PubMed

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.

Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N.

Cancer Cell. 2009 Nov 6;16(5):425-38.PMID: 19878874 [PubMed - in process]Related articles

pTOM, a vector for expressing two proteins in mammalian cells.

Lin Y, Avruch J.

Anal Biochem. 2009 May 15;388(2):353-5. Epub 2009 Mar 19.PMID: 19303393 [PubMed - indexed for MEDLINE]Related articles

Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor.

Avruch J, Long X, Lin Y, Ortiz-Vega S, Rapley J, Papageorgiou A, Oshiro N, Kikkawa U.

Biochem Soc Trans. 2009 Feb;37(Pt 1):223-6. Review.PMID: 19143636 [PubMed - indexed for MEDLINE]Related articles

Rassf family of tumor suppressor polypeptides.

Avruch J, Xavier R, Bardeesy N, Zhang XF, Praskova M, Zhou D, Xia F.

J Biol Chem. 2009 Apr 24;284(17):11001-5. Epub 2008 Dec 17. Review.PMID: 19091744 [PubMed - indexed for MEDLINE]Related articles

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.

Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20321-6. Epub 2008 Dec 10.PMID: 19073936 [PubMed - indexed for MEDLINE]Related articlesFree article

The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.

Patursky-Polischuk I, Stolovich-Rain M, Hausner-Hanochi M, Kasir J, Cybulski N, Avruch J, Rüegg MA, Hall MN, Meyuhas O.

Mol Cell Biol. 2009 Feb;29(3):640-9. Epub 2008 Dec 1. Erratum in: Mol Cell Biol. 2009 Mar;29(6):1670. PMID: 19047368 [PubMed - indexed for MEDLINE]Related articlesFree article

The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation.

Rapley J, Nicolàs M, Groen A, Regué L, Bertran MT, Caelles C, Avruch J, Roig J.

J Cell Sci. 2008 Dec 1;121(Pt 23):3912-21. Epub 2008 Nov 11.PMID: 19001501 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of two Mst1-deficient mouse models.

Anguera MC, Liu M, Avruch J, Lee JT.

Dev Dyn. 2008 Nov;237(11):3424-34.PMID: 18942145 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acid regulation of TOR complex 1.

Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E592-602. Epub 2008 Sep 2. Review.PMID: 18765678 [PubMed - indexed for MEDLINE]Related articles

A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.

Hagan GN, Lin Y, Magnuson MA, Avruch J, Czech MP.

Mol Cell Biol. 2008 Jul;28(13):4215-26. Epub 2008 Apr 21.PMID: 18426911 [PubMed - indexed for MEDLINE]Related articlesFree article

MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.

Praskova M, Xia F, Avruch J.

Curr Biol. 2008 Mar 11;18(5):311-21.PMID: 18328708 [PubMed - indexed for MEDLINE]Related articles

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.

Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K.

J Biol Chem. 2007 Jul 13;282(28):20329-39. Epub 2007 May 21.PMID: 17517883 [PubMed - indexed for MEDLINE]Related articlesFree article

The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.

Long X, Lin Y, Ortiz-Vega S, Busch S, Avruch J.

J Biol Chem. 2007 Jun 22;282(25):18542-51. Epub 2007 Apr 30.PMID: 17470430 [PubMed - indexed for MEDLINE]Related articlesFree article

MAP kinase pathways: the first twenty years.

Avruch J.

Biochim Biophys Acta. 2007 Aug;1773(8):1150-60. Epub 2006 Nov 15. Review.PMID: 17229475 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase.

Avruch J, Hara K, Lin Y, Liu M, Long X, Ortiz-Vega S, Yonezawa K.

Oncogene. 2006 Oct 16;25(48):6361-72. Review.PMID: 17041622 [PubMed - indexed for MEDLINE]Related articles

Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases.

Avruch J, Praskova M, Ortiz-Vega S, Liu M, Zhang XF.

Methods Enzymol. 2006;407:290-310.PMID: 16757333 [PubMed - indexed for MEDLINE]Related articles

Nore1B regulates TCR signaling via Ras and Carma1.

Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R.

