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    Results: 1 to 50 of 76

    1.

    Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats.

    Soesanto W, Lin HY, Hu E, Lefler S, Litwin SE, Sena S, Abel ED, Symons JD, Jalili T.

    Hypertension. 2009 Dec;54(6):1321-7. Epub 2009 Nov 2.PMID: 19884565 [PubMed - in process]Related articles

    2.

    Lipotoxicity in the heart.

    Wende AR, Abel ED.

    Biochim Biophys Acta. 2009 Oct 8. [Epub ahead of print]PMID: 19818871 [PubMed - as supplied by publisher]Related articles

    3.

    Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.

    Ikeda H, Shiojima I, Ozasa Y, Yoshida M, Holzenberger M, Kahn CR, Walsh K, Igarashi T, Abel ED, Komuro I.

    J Mol Cell Cardiol. 2009 Nov;47(5):664-75. Epub 2009 Sep 8.PMID: 19744489 [PubMed - in process]Related articles

    4.

    Rodent models of diabetic cardiomyopathy.

    Bugger H, Abel ED.

    Dis Model Mech. 2009 Sep-Oct;2(9-10):454-66.PMID: 19726805 [PubMed - in process]Related articles

    5.

    Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.

    Bugger H, Chen D, Riehle C, Soto J, Theobald HA, Hu XX, Ganesan B, Weimer BC, Abel ED.

    Diabetes. 2009 Sep;58(9):1986-97. Epub 2009 Jun 19.PMID: 19542201 [PubMed - indexed for MEDLINE]Related articles

    6.

    Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases.

    Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD.

    J Physiol. 2009 Aug 1;587(Pt 15):3911-20. Epub 2009 Jun 8.PMID: 19505983 [PubMed - indexed for MEDLINE]Related articles

    7.

    Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues.

    Bakirtzi K, Belfort G, Lopez-Coviella I, Kuruppu D, Cao L, Abel ED, Brownell AL, Kandror KV.

    J Neurosci. 2009 Apr 22;29(16):5193-201.PMID: 19386915 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.

    Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel ED.

    Circ Res. 2009 May 8;104(9):1085-94. Epub 2009 Apr 2.PMID: 19342603 [PubMed - indexed for MEDLINE]Related articles

    9.

    Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction.

    Sena S, Hu P, Zhang D, Wang X, Wayment B, Olsen C, Avelar E, Abel ED, Litwin SE.

    J Mol Cell Cardiol. 2009 Jun;46(6):910-8. Epub 2009 Feb 26.PMID: 19249310 [PubMed - indexed for MEDLINE]Related articles

    10.

    Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.

    Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED.

    Circulation. 2009 Mar 10;119(9):1272-83. Epub 2009 Feb 23.PMID: 19237663 [PubMed - indexed for MEDLINE]Related articles

    11.

    The role of mPer2 clock gene in glucocorticoid and feeding rhythms.

    Yang S, Liu A, Weidenhammer A, Cooksey RC, McClain D, Kim MK, Aguilera G, Abel ED, Chung JH.

    Endocrinology. 2009 May;150(5):2153-60. Epub 2009 Jan 29.PMID: 19179447 [PubMed - indexed for MEDLINE]Related articles

    12.

    Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding.

    Wright JJ, Kim J, Buchanan J, Boudina S, Sena S, Bakirtzi K, Ilkun O, Theobald HA, Cooksey RC, Kandror KV, Abel ED.

    Cardiovasc Res. 2009 May 1;82(2):351-60. Epub 2009 Jan 15.PMID: 19147655 [PubMed - indexed for MEDLINE]Related articles

    13.

    Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.

    Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel ED.

    Mol Endocrinol. 2008 Nov;22(11):2531-43. Epub 2008 Sep 18.PMID: 18801929 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism.

    Augustus AS, Buchanan J, Gutman E, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP.

    Cell Cycle. 2008 Aug 15;7(16):2509-18. Epub 2008 Aug 26.PMID: 18719368 [PubMed - indexed for MEDLINE]Related articles

    15.

    Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.

    Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel ED.

    Diabetes. 2008 Nov;57(11):2924-32. Epub 2008 Aug 4.PMID: 18678617 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Reversal of oxidative stress in endothelial cells by controlled release of adiponectin.

    Mossalam M, Jeong JH, Abel ED, Kim SW, Kim YH.

    J Control Release. 2008 Sep 24;130(3):234-7. Epub 2008 Jun 19.PMID: 18619503 [PubMed - indexed for MEDLINE]Related articles

    17.

    Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts.

    Augustus AS, Buchanan J, Addya S, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP.

    Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H657-66. Epub 2008 Jun 13.PMID: 18552160 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Ceramide is a cardiotoxin in lipotoxic cardiomyopathy.

    Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel ED, Goldberg IJ.

    J Lipid Res. 2008 Oct;49(10):2101-12. Epub 2008 May 30.PMID: 18515784 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

    Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

    Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. Epub 2008 May 16.PMID: 18487436 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity.

    Fang C, Gu J, Xie F, Behr M, Yang W, Abel ED, Ding X.

    Drug Metab Dispos. 2008 Aug;36(8):1722-8. Epub 2008 May 7.PMID: 18463197 [PubMed - indexed for MEDLINE]Related articlesFree article

    21.

    Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts.

    Tabbi-Anneni I, Buchanan J, Cooksey RC, Abel ED.

    Endocrinology. 2008 Aug;149(8):4043-50. Epub 2008 May 1.PMID: 18450963 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    Cardiac remodeling in obesity.

    Abel ED, Litwin SE, Sweeney G.

    Physiol Rev. 2008 Apr;88(2):389-419. Review.PMID: 18391168 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis.

    Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA.

    Mol Med. 2008 Mar-Apr;14(3-4):98-108.PMID: 18317567 [PubMed - indexed for MEDLINE]Related articlesFree article

    24.

    Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.

    Yin Z, Jones GN, Towns WH 2nd, Zhang X, Abel ED, Binkley PF, Jarjoura D, Kirschner LS.

    Circulation. 2008 Mar 18;117(11):1414-22. Epub 2008 Mar 3.PMID: 18316483 [PubMed - indexed for MEDLINE]Related articlesFree article

    25.

    Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations.

    Amiott EA, Lott P, Soto J, Kang PB, McCaffery JM, DiMauro S, Abel ED, Flanigan KM, Lawson VH, Shaw JM.

    Exp Neurol. 2008 May;211(1):115-27. Epub 2008 Jan 26.PMID: 18316077 [PubMed - indexed for MEDLINE]Related articlesFree article

    26.

    Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome.

    Bugger H, Abel ED.

    Clin Sci (Lond). 2008 Feb;114(3):195-210. Review.PMID: 18184113 [PubMed - indexed for MEDLINE]Related articles

    27.

    Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.

    Bray MS, Shaw CA, Moore MW, Garcia RA, Zanquetta MM, Durgan DJ, Jeong WJ, Tsai JY, Bugger H, Zhang D, Rohrwasser A, Rennison JH, Dyck JR, Litwin SE, Hardin PE, Chow CW, Chandler MP, Abel ED, Young ME.

    Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H1036-47. Epub 2007 Dec 21.PMID: 18156197 [PubMed - indexed for MEDLINE]Related articlesFree article

    28.

    A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.

    O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED.

    Cell Metab. 2007 Oct;6(4):294-306.PMID: 17908558 [PubMed - indexed for MEDLINE]Related articlesFree article

    29.

    PAS kinase is required for normal cellular energy balance.

    Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Boudina S, Abel ED, McClain DA, Rutter J.

    Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15466-71. Epub 2007 Sep 18.PMID: 17878307 [PubMed - indexed for MEDLINE]Related articlesFree article

    30.

    CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice.

    Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor RP, Rajasekaran NS, Gottlieb R, Wawrousek EF, Abel ED, Bolli R.

    Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3201-9. Epub 2007 Sep 14.PMID: 17873008 [PubMed - indexed for MEDLINE]Related articlesFree article

    31.

    Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling.

    Sena S, Rasmussen IR, Wende AR, McQueen AP, Theobald HA, Wilde N, Pereira RO, Litwin SE, Berger JP, Abel ED.

    Endocrinology. 2007 Dec;148(12):6047-53. Epub 2007 Sep 6.PMID: 17823261 [PubMed - indexed for MEDLINE]Related articlesFree article

    32.

    Glucose for the aging heart?

    Abel ED.

    Circulation. 2007 Aug 21;116(8):884-7. No abstract available. PMID: 17709649 [PubMed - indexed for MEDLINE]Related articlesFree article

    33.

    Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.

    Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED.

    Diabetes. 2007 Oct;56(10):2457-66. Epub 2007 Jul 10.PMID: 17623815 [PubMed - indexed for MEDLINE]Related articlesFree article

    34.

    Diabetic cardiomyopathy revisited.

    Boudina S, Abel ED.

    Circulation. 2007 Jun 26;115(25):3213-23. Review.PMID: 17592090 [PubMed - indexed for MEDLINE]Related articlesFree article

    35.

    Recipes for creating animal models of diabetic cardiovascular disease.

