, Accili D.

Mol Cell Biol. 2009 Aug;29(16):4417-30. Epub 2009 Jun 8.PMID: 19506018 [PubMed - indexed for MEDLINE]Related articles

Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice.

Han S, Liang CP, Westerterp M, Senokuchi T, Welch CL, Wang Q, Matsumoto M, Accili D, Tall AR.

J Clin Invest. 2009 Apr;119(4):1029-41. doi: 10.1172/JCI36523. Epub 2009 Mar 9.PMID: 19273907 [PubMed - indexed for MEDLINE]Related articlesFree article

SirT1 gain of function increases energy efficiency and prevents diabetes in mice.

Banks AS, Kon N, Knight C, Matsumoto M, Gutiérrez-Juárez R, Rossetti L, Gu W, Accili D.

Cell Metab. 2008 Oct;8(4):333-41.PMID: 18840364 [PubMed - indexed for MEDLINE]Related articles

Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress.

Senokuchi T, Liang CP, Seimon TA, Han S, Matsumoto M, Banks AS, Paik JH, DePinho RA, Accili D, Tabas I, Tall AR.

Diabetes. 2008 Nov;57(11):2967-76. Epub 2008 Aug 26.PMID: 18728232 [PubMed - indexed for MEDLINE]Related articlesFree article

The double life of Irs.

Haeusler RA, Accili D.

Cell Metab. 2008 Jul;8(1):7-9. Review.PMID: 18590687 [PubMed - indexed for MEDLINE]Related articlesFree article

Lectin histochemistry for in situ profiling of rat colon sialoglycoconjugates.

Accili D, Menghi G, Gabrielli MG.

Histol Histopathol. 2008 Jul;23(7):863-75.PMID: 18437685 [PubMed - indexed for MEDLINE]Related articles

The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis.

Tabas I, Seimon T, Arellano J, Li Y, Forcheron F, Cui D, Han S, Liang CP, Tall A, Accili D.

Novartis Found Symp. 2007;286:99-109; discussion 109-12, 162-3, 196-203.PMID: 18269177 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes.

Leroith D, Accili D.

Nat Clin Pract Endocrinol Metab. 2008 Mar;4(3):164-72. Epub 2008 Jan 22. Review.PMID: 18212763 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.

Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L.

Endocr Rev. 2008 Feb;29(1):62-75. Epub 2008 Jan 16. Review. Erratum in: Endocr Rev. 2009 Feb;30(1):117. PMID: 18199690 [PubMed - indexed for MEDLINE]Related articlesFree article

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression.

Shawber CJ, Funahashi Y, Francisco E, Vorontchikhina M, Kitamura Y, Stowell SA, Borisenko V, Feirt N, Podgrabinska S, Shiraishi K, Chawengsaksophak K, Rossant J, Accili D, Skobe M, Kitajewski J.

J Clin Invest. 2007 Nov;117(11):3369-82.PMID: 17948123 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of pancreatic beta-cell function by the forkhead protein FoxO1.

Buteau J, Accili D.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:140-6. Review.PMID: 17919188 [PubMed - indexed for MEDLINE]Related articles

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.

Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D.

Cell Metab. 2007 Sep;6(3):208-16.PMID: 17767907 [PubMed - indexed for MEDLINE]Related articles

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.

Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, DePinho RA, Kitajewski J, Accili D.

J Clin Invest. 2007 Sep;117(9):2477-85.PMID: 17717603 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice.

Lin HV, Kim JY, Pocai A, Rossetti L, Shapiro L, Scherer PE, Accili D.

Diabetes. 2007 Aug;56(8):1969-76. Epub 2007 May 2.PMID: 17475934 [PubMed - indexed for MEDLINE]Related articlesFree article

The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells.

Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D, Brenner DA.

Gastroenterology. 2007 Apr;132(4):1434-46. Epub 2007 Jan 25.PMID: 17408630 [PubMed - indexed for MEDLINE]Related articles

Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes.

