PubMed

Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells.

Jones TG, Hallgren J, Humbles A, Burwell T, Finkelman FD, Alcaide P, Austen KF, Gurish MF.

J Immunol. 2009 Oct 15;183(8):5251-60. Epub 2009 Sep 25.PMID: 19783672 [PubMed - indexed for MEDLINE]Related articlesFree article

Innate cells and T helper 2 cell immunity in airway inflammation.

Barrett NA, Austen KF.

Immunity. 2009 Sep 18;31(3):425-37. Review.PMID: 19766085 [PubMed - indexed for MEDLINE]Related articles

The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications.

Austen KF, Maekawa A, Kanaoka Y, Boyce JA.

J Allergy Clin Immunol. 2009 Sep;124(3):406-14; quiz 415-6. Epub 2009 Aug 3. Review.PMID: 19647860 [PubMed - indexed for MEDLINE]Related articles

GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4.

Maekawa A, Balestrieri B, Austen KF, Kanaoka Y.

Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11685-90. Epub 2009 Jun 26.PMID: 19561298 [PubMed - indexed for MEDLINE]Related articles

Density functional theory study of the binding of glycine, proline, and hydroxyproline to the hydroxyapatite (0001) and (0110) surfaces.

Almora-Barrios N, Austen KF, de Leeuw NH.

Langmuir. 2009 May 5;25(9):5018-25.PMID: 19397352 [PubMed - indexed for MEDLINE]Related articles

Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.

Barrett NA, Maekawa A, Rahman OM, Austen KF, Kanaoka Y.

J Immunol. 2009 Jan 15;182(2):1119-28.PMID: 19124755 [PubMed - indexed for MEDLINE]Related articles

New tools to support collaboration and virtual organizations.

Frame I, Austen KF, Calleja M, Dove MT, White TO, Wilson DJ.

Philos Transact A Math Phys Eng Sci. 2009 Mar 13;367(1890):1051-6.PMID: 19087936 [PubMed - indexed for MEDLINE]Related articlesFree article

eScience for molecular-scale simulations and the eMinerals project.

Salje EK, Artacho E, Austen KF, Bruin RP, Calleja M, Chappell HF, Chiang GT, Dove MT, Frame I, Goodwin AL, Kleese van Dam K, Marmier A, Parker SC, Pruneda JM, Todorov IT, Trachenko K, Tyer RP, Walker AM, White TO.

Philos Transact A Math Phys Eng Sci. 2009 Mar 13;367(1890):967-85.PMID: 19087935 [PubMed - indexed for MEDLINE]Related articlesFree article

Outbreak of adverse reactions associated with contaminated heparin.

Blossom DB, Kallen AJ, Patel PR, Elward A, Robinson L, Gao G, Langer R, Perkins KM, Jaeger JL, Kurkjian KM, Jones M, Schillie SF, Shehab N, Ketterer D, Venkataraman G, Kishimoto TK, Shriver Z, McMahon AW, Austen KF, Kozlowski S, Srinivasan A, Turabelidze G, Gould CV, Arduino MJ, Sasisekharan R.

N Engl J Med. 2008 Dec 18;359(25):2674-84. Epub 2008 Dec 3.PMID: 19052120 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors.

Maekawa A, Kanaoka Y, Xing W, Austen KF.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16695-700. Epub 2008 Oct 17.PMID: 18931305 [PubMed - indexed for MEDLINE]Related articlesFree article

Contaminated heparin associated with adverse clinical events and activation of the contact system.

Kishimoto TK, Viswanathan K, Ganguly T, Elankumaran S, Smith S, Pelzer K, Lansing JC, Sriranganathan N, Zhao G, Galcheva-Gargova Z, Al-Hakim A, Bailey GS, Fraser B, Roy S, Rogers-Cotrone T, Buhse L, Whary M, Fox J, Nasr M, Dal Pan GJ, Shriver Z, Langer RS, Venkataraman G, Austen KF, Woodcock J, Sasisekharan R.

N Engl J Med. 2008 Jun 5;358(23):2457-67. Epub 2008 Apr 23.PMID: 18434646 [PubMed - indexed for MEDLINE]Related articlesFree article

The cysteinyl leukotrienes: where do they come from? What are they? Where are they going?

Austen KF.

Nat Immunol. 2008 Feb;9(2):113-5.PMID: 18204420 [PubMed - indexed for MEDLINE]Related articles

Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors.

Hallgren J, Jones TG, Abonia JP, Xing W, Humbles A, Austen KF, Gurish MF.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20478-83. Epub 2007 Dec 10.PMID: 18077323 [PubMed - indexed for MEDLINE]Related articlesFree article

Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis.

Zhou JS, Xing W, Friend DS, Austen KF, Katz HR.

J Exp Med. 2007 Nov 26;204(12):2797-802. Epub 2007 Nov 6.PMID: 17998392 [PubMed - indexed for MEDLINE]Related articlesFree article

Doing what I like.

Austen KF.

