PubMed

Drug Burden Index and physical function in older Australian men.

Gnjidic D, Cumming RG, Le Couteur DG, Handelsman DJ, Naganathan V, Abernethy DR, Hilmer SN.

Br J Clin Pharmacol. 2009 Jul;68(1):97-105.PMID: 19660007 [PubMed - in process]Related articles

Change in criteria for USP dissolution performance verification tests.

Hauck WW, DeStefano AJ, Brown WE, Stippler ES, Abernethy DR, Koch WF, Williams RL.

AAPS PharmSciTech. 2009;10(1):21-6. Epub 2009 Jan 9.PMID: 19132536 [PubMed - indexed for MEDLINE]Related articles

Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes.

Woo AY, Wang TB, Zeng X, Zhu W, Abernethy DR, Wainer IW, Xiao RP.

Mol Pharmacol. 2009 Jan;75(1):158-65. Epub 2008 Oct 7.PMID: 18838481 [PubMed - indexed for MEDLINE]Related articlesFree article

Measures of drug toxicity in older adults.

Hilmer SN, Abernethy DR.

Arch Intern Med. 2008 Sep 22;168(17):1930-1; author reply 1931-2. No abstract available. PMID: 18809825 [PubMed - indexed for MEDLINE]Related articles

Metrologic approaches to setting acceptance criteria: unacceptable and unusual characteristics.

Hauck WW, Abernethy DR, Williams RL.

J Pharm Biomed Anal. 2008 Nov 4;48(3):1042-5. Epub 2008 Aug 9.PMID: 18801635 [PubMed - indexed for MEDLINE]Related articles

Finding the right research question: quality science depends on quality careers.

Flockhart DA, Abernethy DR.

Clin Pharmacol Ther. 2008 Sep;84(3):427-9. Epub 2008 Jul 9.PMID: 18615005 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum protein signatures detect early radiographic osteoarthritis.

Ling SM, Patel DD, Garnero P, Zhan M, Vaduganathan M, Muller D, Taub D, Bathon JM, Hochberg M, Abernethy DR, Metter EJ, Ferrucci L.

Osteoarthritis Cartilage. 2009 Jan;17(1):43-8. Epub 2008 Jun 20.PMID: 18571442 [PubMed - indexed for MEDLINE]Related articles

Adulteration of drugs and foods: compendial approaches to lowering risk.

Abernethy DR, Sheehan C, Griffiths JC, Williams RL; United States Pharmacopeial Convention Council of Experts Excipients and Food Ingredient Expert Committees.

Clin Pharmacol Ther. 2009 Apr;85(4):444-7. Epub 2008 May 7. Review. No abstract available. PMID: 18463621 [PubMed - indexed for MEDLINE]Related articles

Using Medicare administrative data to conduct postmarketing surveillance of follow-on biologics: issues and opportunities.

DiMartino LD, Curtis LH, Williams RL, Abernethy DR, Schulman KA.

Food Drug Law J. 2008;63(4):891-900. No abstract available. PMID: 19601387 [PubMed - indexed for MEDLINE]Related articles

Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women.

Cao YJ, Mager DE, Simonsick EM, Hilmer SN, Ling SM, Windham BG, Crentsil V, Yasar S, Fried LP, Abernethy DR.

Clin Pharmacol Ther. 2008 Mar;83(3):422-9. Epub 2007 Aug 22.PMID: 17713474 [PubMed - indexed for MEDLINE]Related articles

Analysis of functional signaling domains from fluorescence imaging and the two-dimensional continuous wavelet transform.

Mager DE, Kobrinsky E, Masoudieh A, Maltsev A, Abernethy DR, Soldatov NM.

Biophys J. 2007 Oct 15;93(8):2900-10. Epub 2007 Jun 22.PMID: 17586569 [PubMed - indexed for MEDLINE]Related articlesFree article

Electromyographic patterns suggest changes in motor unit physiology associated with early osteoarthritis of the knee.

Ling SM, Conwit RA, Talbot L, Shermack M, Wood JE, Dredge EM, Weeks MJ, Abernethy DR, Metter EJ.