Naïmi M, Gautier N, Chaussade C, Valverde AM, Accili D, Van Obberghen E.

Endocrinology. 2007 May;148(5):2424-34. Epub 2007 Feb 15. Erratum in: Endocrinology. 2007 Jul;148(7):3517. PMID: 17303659 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2.

Kim JJ, Kido Y, Scherer PE, White MF, Accili D.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1694-701. Epub 2007 Feb 13.PMID: 17299086 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic diapause in pancreatic beta-cells expressing a gain-of-function mutant of the forkhead protein Foxo1.

Buteau J, Shlien A, Foisy S, Accili D.

J Biol Chem. 2007 Jan 5;282(1):287-93. Epub 2006 Nov 15.PMID: 17107961 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism.

Matsumoto M, Han S, Kitamura T, Accili D.

J Clin Invest. 2006 Sep;116(9):2464-72. Epub 2006 Aug 10.PMID: 16906224 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.

Buteau J, Spatz ML, Accili D.

Diabetes. 2006 May;55(5):1190-6.PMID: 16644672 [PubMed - indexed for MEDLINE]Related articlesFree article

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake.

Kitamura T, Feng Y, Kitamura YI, Chua SC Jr, Xu AW, Barsh GS, Rossetti L, Accili D.

Nat Med. 2006 May;12(5):534-40. Epub 2006 Apr 9.PMID: 16604086 [PubMed - indexed for MEDLINE]Related articles

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

Han S, Liang CP, DeVries-Seimon T, Ranalletta M, Welch CL, Collins-Fletcher K, Accili D, Tabas I, Tall AR.

Cell Metab. 2006 Apr;3(4):257-66.PMID: 16581003 [PubMed - indexed for MEDLINE]Related articles

Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance.

Okamoto H, Hribal ML, Lin HV, Bennett WR, Ward A, Accili D.

J Clin Invest. 2006 Mar;116(3):775-82. Epub 2006 Feb 16.PMID: 16485043 [PubMed - indexed for MEDLINE]Related articlesFree article

The tangled path to glucose production.

Matsumoto M, Accili D.

Nat Med. 2006 Jan;12(1):33-4; discussion 34. No abstract available. PMID: 16397556 [PubMed - indexed for MEDLINE]Related articles

Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.

Federici M, Hribal ML, Menghini R, Kanno H, Marchetti V, Porzio O, Sunnarborg SW, Rizza S, Serino M, Cunsolo V, Lauro D, Mauriello A, Smookler DS, Sbraccia P, Sesti G, Lee DC, Khokha R, Accili D, Lauro R.

J Clin Invest. 2005 Dec;115(12):3494-505. Epub 2005 Nov 17.PMID: 16294222 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.

Maddux BA, Chang YN, Accili D, McGuinness OP, Youngren JF, Goldfine ID.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E746-9. Epub 2005 Nov 8.PMID: 16278247 [PubMed - indexed for MEDLINE]Related articlesFree article

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.

Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, Gu W, Accili D.

Cell Metab. 2005 Sep;2(3):153-63.PMID: 16154098 [PubMed - indexed for MEDLINE]Related articles

Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.

Banks AS, Li J, McKeag L, Hribal ML, Kashiwada M, Accili D, Rothman PB.

J Clin Invest. 2005 Sep;115(9):2462-71. Epub 2005 Aug 25.PMID: 16127460 [PubMed - indexed for MEDLINE]Related articlesFree article

All roads lead to FoxO.

Matsumoto M, Accili D.

Cell Metab. 2005 Apr;1(4):215-6.PMID: 16054064 [PubMed - indexed for MEDLINE]Related articles

Retraction: Turning up the heat in the fat cell.

Accili D, Valenti L.

Nat Med. 2005 Jun;11(6):690. No abstract available. PMID: 15937474 [PubMed - indexed for MEDLINE]Related articles

Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action.

Okamoto H, Obici S, Accili D, Rossetti L.