Cell Signal. 2006 Oct;18(10):1647-54. Epub 2006 Mar 7.PMID: 16520020 [PubMed - indexed for MEDLINE]Related articles

Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.

Lenz G, Avruch J.

J Biol Chem. 2005 Nov 18;280(46):38121-4. Epub 2005 Sep 22.PMID: 16183639 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding.

Zhu J, Balan V, Bronisz A, Balan K, Sun H, Leicht DT, Luo Z, Qin J, Avruch J, Tzivion G.

Mol Biol Cell. 2005 Oct;16(10):4733-44. Epub 2005 Aug 10.PMID: 16093354 [PubMed - indexed for MEDLINE]Related articlesFree article

Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly.

Roig J, Groen A, Caldwell J, Avruch J.

Mol Biol Cell. 2005 Oct;16(10):4827-40. Epub 2005 Aug 3.PMID: 16079175 [PubMed - indexed for MEDLINE]Related articlesFree article

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency.

Long X, Ortiz-Vega S, Lin Y, Avruch J.

J Biol Chem. 2005 Jun 24;280(25):23433-6. Epub 2005 May 5.PMID: 15878852 [PubMed - indexed for MEDLINE]Related articlesFree article

Rheb binds and regulates the mTOR kinase.

Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J.

Curr Biol. 2005 Apr 26;15(8):702-13.PMID: 15854902 [PubMed - indexed for MEDLINE]Related articles

Recent advances in the regulation of the TOR pathway by insulin and nutrients.

Avruch J, Lin Y, Long X, Murthy S, Ortiz-Vega S.

Curr Opin Clin Nutr Metab Care. 2005 Jan;8(1):67-72. Review.PMID: 15586002 [PubMed - indexed for MEDLINE]Related articles

Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras.

Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J.

Biochem J. 2004 Jul 15;381(Pt 2):453-62.PMID: 15109305 [PubMed - indexed for MEDLINE]Related articlesFree article

The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.

Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B.

J Biol Chem. 2004 Jul 9;279(28):29247-54. Epub 2004 Apr 9.PMID: 15075335 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function.

Oshiro N, Yoshino K, Hidayat S, Tokunaga C, Hara K, Eguchi S, Avruch J, Yonezawa K.

Genes Cells. 2004 Apr;9(4):359-66. Erratum in: Genes Cells. 2004 May;9(5):497. PMID: 15066126 [PubMed - indexed for MEDLINE]Related articles

Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinases.

Aoyama Y, Avruch J, Zhang XF.

Oncogene. 2004 Apr 22;23(19):3426-33.PMID: 15007383 [PubMed - indexed for MEDLINE]Related articles

TOR action in mammalian cells and in Caenorhabditis elegans.

Long X, Müller F, Avruch J.

Curr Top Microbiol Immunol. 2004;279:115-38. Review.PMID: 14560955 [PubMed - indexed for MEDLINE]Related articles

Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding.

Shen YH, Godlewski J, Bronisz A, Zhu J, Comb MJ, Avruch J, Tzivion G.

Mol Biol Cell. 2003 Nov;14(11):4721-33. Epub 2003 Aug 7.PMID: 14551260 [PubMed - indexed for MEDLINE]Related articlesFree article

A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.

Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J.

J Biol Chem. 2003 Sep 12;278(37):34897-909. Epub 2003 Jul 2.PMID: 12840024 [PubMed - indexed for MEDLINE]Related articlesFree article

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.

Nojima H, Tokunaga C, Eguchi S, Oshiro N, Hidayat S, Yoshino K, Hara K, Tanaka N, Avruch J, Yonezawa K.

J Biol Chem. 2003 May 2;278(18):15461-4. Epub 2003 Feb 25.PMID: 12604610 [PubMed - indexed for MEDLINE]Related articlesFree article

Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis.

Lin Y, Khokhlatchev A, Figeys D, Avruch J.

J Biol Chem. 2002 Dec 13;277(50):47991-8001. Epub 2002 Oct 15.PMID: 12384512 [PubMed - indexed for MEDLINE]Related articlesFree article

TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation.

Long X, Spycher C, Han ZS, Rose AM, Müller F, Avruch J.