Osteoarthritis Cartilage. 2007 Oct;15(10):1134-40. Epub 2007 May 31.PMID: 17543548 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.

Jozwiak K, Khalid C, Tanga MJ, Berzetei-Gurske I, Jimenez L, Kozocas JA, Woo A, Zhu W, Xiao RP, Abernethy DR, Wainer IW.

J Med Chem. 2007 Jun 14;50(12):2903-15. Epub 2007 May 17.PMID: 17506540 [PubMed - indexed for MEDLINE]Related articles

A drug burden index to define the functional burden of medications in older people.

Hilmer SN, Mager DE, Simonsick EM, Cao Y, Ling SM, Windham BG, Harris TB, Hanlon JT, Rubin SM, Shorr RI, Bauer DC, Abernethy DR.

Arch Intern Med. 2007 Apr 23;167(8):781-7.PMID: 17452540 [PubMed - indexed for MEDLINE]Related articlesFree article

Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid.

Jamieson HA, Hilmer SN, Cogger VC, Warren A, Cheluvappa R, Abernethy DR, Everitt AV, Fraser R, de Cabo R, Le Couteur DG.

Exp Gerontol. 2007 Apr;42(4):374-8. Epub 2007 Jan 3.PMID: 17204388 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of wavelet and fast Fourier transforms in pharmacodynamics.

Mager DE, Abernethy DR.

J Pharmacol Exp Ther. 2007 May;321(2):423-30. Epub 2006 Dec 1. Review.PMID: 17142645 [PubMed - indexed for MEDLINE]Related articlesFree article

Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit.

Tiwari S, Zhang Y, Heller J, Abernethy DR, Soldatov NM.

Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):17024-9. Epub 2006 Oct 27.PMID: 17071743 [PubMed - indexed for MEDLINE]Related articlesFree article

Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol.

Beigi F, Bertucci C, Zhu W, Chakir K, Wainer IW, Xiao RP, Abernethy DR.

Chirality. 2006 Nov;18(10):822-7.PMID: 16917835 [PubMed - indexed for MEDLINE]Related articles

Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats.

Mager DE, Wan R, Brown M, Cheng A, Wareski P, Abernethy DR, Mattson MP.

FASEB J. 2006 Apr;20(6):631-7.PMID: 16581971 [PubMed - indexed for MEDLINE]Related articlesFree article

Mapping the dose-effect relationship of orbofiban from sparse data with an artificial neural network.

Mager DE, Shirey JD, Cox D, Fitzgerald DJ, Abernethy DR.

J Pharm Sci. 2005 Nov;94(11):2475-86.PMID: 16200613 [PubMed - indexed for MEDLINE]Related articles

Identification of plasma membrane macro- and microdomains from wavelet analysis of FRET microscopy.

Kobrinsky E, Mager DE, Bentil SA, Murata S, Abernethy DR, Soldatov NM.

Biophys J. 2005 May;88(5):3625-34. Epub 2005 Feb 18.PMID: 15722423 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions.

Kobrinsky E, Tiwari S, Maltsev VA, Harry JB, Lakatta E, Abernethy DR, Soldatov NM.

J Biol Chem. 2005 Apr 1;280(13):12474-85. Epub 2005 Jan 25.PMID: 15671035 [PubMed - indexed for MEDLINE]Related articlesFree article

New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel.

Harry JB, Kobrinsky E, Abernethy DR, Soldatov NM.

J Biol Chem. 2004 Nov 5;279(45):46367-72. Epub 2004 Aug 31.PMID: 15339916 [PubMed - indexed for MEDLINE]Related articlesFree article

Voltage-gated rearrangements associated with differential beta-subunit modulation of the L-type Ca(2+) channel inactivation.

Kobrinsky E, Kepplinger KJ, Yu A, Harry JB, Kahr H, Romanin C, Abernethy DR, Soldatov NM.

Biophys J. 2004 Aug;87(2):844-57.PMID: 15298893 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique.