J Clin Invest. 2005 May;115(5):1314-22.PMID: 15864351 [PubMed - indexed for MEDLINE]Related articlesFree article

Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes.

Frescas D, Valenti L, Accili D.

J Biol Chem. 2005 May 27;280(21):20589-95. Epub 2005 Mar 22.PMID: 15788402 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.

Dong H, Maddux BA, Altomonte J, Meseck M, Accili D, Terkeltaub R, Johnson K, Youngren JF, Goldfine ID.

Diabetes. 2005 Feb;54(2):367-72.PMID: 15677494 [PubMed - indexed for MEDLINE]Related articlesFree article

Turning up the heat in the fat cell.

Accili D, Valenti L.

Nat Med. 2004 Nov;10(11):1168-9. No abstract available. Retraction in: Accili D, Valenti L. Nat Med. 2005 Jun;11(6):690. PMID: 15516912 [PubMed - indexed for MEDLINE]Related articles

A note of caution on the Knockout Mouse Project.

Accili D.

Nat Genet. 2004 Nov;36(11):1132. No abstract available. PMID: 15514659 [PubMed - indexed for MEDLINE]Related articles

Transgenic rescue of insulin receptor-deficient mice.

Okamoto H, Nakae J, Kitamura T, Park BC, Dragatsis I, Accili D.

J Clin Invest. 2004 Jul;114(2):214-23.PMID: 15254588 [PubMed - indexed for MEDLINE]Related articlesFree article

Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic.

Accili D.

Diabetes. 2004 Jul;53(7):1633-42.PMID: 15220184 [PubMed - indexed for MEDLINE]Related articlesFree article

Mucoadhesion dependence of pharmaceutical polymers on mucosa characteristics.

Accili D, Menghi G, Bonacucina G, Martino PD, Palmieri GF.

Eur J Pharm Sci. 2004 Jul;22(4):225-34.PMID: 15196578 [PubMed - indexed for MEDLINE]Related articles

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation.

Accili D, Arden KC.

Cell. 2004 May 14;117(4):421-6. Review.PMID: 15137936 [PubMed - indexed for MEDLINE]Related articles

Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.

Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, Kamon J, Kobayashi M, Suzuki R, Hara K, Kubota N, Terauchi Y, Froguel P, Nakae J, Kasuga M, Accili D, Tobe K, Ueki K, Nagai R, Kadowaki T.

J Biol Chem. 2004 Jul 16;279(29):30817-22. Epub 2004 Apr 29.PMID: 15123605 [PubMed - indexed for MEDLINE]Related articlesFree article

Mouse models of insulin resistance.

Nandi A, Kitamura Y, Kahn CR, Accili D.

Physiol Rev. 2004 Apr;84(2):623-47. Review.PMID: 15044684 [PubMed - indexed for MEDLINE]Related articlesFree article

New insights into the integrated physiology of insulin action.

Kitamura Y, Accili D.

Rev Endocr Metab Disord. 2004 May;5(2):143-9. Review. No abstract available. PMID: 15041790 [PubMed - indexed for MEDLINE]Related articles

Increased CD36 protein as a response to defective insulin signaling in macrophages.

Liang CP, Han S, Okamoto H, Carnemolla R, Tabas I, Accili D, Tall AR.

J Clin Invest. 2004 Mar;113(5):764-73.PMID: 14991075 [PubMed - indexed for MEDLINE]Related articlesFree article

Mosaic analysis of insulin receptor function.

Kitamura T, Kitamura Y, Nakae J, Giordano A, Cinti S, Kahn CR, Efstratiadis A, Accili D.

J Clin Invest. 2004 Jan;113(2):209-19.PMID: 14722613 [PubMed - indexed for MEDLINE]Related articlesFree article

Testis determination requires insulin receptor family function in mice.

Nef S, Verma-Kurvari S, Merenmies J, Vassalli JD, Efstratiadis A, Accili D, Parada LF.

Nature. 2003 Nov 20;426(6964):291-5.PMID: 14628051 [PubMed - indexed for MEDLINE]Related articles