Curr Biol. 2002 Sep 3;12(17):1448-61.PMID: 12225660 [PubMed - indexed for MEDLINE]Related articles

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K.

Cell. 2002 Jul 26;110(2):177-89.PMID: 12150926 [PubMed - indexed for MEDLINE]Related articles

Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression.

Roig J, Mikhailov A, Belham C, Avruch J.

Genes Dev. 2002 Jul 1;16(13):1640-58.PMID: 12101123 [PubMed - indexed for MEDLINE]Related articlesFree article

RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1.

Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J, Pfeifer GP.

Oncogene. 2002 Apr 18;21(17):2713-20.PMID: 11965544 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a novel Ras-regulated proapoptotic pathway.

Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J.

Curr Biol. 2002 Feb 19;12(4):253-65.PMID: 11864565 [PubMed - indexed for MEDLINE]Related articles

The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1.

Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J.

Oncogene. 2002 Feb 21;21(9):1381-90. Erratum in: Oncogene 2002 Mar 14;21(12):1943. PMID: 11857081 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of ubiquilin 1, an mTOR-interacting protein.

Wu S, Mikhailov A, Kallo-Hosein H, Hara K, Yonezawa K, Avruch J.

Biochim Biophys Acta. 2002 Jan 30;1542(1-3):41-56.PMID: 11853878 [PubMed - indexed for MEDLINE]Related articles

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation.

Tang H, Hornstein E, Stolovich M, Levy G, Livingstone M, Templeton D, Avruch J, Meyuhas O.

Mol Cell Biol. 2001 Dec;21(24):8671-83.PMID: 11713299 [PubMed - indexed for MEDLINE]Related articlesFree article

14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation.

Tzivion G, Avruch J.

J Biol Chem. 2002 Feb 1;277(5):3061-4. Epub 2001 Nov 14. Review. No abstract available. PMID: 11709560 [PubMed - indexed for MEDLINE]Related articlesFree article

The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.

Avruch J, Belham C, Weng Q, Hara K, Yonezawa K.

Prog Mol Subcell Biol. 2001;26:115-54. Review. No abstract available. PMID: 11575164 [PubMed - indexed for MEDLINE]Related articles

Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase.

Belham C, Comb MJ, Avruch J.

Curr Biol. 2001 Aug 7;11(15):1155-67.PMID: 11516946 [PubMed - indexed for MEDLINE]Related articles

Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures.

Lenz G, Gonçalves D, Luo Z, Avruch J, Rodnight R, Neary JT.

J Neurochem. 2001 May;77(4):1001-9.PMID: 11359865 [PubMed - indexed for MEDLINE]Related articles

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.

Kyriakis JM, Avruch J.

Physiol Rev. 2001 Apr;81(2):807-69. Review.PMID: 11274345 [PubMed - indexed for MEDLINE]Related articlesFree article

Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade.

Avruch J, Khokhlatchev A, Kyriakis JM, Luo Z, Tzivion G, Vavvas D, Zhang XF.

Recent Prog Horm Res. 2001;56:127-55. Review.PMID: 11237210 [PubMed - indexed for MEDLINE]Related articlesFree article

Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo.

Tzivion G, Luo ZJ, Avruch J.

J Biol Chem. 2000 Sep 22;275(38):29772-8.PMID: 10887173 [PubMed - indexed for MEDLINE]Related articlesFree article

P(2Y) purinoceptor subtypes recruit different mek activators in astrocytes.

Lenz G, Gottfried C, Luo Z, Avruch J, Rodnight R, Nie WJ, Kang Y, Neary JT.

Br J Pharmacol. 2000 Mar;129(5):927-36.PMID: 10696092 [PubMed - indexed for MEDLINE]Related articlesFree article

Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR.

Yokogami K, Wakisaka S, Avruch J, Reeves SA.

Curr Biol. 2000 Jan 13;10(1):47-50.PMID: 10660304 [PubMed - indexed for MEDLINE]Related articles

Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.

Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR.

J Biol Chem. 1999 Dec 24;274(52):37400-6.PMID: 10601311 [PubMed - indexed for MEDLINE]Related articlesFree article