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Prognostic role of pre-treatment serum AFP-L3% in hepatocellular carcinoma: systematic review and meta-analysis.
Cheng J, Wang W, Zhang Y, Liu X, Li M, Wu Z, Liu Z, Lv Y, Wang B. Cheng J, et al. PLoS One. 2014 Jan 30;9(1):e87011. doi: 10.1371/journal.pone.0087011. eCollection 2014. PLoS One. 2014. PMID: 24498011 Free PMC article. Review.
However, the prognostic value of high pre-treatment serum AFP-L3% in patients with hepatocellular carcinoma (HCC) remains controversial. ...CONCLUSION: The current evidence suggests that high pre-treatment serum AFP-L3% levels indicated a poor prognosi …
However, the prognostic value of high pre-treatment serum AFP-L3% in patients with hepatocellular carcinoma (HCC) remains cont …
A meta-analysis and of clinical values of 11 blood biomarkers, such as AFP, DCP, and GP73 for diagnosis of hepatocellular carcinoma.
Pang BY, Leng Y, Wang X, Wang YQ, Jiang LH. Pang BY, et al. Ann Med. 2023 Dec;55(1):42-61. doi: 10.1080/07853890.2022.2153163. Ann Med. 2023. PMID: 36476015 Free PMC article.
The AUC and sum of sensitivity and specificity of the combination of AFP and other biomarkers were all significantly higher than that of AFP, including AFP + AFP-L3 + DCP, AFP + DCP, AFP/DCP, AFP + GPC3. Among other biomarkers, the AUC and sum of sensitivity and spe …
The AUC and sum of sensitivity and specificity of the combination of AFP and other biomarkers were all significantly higher than that of AFP …
Evaluation of the Combined Application of AFP, AFP-L3%, and DCP for Hepatocellular Carcinoma Diagnosis: A Meta-analysis.
Wang X, Zhang Y, Yang N, He H, Tao X, Kou C, Jiang J. Wang X, et al. Biomed Res Int. 2020 Sep 17;2020:5087643. doi: 10.1155/2020/5087643. eCollection 2020. Biomed Res Int. 2020. PMID: 33015170 Free PMC article.
Subgroup analysis showed that the pooled sensitivity and specificity of AFP+AFP-L3%+DCP in the diagnosis of HCC versus cirrhosis patients were 0.81 and 0.82, respectively. In conclusion, the combination of AFP, AFP-L3%, and DCP may prove to be useful i …
Subgroup analysis showed that the pooled sensitivity and specificity of AFP+AFP-L3%+DCP in the diagnosis of HCC versus cirrhos …
Do combined assays of serum AFP, AFP-L3, DCP, GP73, and DKK-1 efficiently improve the clinical values of biomarkers in decision-making for hepatocellular carcinoma? A meta-analysis.
Fang YS, Wu Q, Zhao HC, Zhou Y, Ye L, Liu SS, Li XX, Du WD. Fang YS, et al. Expert Rev Gastroenterol Hepatol. 2021 Sep;15(9):1065-1076. doi: 10.1080/17474124.2021.1900731. Epub 2021 Mar 18. Expert Rev Gastroenterol Hepatol. 2021. PMID: 33691550
Importantly, the sum of sensitivity and specificity of AFP+GP73 was 1.76 (P= 0.0001), which was the best among all the panels. The sum of the triple biomarker panel of AFP, AFP-L3, and DCP was larger (1.64, P= 0.0001) than those of any double biomarker panels of AFP …
Importantly, the sum of sensitivity and specificity of AFP+GP73 was 1.76 (P= 0.0001), which was the best among all the panels. The sum of th …
Performance of GALAD score and serum biomarkers for detecting NAFLD-related HCC: a systematic review and network meta-analysis.
Li H, Liu H, Yan LJ, Ding ZN, Zhang X, Pan GQ, Han CL, Tian BW, Tan SY, Dong ZR, Wang DX, Yan YC, Li T. Li H, et al. Expert Rev Gastroenterol Hepatol. 2023 Jul-Dec;17(11):1159-1167. doi: 10.1080/17474124.2023.2279175. Epub 2023 Nov 23. Expert Rev Gastroenterol Hepatol. 2023. PMID: 37929312 Review.
We aimed to assess the performance of alpha-fetoprotein (AFP), AFP-L3, des-gamma-carboxy prothrombin (DCP), and GALAD score in detecting NAFLD-related HCC. ...In detecting all-stage NAFLD-related HCC, GALAD score (sensitivity = 0.87; YI = 0.77) performed better than …
We aimed to assess the performance of alpha-fetoprotein (AFP), AFP-L3, des-gamma-carboxy prothrombin (DCP), and GALAD score in …
Alpha-fetoprotein-L3 in hepatocellular carcinoma: a meta-analysis.
Yi X, Yu S, Bao Y. Yi X, et al. Clin Chim Acta. 2013 Oct 21;425:212-20. doi: 10.1016/j.cca.2013.08.005. Epub 2013 Aug 13. Clin Chim Acta. 2013. PMID: 23954771 Review.
The percentage of lens culinaris agglutinin-reactive alpha-fetoprotein (AFP-L3%) has long been proposed as a marker for HCC, but has not been widely adopted due to inconsistent results reported in the literature. ...CONCLUSIONS: AFP-L3% could be comple …
The percentage of lens culinaris agglutinin-reactive alpha-fetoprotein (AFP-L3%) has long been proposed as a marker for HCC, b …
Diagnostic accuracy of tumor markers for hepatocellular carcinoma: a systematic review.
Tateishi R, Yoshida H, Matsuyama Y, Mine N, Kondo Y, Omata M. Tateishi R, et al. Hepatol Int. 2008 Mar;2(1):17-30. doi: 10.1007/s12072-007-9038-x. Epub 2007 Dec 29. Hepatol Int. 2008. PMID: 19669276 Free PMC article.
Results Seventeen articles on three tumor markers-AFP, des-gamma-carboxyprothrombin (DCP), and Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3)-were enrolled after full-text evaluation. AFP was inferior to DCP and AFP-L3 in both DOR (4.50 vs …
Results Seventeen articles on three tumor markers-AFP, des-gamma-carboxyprothrombin (DCP), and Lens culinaris agglutinin-reactive fraction o …