Annu Rev Immunol. 2008;26:1-28.PMID: 17877459 [PubMed - indexed for MEDLINE]Related articles

Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis.

Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M.

Nature. 2007 Aug 2;448(7153):609-12. Epub 2007 Jul 15.PMID: 17632548 [PubMed - indexed for MEDLINE]Related articles

Additional functions for the cysteinyl leukotrienes recognized through studies of inflammatory processes in null strains.

Austen KF.

Prostaglandins Other Lipid Mediat. 2007 May;83(3):182-7. Epub 2007 Jan 17. Review.PMID: 17481553 [PubMed - indexed for MEDLINE]Related articles

The National Institute of Allergy and Infectious Diseases' Asthma and Allergic Disease Centers: a personal commentary.

Austen KF.

J Allergy Clin Immunol. 2007 Jan;119(1):34-5. Epub 2006 Dec 4.PMID: 17141857 [PubMed - indexed for MEDLINE]Related articles

Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung.

Abonia JP, Hallgren J, Jones T, Shi T, Xu Y, Koni P, Flavell RA, Boyce JA, Austen KF, Gurish MF.

Blood. 2006 Sep 1;108(5):1588-94. Epub 2006 May 2.PMID: 16670268 [PubMed - indexed for MEDLINE]Related articlesFree article

The mast cell and the cysteinyl leukotrienes.

Austen KF.

Novartis Found Symp. 2005;271:166-75; discussion 176-8, 198-9. Review.PMID: 16605134 [PubMed - indexed for MEDLINE]Related articles

Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma.

Adamjee J, Suh YJ, Park HS, Choi JH, Penrose JF, Lam BK, Austen KF, Cazaly AM, Wilson SJ, Sampson AP.

J Pathol. 2006 Jul;209(3):392-9.PMID: 16583357 [PubMed - indexed for MEDLINE]Related articles

Neutrophil-derived leukotriene B4 is required for inflammatory arthritis.

Chen M, Lam BK, Kanaoka Y, Nigrovic PA, Audoly LP, Austen KF, Lee DM.

J Exp Med. 2006 Apr 17;203(4):837-42. Epub 2006 Mar 27.PMID: 16567388 [PubMed - indexed for MEDLINE]Related articlesFree article

Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation.

Kim DC, Hsu FI, Barrett NA, Friend DS, Grenningloh R, Ho IC, Al-Garawi A, Lora JM, Lam BK, Austen KF, Kanaoka Y.

J Immunol. 2006 Apr 1;176(7):4440-8.PMID: 16547282 [PubMed - indexed for MEDLINE]Related articlesFree article

The interaction of dolomite surfaces with metal impurities: a computer simulation study.

Austen KF, Wright K, Slater B, Gale JD.

Phys Chem Chem Phys. 2005 Dec 21;7(24):4150-6. Epub 2005 Oct 17.PMID: 16474881 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis.

Arinobu Y, Iwasaki H, Gurish MF, Mizuno S, Shigematsu H, Ozawa H, Tenen DG, Austen KF, Akashi K.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18105-10. Epub 2005 Dec 5.PMID: 16330751 [PubMed - indexed for MEDLINE]Related articlesFree article

No audible wheezing: nuggets and conundrums from mouse asthma models.

Boyce JA, Austen KF.

J Exp Med. 2005 Jun 20;201(12):1869-73.PMID: 15967817 [PubMed - indexed for MEDLINE]Related articlesFree article

Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle.

Abonia JP, Friend DS, Austen WG Jr, Moore FD Jr, Carroll MC, Chan R, Afnan J, Humbles A, Gerard C, Knight P, Kanaoka Y, Yasuda S, Morokawa N, Austen KF, Stevens RL, Gurish MF.

J Immunol. 2005 Jun 1;174(11):7285-91.PMID: 15905575 [PubMed - indexed for MEDLINE]Related articlesFree article

gp49B1 deficiency is associated with increases in cytokine and chemokine production and severity of proliferative synovitis induced by anti-type II collagen mAb.

Zhou JS, Friend DS, Lee DM, Li L, Austen KF, Katz HR.

Eur J Immunol. 2005 May;35(5):1530-8.PMID: 15827966 [PubMed - indexed for MEDLINE]Related articles

Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2.

Abonia JP, Austen KF, Rollins BJ, Joshi SK, Flavell RA, Kuziel WA, Koni PA, Gurish MF.

Blood. 2005 Jun 1;105(11):4308-13. Epub 2005 Feb 10.PMID: 15705791 [PubMed - indexed for MEDLINE]Related articlesFree article

Human leukotriene C(4) synthase at 4.5 A resolution in projection.

Schmidt-Krey I, Kanaoka Y, Mills DJ, Irikura D, Haase W, Lam BK, Austen KF, Kühlbrandt W.

Structure. 2004 Nov;12(11):2009-14.PMID: 15530365 [PubMed - indexed for MEDLINE]Related articles

Acceptance of the Kober Medal: It only gets better.

Austen KF.