Mager DE, Abernethy DR, Egan JM, Elahi D.

J Pharmacol Exp Ther. 2004 Nov;311(2):830-5. Epub 2004 Jun 15.PMID: 15199095 [PubMed - indexed for MEDLINE]Related articlesFree article

Kullback-Leibler clustering of continuous wavelet transform measures of heart rate variability.

Mager DE, Merritt MM, Kasturi J, Witkin LR, Urdiqui-Macdonald M, Sollers JJ 3rd, Evans MK, Zonderman AB, Abernethy DR, Thayer JF.

Biomed Sci Instrum. 2004;40:337-42.PMID: 15133981 [PubMed - indexed for MEDLINE]Related articles

Abciximab pharmacodynamic model with neural networks used to integrate sources of patient variability.

Urquidi-Macdonald M, Mager DE, Mascelli MA, Frederick B, Freedman J, Fitzgerald DJ, Kleiman NS, Abernethy DR.

Clin Pharmacol Ther. 2004 Jan;75(1):60-9.PMID: 14749692 [PubMed - indexed for MEDLINE]Related articles

Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans.

Thayer JF, Merritt MM, Sollers JJ 3rd, Zonderman AB, Evans MK, Yie S, Abernethy DR.

Am J Cardiol. 2003 Dec 15;92(12):1487-90.PMID: 14675596 [PubMed - indexed for MEDLINE]Related articles

Simultaneous modeling of abciximab plasma concentrations and ex vivo pharmacodynamics in patients undergoing coronary angioplasty.

Mager DE, Mascelli MA, Kleiman NS, Fitzgerald DJ, Abernethy DR.

J Pharmacol Exp Ther. 2003 Dec;307(3):969-76. Epub 2003 Oct 8.PMID: 14534354 [PubMed - indexed for MEDLINE]Related articlesFree article

Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction.

Nagababu E, Ramasamy S, Abernethy DR, Rifkind JM.

J Biol Chem. 2003 Nov 21;278(47):46349-56. Epub 2003 Sep 2.PMID: 12952953 [PubMed - indexed for MEDLINE]Related articlesFree article

Voltage-gated mobility of the Ca2+ channel cytoplasmic tails and its regulatory role.

Kobrinsky E, Schwartz E, Abernethy DR, Soldatov NM.

J Biol Chem. 2003 Feb 14;278(7):5021-8. Epub 2002 Dec 6.PMID: 12473653 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol.

Tanus-Santos JE, Desai M, Deak LR, Pezzullo JC, Abernethy DR, Flockhart DA, Freedman JE.

Pharmacogenetics. 2002 Jul;12(5):407-13.PMID: 12142730 [PubMed - indexed for MEDLINE]Related articles

Pharmacodynamics of abciximab during angioplasty: comparison to healthy subjects.

Abernethy DR, Pezzullo J, Mascelli MA, Frederick B, Kleiman NS, Freedman J.

Clin Pharmacol Ther. 2002 Mar;71(3):186-95.PMID: 11907493 [PubMed - indexed for MEDLINE]Related articles

Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets.

Abernethy DR, Soldatov NM.

J Pharmacol Exp Ther. 2002 Mar;300(3):724-8. Review.PMID: 11861774 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacodynamic profile of short-term readministration of abciximab in healthy subjects.

Freedman J, Mascelli MA, Pezzullo JC, Barnathan ES, Frederick B, Jordan RE, Abernethy DR.

Am Heart J. 2002 Jan;143(1):87-94.PMID: 11773917 [PubMed - indexed for MEDLINE]Related articles

Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation.

Abernethy DR, Wesche DL, Barbey JT, Ohrt C, Mohanty S, Pezzullo JC, Schuster BG.

Br J Clin Pharmacol. 2001 Mar;51(3):231-7.PMID: 11298069 [PubMed - indexed for MEDLINE]Related articlesFree article

Loratadine and terfenadine interaction with nefazodone: Both antihistamines are associated with QTc prolongation.