    Hsueh W, Abel ED, Breslow JL, Maeda N, Davis RC, Fisher EA, Dansky H, McClain DA, McIndoe R, Wassef MK, Rabadán-Diehl C, Goldberg IJ.

    Circ Res. 2007 May 25;100(10):1415-27. Review.PMID: 17525381 [PubMed - indexed for MEDLINE]Related articlesFree article

    36.

    Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.

    Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Mäkelä TP, Schneider MD.

    Cell Metab. 2007 Feb;5(2):129-42.PMID: 17276355 [PubMed - indexed for MEDLINE]Related articles

    37.

    Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

    Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.

    PLoS Biol. 2006 Nov;4(11):e369.PMID: 17090215 [PubMed - indexed for MEDLINE]Related articlesFree article

    38.

    Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.

    Boudina S, Abel ED.

    Physiology (Bethesda). 2006 Aug;21:250-8. Review.PMID: 16868314 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase.

    Buerger A, Rozhitskaya O, Sherwood MC, Dorfman AL, Bisping E, Abel ED, Pu WT, Izumo S, Jay PY.

    J Card Fail. 2006 Jun;12(5):392-8.PMID: 16762803 [PubMed - indexed for MEDLINE]Related articles

    40.

    Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin.

    Durgan DJ, Smith JK, Hotze MA, Egbejimi O, Cuthbert KD, Zaha VG, Dyck JR, Abel ED, Young ME.

    Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2480-97. Epub 2006 Jan 20.PMID: 16428347 [PubMed - indexed for MEDLINE]Related articlesFree article

    41.

    Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction.

    Augustus AS, Buchanan J, Park TS, Hirata K, Noh HL, Sun J, Homma S, D'armiento J, Abel ED, Goldberg IJ.

    J Biol Chem. 2006 Mar 31;281(13):8716-23. Epub 2006 Jan 12.PMID: 16410253 [PubMed - indexed for MEDLINE]Related articlesFree article

    42.

    Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity.

    Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel ED.

    Circulation. 2005 Oct 25;112(17):2686-95.PMID: 16246967 [PubMed - indexed for MEDLINE]Related articlesFree article

    43.

    Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density.

    McQueen AP, Zhang D, Hu P, Swenson L, Yang Y, Zaha VG, Hoffman JL, Yun UJ, Chakrabarti G, Wang Z, Albertine KH, Abel ED, Litwin SE.

    J Mol Cell Cardiol. 2005 Dec;39(6):882-92. Epub 2005 Oct 10.PMID: 16216265 [PubMed - indexed for MEDLINE]Related articles

    44.

    Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.

    Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, Cooksey RC, Litwin SE, Abel ED.

    Endocrinology. 2005 Dec;146(12):5341-9. Epub 2005 Sep 1.PMID: 16141388 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    Myocardial insulin resistance and cardiac complications of diabetes.

    Abel ED.

    Curr Drug Targets Immune Endocr Metabol Disord. 2005 Jun;5(2):219-26. Review.PMID: 16089356 [PubMed - indexed for MEDLINE]Related articles

    46.

    Akt1 in the cardiovascular system: friend or foe?

    O'Neill BT, Abel ED.

    J Clin Invest. 2005 Aug;115(8):2059-64.PMID: 16075047 [PubMed - indexed for MEDLINE]Related articlesFree article

    47.

    Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action.

    Graveleau C, Zaha VG, Mohajer A, Banerjee RR, Dudley-Rucker N, Steppan CM, Rajala MW, Scherer PE, Ahima RS, Lazar MA, Abel ED.

    J Biol Chem. 2005 Sep 9;280(36):31679-85. Epub 2005 Jun 27.PMID: 15983036 [PubMed - indexed for MEDLINE]Related articlesFree article

    48.

    The intrinsic circadian clock within the cardiomyocyte.

    Durgan DJ, Hotze MA, Tomlin TM, Egbejimi O, Graveleau C, Abel ED, Shaw CA, Bray MS, Hardin PE, Young ME.

    Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1530-41. Epub 2005 Jun 3.PMID: 15937094 [PubMed - indexed for MEDLINE]Related articlesFree article

    49.

    PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

    Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP.

    PLoS Biol. 2005 Apr;3(4):e101. Epub 2005 Mar 15.PMID: 15760270 [PubMed - indexed for MEDLINE]Related articlesFree article

    50.

    Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1.

    Rui T, Feng Q, Lei M, Peng T, Zhang J, Xu M, Abel ED, Xenocostas A, Kvietys PR.

    Cardiovasc Res. 2005 Feb 15;65(3):719-27.PMID: 15664399 [PubMed - indexed for MEDLINE]Related articlesFree article

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