J Clin Invest. 2004 Oct;114(8):1177. No abstract available. PMID: 15489967 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice.

Beller TC, Maekawa A, Friend DS, Austen KF, Kanaoka Y.

J Biol Chem. 2004 Oct 29;279(44):46129-34. Epub 2004 Aug 24.PMID: 15328359 [PubMed - indexed for MEDLINE]Related articlesFree article

Lysophosphatidic acid accelerates the development of human mast cells.

Bagga S, Price KS, Lin DA, Friend DS, Austen KF, Boyce JA.

Blood. 2004 Dec 15;104(13):4080-7. Epub 2004 Aug 19.PMID: 15319282 [PubMed - indexed for MEDLINE]Related articlesFree article

Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition.

Sloane DE, Tedla N, Awoniyi M, Macglashan DW Jr, Borges L, Austen KF, Arm JP.

Blood. 2004 Nov 1;104(9):2832-9. Epub 2004 Jul 8.PMID: 15242876 [PubMed - indexed for MEDLINE]Related articlesFree article

Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis.

Beller TC, Friend DS, Maekawa A, Lam BK, Austen KF, Kanaoka Y.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3047-52. Epub 2004 Feb 17.PMID: 14970333 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils.

Zhou JS, Friend DS, Feldweg AM, Daheshia M, Li L, Austen KF, Katz HR.

J Exp Med. 2003 Oct 20;198(8):1243-51. Epub 2003 Oct 13.PMID: 14557414 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R.

Mellor EA, Frank N, Soler D, Hodge MR, Lora JM, Austen KF, Boyce JA.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11589-93. Epub 2003 Sep 17.PMID: 13679572 [PubMed - indexed for MEDLINE]Related articlesFree article

gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo.

Feldweg AM, Friend DS, Zhou JS, Kanaoka Y, Daheshia M, Li L, Austen KF, Katz HR.

Eur J Immunol. 2003 Aug;33(8):2262-8.PMID: 12884301 [PubMed - indexed for MEDLINE]Related articles

Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes.

Lam BK, Austen KF.

Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:511-20. Review.PMID: 12432940 [PubMed - indexed for MEDLINE]Related articles

Leukotriene receptors and aspirin sensitivity.

Arm JP, Austen KF.

N Engl J Med. 2002 Nov 7;347(19):1524-6. No abstract available. PMID: 12421897 [PubMed - indexed for MEDLINE]Related articles

CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis.

Gurish MF, Humbles A, Tao H, Finkelstein S, Boyce JA, Gerard C, Friend DS, Austen KF.

J Immunol. 2002 Jun 1;168(11):5730-6. Erratum in: J Immunol 2002 Oct 1;169(7):4054. J Immunol 2002 Sep 1;169(5):2797. PMID: 12023373 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses.

Maekawa A, Austen KF, Kanaoka Y.

J Biol Chem. 2002 Jun 7;277(23):20820-4. Epub 2002 Apr 3.PMID: 11932261 [PubMed - indexed for MEDLINE]Related articlesFree article

Mastocytosis: mediator-related signs and symptoms.

Castells M, Austen KF.

Int Arch Allergy Immunol. 2002 Feb;127(2):147-52. Review.PMID: 11919427 [PubMed - indexed for MEDLINE]Related articles

Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists.

Mellor EA, Austen KF, Boyce JA.

J Exp Med. 2002 Mar 4;195(5):583-92.PMID: 11877481 [PubMed - indexed for MEDLINE]Related articlesFree article

Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics.

Seymour ML, Rak S, Aberg D, Riise GC, Penrose JF, Kanaoka Y, Austen KF, Holgate ST, Sampson AP.

Am J Respir Crit Care Med. 2001 Dec 1;164(11):2051-6.PMID: 11739134 [PubMed - indexed for MEDLINE]Related articlesFree article

Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing.

Gurish MF, Tao H, Abonia JP, Arya A, Friend DS, Parker CM, Austen KF.

J Exp Med. 2001 Nov 5;194(9):1243-52.PMID: 11696590 [PubMed - indexed for MEDLINE]Related articlesFree article

Mast cell mediation of muscle and pulmonary injury following hindlimb ischemia-reperfusion.

Mukundan C, Gurish MF, Austen KF, Hechtman HB, Friend DS.

J Histochem Cytochem. 2001 Aug;49(8):1055-6.PMID: 11457933 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice.

Daheshia M, Friend DS, Grusby MJ, Austen KF, Katz HR.

J Exp Med. 2001 Jul 16;194(2):227-34.PMID: 11457897 [PubMed - indexed for MEDLINE]Related articlesFree article

Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells.

Mellor EA, Maekawa A, Austen KF, Boyce JA.

Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7964-9.PMID: 11438743 [PubMed - indexed for MEDLINE]Related articlesFree article

The diverse roles of mast cells.

Gurish MF, Austen KF.

J Exp Med. 2001 Jul 2;194(1):F1-5. Review. No abstract available. PMID: 11435478 [PubMed - indexed for MEDLINE]Related articlesFree article