Abernethy DR, Barbey JT, Franc J, Brown KS, Feirrera I, Ford N, Salazar DE.

Clin Pharmacol Ther. 2001 Mar;69(3):96-103.PMID: 11240972 [PubMed - indexed for MEDLINE]Related articles

Ca(2+) sensors of L-type Ca(2+) channel.

Romanin C, Gamsjaeger R, Kahr H, Schaufler D, Carlson O, Abernethy DR, Soldatov NM.

FEBS Lett. 2000 Dec 29;487(2):301-6.PMID: 11150529 [PubMed - indexed for MEDLINE]Related articles

New molecular determinant for inactivation of the human L-type alpha1C Ca2+ channel.

Soldatov NM, Zhenochin S, AlBanna B, Abernethy DR, Morad M.

J Membr Biol. 2000 Sep 15;177(2):129-35.PMID: 11003687 [PubMed - indexed for MEDLINE]Related articles

Verapamil metabolite exposure in older and younger men during steady-state oral verapamil administration.

Abernethy DR, Wainer IW, Anacleto AI.

Drug Metab Dispos. 2000 Jul;28(7):760-5.PMID: 10859149 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular basis of cardiovascular drug metabolism: implications for predicting clinically important drug interactions.

Abernethy DR, Flockhart DA.

Circulation. 2000 Apr 11;101(14):1749-53. Review. No abstract available. PMID: 10758060 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment and reporting of clinical pharmacology information in drug labeling.

Spyker DA, Harvey ED, Harvey BE, Harvey AM, Rumack BH, Peck CC, Atkinson AJ Jr, Woosley RL, Abernethy DR, Cantilena LR.

Clin Pharmacol Ther. 2000 Mar;67(3):196-200. No abstract available. PMID: 10741621 [PubMed - indexed for MEDLINE]Related articles

A pharmacokinetic and pharmacodynamic study of the potential drug interaction between tasosartan and atenolol in patients with stage 1 and 2 essential hypertension.

Andrawis NS, Battle MM, Klamerus KJ, Burghart PH, Neefe L, Weinryb I, Mayer P, Abernethy DR.

J Clin Pharmacol. 2000 Mar;40(3):231-41.PMID: 10709151 [PubMed - indexed for MEDLINE]Related articles

Aging is associated with endothelial dysfunction in the human forearm vasculature.

Andrawis N, Jones DS, Abernethy DR.

J Am Geriatr Soc. 2000 Feb;48(2):193-8.PMID: 10682949 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics and clinical effectiveness of methylphenidate.

Kimko HC, Cross JT, Abernethy DR.

Clin Pharmacokinet. 1999 Dec;37(6):457-70. Review.PMID: 10628897 [PubMed - indexed for MEDLINE]Related articles

Ticlopidine inhibits phenytoin clearance.

Donahue S, Flockhart DA, Abernethy DR.

Clin Pharmacol Ther. 1999 Dec;66(6):563-8.PMID: 10613611 [PubMed - indexed for MEDLINE]Related articles

Calcium-antagonist drugs.

Abernethy DR, Schwartz JB.

N Engl J Med. 1999 Nov 4;341(19):1447-57. Review. No abstract available. PMID: 10547409 [PubMed - indexed for MEDLINE]Related articles

Aging effects on drug disposition and effect.

Abernethy DR.

Geriatr Nephrol Urol. 1999;9(1):15-9. Review.PMID: 10435223 [PubMed - indexed for MEDLINE]Related articles

Regulating manufacturer-affiliated communication in the information age.

Schulman KA, Abernethy DR, Rathore SS, Woosley RL.

Clin Pharmacol Ther. 1999 Jun;65(6):593-7. No abstract available. PMID: 10391664 [PubMed - indexed for MEDLINE]Related articles

Impaired endothelial-dependent forearm vascular relaxation in black Americans.

Jones DS, Andrawis NS, Abernethy DR.

Clin Pharmacol Ther. 1999 Apr;65(4):408-12.PMID: 10223778 [PubMed - indexed for MEDLINE]Related articles